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Stimulated Brillouin interaction between guided phonons and photons in a lithium niobate waveguide

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 173-175页

作者： Yuan-Hao Yang Jia-Qi Wang Zheng-Xu Zhu Xin-Biao Xu Qiang Zhang Juanjuan Lu Yu Zeng Chun-Hua Dong Luyan Sun Guang-Can Guo Chang-ling zou CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Opto-ElectronicsShanxi UniversityTaiyuan 030006China School of Information Science and Technology ShanghaiTech UniversityShanghai 201210China Center for Quantum Information Institute for Interdisciplinary Information SciencesTsinghua UniversityBeijing 100084China

The Brillouin scattering is one of the strongest nonlinear optical effects in dielectrics[1].In particular,the backward Brillouin scattering(BBS)provides an efficient method to achieve low-noise optical gain for active photonics[2]and the coherent interconnects between 10 GHz phonons and photons[3].However,previous studies on BBS are primarily limited to the unconfined phonons[1]or phonon confined in suspended structures[4-6].

关键词： scattering waveguide Brillouin

2-APQC,a small-molecule activator of Sirtuin-3(SIRT3),alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2748-2764页

作者： Fu Peng Minru Liao Wenke Jin Wei Liu Zixiang Li Zhichao Fan ling zou Siwei Chen lingjuan Zhu Qian Zhao Gu Zhan Liang Ouyang Cheng Peng Bo Han Jin Zhang Leilei Fu West China School of Pharmacy and Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China State Key Laboratory of Southwestern Chinese Medicine Resources Hospital of Chengdu University of Traditional Chinese MedicineSchool of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China School of Pharmaceutical Sciences Health Science CenterShenzhen UniversityShenzhen 518060China School of Traditional Chinese Materia Medica Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China

Sirtuin 3(SIRT3)is well known as a conserved nicotinamide adenine dinucleotide^(+)(NAD^(+))-dependent deacetylase located in the mitochondria that may regulate oxidative stress,catabolism and ATP *** evidence has recently revealed that SIRT3 plays its critical roles in cardiac fibrosis,myocardial fibrosis and even heart failure(HF),through its deacetylation ***,discovery of SIRT3 activators and elucidating their underlying mechanisms of HF should be urgently ***,we identified a new small-molecule activator of SIRT3(named 2-APQC)by the structure-based drug designing strategy.2-APQC was shown to alleviate isoproterenol(ISO)-induced cardiac hypertrophy and myocardial fibrosis in vitro and in vivo rat ***,in SIRT3 knockout mice,2-APQC could not relieve HF,suggesting that 2-APQC is dependent on SIRT3 for its protective ***,2-APQC was found to inhibit the mammalian target of rapamycin(mTOR)-p70 ribosomal protein S6 kinase(p70S6K),c-jun N-terminal kinase(JNK)and transforming growth factor-β(TGF-β)/small mother against decapentaplegic 3(Smad3)pathways to improve ISO-induced cardiac hypertrophy and myocardial *** upon RNA-seq analyses,we demonstrated that SIRT3-pyrroline-5-carboxylate reductase 1(PYCR1)axis was closely assoiated with *** activating PYCR1,2-APQC was shown to enhance mitochondrial proline metabolism,inhibited reactive oxygen species(ROS)-p38 mitogen activated protein kinase(p38MAPK)pathway and thereby protecting against ISO-induced mitochondrialoxidative ***,activation of SIRT3 by 2-APQC could facilitate AMP-activated protein kinase(AMPK)-Parkin axis to inhibit ISO-induced ***,our results demonstrate that 2-APQC is a targeted SIRT3 activator that alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis,which may provide a new clue on exploiting a promising drug candidate for the future HF therapeutics.

