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World Journal of Psychiatry 2023年第2期13卷 75-83页

作者： Pan Jing Xi Mei Yuan-Yuan Zhang Fei-Jie Zheng Xiao-Min Luo ling-jiang liu Hai-Hang Yu Xiao-Bin Zhang Department of Psychiatric Ningbo Kangning HospitalNingbo 315201Zhejiang ProvinceChina Department of Psychiatry Suzhou Guangji HospitalSuzhou 215003Jiangsu ProvinceChina

BACKGROUND Major depressive disorder(MDD)is the most frequent reason of disabled people in the world,as reported by the World Health ***,the diagnosis of MDD is mainly based on clinical *** SUMMARY The clinical,genetic,and molecular characteristics of two Chinese families with MDD are described in this *** were variable ages of onset and severity in depression among the *** Chinese families had a very low prevalence of *** mitochondrial genomes of these pedigrees were sequenced and indicated a homoplasmic T3394C(Y30H)mutation,with the polymorphism located at a highly conserved tyrosine at position 30 of *** analysis also revealed unique sets of mitochondrial DNA(mtDNA)polymorphisms originating from haplogroups M9a3 and *** This finding of the T3394C mutation in two unrelated depressed patients provides strong evidence that this mutation may have a part in the etiology of ***,In these two Chinese families having the T3394C mutation,no functional mt DNA mutation was ***,T3394C mutations are related with MDD,and the phenotypic manifestation of these mutations may be affected by changes in nuclear genes or environmental factors.

关键词： Major depressive disorder Mitochondrial DNA ND1 Mutation Haplogroup Chinese Case report

Major depressive disorder is associated with mitochondrial ND6 T14502C mutation in two Han Chinese families

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World Journal of Psychiatry 2024年第11期14卷 1746-1754页

作者： Pan Jing Hai-Hang Yu Ting-Ting Wu Bi-Hua Yu Ming Liang Ting-Ting Xia Xue-Wen Xu Ting Xu ling-jiang liu Xiao-Bin Zhang Suzhou Medical College Soochow UniversitySuzhou 215123Jiangsu ProvinceChina Department of Psychiatry Affiliated Kangning Hospital of Ningbo UniversityNingbo Kangning HospitalNingbo 315201Zhejiang ProvinceChina Department of Psychiatry Xiangshan Third People’s HospitalNingbo 315700Zhejiang ProvinceChina Department of Psychiatry Suzhou Guangji HospitalThe Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina

BACKGROUND Globally,the World Health Organization ranks major depressive disorder(MDD)as the leading cause of ***,MDD molecular etiology is still poorly *** To explore the possible association between mitochondrial ND6 T14502C mutation and *** Clinical data were collected from two pedigrees,and detailed mitochondrial genomes were obtained for the two proband *** assessment of the resulting variants included an evaluation of their evolutionary conservation,allelic frequencies,as well as their structural and functional *** mitochondrial whole genome analysis,phylogenetic,and haplotype analysis were performed on the *** Herein,we reported the clinical,genetic,and molecular profiling of two Chinese families afflicted with *** Chinese families exhibited not only a range of onset and severity ages in their depression but also extremely low penetrances to *** analyses of mitochondrial genomes from these pedigrees have resulted in the identification of a homoplasmic T14502C(I58V)*** polymorphism is located at a highly conserved isoleucine at position 58 of ND6 and distinct mitochondrial DNA(mtDNA)polymorphisms originating from haplogroups M10 and *** Identifying the T14502C mutation in two individuals with no genetic relation who exhibit symptoms of depression provides compelling evidence that this mutation may be implicated in MDD ***,the two Chinese pedigrees that carried the T14502C mutation did not exhibit any functionally significant mutations in their ***,the phenotypic expression of the T14502C mutation related to MDD may be influenced by the nuclear modifier gene(s)or environmental factors.

关键词： Major depressive disorder Mitochondrial DNA ND6 T14502C Mutation Haplogroup Chinese

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong Qin Zhou ling-Qiang Zhu Dan liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

多速混合车辆单车道元胞自动机交通流模型的研究

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物理学报 2004年第9期53卷 2894-2898页

作者：邝华孔令江刘慕仁广西师范大学物理与信息工程学院桂林541004

在交通流NS模型的基础上 ,建立了多速混合车辆单车道元胞自动机交通流模型 ,通过计算机数值模拟 ,得到了混合车辆在不同参数下交通流模型的基本图。

关键词：元胞自动机混合交通流模型计算机模拟交通流

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各向异性场对三明治膜巨磁阻抗效应的影响

物理学报 2004年第3期53卷 905-910页

作者：王艾玲刘江涛周云松姜宏伟郑鹉首都师范大学物理系北京100037

根据具有巨磁阻抗 (GMI)效应的实际三明治样品的状况 ,提出三明治结构作为理论计算的模型 ,考虑了磁性层的各向异性场 ,利用一定边界条件下的Maxwell方程和Landau_Lifshitz方程对模型进行了理论计算 ,得到了阻抗与频率、各向异性场等因... 详细信息

根据具有巨磁阻抗 (GMI)效应的实际三明治样品的状况 ,提出三明治结构作为理论计算的模型 ,考虑了磁性层的各向异性场 ,利用一定边界条件下的Maxwell方程和Landau_Lifshitz方程对模型进行了理论计算 ,得到了阻抗与频率、各向异性场等因素间的函数关系 .在此基础上 ,着重讨论了各向异性场Hk 的作用 .Hk 的大小、方向均会对GMI效应造成影响 ,最佳的Hk 应在 4 0 0A m左右 ,位于面内并与电流垂直 .

