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Sleep disturbances and psychomotor retardation in the prediction of cognitive impairments in patients with major depressive disorder

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World Journal of Psychiatry 2024年第10期14卷 1474-1483页

作者： Mi Wang Wen-Tao Chen Hao-Ting Wang Bang-Shan liu Yu-Meng Ju Qiang-li Dong Xiao-Wen Lu Jin-Rong Sun liang Zhang Hua Guo Fu-Tao Zhao Wei-Hui li li Zhang Ze-Xuan li Mei liao Yan Zhang Jin liu ling-jiang li Department of Mental Health Center Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina National Clinical Research Center of Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Psychiatry National Clinical Research Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina Department of Psychiatry Zhumadian Psychiatric HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Symptoms of depression and comorbid anxiety are known risk factors for cognitive impairment in major depressive disorder(MDD).Understanding their relationships is crucial for developing targeted interventions to mitigate cognitive impairments in MDD *** expect that the severity of sleep disturbances and other depressive symptoms will be positively correlated with the degree of cognitive *** also hypothesize that anxiety symptoms,especially psychic anxiety,is a key factor in predicting cognitive performance in MDD patients and may indirectly contribute to cognitive impairment by affecting sleep disturbances and other potential *** To determine which dimension of the depressive and anxiety symptoms predicts cognitive impairment during a depressive *** A comprehensive neurocognitive test battery assessed executive function,attention,processing speed,and memory in 162 medication-free MDD patients and 142 matched healthy *** 24-item Hamilton Depression Rating Scale was used to assess depressive symptoms,and the 14-item Hamilton Anxiety Scale was used to assess anxiety *** regression analyses and mediation analyses were conducted to evaluate the impact of depressive and anxiety symptoms,as well as their interactions,on cognitive *** Among the depressive symptoms,sleep disturbances were associated with poorer executive function(P=0.004),lower processing speed(P=0.047),and memory impairments(P<0.001),and psychomotor retardation(PR)was associated with lower processing speed in patients with MDD(P=0.019).Notably,PR was found to mediate the impact of sleep disturbances on the processing *** anxiety symptoms,psychic anxiety,rather than somatic anxiety,was associated with cognitive impairments in all *** disturbances mediated the effect of psychic anxiety on executive function[β=-0.013,BC CI(-0.027,-0.001)]and memory[β=-0.149,BC CI(-0.237,-0.063)],while PR mediated its ef

关键词： Major depressive disorder Cognitive impairment Depressive symptoms Anxiety symptoms Sleep disturbance Psychomotor retardation

进口蜂蜜中幼虫芽孢杆菌分子分型方法的比较研究

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动物医学进展 2024年第8期45卷 78-82页

作者：俞佳高有领王建峰赵秀玲李如松王春杨伯龙于纪棉江玲丽浙江万里学院生物与环境学院浙江宁波315100 宁波检验检疫科学技术研究院浙江宁波315100 宁波海关技术中心浙江宁波315100 宁波市口岸生物与食品安全检测重点实验室浙江宁波315100 宁波卫生职业技术学院浙江宁波315100

为研究来自不同地域幼虫芽孢杆菌的进化关系,建立其分子分型方法,对来自11个国家和地区的50株幼虫芽孢杆菌分离株进行MLST分型分析,并与ERIC分型比较。结果显示,ERIC法将50株分离株分为ERICⅠ、ERICⅡ与ERICⅣ型,但不能区分不同区域菌株... 详细信息

为研究来自不同地域幼虫芽孢杆菌的进化关系,建立其分子分型方法,对来自11个国家和地区的50株幼虫芽孢杆菌分离株进行MLST分型分析,并与ERIC分型比较。结果显示,ERIC法将50株分离株分为ERICⅠ、ERICⅡ与ERICⅣ型,但不能区分不同区域菌株;MLST法将菌株分为ST1至ST8共8种序列型,其中ST1为优势型,占比高且分布广泛;其次为ST5(主要为加拿大分离株),ST3(澳大利亚分离株),ST4(法国与匈牙利分离株),ST6(新西兰分离株),ST2(西班牙分离株),ST7(匈牙利分离株)和ST8(澳大利亚分离株)。与ERIC相比,MLST可以对不同地域的幼虫芽孢杆菌进行有效分型,具有更高的分辨率,可作为后续进口蜂蜜中幼虫芽孢杆菌流行病学调查的工具。