关键词： SIRT3 homeostasis metabolism

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颌骨修复重建的分子调控机制研究进展

四川大学学报（医学版） 2024年第1期55卷 224-229页

作者：杜信眉谢静邹玲口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙体牙髓科成都610041

临床上常见因外伤、肿瘤及炎症等导致的颌骨损伤。由于颌骨独特的生物力学特性和生理功能,如何精确有效地修复重建颌骨并恢复其功能和美观是口腔颌面外科领域的一项重要挑战。颌骨损伤后的自然修复过程,包括血肿形成、炎症反应、骨化以... 详细信息

临床上常见因外伤、肿瘤及炎症等导致的颌骨损伤。由于颌骨独特的生物力学特性和生理功能,如何精确有效地修复重建颌骨并恢复其功能和美观是口腔颌面外科领域的一项重要挑战。颌骨损伤后的自然修复过程,包括血肿形成、炎症反应、骨化以及骨重塑等阶段。骨形态发生蛋白(bone morphogenetic proteins,BMPs)、转化生长因子-β(transforming growth factor beta,TGF-β)、血管内皮生长因子(vascular endothelial-derived growth factor,VEGF)等生长因子在促进颌骨骨再生中发挥着重要的作用。细胞因子如白细胞介素和肿瘤坏死因子在调节炎症反应和骨修复中具有双重作用。近年来,分子生物学研究在颌骨修复重建领域中已经取得了显著进展。组织工程技术在颌骨修复中有着重要的应用,包括干细胞疗法、生物活性支架和生长因子递送系统。但这些治疗手段所涉及的复杂的颌骨修复重建分子调控机制尚不清晰,有待进一步研究。未来的研究方向将集中在精确控制这些分子过程,以及开发更高效的组合治疗策略,以促进颌骨的有效和功能性重建。本综述旨在探讨颌骨修复重建的分子调控机制及其治疗策略的最新进展,为颌骨修复重建的机制提供分子层面的理解。

关键词：骨重建骨形态发生蛋白转化生长因子-β 血管内皮生长因子组织工程综述

Atom-referenced and stabilized soliton microcomb

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 2-8页

作者： Rui Niu Shuai Wan Tian-Peng Hua Wei-Qiang Wang Zheng-Yu Wang Jin Li Zhu-Bo Wang Ming Li Zhen Shen Yu Robert Sun Shui-Ming Hu Brent ELittle Sai Tak Chu Wei Zhao Guang-Can Guo Chang-ling zou Yun-Feng Xiao Wen-Fu Zhang Chun-Hua Dong State Key Laboratory of Transient Optics and Photonics Xi’an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi’an 710119China CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China University of Chinese Academy of Sciences Beijing 100049China Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China Department of Physics and Materials Science City University of Hong KongHong Kong 999077China State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China

For the applications of the frequency comb in microresonators,it is essential to obtain a fully frequency-stabilized microcomb laser *** this study,we present a system for generating a fully atom-referenced stabilized soliton *** pump light around 1560.48 nm is locked to an ultra-low-expansion(ULE)*** pump light is then frequency-doubled and referenced to the atomic transition *** repetition rate of the soliton microcomb is injection-locked to an atomic-clockstabilized radio frequency(RF)source,leading to mHz stabilization at 1 *** a result,all comb lines have been frequencystabilized based on the atomic reference and the ULE cavity,achieving a very high precision of approximately 18 Hz at 1 s,corresponding to the frequency stability of 9.5×10^(-14).Our approach provides a fully stabilized microcomb experiment scheme with no requirement of f-2f technique,which could be easily implemented and generalized to various photonic platforms,thus paving the way towards the ultraprecise optical sources for high precision spectroscopy.

关键词： microcavity frequency comb dissipative Kerr solitons fully stabilized microcomb

Multi-h C波段导航信号调制方式及性能评估

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信号处理 2024年第2期40卷 301-312页

作者：倪育德易茉涵刘瑞华邹玲中国民航大学电子信息与自动化学院天津300300

近年来,L波段(1164~1610 MHz)频谱拥挤日渐严重,我国北斗卫星导航系统可用资源明显不足,基于频谱资源的不可再生性,探索研究新频段迫在眉睫。鉴于目前C波段导航信号设计尚不成熟,各国对C波段卫星导航信号体制也都还处于探索研究阶段,我... 详细信息

