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Elevated peripheral levels of receptor-interacting protein kinase 1(RIPK1)and IL-8 as biomarkers of human amyotrophic lateral sclerosis

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Signal Transduction and Targeted Therapy 2024年第1期9卷 271-278页

作者： Jun Wei Min Li Zhi Ye Xinqian Hu Xiaoyan He Jia Wang Gaofeng Chen Chengyu Zou Daichao Xu Hongbing zhang Junying Yuan Yunhong zha Institute of Neural Regeneration and Repair and Department of Neurology The First College of Clinical Medical ScienceYichang Central HospitalCollege of Basic Medical ScienceChina Three Gorges UniversityHubei Province Clinical Medical Research Center for Rare Diseases of Nervous SystemYichang 443000China Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai Key Laboratory of Aging StudiesShanghai 201210China State Key Laboratory of Common Mechanism Research for Major Diseases Haihe Laboratory of Cell EcosystemDepartment of PhysiologyInstitute of Basic Medical Sciences and School of Basic MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Amyotrophic lateral sclerosis(ALS)is a devastating fatal neurodegenerative disease with no ***-interacting protein kinase 1(RIPK1)has been proposed to mediate pathogenesis of *** has been identified as an old drug that can also inhibit RIPK1 *** conducted a drug-repurposing biomarker study of primidone as a RIPK1 inhibitor using SOD1G93A mice and ALS ***1G93A mice treated with primidone showed significant delay of symptomatic onset and improved motor ***-hundred-sixty-two ALS participants dosed daily with primidone(62.5 mg)completed 24-week follow-up.A significant reduction was showed in serum levels of RIPK1 and IL-8,which were significantly higher in ALS patients than that of healthy controls(P<0.0001).Serum RIPK1 levels were correlated positively with the severity of bulbar symptoms(P<0.05).Our study suggests that serum levels of RIPK1 and IL-8 in peripheral can be used as clinical biomarkers for the activation of RIPK1 in central nervous system in human ALS *** primidone may provide a promising therapeutic strategy for *** effect of primidone for the treatment of other inflammatory diseases may also be considered,since the activation of RIPK1 has been implicated in mediating a variety of inflammatory diseases including COVID-19-associated cytokine release syndrome(CRS).(ChiCTR2200060149).

关键词： RIPK1 diseases Serum

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Translocation of telomerase reverse transcriptase coincided with ATP release in postnatal cochlear supporting cells

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Neural Regeneration Research 2024年第5期19卷 1119-1125页

作者： Yukai zhang Keyong Tian Wei Wei Wenjuan Mi Fei Lu Zhenzhen Liu Qingwen Zhu Xinyu zhang Panling Geng Jianhua Qiu Yongli Song Dingjun zha Department of Otolaryngology Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

The spontaneous bursts of electrical activity in the developing auditory system are derived from the periodic release of adenosine triphosphate(ATP)by supporting cells in the Kölliker’s ***,the mechanisms responsible for initiating spontaneous ATP release have not been *** previous study revealed that telomerase reverse transcriptase(TERT)is expressed in the basilar membrane during the first postnatal *** role in cochlear development remains *** this study,we investigated the expression and role of TERT in postnatal cochlea supporting *** results revealed that in postnatal cochlear Kölliker’s organ supporting cells,TERT shifts from the nucleus into the cytoplasm over *** found that the TERT translocation tendency in postnatal cochlear supporting cells in vitro coincided with that observed in *** analysis showed that TERT in the cytoplasm was mainly located in mitochondria in the absence of oxidative stress or apoptosis,suggesting that TERT in mitochondria plays roles other than antioxidant or anti-apoptotic *** observed increased ATP synthesis,release and activation of purine signaling systems in supporting cells during the first 10 postnatal *** phenomenon that TERT translocation coincided with changes in ATP synthesis,release and activation of the purine signaling system in postnatal cochlear supporting cells suggested that TERT may be involved in regulating ATP release and activation of the purine signaling *** study provides a new research direction for exploring the spontaneous electrical activity of the cochlea during the early postnatal period.

