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Feasibility and Stability of a Kind of Model Predictive Control with Additive Uncertainties

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Communications in Mathematical Research 2009年第4期25卷 299-308页

作者： LI jun-ling zhang SHU-GONG Institute of Mathematics Jilin University Changchun 130012

In this paper the feasibility and stability of open-loop rain-max model predictive control （OL-MMMPC） for systems with additive bounded uncertainties are considered. It is found that the OL-MMMPC may be infeasible and unstable if it is initially feasible. A sufficient condition for feasibility and stability of the OL- MMMPC is presented. Then an improved OL-MMMPC algorithm is proposed, which guarantees the robust stability of the closed-loop system once it is initially feasible. The effectiveness of this algorithm is illustrated by a simulation example.

关键词： additive bounded uncertainty predictive control feasibility stability

Therapeutic effects of mesenchymal stem cells administered at later phase of recurrent experimental autoimmune uveitis

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1381-1389页

作者： Ping-Ting Zhao ling-jun zhang Hui Shao ling-ling Bai Bo Yu Chang Su Li-Jie Dong Xun Liu Xiao-Rong Li Xiao-Min zhang Eye Institute & School of Optometry and Ophthalmology Tianjin Medical University Eye Hospital Department of Ophthalmology and Visual Sciences Kentucky Lions Eye CenterUniversity of Louisville

AIM：To test the therapeutic effects of delayed treatment of mesenchymal stem cells（MSCs） in recurrent experimental autoimmune uveitis（r EAU）.METHODS： The efficacy of different regimens of MSC administration in r EAU were tested by evaluation of clinical and pathological intraocular inflammation,as well as retinal structural and functional integrity using optical coherence tomography（OCT） and electroretinogram（ERG）.The retinal sections were also immunostained with antibodies to glial fibrillary acidic protein（GFAP）and rhodopsin（RHO）. RESULTS： Delayed treatment of MSCs effectively alleviated the severity of intraocular inflammation with relative intact of outer retinal structure and ***,double therapies with longer interval led to an even better clinical evaluation,as well as a trend of decrease in relapse and amelioration of retinal *** therapies also effectively reduced GFAP expression and increased RHO expression in the ***： MSC administration can effectively treat developed diseases of rEAU,and multiple therapies can provide additional therapeutic benefits.

关键词： mesenchymal stem cells recurrent experimental autoimmune uveitis electroretinogram optical coherence tomography

FGFR2-TSC22D1,a novel FGFR2 fusion gene identified in a patient with colorectal cancer:A case report

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World Journal of Clinical Cases 2021年第23期9卷 6867-6871页

作者： Xiao-Ming Kao Xi Zhu jun-ling zhang Shi-Qing Chen Chao-Gang Fan Research Institure of General Surgery Jinling HospitalNanjing 210002Jiangsu ProvinceChina Department of Medical 3D Medicines Inc.Shanghai 201114China Department of General Surgery The Affiliated BenQ Hospital of Nanjing Medical UniversityNanjing 210002Jiangsu ProvinceChina

BACKGROUND The FGFR signaling pathway is activated in multiple tumor types through gene amplifications,single base substitutions,or gene *** FGFR gene fusions may represent candidate targets for the development of tyrosine kinase *** SUMMARY Herein,we report a patient with colorectal cancer(CRC)harboring a novel FGFR2 fusion gene.A 59-year-old man felt discomfort in his right upper abdomen with loss of appetite for 6 *** abdominal computed tomography scan revealed the existence of a space-occupying lesion in the ascending *** pathological diagnosis was a poorly differentiated *** biopsy specimen was subjected to next-generation sequencing analysis,and a novel FGFR2-TSC22D1 fusion with complete kinase structure of FGFR2 protein was *** We report the first case of CRC harboring FGFR2-TSC22D1,which enriches the FGFR2 fusion ***2 inhibitors might be effective in the later treatment for this patient.

