检索结果-南通市图书馆

Agricultural Sciences in China 2008年第5期7卷 591-598页

作者： YANG Mei-ling zhang jian-zhen zhang jian-qin GUO Ya-ping MA En-bo Institute of Applied Biology Shanxi University Taiyuan 030006 P.R. China

Carboxylesterases （CarEs） from two field populations of the oriental migratory locust, Locusta migratoria manilensis （Meyen）, were examined to try to understand their contribution to malathion insensitivity. The CarEs activities in Wudi population （WD） were 1.75- and 1.50-fold significantly higher than those in Huangliu population （HL） when a-naphthyl acetate （a-NA） and [3-naphthyl acetate were used as substrates, respectively. Such elevated CarEs activities presented in the WD could be because of an increased staining intensity of the a-NA-hydrolyzing CarEs as shown on the nondenaturing polyacrylamide gel electrophoresis. Inhibition studies of CarEs using paraoxon and malaoxon indicated that CarE activities in the HL were more strongly inhibited than those in the WD. Furthermore, a 449-bp DNA fragment of CarE was obtained from L. migratoria manilensis. Hemiquantity reverse transcription-polymerase chain reaction analysis showed that CarE gene expression level in the WD was higher than that in the HL. The higher CarE activities and the increased CarE mRNA level in the WD appeared to be associated with decreased susceptibility to malathion in the WD due to the application of organophosphorus insecticides.

关键词： carboxylesterases enzyme kinetics enzyme inhibition RT-PCR Locusta migratoria manilensis

Identification of a novel p.R1443W mutation in RP1 gene associated with retinitis pigmentosa sine pigmento

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2013年第4期6卷 430-435页

作者： Li Ma Xun-Lun Sheng Hui-Ping Li Fang-Xia zhang Ya-Ni Liu Wei-Ning Rong jian-ling zhang Ningxia Eye Hospital People's Hospital of Ningxia Hui Autonomous Region

AIM:To screen mutations in the retinitis pigmentosa 1(RP1) gene and the rhodopsin(RHO) gene in Chinese patients with retinitis pigmentosa sine pigmento(RPSP)and describe the genotype-phenotype relationship of the mutations.·METHODS:Twenty affected,unrelated Chinese individuals with RPSP(4 autosomal dominant RPSP,12autosomal recessive RPSP and 4 unknown inheritance pattern) were recruited between 2009 and *** clinical features were determined by complete ophthalmologic *** chain reaction(PCR) and direct DNA sequencing were used to screen the entire coding region and splice junctions of the RP1gene and the RHO *** cosegregation analysis and population frequency studies were performed for patients with identified mutations.·RESULTS:Five variants in the RP1 gene and one in the RHO gene were detected in 20 *** missense changes(rs444772,rs446227,rs414352,rs441800) and one non-coding variant(rs56340615) were common SNPs and none of them showed a significant relationship with RPSP.A missense mutation p.R1443W was identified in the RP1 gene in three affected individuals from a family with autosomal dominant RPSP and was found to cosegregate with the phenotype in this family,suggestive of *** addition,population frequency analysis showed the p.R1443W mutation was absent in 300 healthy controls.·CONCLUSION:The identification of p.R1443W mutationcosegregating in a family with autosomal dominant RPSP highlights an atypical phenotype of the RP1 gene mutation,while RHO gene is not associated with the pathogenesis of RPSP in this *** our knowledge,this is the fist mutation identified to associate with RPSP.

关键词： retinitis pigmentosa sine pigmento RP1 and RHO gene gene mutation

Efficacy and Safety of Huachansu Capsules for the Treatment of Esophageal Cancer: A Systematic Review and Meta-analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Traditional Chinese Medicine 2023年第3期9卷 270-277页

作者： Meng-Meng Wang Xing-Hui zhang Jun-Yan Wang Jing Xu Ming-Zhu Chen Shu-Yue Wang Min Jia Zhi-Wen Shen ling-jian zhang Yang Gong jian Gong Research Group of jian Gong on Pharmacoepidemiology and Clinical Drug Evaluation Scool of Life Science and BiopharmaceuticsShenyang Pharmaceutical UniversityShenyangChina School of Biomedical Informatics University of Texas Health Science CenterHoustonTexasUSA