关键词： apoptosis ATP release Ca2+transients cochlea mitochondrial function reactive oxygen species spontaneous electrical activity supporting cells

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击实和三轴压缩条件下炭质泥岩的颗粒破碎及力学响应研究

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中南大学学报（自然科学版） 2024年第3期55卷 1120-1131页

作者：刘琼曾铃查焕奕陈佳艳卞汉兵长沙理工大学土木工程学院湖南长沙410114 长沙理工大学交通运输工程学院湖南长沙410114 法国里尔大学土木工程与岩土环境工程实验室法国里尔59000

为充分认识炭质泥岩的颗粒破碎行为及力学特性,对不同粗粒质量分数的炭质泥岩在最佳击实状态下的破碎程度进行三轴剪切试验,分析粗粒质量分数对炭质泥岩粒径级配及力学性能的影响规律,明确炭质泥岩颗粒破碎与围压、粗粒质量分数间的关... 详细信息

为充分认识炭质泥岩的颗粒破碎行为及力学特性,对不同粗粒质量分数的炭质泥岩在最佳击实状态下的破碎程度进行三轴剪切试验,分析粗粒质量分数对炭质泥岩粒径级配及力学性能的影响规律,明确炭质泥岩颗粒破碎与围压、粗粒质量分数间的关系。研究结果表明:在压实过程中,炭质泥岩存在明显的颗粒破碎现象,且粗粒质量分数越高,其颗粒破碎越明显;炭质泥岩的水敏性远大于硬质岩的土石混合体的水敏性,击实曲线更陡峭,且在粗粒质量分数为60%时具有最佳的击实状态;随着粗粒质量分数增大,炭质泥岩的抗剪强度呈现出先增长后减小的趋势,且在粗粒质量分数为60%时黏聚力达到最大,内摩擦角与粗粒质量分数呈负相关;当粗粒质量分数较小时,炭质泥岩抗剪强度主要由细粒间的黏聚力及粗粒与细粒间的咬合力提供,粗粒破碎较少;随着粗粒质量分数增大,试样中颗粒破碎现象更明显,颗粒间重新分布和咬合使其内摩擦力逐渐增大,抗剪强度由粗粒破碎及粗粒与细粒间的咬合力提供,细粒间的黏聚力较小;炭质泥岩的颗粒相对破碎率随围压、粗粒质量分数的增大而增大,且相对破碎率与粗粒质量分数和围压之间存在非线性关系。

关键词：路堤工程炭质泥岩颗粒破碎力学特性相对破碎率

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茅苍术转录因子AlWRKY65的克隆与功能初探

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药学学报 2024年第5期59卷 1494-1502页

作者：管凤雅刘巍玮迟凯文曾凯玲谢晋查良平安徽中医药大学药学院安徽合肥230012 安徽医科大学药学院安徽合肥230032

WRKY转录因子是植物特有的一类转录因子,在植物多种生理过程中发挥重要的作用。本研究以茅苍术转录组数据为依据,对茅苍术AlWRKY基因与AlTPS基因的FPKM值进行相关性分析,结合分析结果筛选出与AlTPS1、AlTPS6基因表达量具有显著正相关性... 详细信息

WRKY转录因子是植物特有的一类转录因子,在植物多种生理过程中发挥重要的作用。本研究以茅苍术转录组数据为依据,对茅苍术AlWRKY基因与AlTPS基因的FPKM值进行相关性分析,结合分析结果筛选出与AlTPS1、AlTPS6基因表达量具有显著正相关性且FPKM值相对较高的候选基因AlWRKY65,对该候选基因进行克隆,获得AlWRKY65基因的开放阅读框(ORF),分析其编码蛋白的相关信息并进行基因表达研究。研究结果表明,AlWRKY65包含一个681bp的开放阅读框,编码226个氨基酸。AlWRKY65基因编码的氨基酸序列与向日葵HaWRKY65、莴苣LsWRKY65等植物基因编码的氨基酸序列具有较高同源性;该蛋白具有1个WRKYGQK保守结构域,属于WRKY基因家族的第IIe组;系统进化树分析显示,茅苍术AlWRKY65与洋蓟CcWRKY65蛋白亲缘关系较近;运用实时荧光定量PCR检测AlWRKY65基因在2个产地不同组织中的表达水平,结果表明,不同产地的茅苍术AlWRKY65基因具有组织表达差异性,均在叶片中表达量较高;在茉莉酸甲酯(MeJA)诱导处理48 h内,AlWRKY65基因的表达量下调;亚细胞定位和转录自激活活性分析显示,AlWRKY65定位于细胞核,不具有自激活活性。这些结果为进一步研究AlWRKY65在茅苍术中的生物学功能提供参考。

