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Amylose-and cyclodextrin-catalyzed deprotonation of β-*** observation of a“location effect”in the amylose system

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Acta Chimica Sinica(English Edition) 1985年第1期 84-88页

作者： CHENG Xian-En jianG Xi-Kui GU jian-Hua SHEN You-Di Shanghai Institute of Organic Chemistry,Academia Sinica,345 ling ling Lu,Shanghai

In host-guest chemistry cyclodextrin(CD)is among the most extensively investigated,and very recently,amylose(A)and its derivatives have been established as a new class ofhost *** present work reports that the hydroxyl groups attached to eitherCD or A play the role of general base in promoting the deprotonation of β-*** CD and A are composed of D-glucose residues,the cavities of A-helices and CD’s are

关键词： location effect ketoesters.First observation of a in the amylose system

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大学新生适应特征与影响因素的实证分析

东北大学学报（社会科学版） 2015年第4期17卷 416-421页

作者：朱凌云李健北京大学教育学院北京100871 中央财经大学学生处北京100081

基于大学新生适应不佳的现象和院校影响力、学生发展理论,构建了大学新生适应影响因素的多元线性回归模型;运用对北京高校本科新生的抽样调查数据,考察了大学新生的适应特征,并重点关注了院校环境对大学新生适应的影响。研究发现,女生... 详细信息

基于大学新生适应不佳的现象和院校影响力、学生发展理论,构建了大学新生适应影响因素的多元线性回归模型;运用对北京高校本科新生的抽样调查数据,考察了大学新生的适应特征,并重点关注了院校环境对大学新生适应的影响。研究发现,女生的择业适应和情绪适应较男生更有优势,城市新生适应情况普遍显著好于农村新生;院校环境整体情况对新生适应具有显著正向影响,同学关系和多样化发展等院校环境具体维度对大学新生适应意义重大。建议高校深入了解新生群体特征、全面优化院校环境、构建多元化新生适应机制,促进学生多样化发展。

关键词：大学新生学生适应院校环境

上市公司年报披露及时性:基于自由裁量权视角的分析

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商业经济与管理 2009年第6期212卷 90-96页

作者：王建玲宋林西安交通大学管理学院陕西西安710049 西安交通大学经济与金融学院陕西西安710061

及时性是上市公司信息披露的重要质量特征要求。文章以年报披露制度为起点,通过对年报披露时滞形成机理的理论分析,揭示了在时间维度上年报披露自由裁量权产生的内在逻辑和对信息及时性的影响,并对影响年报披露裁量权的因素进行了实证... 详细信息

及时性是上市公司信息披露的重要质量特征要求。文章以年报披露制度为起点,通过对年报披露时滞形成机理的理论分析,揭示了在时间维度上年报披露自由裁量权产生的内在逻辑和对信息及时性的影响,并对影响年报披露裁量权的因素进行了实证检验。研究结果表明,在研究期间内,上市公司自由裁量年报披露的区间分布为[0,84]天,占年报披露限定期的70%。其中审计意见和盈余消息是影响裁量权大小的重要因素,而董事会内部治理对管理者裁量权的监督作用未得到全面的发挥。因此,为规避年报披露自由裁量的滥用危机,监管部门应进一步加强信息披露制度建设和董事会治理机制的完善,同时呼唤公司管理者的德性崇高,强化信息的及时披露。

关键词：年报披露自由裁量权报告消息董事会治理

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手术室护理缺陷的风险分析及防范对策

中国继续医学教育 2016年第29期8卷 252-253页

作者：孔玲江苏省兴化市人民医院普外科江苏兴化225700

目的：对手术室内各种护理缺陷风险因素进行分析，并总结防范措施。方法筛选60例于2015年7月～2016年6月因胃肠疾病进入我院普外科手术的患者，随机分为两组，常规组29例手术室内行基础护理，分析组31例则行缺陷防范护理，对比两组风险... 详细信息