The objective of this study was to systematically evaluate the efficacy and safety of Huachansu capsules in the treatment of esophageal *** searched all relevant Chine se and English documents in the Cochrane Libraty Clinical Controlled Trials,PubMed,EMB ASE,CNKI,and VIP databases,from the time the databases were established to December *** studies were selected according to the inclusion and exclusion criteria,and their quality was *** used RevMan 5.4 to conduct the meta-analysis of measurement indicators and intervention *** randomized controlled trials comprising 526 patients with esophageal cancer were included in the *** with radiotherapy and chemotherapy alone,oral Huachansu capsules combined with radiotherapy and chemotherapy improved the clinical efficacy(risk ratio[RR]=1.35,95%confidence interval[CI],1.17-1.55,P<0.0001),quality of life(weighted mean difference[MD]=10.01,95%CI[3.39-16.64],P=0.003),and immune level(CD3+:MD=4.99,95%CI[3.70-6.29],P<0.0001;CD4+:MD=6.49,95%CI[5.55-7.42],P<0.0001;CD5+:MD=0.20,95%CI[0.11-0.28],P<0.0001),and reduced toxic and side effects(reductions in white blood cell count:RR=0.63,95%CI[0.44-0.90],P=0.01;Reductions in blood platelet:RR=0.70,95%CI[0.52-0.94],P=0.02;Gastrointestinal reaction:RR=0.73,95%CI[0.59-0.89],P=0.002).However,the number of included studies was small,and conclusions still need to be further verified using larger samples and high-quality randomized,double-blind controlled trials.

关键词： Cinobufagin efficacy esophageal cancer meta-analysis safety

Cross-reactivity of anti-H pylori antibodies with membrane antigens of human erythrocytes

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第27期13卷 3742-3746页

作者： Feng-Hua Guo Xiao-Mei Yan Chun-Xiang Fan Fei Zhao Yuan Hu Di Xiao Xun Zeng Mao-Jun zhang Li-Hua He Fan-ling Meng jian-Zhong zhang National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention PO Box 5 Changping Beijing 102206 China

AIM： To investigate whether anti-H pylori antibodies have cross-reaction with antigens of erythrocyte membrane. METHODS： Blood samples were collected from 14 volunteers （8 positive and 6 negative for Hpylori detected by ^13C-urea breath test） of the general population. Erythrocyte membrane proteins of the subjects were examined by Western blot using anti-H pylori serum. The proteins related to the positive bands were identified by mass spectrum analysis. RESULTS： Anti-Hpylori antibodies had cross-reaction with the proteins of about 50 kDa of erythrocyte membranes in all samples independent of H pylori infection. One protein in the positive band was identified as Chain S, the crystal structure of the cytoplasmic domain of human erythrocyte Band-3 protein. CONCLUSION： Anti-HpyloH antibodies cross-react with some antigens of human erythrocyte membrane, which may provide a clue for the relationship between Hpylori infection and vascular disorders.

关键词： H pylori Antibodies Erythrocyte Crossreactivity

Prevalence and associated factors of corneal blindness in Ningxia in northwest China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2014年第3期7卷 557-562页

作者： Xun-Lun Sheng Hui-Ping Li Qing-Xia Liu Wei-Ning Rong Wen-zhang Du Li Ma Guang-Hui Yan Run-Qing Ma jian-ling zhang Hui-Fang Xu Wen-Qing Zou Xiao-Jun Bi Ningxia Eye Hospital Ningxia People's Hospital Department of Ophthalmology Tongxin Hospital Ningxia Hui Autonomous Region China Department of Ophthalmology Ningxia Medical University

