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Recovery and in-situ reduction of precious metals by graphdiyne and graphdiyne oxide for antibacterial use

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Rare Metals 2024年第4期43卷 1747-1757页

作者： Ming-Ji Jiang Ya-Na Zhang ling-shen Meng Jing Kang Yong-Jun Li Alideertu Dong College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot010021China Engineering Research Center of Dairy Quality and Safety Control Technology Ministry of EducationInner Mongolia UniversityHohhot010021China Department of Chemistry University of ZurichCH-8057ZurichSwitzerland Laboratory of Organic Solids and Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing100190China

Based on the in-situ self-reduction and chemical stability,graphdiyne(GDY)and graphdiyne oxide(GDYO)are used as trapping agents to investigate the ability for recovering Au^(3+),Ag^+,and Pd^(2+)under different pH values and interfering *** strong acidity at pH=1,these two agents demonstrate high select recovery towards the three precious metal ions,which could be insitu reduced to nanoparticles(NPs).In addition,superparamagnetic Fe_(3)O_(4)NPs are deposited on the surfaces of GDY and *** magnetic responses enable GDYFe_(3)O_(4)to recover precious metals conveniently and efficiently by the aid of an external magnetic *** study also confirms the antibacterial activity of the as-recovered NPs deposited on GDY and GDYO against Escherichia coli and Staphylococcus aureus(1×10^(5)colony-forming unit(CFU)·mL^(-1)),and the antibacterial rates are 100%.This strategy of recovering precious metals and subsequently reusing to combat pathogens will be of great significance for environmental remediation and biomedical applications.

关键词： Graphdiyne In-situ reduction Recovery Precious metals Antibacterial

罗浮山风湿膏药联合硫酸氨基葡萄糖治疗风寒湿痹型膝骨关节炎临床观察

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药物评价研究 2024年第4期47卷 823-830页

作者：沈凌韩菲中国中医科学院广安门医院骨科北京100029 中国中医科学院广安门医院儿科北京100053

目的探讨罗浮山风湿膏药联合硫酸氨基葡萄糖治疗风寒湿痹型膝骨关节炎临床疗效。方法选择中国中医科学院广安门医院2021年9月—2022年5月收治的膝骨关节炎(风寒湿痹型)患者122例,依照随机数字表法分为对照组、试验组,每组61例,对照组采... 详细信息

目的探讨罗浮山风湿膏药联合硫酸氨基葡萄糖治疗风寒湿痹型膝骨关节炎临床疗效。方法选择中国中医科学院广安门医院2021年9月—2022年5月收治的膝骨关节炎(风寒湿痹型)患者122例,依照随机数字表法分为对照组、试验组,每组61例,对照组采用硫酸氨基葡萄糖,试验组联合罗浮山风湿膏药治疗,比较两组临床疗效,比较两组治疗前后中医证候积分,病情严重程度[骨关节炎指数(WOMAC)]、膝关节功能[Lysholm膝关节评分表(LKSS)]、生活质量[日常生活活动能力(ADL)],骨代谢指标[骨钙素(BGP)、骨保护素(OPG)、血清I型胶原交联C末端肽(CTX-I)、CTX-II],疼痛相关介质[血清P物质(SP)、前列腺素E2(PGE_(2))、5-羟色胺(5-HT)],炎症因子水平[白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)],并统计不良反应发生率。结果两组的总有效率相比,试验组更高(P0.05)。治疗后,两组患者中医证候各项积分均较本组治疗前显著降低(P0.05);两组疼痛相关介质SP、PGE_(2)、5-HT均较本组治疗前显著降低(P0.05)。结论罗浮山风湿膏药联合硫酸氨基葡萄糖治疗风寒湿痹型膝骨关节炎患者的效果明显,可减轻病情、改善膝关节功能、提高生活质量,还可减少疼痛介质,减轻炎症反应,且安全性高。

关键词：罗浮山风湿膏药硫酸氨基葡萄糖膝骨关节炎膝关节功能骨代谢疼痛

Transient diabetes mellitus with ABCC8 variant successfully treated with sulfonylurea:Two case reports and review of literature

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World Journal of Diabetes 2024年第8期15卷 1811-1819页