关键词：幼虫芽孢杆菌多位点序列分型管家基因肠杆菌基因间重复共有序列分型

Systemin/Jasmonate-Mediated Systemic Defense Signaling in Tomato

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Molecular Plant 2011年第4期4卷 607-615页

作者： Jia-Qiang Sun Hong-ling jiang Chuan-You li State Key Laboratory of Plant Genomics National Centre for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy ofSciences Datun Road Beijing 100101 China

Wound-inducible proteinase inhibitors （PIs） in tomato plants provide a useful model system to elucidate the signal transduction pathways that regulate systemic defense response. Among the proposed intercellular signals for wound-induced PIs expression are the peptide systemin and the oxylipin-derived phytohormone jasmonic acid （JA）. An increasing body of evidence indicates that systemin and JA work in the same signaling pathway to activate the ex- pression of PIs and other defense-related genes. However, relatively less is known about how these signals interact to promote cell-to-cell communication over long distances. Genetic analysis of the systemin/JA signaling pathway in tomato plants provides a unique opportunity to study, in a single experimental system, the mechanism by which peptide and oxylipin signals interact to coordinate systemic expression of defense-related genes. Previously, it has been proposed that systemin is the long-distance mobile signal for defense gene expression. Recently, grafting experiments with tomato mutants defective in JA biosynthesis and signaling provide new evidence that JA, rather than systemin, functions as the systemic wound signal, and that the biosynthesis of JA is regulated by the peptide systemin. Further understanding of the systemin/JA signaling pathway promises to provide new insights into the basic mechanisms governing plant defense to biotic stress.

关键词： Systemic defense response systemin jasmonic acid tomato Arabidopsis.

Effect of SiO_(2) and B_(2)O_(3) on crystallization and structure of CaF2–CaO–Al_(2)O_(3)-based slag for electroslag remelting of ultra-supercritical rotor steel

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Journal of Iron and Steel Research International 2021年第12期28卷 1530-1540页

作者： Yi Huang Cheng-bin Shi Xiu-xiu Wan jiang-ling li Ding-li Zheng Jing li State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing100083China College of Materials Science and Engineering Chongqing UniversityChongqing400044China The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina

Regarding development of the dedicated slag for electroslag remelting,crystallization characteristics of the slag exert a strong influence on the initial solidification of liquid metal in mold and surface quality of as-cast *** crystallization behavior of CaF_(2)-CaO-Al_(2)O_(3)-based slag with varying SiO_(2)and B_(2)O_(3)contents and their correlation with the slag structure were *** SiO_(2)(0.24-8.95 mass%)and B_(2)O_(3)(0-3.20 mass%)contents lowers the crystallization temperature and suppresses the crystallization of the slag melts,as well as decreases the sizes of the crystalline *** crystalline phases precipitated during continuous cooling of the slag melts are faceted 11CaO·7Al_(2)O_(3)·CaF_(2),faceted or spherical CaF_(2),and non-faceted MgO·Al_(2)O_(3)(or MgO)in sequence irrespective of the SiO_(2)and B_(2)O_(3)contents of the *** polymerization degree of slag melts increases with increasing either SiO_(2)or B_(2)O_(3)*** crystallization of the slag melts is increasingly retarded with increasing the SiO_(2)and B_(2)O_(3)contents of the slag caused by increased component diffusion resistance originating from increased polymerization degree of the slag melts.

关键词： Crystallization Slag structure Polymerization degree Electroslag remelting Ultra-supercritical rotor steel

A simulation study of field plate termination in Ga2O3 Schottky barrier diodes

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Chinese Physics B 2018年第12期27卷 455-460页

作者： Hui Wang ling-li jiang Xin-Peng lin Si-Qi Lei Hong-Yu Yu Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen 518055China School of Electronic Science and Engineering Southeast UniversityNanjing 210096China Shenzhen Key Laboratory of The Third Generation Semiconductor Shenzhen 518055China Guangdong GaN Devices Engineering and Technical Research Center Shenzhen 518055China

In this work, the field plate termination is studied for Ga2O3Schottky barrier diodes(SBDs) by simulation. The influence of field plate overlap, dielectric material and thickness on the termination electric field distribution are *** is found that the optimal thickness increases with reverse bias increasing for all the three dielectrics of SiO2, Al2O3, and HfO2. As the thickness increases, the maximum electric field intensity decreases in SiO2and Al2O3, but increases in ***, it is found that SiO2and HfO2are suitable for the 600 V rate Ga2O3SBD, and Al2O3is suitable for both600 V and 1200 V rate Ga2O3SBD. In addition, the comparison of Ga2O3SBDs between the SiC and GaN counterpart reveals that for Ga2O3, the breakdown voltage bottleneck is the dielectric. While, for SiC and GaN, the bottleneck is mainly the semiconductor itself.

