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Stimulated Brillouin interaction between guided phonons and photons in a lithium niobate waveguide

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 173-175页

作者： Yuan-Hao Yang Jia-Qi Wang Zheng-Xu Zhu Xin-Biao Xu Qiang Zhang Juanjuan Lu Yu Zeng Chun-Hua Dong Luyan Sun Guang-Can Guo Chang-ling zou CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Opto-ElectronicsShanxi UniversityTaiyuan 030006China School of Information Science and Technology ShanghaiTech UniversityShanghai 201210China Center for Quantum Information Institute for Interdisciplinary Information SciencesTsinghua UniversityBeijing 100084China

The Brillouin scattering is one of the strongest nonlinear optical effects in dielectrics[1].In particular,the backward Brillouin scattering(BBS)provides an efficient method to achieve low-noise optical gain for active photonics[2]and the coherent interconnects between 10 GHz phonons and photons[3].However,previous studies on BBS are primarily limited to the unconfined phonons[1]or phonon confined in suspended structures[4-6].

关键词： scattering waveguide Brillouin

2-APQC,a small-molecule activator of Sirtuin-3(SIRT3),alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2748-2764页

作者： Fu Peng Minru Liao Wenke Jin Wei Liu Zixiang Li Zhichao Fan ling zou Siwei Chen lingjuan Zhu Qian Zhao Gu Zhan Liang Ouyang Cheng Peng Bo Han Jin Zhang Leilei Fu West China School of Pharmacy and Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China State Key Laboratory of Southwestern Chinese Medicine Resources Hospital of Chengdu University of Traditional Chinese MedicineSchool of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China School of Pharmaceutical Sciences Health Science CenterShenzhen UniversityShenzhen 518060China School of Traditional Chinese Materia Medica Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China

Sirtuin 3(SIRT3)is well known as a conserved nicotinamide adenine dinucleotide^(+)(NAD^(+))-dependent deacetylase located in the mitochondria that may regulate oxidative stress,catabolism and ATP *** evidence has recently revealed that SIRT3 plays its critical roles in cardiac fibrosis,myocardial fibrosis and even heart failure(HF),through its deacetylation ***,discovery of SIRT3 activators and elucidating their underlying mechanisms of HF should be urgently ***,we identified a new small-molecule activator of SIRT3(named 2-APQC)by the structure-based drug designing strategy.2-APQC was shown to alleviate isoproterenol(ISO)-induced cardiac hypertrophy and myocardial fibrosis in vitro and in vivo rat ***,in SIRT3 knockout mice,2-APQC could not relieve HF,suggesting that 2-APQC is dependent on SIRT3 for its protective ***,2-APQC was found to inhibit the mammalian target of rapamycin(mTOR)-p70 ribosomal protein S6 kinase(p70S6K),c-jun N-terminal kinase(JNK)and transforming growth factor-β(TGF-β)/small mother against decapentaplegic 3(Smad3)pathways to improve ISO-induced cardiac hypertrophy and myocardial *** upon RNA-seq analyses,we demonstrated that SIRT3-pyrroline-5-carboxylate reductase 1(PYCR1)axis was closely assoiated with *** activating PYCR1,2-APQC was shown to enhance mitochondrial proline metabolism,inhibited reactive oxygen species(ROS)-p38 mitogen activated protein kinase(p38MAPK)pathway and thereby protecting against ISO-induced mitochondrialoxidative ***,activation of SIRT3 by 2-APQC could facilitate AMP-activated protein kinase(AMPK)-Parkin axis to inhibit ISO-induced ***,our results demonstrate that 2-APQC is a targeted SIRT3 activator that alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis,which may provide a new clue on exploiting a promising drug candidate for the future HF therapeutics.