关键词：茅苍术 WRKY转录因子基因克隆表达分析亚细胞定位

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Geology and mineralization of the Dongping supergiant alkalic-hosted Au-Te deposit(>100 t Au)in Northern Hebei Province,China:A review

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China Geology 2024年第3期7卷 533-550页

作者： Shi-min Zhen Da-zhao Wang Zhong-jian zha Hai-jun Bai Jiang Wang Development and Research Center of China Geological Survey Ministry of Natural ResourcesBeijing 100037China Technical Guidance Center for Mineral Resources Exploration Ministry of Natural ResourcesBeijing 100037China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China Institute of Geological Surveying and Mapping Technology of Anhui Province Hefei 230022China Third Geological Brigade of Hebei Bureau of Geology and Mineral Resources Zhangjiakou 075000China Ulanqab Real Estate Registration Center Ulanqab 012099China

The Dongping deposit is the largest alkalic-hosted gold deposit in China containing>100 t of *** paper presents a new understanding for Dongping ore system,based on the previous *** mineralization originally occurred at 400-380 Ma,simultaneous with emplacement of the Shuiquangou alkaline complex,and was overprinted by the hydrothermal activity in the *** compositions of ores indicate metals of the deposit are mainly provided by the Shuiquangou ***-forming fluids are characterized by increasing oxygen fugacity and decreasing sulfur fugacity,while tellurium fugacity increased in the Stage II-2 and decreased in Stage *** systematic changes are closely related to the processes of mineral precipitation and fluid *** precipitation from Stage Ⅰ to Stage Ⅱ was triggered by fluid boiling,which leads to the precipitation of Pb-Bi-Te,due to decrement of sulfur *** of gas phase containing high concentration of H_2Te leads to precipitation of Te-Au-Ag minerals and native *** on these hypotheses,this paper present a polyphase metallogenic model as *** the Devonian,fluids were released from alkaline magmas,which carried ore-forming materials form the surrounding rocks and precipitate the early *** the Jurassic-Cretaceous,fluorine-rich fluids exsolved from highly factionated Shangshuiquan granite,which extracted and concentrated Au from the Shuiquangou complex and the Sanggan Group metamorphic rocks,and finally formed the Dongping gold deposit.

关键词： Mineralization and alteration Alkaline intrusion Au deposit Physicochemical conditions Metallogenic model Oxygen fugacity Sulfur fugacity Mechanisms of mineral precipitation Fluid boiling Fluorine-enriched fluid Dongping gold deposit North China Craton Mineral exploration engineering

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芬太尼问题与中美关系

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国际政治研究 2024年第2期45卷 101-119,7,8页

作者：查道炯北京大学国际关系学院、南南合作与发展学院 100871

芬太尼自70年前问世以来,因其既是为满足镇痛管理的正当合理需求而成为不断被研发和生产的药物,又因合成化学知识和技术被国际毒品市场滥用,从而成为各国药物监管、司法、国际禁毒合作的常规性挑战。中美两国的科学研究、医疗和执法部... 详细信息