AIM:To describe the prevalence and demographic characteristics of corneal blindness in an urban and rural region of Ningxia,located in the northwest part of ***:A stratified,randomized sampling procedure was employed in the study,including urban and rural area of all age *** acuity,anterior segment and ocular fundus were *** factor of corneal disease,including age,gender,education status,ethnic group,location and occupation,were identified according to uniform customized *** eye was defined to be corneal blindness if the visual acuity was<20/400 due to a corneal ***:Three thousand individuals(1290 from urban area and 1710 from rural area)participated in the investigation,with a response rate of 80.380%.The prevalence of corneal blindness was 0.023%in both eyes and 0.733%in at least one *** blindness in at least one eye with varied causes was present in 106participants(3.533%)and in bilateral eyes in 34participants(1.133%).The corneal diseases accounted for 20.754%of blindness in at least one eye and 20.588%of bilateral *** prevalence of corneal disease was higher in older and Han ethnic group,especially those who occupied in agriculture and outdoor *** with corneal blindness were more likely to be older and lower *** population were more likely to suffer from bilateral corneal blindness than the urban population in≥59-year group(χ2=6.716,P=0.019).Infectious,trauma and immune corneal disease were the three leading causes of corneal *** cornealdisease was more likely leading to blindness in one ***,infectious and immune corneal diseases make more contribution to the bilateral corneal ***:Corneal blindness is a significant burden of in Ningxia population,encompassing a variety of corneal infections and trauma;the majority of those were *** promotion strategies and good hygienic conditions have to be developed.

关键词： corneal disease epidemiology blindness infectious keratitis trauma

江山靠谁守才不付东流？--控股家族非经济目标与经营权释出倾向实证研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

南方经济 2017年第8期46卷 29-48页

作者：朱建安陈凌巩键张玮浙江大学城市学院家族企业研究所 310015 浙江大学管理学院中国电子信息产业发展研究院浙江大学经济学院

让子女接班还是将经营权释出给职业经理人,是代际传承时代背景下企业主的重要战略决策。文章基于委托代理理论,展示了家族/非家族高管在实现家族的非经济/经济目标上的各自优势,从控股家族非经济目标解释了企业CEO聘任决策,解构了能力... 详细信息

让子女接班还是将经营权释出给职业经理人,是代际传承时代背景下企业主的重要战略决策。文章基于委托代理理论,展示了家族/非家族高管在实现家族的非经济/经济目标上的各自优势,从控股家族非经济目标解释了企业CEO聘任决策,解构了能力与情感冲突的选择困境。根据全国工商联"中国非公有制经济健康状况评价"抽样调查数据发现,在家族成员与职业经理人都可兹聘任的情况下,那些更看重非经济目标的家族越不倾向于聘请职业经理人担任CEO作为企业下一代领导人。一代企业家的决策权力缺乏有效制衡将会强化非经济目标重要性与经营权释出之间的负效应;企业主与各级官员的频繁互动,加深社会联系巩固家族产权,有助于降低职业经理人的代理成本,显著地弱化非经济目标与经营权释出的负效用。文章的意义在于从控股家族所追求的目标解释为什么有的企业宁愿忍受企业绩效下降的经济后果仍然要雇佣家族成员担任CEO这个看似"非理性"现象。

关键词：家族企业经营权更替非经济目标职业经理人委托代理

High-throughput screening of CO_(2) cycloaddition MOF catalyst with an explainable machine learning model

在线全文

学校读者我要写书评

暂无评论

Green Energy & Environment 2025年第1期10卷 132-138页

作者： Xuefeng Bai Yi Li Yabo Xie Qiancheng Chen Xin zhang jian-Rong Li Beijing Key Laboratory for Green Catalysis and Separation and Department of Chemical Engineering College of Materials Science&EngineeringBeijing University of TechnologyBeijing100124China

The high porosity and tunable chemical functionality of metal-organic frameworks(MOFs)make it a promising catalyst design ***-throughput screening of catalytic performance is feasible since the large MOF structure database is *** this study,we report a machine learning model for high-throughput screening of MOF catalysts for the CO_(2) cycloaddition *** descriptors for model training were judiciously chosen according to the reaction mechanism,which leads to high accuracy up to 97%for the 75%quantile of the training set as the classification *** feature contribution was further evaluated with SHAP and PDP analysis to provide a certain physical understanding.12,415 hypothetical MOF structures and 100 reported MOFs were evaluated under 100℃ and 1 bar within one day using the model,and 239 potentially efficient catalysts were *** them,MOF-76(Y)achieved the top performance experimentally among reported MOFs,in good agreement with the prediction.