目的：对手术室内各种护理缺陷风险因素进行分析，并总结防范措施。方法筛选60例于2015年7月～2016年6月因胃肠疾病进入我院普外科手术的患者，随机分为两组，常规组29例手术室内行基础护理，分析组31例则行缺陷防范护理，对比两组风险发生情况及满意度情况。结果常规组29例中出现有了5起护理缺陷事件，分析组31例中未出现护理缺陷事件（P＜0.05）。结论胃肠疾病患者接受手术治疗时，于手术室内加强风险护理效果较好。

关键词：胃肠疾病手术室护理缺陷事件满意度防范措施

Distinctive distribution of defects in CdZnTe:In ingots and their effects on the photoelectric properties

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Chinese Physics B 2018年第3期27卷 417-421页

作者： Xu Fu Fang-Bao Wang Xi-Ran Zuo Ze-jian Wang Qian-Ru Wang Ke-Qin Wang ling-Yan Xu Ya-Dong Rong-Rong Guo Hui Yu Wan-Qi Jie State Key Laboratory of Solidification Processing and Ministry of Industry and Information Technology(MIIT)Key Laboratoryof Radiation Detection Materials and DevicesNorthwestern Polytechnical UniversityXi'an 710072China School of Opto-electronic and Communication Engineering Xiamen University of TechnologyXiamen 361024China

Photoelectric properties of CdZnTe:In samples with distinctive defect distributions are investigated using various *** cut from the head(T04)and tail(W02)regions of a crystal ingot show distinct differences in Te inclusion *** difference is not observed in Fourier transform infrared(FTIR)spectra,UV-Vis-NIR transmittance spectra,and I-V ***,carrier mobility of the tip sample is higher than that of the tail according to the laser beam induced current(LBIC)*** temperature photoluminescence(PL)measurement presents sharp emission peaks of D^(0)X and A^(0)X,and relatively large peak of D^(0)X(or A^(0)X)/Dcomplex for T04,indicating a better crystalline *** stimulated current(TSC)spectrum shows higher density of shallow point defects,i.e.,Cd vacancies,In^(+)_(Cd),etc.,in W02 sample,which could be responsible for the deterioration of electron mobility.

关键词： defects Te inclusions semiconducting II-VI materials CdZnTe

苦瓜过氧化物酶对阿魏酸的生物转化及其产物的分离鉴定

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中国天然药物 2006年第2期4卷 146-150页

作者：刘海利孔令义中国药科大学天然药物化学教研室南京210038

目的:深入研究苦瓜过氧化物酶(Momordica charantiaperoxidase)对阿魏酸的生物转化作用。方法:利用苦瓜过氧化物酶在醋酸缓冲液(pH 5.0)/丙酮反应体系、室温条件下对阿魏酸进行生物转化,转化产物经ODS-C18反相柱层析和Sephadex LH-20凝... 详细信息

目的:深入研究苦瓜过氧化物酶(Momordica charantiaperoxidase)对阿魏酸的生物转化作用。方法:利用苦瓜过氧化物酶在醋酸缓冲液(pH 5.0)/丙酮反应体系、室温条件下对阿魏酸进行生物转化,转化产物经ODS-C18反相柱层析和Sephadex LH-20凝胶柱层析等手段进行分离。运用现代光谱学技术确定化合物结构。结果:分离得到2个阿魏酸脱氢三聚体,2个阿魏酸脱氢二聚体,分别为triFA3(1),triFA4(2),diFA1(3),diFA2(4)。结论:以上化合物均为首次利用苦瓜过氧化物酶实现阿魏酸生物转化而获得的化合物,并首次确定了化合物1的立体构型。

关键词：苦瓜过氧化物酶阿魏酸生物转化阿魏酸脱氢三聚体阿魏酸脱氢二聚体

Association between blood cadmium and vitamin D levels in the Yangtze Plain of China in the context of rapid urbanization

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Chinese Medical Journal 2021年第1期134卷 53-59页

作者： Chi Chen Hao-Jie Zhang Hua-ling Zhai Yi Chen Bing Han Qin Li Fang-Zhen Xia Ning-jian Wang Ying-Li Lu Institute and Department of Endocrinology and Metabolism Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200011China.