芬太尼自70年前问世以来,因其既是为满足镇痛管理的正当合理需求而成为不断被研发和生产的药物,又因合成化学知识和技术被国际毒品市场滥用,从而成为各国药物监管、司法、国际禁毒合作的常规性挑战。中美两国的科学研究、医疗和执法部门在芬太尼问题上走过了40多年的机制性交流与合作的过程。拜登政府延续特朗普政府的政策取向,不仅在2023年11月中美元首会晤场合将在美国更严重的芬太尼物质滥用与中国管理涉芬太尼物质的跨国流动程度直接挂钩,而且将之提到与军事交流同等重要的高度,芬太尼问题在两国关系中的分量俨然具有杠杆性。但是,在中美两国,芬太尼问题的叙事都具有多元性。更有效地监管芬太尼物质的跨国流通、打击过程中的违规和非法行为,有赖于双方都从功能性合作的理念出发,强化公共卫生和司法合作两大领域的互动机制。

关键词：非传统安全芬太尼芬太尼问题中美关系禁毒合作公共卫生司法合作

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Chiral transfer amidst one-dimensional linear polymers and twodimensional network covalent organic frameworks:Striking a fine balance between helicity and crystallinity

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Nano Research 2024年第6期17卷 5726-5734页

作者： Xinlin zha Mengjuan Zuo Guilin Xu Zhong Yan Haining You Yi Xiong Ying Liu Yingying Li Liyan Yang Ke Liu Mufang Li Tao zhao Dong Wang College of Chemistry and Chemical Engineering Donghua UniversityShanghai 201620China Key Laboratory of Textile Fiber and Products Ministry of EducationWuhan Textile UniversityWuhan 430200China

The current landscape of chiral covalent organic frameworks(COFs)predominantly centered on constructing asymmetric molecular-scale chirality,often introducing an inherent contradiction to the COF symmetry and limiting ***,we overcome these challenges by achieving chiral transfer between one-dimensional(1D)imine linear polymers(LPs)and two-dimensional(2D)networkβ-ketoenamine COFs composed of achiral *** successfully synthesize several 1D imine LPs with mesoscopic helical chirality,comprising achiral C2-symmetric terephthalaldehyde and diamine linkers in a chiral supramolecular transcription *** the irreversible tautomerism mechanism within the linker replacement approach,terephthalaldehyde(TPA)units in these helical 1D LPs are substituted with C3-symmetric 1,3,5-triformylphloroglucinol(TP),yielding the corresponding 2D networkβ-ketoenamine *** and helicity of the resultantβ-ketoenamine COFs intimately hinge on reaction conditions,including the aldehyde stoichiometry of Tp and TPA,as well as the quantity and concentration of the catalyst *** optimized conditions,the nucleation and growth were precisely governed,achieving a harmonious equilibrium of crystallinity and helicity within the generated 2D networkβ-ketoenamine COFs,even with covalent bond rupture,recombination,and topological transition(from[C2+C2]to[C3+C2]).Impressively,the ground state chirality inherent to helical 1D LPs seamlessly transfers to helical 2D networkβ-ketoenamine *** study not only offers new perspectives on the development of chiral functional COFs,but also provides fresh insights into the precise control of COFs'microscopic morphology.

关键词： chiral covalent organic frameworks chiral transfer dimensional transformation helicity

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Acupuncture for cervical dystonia associated with anxiety and depression: A case report

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World Journal of Clinical Cases 2024年第1期12卷 204-209页

作者： Ya-Ting zhang Jin-Jing zhang Bi-Xiang zha Yin-Qiu Fan Yuan-Bo Xu Jun Yang Qing-Ping zhang The First School of Clinical Medicine Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina Acupuncture and Rehabilitation Department First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina College of Acupuncture and Tuina Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina

BACKGROUND Cervical dystonia(CD)is a type of muscle tone disorder that usually occurs in the neck *** to the intermittent or continuous involuntary contraction of the neck muscles,the head and neck are twisted and skewed and some postural abnormalities ***-term abnormal posture or pain can cause negative emotions in patients,which can affect their quality of *** SUMMARY This case report included a 37-year-old woman who was diagnosed with CD associated with anxiety and depression;the accompanying symptoms were head and neck tilt of approximately 90°to the right and mental *** two courses of acupuncture treatment,the patient’s head and neck can be maintained in a normal position,and the negative emotions can be *** This case indicates that acupuncture can effectively improve CD and the emotional state and quality of life of patients,making it an effective alternative treatment for the condition.