作者： ling-Hua shen Yan Cui Dong-Xia Fu Wei Yang sheng-Nan Wu Hui-Zhen Wang Hai-Hua Yang Yong-Xing Chen Hai-Yan Wei Department of Endocrinology and Metabolism Henan Key Laboratory of Children's Genetics and Metabolic DiseasesChildren's Hospital Affiliated to Zhengzhou UniversityHenan Children's Hospital Zhengzhou Children's HospitalZhengzhou 450018Henan ProvinceChina

BACKGROUND Transient neonatal diabetes mellitus(TNDM)is a rare form of diabetes mellitus that usually presents within the first 6 mo of *** often enter remission within several months,although relapse can occur later in *** in the ABCC8 gene,which encodes the sulfonylurea receptor 1 of the ATP-sensitive potassium channel in pancreatic beta cells,are associated with TNDM and permanent neonatal *** study describes a novel de novo c.3880C>T heterozygous ABCC8 variant that causes TNDM and can be treated with sulfonylurea *** SUMMARY We retrospectively analyzed 2 Chinese patients with TNDM who were diagnosed,treated,or referred for follow-up between September 2017 and September *** patients were tested for mutations using targeted next-generation *** with neonatal diabetes mellitus caused by a c.3880C>T heterozygous missense variant in the ABCC8 gene have not been reported *** children had an onset of post-infectious diabetic ketoacidosis,which is worth *** a follow-up visit after discontinuing insulin injection,oral glyburide was found to be effective with no adverse *** Early genetic testing of neonatal diabetes mellitus aids in accurate diagnosis and treatment and helps avoid daily insulin injections that may cause pain.

关键词： Neonatal diabetes mellitus ABCC8 Sulfonylurea receptors 1 KATP channels Sulfonylurea Glyburide Insulinulin Case report

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多域网络中单节点失效的虚拟网络恢复策略

北京邮电大学学报 2024年第1期47卷 72-77页

作者：凌申武穆清赵敏北京邮电大学信息与通信工程学院北京100876

目前针对节点失效的虚拟网络恢复问题研究都是针对单域物理网络,而现实网络都是多域分布的。因此,提出了针对多域网络中的单节点失效(SNFMDN)问题的虚拟网络恢复策略。以最大化恢复率和最小化恢复成本为目标,建立了SNFMDN问题的整数规... 详细信息

目前针对节点失效的虚拟网络恢复问题研究都是针对单域物理网络,而现实网络都是多域分布的。因此,提出了针对多域网络中的单节点失效(SNFMDN)问题的虚拟网络恢复策略。以最大化恢复率和最小化恢复成本为目标,建立了SNFMDN问题的整数规划模型;为快速求解该问题,提出了2种基于带宽消耗的虚拟网络恢复算法。实验结果表明,所提出的恢复策略可以有效地恢复受影响的虚拟网络,且恢复成本也相对较低。

关键词：网络虚拟化多域网络虚拟网络恢复节点失效虚拟网络映射

环状RNA对神经血管单元的调控作用及其应用进展

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中国药学杂志 2024年第11期59卷 970-973页

作者：沈灵姚红红东南大学医学院南京210009

环状RNA(circular RNA,circRNA)是一类具有共价闭合环状结构的单链RNA分子,在疾病发生发展中具有重要作用。神经血管单元是指脑微血管细胞、胶质细胞、神经元和细胞外基质等组成的脑功能的基本结构单元,对维持大脑稳态具有重要意义,近... 详细信息

环状RNA(circular RNA,circRNA)是一类具有共价闭合环状结构的单链RNA分子,在疾病发生发展中具有重要作用。神经血管单元是指脑微血管细胞、胶质细胞、神经元和细胞外基质等组成的脑功能的基本结构单元,对维持大脑稳态具有重要意义,近年来已成为多种复杂脑疾病的研究热点。然而circRNA对于神经血管单元的调控作用目前尚未明确,本文就circRNA对神经血管单元的调控作用及其应用的研究进展进行综述,以期为相关疾病提供治疗新靶点和新策略。