关键词： FGFR2-TSC22D1 Colorectal cancer Next-generation sequencing Case report

Efficacy of afatinib in a patient with rare EGFR(G724S/R776H)mutations and amplification in lung adenocarcinoma:A case report

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World Journal of Clinical Cases 2021年第6期9卷 1329-1335页

作者： Shu-Yan He Qing-Feng Lin Jie Chen Gui-Ping Yu jun-ling zhang Dong Shen Department of Medical Oncology The Jiangyin Clinical College of Xuzhou Medical UniversityJiangyin 214400Jiangsu ProvinceChina Department of Cardiothoracic Surgery The Affiliated Jiangyin Hospital of Southeast UniversityJiangyin 214400Jiangsu ProvinceChina Medical Department 3D Medicines Inc.Shanghai 201114China

BACKGROUND The most common EGFR mutations are in-frame deletions in exon 19 and point mutations in exon *** with classical EGFR mutations show a good response to EGFR tyrosine kinase inhibitors(TKIs),the standard first-line *** the development of next generation sequencing,some uncommon genomic mutations have been ***,the effect of TKIs on such uncommon EGFR mutations remains *** SUMMARY Here,we report a case of rare EGFR co-mutation in non-small cell lung cancer and the efficacy of afatinib on this EGFR co-mutation.A 64-year-old woman was diagnosed with thoracolumbar and bilateral local rib bone metastases,bilateral pulmonary nodules,and pericardial and left pleural *** pathological diagnosis was lung *** seek potential therapeutic regimens,rare co-mutation comprising rare EGFR G724S/R776H mutations and amplification were *** patient experienced a significant clinical response with a progression-free survival of 17 *** A case of non-small cell lung cancer with rare EGFR G724S/R776H mutations and EGFR amplification responds well to TKI treatment.

关键词： EGFR G724S and R776H Afatinib Non-small cell lung cancer Case report

Boron-doped three-dimensional MXene host for durable lithium-metal anode

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Rare Metals 2022年第7期41卷 2217-2222页

作者： Na Wu Qi-Yue zhang Yu-Jie Guo Lu Zhou ling-jun zhang Ming-Xing Wu Wen-Peng Wang Ya-Xia Yin Peng Sheng Sen Xin Key Laboratory of Inorganic Nanomaterials of Hebei Province College of Chemistry and Material ScienceHebei Normal UniversityShijiazhuang 050024China CAS Key Laboratory of Molecular Nanostructure and Nanotechnology Beijing National Laboratory for Molecular Sciences(BNLMs)CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China Material Laboratory of State Grid Corporation of China State Key Laboratory of Advanced Transmission TechnologyGlobal Energy Interconnection Research Institute Co.Ltd.Beijing 102209China

Lithium metal has been widely studied as one of the most promising anode materials for realizing the next-generation high-energy-density rechargeable ***,its practical use in rechargeable batteries has been hindered by hazardous dendrite growth and huge volume variations during Li plating/***,we reported a borondoped three-dimensional(3D)layered MXene(Ti_(3)C_(2)T_(x))as the host of Li metal *** material was synthesized via a facile one-pot hydrothermal *** uniform B-doping,the prepared 3D multilayered MXene sheets provided more sites for nucleation of Li metal,so that the deposited Li metal anode showed favorable cycling stability and a high Coulombic *** the use of the same host material,a hybrid lithium-metal battery with 3D Li anode coupling with LiFePO4 cathode showed long cycle life and favorable electrochemical *** work shed lights on reasonable structural and compositional design of host materials that enables high-performance Li-metal anode toward practical realization of highenergy rechargeable batteries。

关键词： battery lithium MXene

Synthesis of highly concentrated,carrier free ^(188)Re-mercaptoacetyltriglycine

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Nuclear Science and Techniques 2002年第4期13卷 237-243页