关键词： Cervical dystonia Anxiety and depression Neurological disease Acupuncture Case report

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结合色彩补偿与双背景光融合的水下图像复原

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光学精密工程 2024年第7期32卷 1059-1074页

作者：林森查子月沈阳理工大学自动化与电气工程学院辽宁沈阳110159

针对复杂成像环境下,水下图像存在颜色失真、细节模糊以及对比度低的问题,提出结合色彩补偿与双背景光融合的水下图像复原方法。通过分析光在水中的吸收衰减特性,提出改进的水下成像模型,基于Retinex理论与白平衡算法引入色彩补偿分量,... 详细信息

针对复杂成像环境下,水下图像存在颜色失真、细节模糊以及对比度低的问题,提出结合色彩补偿与双背景光融合的水下图像复原方法。通过分析光在水中的吸收衰减特性,提出改进的水下成像模型,基于Retinex理论与白平衡算法引入色彩补偿分量,降低水体背景颜色影响;根据背景光强度和颜色分布特性,提出双候选背景光融合方法,准确估计全局背景光;不依赖任何水体环境参数,根据背景颜色与散射系数的内在关系,采用引导-高通滤波,优化并增强各通道透射率;最后,逆求解成像模型复原水下图像。实验结果表明,在4个不同的水下数据集上与经典及新颖方法对比,所提方法恢复的图像颜色更自然,纹理细节更丰富清晰;色差值改善幅度达5.4%,UCIQE及FDUM指标提升幅度分别达8.3%和4.5%。所提方法在定性和定量实验中更具优势,能够显著提高水下图像质量。

关键词：水下图像复原色彩补偿背景光融合透射率估计

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湿热力作用下粉砂质泥岩开裂特性研究

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湖南大学学报（自然科学版） 2024年第1期51卷 126-136页

作者：曾铃郭雨查焕奕高乾丰黎繁卞汉兵桥梁工程安全控制教育部重点实验室(长沙理工大学) 湖南长沙410114 长沙理工大学土木工程学院湖南长沙410114 长沙理工大学交通运输工程学院湖南长沙410114

为探究湿热力作用下粉砂质泥岩的开裂特性,开展裂隙演化试验,得到湿热力单因素及多因素耦合循环作用下粉砂质泥岩的裂隙演化规律,同时利用X射线衍射、扫描电镜研究其微观结构变化特征,分析宏观和微观试验结果关联性,揭示湿热力作用下粉... 详细信息

为探究湿热力作用下粉砂质泥岩的开裂特性,开展裂隙演化试验,得到湿热力单因素及多因素耦合循环作用下粉砂质泥岩的裂隙演化规律,同时利用X射线衍射、扫描电镜研究其微观结构变化特征,分析宏观和微观试验结果关联性,揭示湿热力作用下粉砂质泥岩裂隙扩展机制.研究结果表明:粉砂质泥岩裂隙发育表现为增长-平缓趋势;在单因素循环作用中,湿度循环(浸水~烘干)最易造成粉砂质泥岩开裂,温度循环(5~60℃)次之,荷载循环(0~50 kPa)最弱;在多因素耦合循环作用中,裂隙发育程度排序为:湿热力>湿热>湿力>热力,验证了湿度循环致裂性最强的结论.湿热力耦合循环作用15次后裂隙率达0.92%,裂隙条数增至30条,平均长度延伸至60.58 mm,而平均宽度稳定在0.47 mm左右.孔隙率与裂隙率的灰关联度最大,为0.813,即微观结构变化中孔隙发育与裂隙扩展的关联程度最大.湿热力耦合循环作用中,湿度循环引起黏土矿物晶层间距变化,导致颗粒破碎、孔隙扩张形成微裂隙,温度循环使试样产生差异性热应力、水分分布,促使微裂隙发育贯通,荷载作用增加尖端应力,最终导致裂隙网络形成.

关键词：边坡工程粉砂质泥岩湿热力作用裂隙发育微观结构

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