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Trehalose attenuates abdominal aortic aneurysm formation by inducing autophagy in smooth muscle cells

Journal of Geriatric Cardiology 2023年第3期20卷 214-222页

作者： Bo JIANG Xuan LI Mo WANG Guang-Xin LI Peng-Wei REN Yu-Qi WANG Shi-Jie XIN ling-feng qin Department of Vascular Surgery the First Hospital of China Medical UniversityKey Laboratory of PathogenesisPrevention and Therapeutics of Aortic AneurysmShenyangChina Department of Surgery Yale School of MedicineNew HavenCTUSA Department of Breast and Thyroid Surgery Peking University Shenzhen HospitalShenzhenChina Yale Stem Cell Center Yale School of MedicineNew HavenCTUSA Department of Biomedical Engineering Yale UniversityNew HavenCTUSA

BACKGROUND Trehalose is a naturally occurring disaccharide,which has been identified as an autophagy inducer and ex-hibits protective effect in cardiovascular diseases such as myocardial infraction and ***,the functional role of trehalose in abdominal aortic aneurysm(AAA)remains *** To study the effect of trehalose in AAA,trehalose(1 g/kg per day)were given for 14 continuous days in a mouse model of elastase-induced abdominal aortic *** day 14,ultrasound was performed to measure aortic diameter before the abdominal aortas were harvested and processed for further ***-Van Gieson staining and TUNEL staining were performed on paraffin sections to evaluate vascular histology and apoptosis,immunofluorescence staining and Western-blot were performed to evaluate expression of autophagy *** Echocardiography and in situ pictures demonstrated that trehalose attenuated infrarenal aorta ***-Van Gieson staining showed elastin degradation was improved in trehalose-treated *** with vehicle-treated mice,trehalose treatment restored smooth muscle cell contractile phenotype with increasedα-SMA,Calponin and Myh11 ***,trehalose also attenuated cell apoptosis and leukocytes ***,trehalose induced autophagy with decrease SQSTM1/p62 accumulation,increased lamp2 expression and LC3B *** Trehalose attenuated AAA progression with decreased inflammation and restored SMC contractile phenotype by inducing *** results demonstrated the therapeutic potential of trehalose in AAA.

关键词： abdominal aneurysm protective

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Anticancer effect of Jinlongshe granules on in situ-transplanted human MKN-45 gastric cancer in nude mice and xenografted sarcoma 180 in Kunming mice and its mechanism

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World Journal of Gastroenterology 2006年第18期12卷 2890-2894页

作者： Zhi-Hong Yu Pin-Kang Wei ling Xu Zhi-feng qin Jun Shi Department of Traditional Chinese Medicine Changzheng Hospital Second Military Medical University Shanghai 200003 China

AIM： To study the antitumor effect of Chinese compound Jinlongshe （JLS） granules on sarcoma 180 and MKN-45 human gastric cancer cell lines in vivo and its mechanism. METHODS： After establishment of S180 sarcoma （S180） and MKN-45 gastric cancer model of nude mice, the tumor-bearing mice were divided into 5 groups at random. Three experimental groups were respectively given the aqueous extract of JLS granules at doses of 120 g, 60 g and 20 g/（kg per 6/wk,i.g） for 3 wk in S180 and 6 wk in nude mice model. Positive control was given cyclophosphamide （Cy） at a dose of 50 mg/（kg per 3/wk, i.g） for 3 wk in S180 models and 5-Fluorouracil （5-FU） 20 mg/（kg per 3/wk, i.g） for 3 wk in nude mice model. Negative control was given normal saline （NS） at a dose of 0.18 g/（kg per 6/wk, i.g） respectively. After 3 wk in mice bearing S180 tumor and 6 wk in nude mice model, the experimental animals were sacrificed and the masses of tumor were weighed, and the rates of tumor inhibition of each treated group were calculated respectively. To determine the antitumor mechanisms, the morphological changes, cell cycle and apoptosis were observed in MKN-45 nude mice model. Annexin V-FITC/PI double staining FCM assay was used to further determine the live cells, apoptotic cells, necrotic cells and debris. RESULTS： The inhibitory rates of JLS granules at the doses of 20 g/kg, 60 g/kg and 120 g/kg were 50.31%, 55.94% and 68.13% （P 〈 0.01） in nude mice models and 40.90%, 50.32% and 58.46% （P 〈 0.01） in S180 model. The inhibitory rate of Cy was 85.22% in S180 models and the inhibitory rate of 5-FU was 53.43% in nude mice model （P 〈 0.01）. Nuclear chromatin and margination were observed under a transmission electron microscope （TEM）. The G0/G1 phase was arrested, typical apoptotic peak appeared, the apoptotic rate was 22.81%-38.54% in three JLS granule-treated groups. Annexin V-FITC/PI double staining FCM assay showed that the apoptotic cells were 4.36%, 3.08% and 7.08% in three dosages, most cell