关键词： SIRT3 homeostasis metabolism

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颌骨修复重建的分子调控机制研究进展

四川大学学报（医学版） 2024年第1期55卷 224-229页

作者：杜信眉谢静邹玲口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙体牙髓科成都610041

临床上常见因外伤、肿瘤及炎症等导致的颌骨损伤。由于颌骨独特的生物力学特性和生理功能,如何精确有效地修复重建颌骨并恢复其功能和美观是口腔颌面外科领域的一项重要挑战。颌骨损伤后的自然修复过程,包括血肿形成、炎症反应、骨化以... 详细信息

临床上常见因外伤、肿瘤及炎症等导致的颌骨损伤。由于颌骨独特的生物力学特性和生理功能,如何精确有效地修复重建颌骨并恢复其功能和美观是口腔颌面外科领域的一项重要挑战。颌骨损伤后的自然修复过程,包括血肿形成、炎症反应、骨化以及骨重塑等阶段。骨形态发生蛋白(bone morphogenetic proteins,BMPs)、转化生长因子-β(transforming growth factor beta,TGF-β)、血管内皮生长因子(vascular endothelial-derived growth factor,VEGF)等生长因子在促进颌骨骨再生中发挥着重要的作用。细胞因子如白细胞介素和肿瘤坏死因子在调节炎症反应和骨修复中具有双重作用。近年来,分子生物学研究在颌骨修复重建领域中已经取得了显著进展。组织工程技术在颌骨修复中有着重要的应用,包括干细胞疗法、生物活性支架和生长因子递送系统。但这些治疗手段所涉及的复杂的颌骨修复重建分子调控机制尚不清晰,有待进一步研究。未来的研究方向将集中在精确控制这些分子过程,以及开发更高效的组合治疗策略,以促进颌骨的有效和功能性重建。本综述旨在探讨颌骨修复重建的分子调控机制及其治疗策略的最新进展,为颌骨修复重建的机制提供分子层面的理解。

关键词：骨重建骨形态发生蛋白转化生长因子-β 血管内皮生长因子组织工程综述

Awake rabbit model of ischemic spinal cord injury with delayed paraplegia: The role of ambient temperature

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Animal Models and Experimental Medicine 2024年第5期 732-739页

作者： Wang Yang Qian-qian Wu Lu Yang Yu-jie Chen Ren-qing Jiang ling zou Qing-shan Liu Guang-you Shi Jiang Cao Xiao-chao Yang Jian Sun School of Biomedical Engineering and Medical Imaging Army Medical University Army Health Service Training Base Army Medical University Department of Neurosurgery Southwest Hospital Army Medical University

Background: Paraplegia after spinal cord ischemia is a devastating condition in the clinic. Here, we develop an awake rabbit model of spinal cord ischemia with delayed paraplegia and explore the influence of ambient temperature on the outcomes after ***: A total of 47 male rabbits were involved in the present study. Transient spinal cord ischemia was induced by occluding the infrarenal abdominal aorta of awake rabbits at different ambient temperatures. To find the optimal conditions for developing delayed paraplegia, hindlimb motor function after ischemia was evaluated between ***: The onset and magnitude of ischemic injury varied with the ambient temperature maintained during the peri-i schemia period. More serious spinal cord injury occurred when ischemia was induced at higher temperatures. At 18°C, 25-minute ischemia resulted in 74% of rabbits developing delayed paraplegia. At a temperature of 28°C or higher, most of the animals developed acute paraplegia immediately. While at 13°C, rabbits usually regained normal motor function without ***: This awake rabbit model is highly reproducible and will be helpful in future studies of delayed paraplegia after spinal cord ischemia. The ambient temperature must be considered while using this model during investigation of therapeutic interventions.

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Atom-referenced and stabilized soliton microcomb

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 2-8页

作者： Rui Niu Shuai Wan Tian-Peng Hua Wei-Qiang Wang Zheng-Yu Wang Jin Li Zhu-Bo Wang Ming Li Zhen Shen Yu Robert Sun Shui-Ming Hu Brent ELittle Sai Tak Chu Wei Zhao Guang-Can Guo Chang-ling zou Yun-Feng Xiao Wen-Fu Zhang Chun-Hua Dong State Key Laboratory of Transient Optics and Photonics Xi’an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi’an 710119China CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China University of Chinese Academy of Sciences Beijing 100049China Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China Department of Physics and Materials Science City University of Hong KongHong Kong 999077China State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China