关键词：巨磁阻抗效应三明治膜各向异性场 Landau—Lifshitz方程 Maxwell方程磁致伸缩

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砂岩底水油藏开采机理及开发策略

石油学报 1997年第2期18卷 61-65页

作者：喻高明凌建军蒋明煊刘德华江汉石油学院

利用数值模拟方法研究分析了采油速度、油层沉积韵律、垂直水平渗透率比、夹层大小及位置、边底水能量、不同油水粘度比、井距、射开程度、毛管压力等对砂岩底水油藏开采效果的影响，同时对有夹层存在时Ｋｖ／Ｋｈ值对底水上升速度及形... 详细信息

利用数值模拟方法研究分析了采油速度、油层沉积韵律、垂直水平渗透率比、夹层大小及位置、边底水能量、不同油水粘度比、井距、射开程度、毛管压力等对砂岩底水油藏开采效果的影响，同时对有夹层存在时Ｋｖ／Ｋｈ值对底水上升速度及形态的影响进行了精细模拟研究。研究表明：影响底水锥进的主要因素是采油速度、垂直水平渗透率比、油水流度比、夹层；砂岩底水油藏底水推进一般以平托为主。文中提出了相应的开发策略。

关键词：砂岩底水油藏锥进策略油藏工程

开放性边界条件下双车道元胞自动机交通流模型耦合效应研究

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物理学报 2003年第12期52卷 3007-3013页

作者：彭麟谭惠丽孔令江刘慕仁广西师范大学物理与电子科学系桂林541004

在一种改进的Nagel Schrekenberg元胞自动机交通流模型的基础上 ,提出一个高速公路双车道元胞自动机模型来模拟开放性边界条件下的车流运动 ,并考虑两车道之间左边界开放程度的比例系数α及车辆加减速概率p的影响 .计算机数值模拟结果表... 详细信息

在一种改进的Nagel Schrekenberg元胞自动机交通流模型的基础上 ,提出一个高速公路双车道元胞自动机模型来模拟开放性边界条件下的车流运动 ,并考虑两车道之间左边界开放程度的比例系数α及车辆加减速概率p的影响 .计算机数值模拟结果表明 ,在车流状态的演化过程中 ,通过确定车道耦合系数b来控制车流量 ,不同的b值车流量不同 ,对车辆运动出现堵塞项的相变点有影响 .

关键词：元胞自动机交通流模型耦合效应开放性边界条件车流量耦合系数双车道模型

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily Choi Michael Qjiang ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

Near-perfect replication on amorphous alloys through active force modulation based on machine learning/neural network parameter prediction

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 181-191页

作者： Senkuan Meng Zheng Wang Ruisong Zhu Ruijie liu jiang Ma Lina Hu Weihua Wang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) School of Materials Science and Engineering Shandong University College of Mechatronics and Control Engineering Shenzhen University Songshan Lake Materials Laboratory Institute of Physics Chinese Academy of Sciences

As a microforming technique, micro/nano-structural replication possesses advantages of high precision and efficiency. With the remarkable superplasticity in the supercooled liquid region, amorphous alloys or metallic glasses(MGs) are regarded as ideal materials for miniature fabrication. However, due to the intrinsic metastable nature of supercooled liquids, the design of imprinting processes for MGs poses a challenge. In the past, process parameters have largely relied on trial-and-error *** this work, a low-frequency active force modulation system is employed to apply a stable, precise, and real-time feedback stress field for imprinting of MG samples. Low-frequency vibrations can facilitate the filling of microstructures on the template surface by reducing the effective viscosity of the supercooled liquid. With the dataset composed of orthogonal experiments, a machine learning strategy based on back-propagation(BP) neural networks was utilized to construct a 3D parameter space for temperature, stress, and time, and to predict the corresponding filling ratio. Furthermore, the optimal combination of imprinting process parameters was identified, and its filling ratio was experimentally validated to reach as high as 0.94. The near-perfect replication of microstructures confirms the superiority of the active force modulation system and the data-driven strategy of machine learning-assisted parameter design. At the same time, this one-step microforming process provides a new approach to addressing the accuracy-cost trade-off dilemma in precision manufacturing.

关键词： metallic glass amorphous alloy microforming imprinting machine learning

评估一种新的检测瘰疬分枝杆菌菌株的real-time PCR方法（英文）

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中国人兽共患病学报 2016年第12期32卷 1108-1113页

作者：纪凌云蒋毅刘海灿万康林温州医科大学检验医学院生命科学学院温州325035 中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室感染性疾病诊治协同创新中心北京102206

目的建立针对非结核分枝杆菌中瘰疬分枝杆菌菌株的real-time PCR检测方法。方法在我们的研究中,根据瘰疬分枝杆菌的SodA基因设计MGB探针和特定的引物,并用来检测模拟样品中的瘰疬分枝杆菌。结果该方法最低瘰疬分枝杆菌DNA检测浓度是101... 详细信息

目的建立针对非结核分枝杆菌中瘰疬分枝杆菌菌株的real-time PCR检测方法。方法在我们的研究中,根据瘰疬分枝杆菌的SodA基因设计MGB探针和特定的引物,并用来检测模拟样品中的瘰疬分枝杆菌。结果该方法最低瘰疬分枝杆菌DNA检测浓度是101拷贝数,标准曲线显示阈值周期和SodA基因片段拷贝数之间的相关系数是0.973,斜率为-3.249,表现出良好的线性关系。此外,模拟样品最低检测浓度是每毫升101个细菌,此外,其他9株菌为阴性结果,验证了良好的特异性。结论该方法对于检测瘰疬分枝杆菌模拟标本显示很高的敏感性和特异性,可用于瘰疬分枝杆菌菌株的生态和流行病学监测。

关键词：瘰疬分枝杆菌 real-time PCR 非结核分枝杆菌