关键词： Ga_2O_3 Schottky barrier diode field plate termination technique

Clinical application of repetitive transcranial magnetic stimulation for post-traumatic stress disorder:A literature review

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World Journal of Clinical Cases 2021年第29期9卷 8658-8665页

作者： Peng Cheng Ying Zhou li-Zhi Xu Ya-Fei Chen Ruo-lin Hu Yi-ling Zou Ze-Xuan li li Zhang Qi Shun Xun Yu ling-jiang li Wei-Hui li National Clinical Research Center for Mental Disorders Department of PsychiatryThe Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina Xiangya Medical School The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Department of Psychiatry The Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina Research Center for Brain Science and Human-like Intelligence Xi’an Jiaotong UniversityXi’an 710049Shannxi ProvinceChina Product Department Solide Brain Medical TechnologyLtd.Xi’an 710043Shannxi ProvinceChina

The efficacy of traditional treatment for post-traumatic stress disorder(PTSD)is still *** transcranial magnetic stimulation(rTMS)has been widely used in the treatment of various types of mental disorders,including *** rTMS has been demonstrated to be effective in many cases,there are still arguments regarding its mechanism and *** review aims to summarize the origin,development,principle,and future direction of rTMS and introduce this neuro-stimulation therapy to relevant clinicians.

关键词： Repetitive transcranial magnetic stimulation Post-traumatic stress disorder Neuro-stimulation Physical therapy

Pharmacokinetics and Pharmacodynamics of Subcutaneous Single Doses of Pegylated Human G-CSF Mutant(PEG30-rhG-CSF) in Beagle Dogs

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Chinese Journal of Clinical Oncology 2008年第5期5卷 326-332页

作者： Yongming Cai Zhengmin Chen ling jiang Ming li Changxiao liu State Key Laboratory of Pharmacokinetics and Pharmacodynamics Tianjin Institute of Pharmaceutical Research Tianjin 300193 China.

OBJECTIVE To compare the pharmacokinetics and pharmacodynamics of PEG30-rhG-CSF administered to beagle dogs at three different dosages with PEG20-rhG-CSF administered at one dosage, and to provide an experimental basis for clinical trials.METHODS Beagle dogs received single, subcutaneous doses of PEG30-rhG-CSF at 100, 200 and 400 μg/kg or PEG20-rhG-CSF at 200 μg/kg. PEG30-rhG-CSF and PEG20-rhG-CSF concentrations in serum were analyzed using an enzymeqinked immunosorbent assay （EliSA）. WBC, ANC and PLT counts of whole blood samples were measured using fully automated analytic instrumentation. Pharmacokinetic and pharmacodynamic parameters were calculated using DAS 2.0 statistical analysis software.METHODS Beagle dogs received single, subcutaneous doses of PEG30-rhG-CSF at 100, 200 and 400 μg/kg or PEG20-rhG-CSF at 200μg/kg. PEG30-rhG-CSF and PEG20-rhG-CSF concentrations in serum were analyzed using an enzyme-linked immunosorbent assay （EliSA）. WBC, ANC and PLT counts of whole blood samples were measured using fully automated analytic instrumentation. Pharmacokinetic and pharmacodynamic parameters were calculated using DAS 2.0 statistical analysis software. RESULTS The pharmacokinetic parameters of PEG30-rhG-CSF calculated from the serum concentration data determined by EliSA were as follows： the mean elimination half-life （t1/2ke） was 40.6 h （33.5-45.4 h）; the mean time to reach peak concentration （Tmax） was 19.2 h （11.7-24.0 h）; the drug clearance from the serum （CL） was decreased with increasing doses; the peak concentration （Cmax） and the area under the serum concentration-time curve （AUC） were increased with increasing doses. For PEG20-rhG- CSF, the half-life was shorter （12 h） and Tmax was achieved much earlier （10 h） relative to PEG30-rhG-CSF. The AUC of PEG30- rhG-CSF was much greater than that of PEG20-rhG-CSF, and the relative bioavailability with a subcutaneous injection was 158.7%. Administration of single doses of PEG30-rhG-CSF resulted in substanti

关键词： PEG30-rhG-CSF PEG20-rhG-CSF pharmacoki-netics pharmacodynamics ANC EliSA beagle dogs.