关键词： Jinlongshe granules Sarcoma 180 Human MKN-45 gastric cancer lines Traditional Chinese medicine

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The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong qin Zhou ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

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改性磷脂的性质及其在乳化炸药中的应用

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火炸药学报 2008年第4期31卷 30-34页

作者：刘燕冯玲琴卫延安南京理工大学化工学院江苏南京210094

为开发用于乳化炸药的新型复合乳化剂,利用化学改性后的大豆磷脂与Span80按照一定比例混合配制复合乳化剂。研究了改性磷脂的乳化力与分散力,采用DSC分析了复合乳化剂与硝酸铵的相容性,并通过单滴法和高低温循环等试验考察了乳化体系的... 详细信息

为开发用于乳化炸药的新型复合乳化剂,利用化学改性后的大豆磷脂与Span80按照一定比例混合配制复合乳化剂。研究了改性磷脂的乳化力与分散力,采用DSC分析了复合乳化剂与硝酸铵的相容性,并通过单滴法和高低温循环等试验考察了乳化体系的油膜强度和稳定性能。结果表明,改性后的磷脂具有良好的乳化力和分散力,与硝酸铵的相容性较好,复合乳化剂的界面吸附膜强度增加,乳胶的稳定性提高。用复合乳化剂制备的乳化炸药爆速达3 300m/s,猛度为12.5mm,殉爆距离超过3 cm,各项性能均符合GB 18095-2000的要求。

关键词：应用化学改性磷脂乳化炸药复合乳化剂大豆磷脂 Span80

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北京市官厅水库水质预报系统

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中国环境科学 2001年第3期21卷 275-278页

作者：胡治飞张振兴郭怀成王建厅冯伶亲北京大学环境科学中心教育部水沙科学重点实验室北京100871 北京市水环境监测中心北京100038

CE-QUAL-W2模型是近年来新开发的水动力学与水质模型,可模拟河流、湖泊、水库等不同条件下多种污染物的迁移转化规律.根据官厅水库狭长、水浅和水文、水力、水质扩散等特点,采用CE-QUAL-W2模型模拟其水质变化,并对模拟模型水质参数进... 详细信息

CE-QUAL-W2模型是近年来新开发的水动力学与水质模型,可模拟河流、湖泊、水库等不同条件下多种污染物的迁移转化规律.根据官厅水库狭长、水浅和水文、水力、水质扩散等特点,采用CE-QUAL-W2模型模拟其水质变化,并对模拟模型水质参数进行验证,将其用于官厅水库水质的预测研究;进而提出官厅水库水污染控制的对策及建议.