For the applications of the frequency comb in microresonators,it is essential to obtain a fully frequency-stabilized microcomb laser *** this study,we present a system for generating a fully atom-referenced stabilized soliton *** pump light around 1560.48 nm is locked to an ultra-low-expansion(ULE)*** pump light is then frequency-doubled and referenced to the atomic transition *** repetition rate of the soliton microcomb is injection-locked to an atomic-clockstabilized radio frequency(RF)source,leading to mHz stabilization at 1 *** a result,all comb lines have been frequencystabilized based on the atomic reference and the ULE cavity,achieving a very high precision of approximately 18 Hz at 1 s,corresponding to the frequency stability of 9.5×10^(-14).Our approach provides a fully stabilized microcomb experiment scheme with no requirement of f-2f technique,which could be easily implemented and generalized to various photonic platforms,thus paving the way towards the ultraprecise optical sources for high precision spectroscopy.

关键词： microcavity frequency comb dissipative Kerr solitons fully stabilized microcomb

雅鲁藏布江大拐弯地区滑坡发育分布特征及其对地貌演化的响应

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地质学报 2024年第10期98卷 3062-3076页

作者：杜国梁邹玲杨志华孙东彦谷丽莹河北地质大学城市地质与工程学院河北石家庄050031 京津冀城市群地下空间智能探测与装备重点实验室河北石家庄050031 河北省地下人工环境智慧开发与管控技术创新中心河北石家庄050031 中国地质科学院地质力学研究所北京100081

雅鲁藏布江大拐弯地区位于青藏高原东南部,是世界上地壳隆升和地貌演化最快的区域之一。在内外动力耦合作用下,区内滑坡灾害极其发育,严重制约着公路、铁路和水电工程的规划建设。本文以滑坡对地貌演化的响应为切入点,剖析了地形地貌、... 详细信息

雅鲁藏布江大拐弯地区位于青藏高原东南部,是世界上地壳隆升和地貌演化最快的区域之一。在内外动力耦合作用下,区内滑坡灾害极其发育,严重制约着公路、铁路和水电工程的规划建设。本文以滑坡对地貌演化的响应为切入点,剖析了地形地貌、河流侵蚀、构造活动与滑坡分布的关系。研究表明:滑坡在地貌演化中扮演着重要角色,区内局部地形起伏度和坡度与滑坡发生呈非线性正相关关系,沟谷地貌通过增加斜坡陡度和滑坡率来适应的区域地壳隆升和河流快速下切;分析不同地貌演化阶段的面积-高程积分,随着地表侵蚀程度的增高,滑坡的面积比、滑坡坡度的平均值和中位数值都逐渐增大,表明滑坡侵蚀在区内快速侵蚀中起着重要支撑作用;河流侵蚀对滑坡的控制作用明显,雅鲁藏布江大拐弯在纵坡降较陡、河流功率大的加拉-金珠藏布口滑坡密集分布;滑坡发育与断裂密度呈正相关关系,与断裂距离呈负相关关系,区内断裂剧烈活动诱发的地震滑坡也是造成地貌侵蚀的重要媒介。研究结果有利于加深对雅鲁藏布江大拐弯地区滑坡孕灾背景的认识,也可为研究区的工程规划建设和防灾减灾提供科学依据。

关键词：雅鲁藏布江大拐弯滑坡构造地貌分布规律

吉林省土地资源承载力时空分异特征及障碍因子分析

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牡丹江师范学院学报（自然科学版） 2024年第3期 45-50页

作者：邹铃石丹吉林师范大学地理科学与旅游学院吉林四平136000

探讨吉林省土地资源承载力时空分异特征及其障碍因子.选择吉林省8个地级市为研究对象,构建吉林省土地资源承载力系统评价指标体系,分析2012-2021年吉林省各地级市土地资源承载力时空演变特征及主要障碍因子.结果表明:吉林省8个地级市的... 详细信息

探讨吉林省土地资源承载力时空分异特征及其障碍因子.选择吉林省8个地级市为研究对象,构建吉林省土地资源承载力系统评价指标体系,分析2012-2021年吉林省各地级市土地资源承载力时空演变特征及主要障碍因子.结果表明:吉林省8个地级市的土地资源承载力区域差异随着时间发展不断扩大,长春市土地资源承载力指数具有明显的增长趋势,其余城市波动变化不大,主要表现为以长春市为中心的区域极化现象;无论是从吉林省整体来看,还是从各地级市来看,林地占比、单位工业用地工业产出、单位商服用地三产产出和地均GDP是影响土地资源承载力的主要障碍因子;建设用地占比和未利用地占比等因子对吉林省土地资源承载力的影响程度较弱.