近年来,L波段(1164~1610 MHz)频谱拥挤日渐严重,我国北斗卫星导航系统可用资源明显不足,基于频谱资源的不可再生性,探索研究新频段迫在眉睫。鉴于目前C波段导航信号设计尚不成熟,各国对C波段卫星导航信号体制也都还处于探索研究阶段,我国有必要预先开展C波段卫星导航信号研究。处于C波段中5010~5030 MHz的卫星导航信号具有较少的频谱干扰、较低的电离层误差等显著优势,但仅有的20 MHz带宽对诸如射电天文业务(Radio Astronomy Service,RAS)和微波着陆系统(Microwave Landing System,MLS)等相邻业务频段的射频兼容性要求极为严苛。首先提出将多调制指数(Multi-h)的正交频分复用-连续相位调制(Orthogonal Frequency Division Multiplexing-Continuous Phase Modulation,OFDM-CPM)联合调制方式应用于C波段卫星导航;其次,在分析关键参数对Multi-h OFDM-CPM信号功率谱特性影响后,选取关联长度L为64、调制指数h为0.5的单调制指数(Single-h)OFDM-CPM(10)信号和h为[1/16,3/16]的Multi-h OFDM-CPM(10)信号作为C波段候选导航信号;最后,对包括兼容性、码跟踪精度、抗多径干扰在内的基础导航性能指标进行评估。研究表明,OFDM-CPM调制方式能很好兼顾C波段信号的带外约束性和导航性能要求,OFDM-CPM(10)h=[1/16,3/16]信号在所述各个基础导航性能指标上均表现最佳,在兼容性方面能弥补OFDM-CPM(10)h=0.5信号的略微不足。然而考虑到多调制指数会增加接收机复杂度,因此在C波段导航中,只有当接收机采用低复杂度检测算法时,Multi-h OFDM-CPM信号才会是比Single-h OFDM-CPM信号更佳的选择。

关键词： C波段导航多调制指数连续相位调制正交频分复用导航性能

吉林省土地资源承载力时空分异特征及障碍因子分析

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牡丹江师范学院学报（自然科学版） 2024年第3期 45-50页

作者：邹铃石丹吉林师范大学地理科学与旅游学院吉林四平136000

探讨吉林省土地资源承载力时空分异特征及其障碍因子.选择吉林省8个地级市为研究对象,构建吉林省土地资源承载力系统评价指标体系,分析2012-2021年吉林省各地级市土地资源承载力时空演变特征及主要障碍因子.结果表明:吉林省8个地级市的... 详细信息

探讨吉林省土地资源承载力时空分异特征及其障碍因子.选择吉林省8个地级市为研究对象,构建吉林省土地资源承载力系统评价指标体系,分析2012-2021年吉林省各地级市土地资源承载力时空演变特征及主要障碍因子.结果表明:吉林省8个地级市的土地资源承载力区域差异随着时间发展不断扩大,长春市土地资源承载力指数具有明显的增长趋势,其余城市波动变化不大,主要表现为以长春市为中心的区域极化现象;无论是从吉林省整体来看,还是从各地级市来看,林地占比、单位工业用地工业产出、单位商服用地三产产出和地均GDP是影响土地资源承载力的主要障碍因子;建设用地占比和未利用地占比等因子对吉林省土地资源承载力的影响程度较弱.

关键词：土地资源承载力时空分异障碍度模型吉林省

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基于改进局部图结构的再认记忆脑电特征提取

电子测量技术 2024年第4期47卷 81-86页

作者：王凯顾翔李文杰王苏弘邹凌常州大学微电子与控制工程学院常州213164 常州市生物医学信息技术重点实验室常州213164 常州大学阿里云大数据学院常州213164 苏州大学附属第三医院临床心理科常州213003

为了研究再认记忆脑电的纹理特征,以及解决垂直对称局部图结构和对称局部图结构在提取脑电纹理特征时结构不稳定的问题。基于新旧范式设计了再认记忆实验,采集医学生和非医学生(均为35名)相关脑电,并且将这些脑电分为学习医学图片阶段... 详细信息