作者： zhang Xiu-Li, WANG Yong-Xian, LI jun-ling, zhang Chun-Fu, WANG Li-Hua,YIN Duan-Zhi(Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800) Shanghai Institute of Nuclear Research the Chinese Academy of Sciences 201800

Chelation of 188Re to compounds such as MAG3 will further reduce the radiation dose to the patient in case of balloon rupture through the rapid excretion from the body. In order to prepare highly concentrated, carrier free 188Re-MAG3, Sbenzoyl mercaptoacetyltriglycine (S-Bz-MAG3) was synthesized, labeled with carrier free 188Re. The overall yield of S-Bz-MAG3 is higher than those published in theliterature. Dependence of the labeling yield of 1ssRe-MAG3 upon concentrations of reducing agent, pH, reaction time, etc. was examined and optimum conditions were confirmed. The concentration procedure was succeeded with Sep-Pak C18 cartridge to obtain highly concentrated 1s8Re-MAG3. In the case of optimun conditions, the labeling yield of 188Re-MAG3 was more than 98%. Radiochemical purity of 188ReMAG3 was more than 92% after 24 hour storage at room temperature.

关键词：放射同位素 ^188Re 放射免疫疗法

Anti-intlammatory effect of cholecystokinin ana its signal transduction mechanism in endotoxic shock rat

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World Journal of Gastroenterology 2002年第4期8卷 712-717页

作者： Ai-Hong Meng Yi-ling ling jun-Lan zhang Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017,Hebei Province,China Xiao-Peng zhang Department of Cardiothoracic Surgery,Hebei Provincial People’s Hospital,Shijiazhuang 050071,Hebei Province,China

AIM: To study the anti-inflammatory effects ofcholecystokinin-octapeptide (CCK-8) onlipopolysaccharide (LPS)-induced endotoxic shock (ES)and further investigate its signal transduction pathwaysinvolving p38 mitogen-activated protein kinase (MAPK)METHODS: Eighty-four rats were divided randomly intofour groups: LPS (8 mg @ kg-1, iv) induced ES; CCK-8(40 μg @ kg-1, iv) pretreatment 10 min before LPS (8mg @ kg-1); CCK-8(40 μ g @ kg-1, iv) or normal saline(control) *** inflammatory changes of lung andspleen, phagocytic function of alveolar macrophage,quantification of inflammatory calls in bronchoalveolarlavage (BAL) were investigated in rats by usinghematoxylin and eosin (HE) staining, phagocytosis ofCandida albicans and differential cell counting. Nitricoxide (NO) production in serum, lung and spleen wasmeasured with the Griess reaction. The mechanisminvestigated by Western ***: Inflammatory changes of lung and spleeninduced by LPS were alleviated by CCK-8, the increaseof NO induced by LPS in serum, lung and spleen wassignificantly inhibited and the neutrophil infiltration inBAL was significantly reduced by CCK-8. The numberof neutrophils was (52±10)× 106 cells. L-1 in LPS group,while it decreased to (18±4)×106 cells@ L-1 in CCK-8+LPS (P＜0.01). The phagocytic rate of CCK-8 groupincreased to (62.49±9.49) %, compared with controlgroup (48.16±14.20) %, P＜0.05. The phagocytosisrate was (85.14±4.64) % in LPS group, which reducedto (59.33±3.14) % in CCK-8+LPS group (P＜0.01). Theresults of phagocytosis indexes showed similar ***-8 may play an important role in increasing theexpression of p38 MAPK and decreasing the degradation of IκB-αin Iung and spleen of ES ***: CCK-8 can result in anti-inflammatoryeffects, which may be related to activation of p38 MAPK and inhibition on the degradation of IκB-α.

关键词：内毒素性休克缩胆囊素信号转导机制治疗抗炎作用动物实验

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong zhang Zhiying Chen Yinyi Xiong Qin Zhou ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

Effects of enalapril and losartan on cardiac ACE2 expression in hypertensive rats with aortic banding

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Effects of enalapril and losartan on cardiac ACE2 expression...