Background:China has experienced rapid urbanization in the past 30 *** aimed to report blood cadmium level(BCL)in the rapidly urbanized Yangtze Plain of China,and explore the association between BCL and 25-hydroxyvitamin D(25(OH)D).Methods:Our data source was the Survey on Prevalence in East China for Metabolic Diseases and Risk Factors(SPECT-China)cross-sectional study(ChiCTR-ECS-14005052,***).We enrolled 3234 subjects from 12 villages in the Yangtze *** were measured by atomic absorption spectrometry.25(OH)D was measured with a chemiluminescence ***:A total of 2560(79.2%)subjects were diagnosed with vitamin D *** median(interquartile range)BCL was 1.80μg/L(0.60-3.42)for men and 1.40μg/L(0.52-3.10)for *** women,mean 25(OH)D concentrations were inversely associated with BCL(0.401,95%confidence interval:-0.697 to-0.105 nmol/L lower with each doubling of the BCL)after adjustment for age,educational status,current smoking,body mass index,diabetes,and ***,there was no significant difference in 25(OH)D across the BCL tertiles for ***:BCL in Chinese residents in the Yangtze Plain were much higher than that in developed *** inverse association between BCL and 25(OH)D was found in general Chinese women after multivariable *** prospective cohort and animal studies are warranted to resolve the direction and temporality of these relationships,and to elucidate the exact mechanisms involved.

关键词： Cadmium Chinese 25-hydroxyvitamin D Urbanization

PEP-1-CAT融合蛋白预处理对过氧化氢诱导的内皮细胞氧化应激损伤的保护作用

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中华心血管病杂志 2006年第10期34卷 932-938页

作者：姚玲玲王家宁黄永章郭凌郧孔霞临床医学研究所郧阳医学院附属人民医院十堰442000

目的采用体外培养的人脐静脉内皮细胞株(CRL-1730),研究 PEP-1肽介导人过氧化氢酶(CAT)穿透细胞的能力,并探讨 PEP-1-CAT 对过氧化氢(H_2O_2)诱导的内皮细胞氧化应激损伤是否有保护作用。方法构建原核表达质粒 pET15b-PEP-1-CAT,将其在... 详细信息

目的采用体外培养的人脐静脉内皮细胞株(CRL-1730),研究 PEP-1肽介导人过氧化氢酶(CAT)穿透细胞的能力,并探讨 PEP-1-CAT 对过氧化氢(H_2O_2)诱导的内皮细胞氧化应激损伤是否有保护作用。方法构建原核表达质粒 pET15b-PEP-1-CAT,将其在基因工程菌中表达出 N 端带有6个组氨酸“标签”(His-tag)的重组蛋白,并通过金属镍螯合亲和层析对其进行纯化,将纯化得到的PEP-1-CAT 融合蛋白加入体外培养的人脐静脉内皮细胞,通过 Western blot 来分析其转导能力,同时对转导人细胞内的蛋白进行酶活性检测。然后以0.5 mmol/L H_2O_2处理细胞建立内皮细胞氧化应激损伤的模型,检测不同浓度的 PEP-1-CAT 蛋白对氧化应激下细胞存活率、乳酸脱氢酶(LDH)活性及丙二醛(MDA)含量的影响。结果 PEP-1-CAT 融合蛋白能以时间、剂量依赖的方式高效转导进入细胞内。正常内皮细胞 LDH 活性和细胞存活率分别为(540.6±65.7)U/L和100%;H_2O_2处理组 LDH活性显著高[(849.3±95.1)U/L,P<0.01],细胞存活率明显低[(37.23±5.68)%,P<0.01],MDA含量亦较正常组显著高[(8.23±1.58)nmol/L 比(2.46±1.42)nmol/L,P<0.01]。用不同浓度的PEP-1-CAT 对细胞进行预保护,均可显著提高细胞存活率、降低 LDH 释放量,并提高细胞的抗氧化能力,表现为 MDA 含量较 H_2O_2处理组低(P<0.05或<0.01)。结论 PEP-1-CAT 融合蛋白能以天然活性形式高效转导入人脐静脉内皮细胞,且转导的蛋白能有效对抗氧化应激损伤。这种蛋白转导方式,为用 CAT 防治各种与氧化应激损伤有关的疾病提供了一个新的治疗途径。