关键词：土地资源承载力时空分异障碍度模型吉林省

Multi-h C波段导航信号调制方式及性能评估

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信号处理 2024年第2期40卷 301-312页

作者：倪育德易茉涵刘瑞华邹玲中国民航大学电子信息与自动化学院天津300300

近年来,L波段(1164~1610 MHz)频谱拥挤日渐严重,我国北斗卫星导航系统可用资源明显不足,基于频谱资源的不可再生性,探索研究新频段迫在眉睫。鉴于目前C波段导航信号设计尚不成熟,各国对C波段卫星导航信号体制也都还处于探索研究阶段,我... 详细信息

近年来,L波段(1164~1610 MHz)频谱拥挤日渐严重,我国北斗卫星导航系统可用资源明显不足,基于频谱资源的不可再生性,探索研究新频段迫在眉睫。鉴于目前C波段导航信号设计尚不成熟,各国对C波段卫星导航信号体制也都还处于探索研究阶段,我国有必要预先开展C波段卫星导航信号研究。处于C波段中5010~5030 MHz的卫星导航信号具有较少的频谱干扰、较低的电离层误差等显著优势,但仅有的20 MHz带宽对诸如射电天文业务(Radio Astronomy Service,RAS)和微波着陆系统(Microwave Landing System,MLS)等相邻业务频段的射频兼容性要求极为严苛。首先提出将多调制指数(Multi-h)的正交频分复用-连续相位调制(Orthogonal Frequency Division Multiplexing-Continuous Phase Modulation,OFDM-CPM)联合调制方式应用于C波段卫星导航;其次,在分析关键参数对Multi-h OFDM-CPM信号功率谱特性影响后,选取关联长度L为64、调制指数h为0.5的单调制指数(Single-h)OFDM-CPM(10)信号和h为[1/16,3/16]的Multi-h OFDM-CPM(10)信号作为C波段候选导航信号;最后,对包括兼容性、码跟踪精度、抗多径干扰在内的基础导航性能指标进行评估。研究表明,OFDM-CPM调制方式能很好兼顾C波段信号的带外约束性和导航性能要求,OFDM-CPM(10)h=[1/16,3/16]信号在所述各个基础导航性能指标上均表现最佳,在兼容性方面能弥补OFDM-CPM(10)h=0.5信号的略微不足。然而考虑到多调制指数会增加接收机复杂度,因此在C波段导航中,只有当接收机采用低复杂度检测算法时,Multi-h OFDM-CPM信号才会是比Single-h OFDM-CPM信号更佳的选择。

关键词： C波段导航多调制指数连续相位调制正交频分复用导航性能

桂枝汤合桂枝甘草龙骨牡蛎汤加减临床治疗失眠症1例

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中西医结合护理 2024年第7期10卷 72-75页

作者：邹玲肖周华北京中医药大学深圳医院(龙岗) 广东深圳518172

本文总结1例采用桂枝汤合桂枝甘草龙骨牡蛎汤加减治疗失眠患者的临床经验。失眠患者多为阴阳不调,久则易伤阴阳,故而引起“不寐”。基于中医辨证分型,桂枝汤合桂枝甘草龙骨牡蛎汤加减,温补心阳,调理营卫,使阴阳调和,并配合环境、饮食、... 详细信息

本文总结1例采用桂枝汤合桂枝甘草龙骨牡蛎汤加减治疗失眠患者的临床经验。失眠患者多为阴阳不调,久则易伤阴阳,故而引起“不寐”。基于中医辨证分型,桂枝汤合桂枝甘草龙骨牡蛎汤加减,温补心阳,调理营卫,使阴阳调和,并配合环境、饮食、运动、心理等护理干预,有效改善了患者睡眠质量。

关键词：失眠桂枝汤中药睡眠质量