关键词：官厅水库 CE-QUAL-W2模型水质模拟水质预测预报系统北京

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基于自适应交互多模滤波的SCNS/RSINS紧组合对准方法（英文）

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中国惯性技术学报 2016年第4期24卷 464-472页

作者：周凌峰董燕琴赵汪洋赵小明屈原津侯志宁哈尔滨工程大学自动化学院哈尔滨150001 天津航海仪器研究所天津300131 火箭军装备研究院北京100092

为了提高船用单轴旋转捷联惯性导航系统(RSINS)初始对准的精度和快速性,针对传统的EKF滤波线性化误差和单传感器精度不高的问题,设计了一种基于自适应交互多模(AIMM)算法的SCNS/RSINS紧组合对准方法。该算法将自适应滤波器与交互多模型... 详细信息

为了提高船用单轴旋转捷联惯性导航系统(RSINS)初始对准的精度和快速性,针对传统的EKF滤波线性化误差和单传感器精度不高的问题,设计了一种基于自适应交互多模(AIMM)算法的SCNS/RSINS紧组合对准方法。该算法将自适应滤波器与交互多模型相结合,利用了两个合理构建状态模型和量测模型的平行滤波来实现对实际模态的覆盖:滤波1应用姿态四元数算法建立了状态方程的模型,量测量为RSINS与SCNS之间的姿态四元数误差;滤波2的根据SCNS/RSINS的误差特性构建了状态方程模型,量测量为RSINS与SCNS位置和航向误差,然后应用自适应IMM算法将两个平行滤波的估计值进行数据融合。在某种程度上,因状态噪声和量测噪声的不确定性,EKF的性能会被降低,而通过模型转换机制,IMM可用于选择一个合理的模型自动计算器来自适应地调整对准过程中噪声的协方差矩阵,因此该算法可以有效地解决SCNS/RSINS组合导航系统的初始对准问题。仿真结果表明:与EKF算法相比,基于自适应IMM算法的SCNS/RSINS组合对准方法的估计精度和对准快速能力都得到了改善,其中对方位陀螺漂移的估计时间缩短了至少40%。

关键词： SCNS/RSINS组合导航系统扩展卡尔曼滤波自适应交互多模滤波算法

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Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： Yi Qi Xueying Chen Bowen Liu Xuliang Lin Xueqing Qiu Yanlin qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

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Brain Dynamic Mechanisms of Scale Effect In Visual Spatial Attention

Brain Dynamic Mechanisms of Scale Effect In Visual Spatial A...

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中国医师协会第二届康复医学论坛、中国康复医学会第四届青年学术会议、北京康复医学会第三届会员代表大会

作者： SONG weiqun, ling feng, WANG Maobin, qin yanjing, YANG yuanbin, LI guangqin LUO yuejia Department of rehabilitation, Xuanwu Hospital, Capital University of Medical Science, Beijing, 100053, China. Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.

The dynamic mechanisms in the brain of the early ERP scale effect of different attentive regions was studied among 16 young subjects through the precue-target visual search paradigm by ERP technique, with the attentive regions cued by different scales of Chinese characters. The results showed that the reaction time was shortened with the reduction of cue scale and fixed target stimulus, while the amplitudes of P1 and N1 components of event-related potentials increased. These results not only provided the electrophysiological evidences which supported the zoom-lens theory, but also indicated that the zoom-lens effect happened at the early selected attention period. The results also showed that there existed two kinds of separation in P2 effect. One was between P1 effect and P2 effect, which meant that additional computation was needed when the spatial scale of attention was enlarged;the other was between the left and right hemisphere of P2 effect, which indicated that the attentive processing of the cue region mainly happened in the left hemisphere.

关键词： Visual spatial attention, Scale effect, Event-related potential

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Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian qin Yuxin Jin Yiming qin Feifei Yuan Hongbin Lu Jianzhong Hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

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浅析GPS在工程测量中的应用

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新疆石油学院学报 2000年第1期12卷 45-48页

作者：计长飞林峰闫琴新疆石油管理局勘察设计研究院

本文介绍了TOPCON双频GPS接收机TorboSⅡ在油田井位工程测量中的应用 ,并进行了GPS卫星网平差后同地面网相比较的精度分析 ,提出了GPS在油田工程测量中应用的前景和局限性。

关键词： GPS 井位工程测量油田

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