关键词： Metal-organic frameworks High-throughput screening Machine learning Explainable model CO_(2)cycloaddition

Effect of Ti Additions on Mechanical and Thermodynamic Properties of W-Ti Alloys: A First-principles Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 246-257页

作者： zhang jian NIE Wei HUANG Jin ZHU Ke LIU Ruxia zhang Ruizhi LUO Guoqiang SHEN Qiang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China

The mechanical and thermodynamic properties of W-Ti alloys(including W_(15)Ti_(1),W_(14)Ti_(2),W_(12)Ti_(4) and W_(8)Ti_(8) alloys)were investigated by the first-principles approach based on density functional *** results indicate that W-Ti alloys except W_(8)Ti_(8) are thermodynamically *** modulus and hardness of W-Ti alloys are smaller than those of pure tungsten and gradually decrease with increasing Ti ***,their B/G ratios and Poisson's ratios exceed those of pure tungsten,suggesting that the introduction of Ti decreases the mechanical strength while enhancing the ductility of W-Ti *** thermal expansion coefficients for W-Ti alloys all surpass those of pure tungsten,indicating that the introduction of titanium exacerbates the thermal expansion behavior of W-Ti ***,elevated pressure has the capacity to suppress the thermal expansion tendencies in titanium-doped tungsten *** study offers theoretical insights for the design of nuclear materials by exploring the mechanical and thermodynamic properties of W-Ti alloys.

关键词： first-principles mechanical properties thermodynamic properties tungsten-titanium alloys

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong zhang Zhiying Chen Yinyi Xiong Qin Zhou ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

Long-term outcomes of drug-eluting versus bare-metal stent implantation in patients with chronic total coronary artery occlusions

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2009年第6期122卷 643-647页

作者： HAN Ya-ling zhang jian LI Yi WANG Shou-li JING Quan-min YI Xian-hua MA Ying-yan LUAN Bo WANG Geng WANG Bin Department of Cardiology Shenyang Northern Hospital Shenyang Liaoning 110016 China

Background There are limited data on the efficacy of drug-eluting stents （DES） for treatment of chronic total occlusions （CTO）. The aim of the study was to evaluate the long-term clinical outcomes of DES implantation for CTO compared with bare-metal stent （BMS） implantation.Methods Between June 1995 and December 2006, a total of 1184 patients with successful recanalization of at least one de novo CTO lesion were consecutively registered, including 660 （55.7%） who underwent DES and 524 （44.3%） who underwent BMS implantation. All patients were followed up for up to 5 years for occurrence of major adverse cardiac events （MACE）. Long-term survival rates were estimated with the Kaplan-Meier method.Results Baseline clinical and angiographic characteristics were comparable between the two groups except that patients in the DES group received longer dual antiplatelet therapy （（7.4±2.5） months vs （1.7±0.8） months, P 〈0.001）. Average follow-up periods were （4.7±0.89） and （3.2±1.3） years for the BMS and DES groups, respectively. There was no significant difference in 5-year survival rates between the two groups （90.3% for DES group vs 89.6% for BMS group, Log-rank P=0.38）, but the 5-year target vessel revascularization （TVR）-free survival rate in the DES group was significantly higher than that in the BMS group （81.6% vs 73.5%, Log-rank P 〈0.001）. The cumulative MACE-free survival in the DES group was also significantly higher than that in the BMS group （80.6% vs 71.5%, Log-rank P〈0.001）. The rates of readmission caused by cardiovascular disease （27.0% vs 37.8%, P 〈0.001） and the need for bypass surgery were significantly lower in the DES group （1.5% vs 3.4%, P 〈0.05）. By multivariable analysis, DES implantation could significantly lower the long-term MACE risk of PCI for CTO patients （HR： 0.492; 95% Cl 0.396-0.656, P 〈0.001）. Left ventricular ejection fraction 〈50% and elderly （〉65 years） were identified as independent predictors of long-term MACE during follow-up.Concl

关键词： chronic disease coronary artery disease percutaneous transluminal coronary angioplasty drug eluting stent