关键词：过氧化氢酶内皮,血管 PEP-1肽氧化应激

Telemonitoring and hemodynamic monitoring to reduce hospitalization rates in heart failure： a systematic review and meta-analysis of randomized controlled trials and real-world studies

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Journal of Geriatric Cardiology 2018年第4期15卷 298-309页

作者： Gary Tse Cynthia Chan Mengqi Gong Lei MENG jian ZHANG Xiao-ling SU Sadeq Ali-Hasan-Al-Saegh Abhishek C Sawant George Bazoukis Yun-Long XIA Ji-Chao Zhao Alex Pui Wai Lee Leonardo Roever Martin CS Wong Adrian Baranchuk Tong Liu Department of Medicine and Therapeutics Faculty of Medicine Chinese University of Hong Kong Hong Kong China Li Ka Shing Institute of Health Sciences Faculty of Medicine Chinese University of Hong Kong Hong Kong China Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology the Second Hospital of Tianjin Medical University Tianjin China State Key Laboratory of Cardiovascular Disease Heart Failure Center Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences Peking Union Medical College Beijing China Department of Cardiology Qinghai Provincial People's Hospital Xining China Cardiovascular Research Center Shahid Sadoughi University of Medical Sciences Yazd Iran Division of Cardiology State University of New York at Buffalo Buffalo NY USA The Second Department of Cardiology Laboratory of Cardiac Electrophystology Evangehsmos General Hospital of Athens Athens Greece Department of Cardiovascular Medicine the First Affiliated Hospital of Dalian Medical University Dalian China Auckland Bioengineering Institute the University of Auckland Auckland New Zealand Department of Clinical Research Federal University of Uberlandia Uberlandia MG Brazil JC School of Public Health and Primary Care Faculty of Medicine the Chinese University of Hong Kong Hong Kong China Division of Cardiology Kingston General Hospital Queen 's University Kingston Ontario Canada

Background Heart failure is a significant problem leading to repeated hospitalizations. Telemonitoring and hemodynamic monitoring have demonstrated success in reducing hospitalization rates, but not all studies reported significant effects. The aim of this systematic review and meta-analysis is to examine the effectiveness of telemonitoring and wireless hemodynamic monitoring devices in reducing hospitalizations in heart failure. Methods ＆ Results PubMed and Cochrane Library were searched up to 1st May 2017 for articles that investigated the effects of telemonitoring or hemodynamic monitoring on hospitalization rates in heart failure. In 31,501 patients （mean age： 68 ± 12 years; 61% male; follow-up 11 ± 8 months）, telemonitoring reduced hospitalization rates with a HR of 0.73 （95% CI： 0.65-0.83; P 〈 0.0001） with significant heterogeneity （I2 = 94%）. These effects were observed in the short-term （≤ 6 months： HR = 0.77, 95% CI： 0.65-0.89; P 〈 0.01） and long-term （≥ 12 months： HR = 0.73, 95% CI： 0.62-0.87; P 〈 0.0001）. In 4831 patients （mean age 66 ± 18 years; 66% male; follow-up 13 ± 4 months）, wireless hemodynamic monitoring also reduced hospitalization rates with a HR of 0.60 （95% CI： 0.53-0.69; P 〈 0.001） with significant heterogeneity （I2 = 64%）.This reduction was observed both in the short-term （HR = 0.55, 95% CI： 0.45-0.68; P 〈 0.001; I2 = 72%） and long-term （HR = 0.64, 95% CI： 0.57-0.72; P 〈 0.001; I2 = 55%）. Conclusions Telemonitoring and hemodynamic monitoring reduce hospitalization in both short- and long-term in heart failure patients

关键词： Heart failure Hemodynamic monitoring Hospitalization Telemedicine Telemonitoring