关键词：环状RNA 神经血管单元缺血性脑卒中抑郁症

Diagnostic efficacy of virtual organ computer-assisted analysis in measuring the volume ratio of subchorionic hematoma with serum progesterone

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World Journal of Clinical Cases 2024年第17期12卷 3053-3060页

作者： Lin-ling shen Jing Shi Chang-Wei Ding Gao-Le Dai Qi Ma Department of Ultrasound The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina Department of Ultrasound Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 211103Jiangsu ProvinceChina

BACKGROUND Subchorionic hematoma(SCH)is a common complication in early pregnancy characterized by the accumulation of blood between the uterine wall and the chorionic *** can lead to adverse pregnancy outcomes such as miscarriage,preterm birth,and other *** detection and accurate assessment of SCH are crucial for appropriate management and improved pregnancy *** To evaluate the diagnostic efficacy of virtual organ computer-assisted analysis(VOCAL)in measuring the volume ratio of SCH to gestational sac(GS)combined with serum progesterone on early pregnancy outcomes in patients with *** A total of 153 patients with SCH in their first-trimester pregnancies between 6 and 11 wk were *** patients were followed up until a gestational age of 20 *** parameters of transvaginal two-dimensional ultrasound,including the circumference of SCH(Cs),surface area of SCH(Ss),circumference of GS(Cg),and surface area of GS(Sg),and the parameters of VOCAL with transvaginal three-dimensional ultrasound,including the three-dimensional volume of SCH(3DVs)and GS(3DVg),were *** size of the SCH and its ratio to the GS size(Cs/Cg,Ss/Sg,3DVs/3DVg)were recorded and *** Compared with those in the normal pregnancy group,the adverse pregnancy group had higher Cs/Cg,Ss/Sg,and 3DVs/3DVg ratios(P<0.05).When 3DVs/3DVg was 0.220,the highest predictive performance predicted adverse pregnancy outcomes,resulting in an AUC of 0.767,and the sensitivity,specificity were 70.2%,75%*** measuring 3DVs/3DVg combined with serum progesterone gave a diagnostic AUC of 0.824 for early pregnancy outcome in SCH patients,with a high sensitivity of 82.1%and a specificity of 72.1%,which showed a significant difference between *** VOCAL-measured 3DVs/3DVg effectively quantifies the severity of SCH,while combined serum progesterone better predicts adverse pregnancy outcomes.

关键词： Subchorionic hematoma Virtual organ computer-assisted analysis Gestational sac Serum progesterone Ultrasound parameters Adverse pregnancy outcomes

Pien Tze Huang Inhibits Proliferation of Colorectal Cancer Cells through Suppressing PNO1 Expression and Activating p53/p21 Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第6期30卷 515-524页

作者： CAO Liu-jing LIU Li-ya CHEN You-qin HAN Yu-ying WEI Li-hui YAO Meng-ying FANG Yi WU Mei-zhu CHENG Ying Thomas J.Sferra LIU Hui-xin LI Li PENG Jun shen A-ling Clinical Research Institute the Second Affiliated Hospital&Academy of Integrative MedicineFujian University of Traditional Chinese MedicineFuzhou350122China Fujian Key Laboratory of Integrative Medicine in Geriatrics Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Pediatrics Case Western Reserve University School of MedicineUH Rainbow Babies and Children’s HospitalClevelandOH44106USA Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Health Management Fujian Provincial HospitalShengli Clinical College of Fujian Medical UniversityFuzhou000000China