Host-induced silencing of MpPar6 confers Myzus persicae resistance in transgenic rape plants

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Journal of Integrative Agriculture 2024年第1期23卷 187-194页

作者： Qi Zhang Wenqin Zhan Chao li ling Chang Yi Dong jiang Zhang State Key Laboratory of Biocatalysis and Enzyme Engineering School of Life SciencesHubei UniversityWuhan 430062China Oil Crops Research Institute Chinese Academy of Agricultural SciencesWuhan 430062China Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhen 518000China

Plant-mediated RNA interference(RNAi)has emerged as a promising technology for insect *** green peach aphid,Myzus persicae,feeds on over 400 species of host *** napus(rape)is the second most important oilseed crop *** persicae is highly reproductive and causes severe damage to the rape plants due to its quite flexible life *** this study,we tested the RNAi effects of transgenic rape plants on *** in vitro feeding *** with artificial diets containing double-stranded RNAs(dsRNAs)targeting seven aphid genes,we identified a new gene encoding the partitioning-defective protein 6(Par6)as the most potent RNAi ***-and stage-expression analysis of Par6 suggested this gene is highly expressed in the embryo and adult stage of *** next generated transgenic rape plants expressing ds Par6 by Agrobacteriummediated transformation and obtained nine independent transgenic *** to wild-type control plants,transgenic rape lines expressing ds Par6 showed strong resistance to *** assays revealed that feeding transgenic rape plants to *** significantly decreased MpPar6 expression and survival rate and impaired ***,we showed that the resistance levels to *** are positively correlated with ds Par6 expression levels in transgenic rape *** study demonstrates that transgenic rape plants expressing ds Par6 are efficiently protected from *** with the genes involved in embryo development could be the effective RNAi targets for controlling aphids and potentially other insect pests.

关键词： oilseed rape pest control aphid double-stranded RNA RNA interference

Ginsenoside Rd Induces Differentiation of Myeloid Leukemia Cells via Regulating ERK/GSK-3βSignaling Pathway

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Chinese Journal of Integrative Medicine 2024年第7期30卷 588-599页

作者： jiang Yu-xia ZHAO Yan-na YU Xiao-ling YIN li-ming Department of Hematology Tongde Hospital of Zhejiang ProvinceHangzhou310012China Institute of Hematology Research the First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou310006China

Objective To investigate the role of ginsenoside Rd(GRd)in acute myeloid leukemia(AML)cell *** AML cells were treated with GRd(25,50,100 and 200µg/mL),retinoic acid(RA,0.1g/L)and PD98059(20 mg/mL)for 72 h,cell survival was detected by methylthiazolyldiphenyl-tetrazolium bromide and colony formation assays,and cell cycle was detected by flow *** morphology and differentiation were observed by Wright-Giemsa staining,peroxidase chemical staining and cellular immunochemistry assay,*** protein expression levels of GATA binding protein 1(GATA-1),purine rich Box-1(PU.1),phosphorylated-extracellular signal-related kinase(p-ERK),ERK,phosphorylated-glycogen synthase kinase-3β(p-GSK3β),GSK3βand signal transducer and activator of transcription 1(STAT1)were detected by Western ***-six mice were randomly divided into 3 groups using a random number table:model control group(non-treated),GRd group[treated with 200 mg/(kg·d)GRd]and homoharringtonine(HTT)group[treated with 1 mg/(kg·d)HTT].A tumor-bearing nude mouse model was established,and tumor weight and volume were *** of subcutaneous tumor tissue were observed after hematoxylin and eosin ***1 and GATA-1 expressions were detected by immunohistochemical *** The cell survival was inhibited by GRd in a dose-dependent manner and GRd caused G0/G1 cell arrest(plicited upregulation of p-ERK,p-GSK-3βand STAT1 expressions in cells,and reversed the effects of PD98059 on inhibiting the expressions of peroxidase,GATA-1 and PU.1(P<0.05).After GRd treatment,tumor weight and volume of mice were decreased,and tumor cells underwent massive apoptosis and necrosis(P<0.05).WT1 level was decreased,and GATA-1 level was significantly increased in subcutaneous tumor ti

关键词： ginsenoside Rd myeloid leukemia survival differentiation extracellular signal-related kinase signaling pathway