ObjectiveTo explore the regulatory effect of Pien Tze Huang (PZH) on targeting partner of NOB1 (PNO1) and it’s down-stream mediators in colorectal cancer (CRC) *** polymerase chain reaction was performed to determine mRNA levels of PNO1, TP53, and CDKN1A. Western blotting was performed to determine protein levels of PNO1, p53, and p21. HCT-8 cells were transduced with a lentivirus over-expressing PNO1. Colony formation assay was used to detect cell survival in PNO1 overexpression of HCT-8 cells after PZH treatment. Cell-cycle distribution, cell viability and cell apoptosis were performed to identify the effect of PNO1 overexpression on cell proliferation and apoptosis of HCT-8 cells after PZH treatment. Xenograft BALB/c nude mice bearing HCT116 cells transduced with sh-PNO1 or sh-Ctrl lentivirus were evaluated. Western blot assay was performed to detect PNO1, p53, p21 and PCNA expression in tumor sections. Terminal deoxynucleotidyl transferase dUTP nick end labling (TUNEL) assay was used to determine the apoptotic cells in *** treatment decreased cell viability, down-regulated PNO1 expression, and up-regulated p53 and p21 expressions in HCT-8 cells (P<0.05). PNO1 overexpression attenuated the effects of PZH treatment, including the expression of p53 and p21, cell growth, cell viability, cell cycle arrest and cell apoptosis in vitro (P<0.05). PNO1 knockdown eliminated the effects of PZH treatment on tumor growth, inhibiting cell proliferation inhibition and apoptosis induction in vivo (P<0.05). Similarly, PNO1 knockdown attenuated the effects of PZH treatment on the down-regulation of PNO1 and up-regulation of p53 and p21 in vivo (P<0.05).ConclusionThe mechanism by which PZH induces its CRC anti-proliferative effect is at least in part by regulating the expression of PNO1 and its downstream targets p53 and p21.

关键词： colorectal cancer Pien Tze Huang Chinese medicine partner of NOB1 proliferation p53/p21 pathway

基于CN-FRAM的公共交通设备设施系统运营安全韧性度量

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中国安全科学学报 2024年第3期34卷 45-54页

作者：申玲唐令怡廖洁三江学院土木工程学院江苏南京210012 东南大学土木工程学院江苏南京211189

设备设施故障是公共交通系统运营安全事故发生的主要原因,为更好地度量和增强系统的安全韧性,提出融合复杂网络(CN)与功能共振分析方法(FRAM)的CN-FRAM运营安全韧性度量模型,并将系统韧性定义为扰动下系统性能损失与性能基线之比。首先... 详细信息

设备设施故障是公共交通系统运营安全事故发生的主要原因,为更好地度量和增强系统的安全韧性,提出融合复杂网络(CN)与功能共振分析方法(FRAM)的CN-FRAM运营安全韧性度量模型,并将系统韧性定义为扰动下系统性能损失与性能基线之比。首先,根据设备设施系统构成和节点功能,建立CN;其次,将FRAM模型嵌入到CN中,以扩展节点和连接,构建CN-FRAM模型;然后,基于CN-FRAM韧性度量模型分析系统组件之间功能变化的聚合,并在量化系统韧性时综合考虑网络整体效益和组件之间的耦合程度;最后,以南京市地铁信号系统为例,验证方法的可行性和有效性。结果表明:该模型可以量化系统破坏-恢复全过程的韧性,计算故障对系统的影响程度,并以韧性值最大化为目标,展现不同修复策略下的韧性表现,从而为确定最佳恢复顺序提供依据。对比现有方法,该方法所确定的最优恢复策略能显著减少系统因故障造成的整体性能损失,从而提高系统的韧性。

关键词：复杂网络(CN)与功能共振分析方法(FRAM) 公共交通设备设施系统运营安全韧性韧性度量

行动者网络视角下中小企业参与产教融合的推进路径

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中国职业技术教育 2024年第13期 20-26页

作者：孙婧申玲三江学院土木工程学院

有效推进面广量大的中小企业积极参与产教融合行动,是深化产教融合的必然要求。针对现有中小企业参与产教融合目标决策与动力机制缺失、模式渠道匮乏、资源利用效率低下、信息沟通交流不畅、运行管理不规范、评价体系不健全等问题,提出... 详细信息

有效推进面广量大的中小企业积极参与产教融合行动,是深化产教融合的必然要求。针对现有中小企业参与产教融合目标决策与动力机制缺失、模式渠道匮乏、资源利用效率低下、信息沟通交流不畅、运行管理不规范、评价体系不健全等问题,提出基于中小企业参与下行动者网络的转译过程,系统构建共立目标协商机制、共建多元动力机制、共创组织平台载体、共商资源协同机制、共设信息协同机制、共定制度协同机制、共构发展评价体系的推进路径,为异质行动者协同推进中小企业参与产教融合行动提供参考。

关键词：产教融合中小企业行动者网络