为了研究再认记忆脑电的纹理特征,以及解决垂直对称局部图结构和对称局部图结构在提取脑电纹理特征时结构不稳定的问题。基于新旧范式设计了再认记忆实验,采集医学生和非医学生(均为35名)相关脑电,并且将这些脑电分为学习医学图片阶段、学习非医学图片阶段、再认旧医学图片阶段、再认旧非医学图片阶段、再认新医学图片阶段和再认新非医学图片阶段。首先,利用二维小波变换得到每位被试脑电的三个子频带,并提出改进集成局部图结构方法对原数据和3个子频带进行特征提取,改进算法纳入了具有稳定结构的扩展对称局部图结构和复合局部图结构;然后对特征进行归一化,避免结果过拟合,使用皮尔逊相关系数筛选出相关系数在0.8~1之间的特征矩阵列。在支持向量机等分类器上验证改进前后的算法,并使用正确率、精确率、召回率和F1评分这四个指标对模型进行评估。与改进前算法相比,改进后算法在支持向量机上的分类正确率分别提升3.8%,0.4%,0.3%,1.6%,5.1%和4.2%。分类结果说明医学生和非医学生在医学图片学习再认阶段存在明显差异,新加入扩展对称局部图结构和复合局部图结构比原算法中垂直对称局部图结构和对称局部图结构具有更好的分类性能。

关键词：脑电再认记忆集成局部图结构特征提取

CT联合MMP-2、MMP-9、CA19-9对早期结直肠癌T分期的预测价值

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中国中西医结合影像学杂志 2024年第4期22卷 449-453页

作者：梅建波滕刚邹玲湖北省麻城市人民医院CT室湖北麻城438399

目的:探讨CT联合血清金属基质蛋白酶2(MMP-2)、金属基质蛋白酶9(MMP-9)、糖类抗原19-9(CA19-9)检测对结直肠癌患者T分期的预测价值。方法:选取结直肠癌患者110例,行CT联合血清MMP-2、MMP-9、CA19-9检测。结果:CT诊断结直肠癌T_(1~2)期、... 详细信息

目的:探讨CT联合血清金属基质蛋白酶2(MMP-2)、金属基质蛋白酶9(MMP-9)、糖类抗原19-9(CA19-9)检测对结直肠癌患者T分期的预测价值。方法:选取结直肠癌患者110例,行CT联合血清MMP-2、MMP-9、CA19-9检测。结果:CT诊断结直肠癌T_(1~2)期、T_(3)期、T_(4)期符合率分别为79.17%(38/48)、84.62%(33/39)、86.96%(20/23),总诊断符合率为82.73%(91/110)。T_(1~2)期、T_(3)期及T_(4)期结直肠癌患者血清MMP-2、MMP-9、CA19-9水平比较差异均有统计学意义(均P<0.05);T_(3)期患者血清MMP-2、MMP-9、CA19-9水平均明显高于T_(1~2)期(均P<0.05);T_(4)期患者血清MMP-2、MMP-9、CA19-9水平均明显高于T_(3)期及T_(1~2)期(均P<0.05)。Spearman相关性分析显示,血清MMP-2、MMP-9、CA19-9水平与结直肠癌T分期呈显著正相关(均P<0.05)。ROC曲线显示,CT联合MMP-2、MMP-9、CA19-9(联合诊断模型)鉴别诊断结直肠癌T_(1~2)期与T_(3)期的AUC明显高于各单项指标(均P<0.05);联合诊断模型鉴别诊断结直肠癌T_(3)期与T_(4)期的AUC明显高于各单项指标(均P<0.05)。结论:CT联合MMP-2、MMP-9、CA19-9检测鉴别诊断结直肠癌T分期具有较高的应用价值。

关键词：结直肠肿瘤体层摄影术,X线计算机金属基质蛋白酶-2 金属基质蛋白酶-9 糖类抗原19-9 浸润深度诊断

Vernier effect facilitates integrated lithium niobate single-mode lasers

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Science China(Physics,Mechanics & Astronomy) 2022年第3期65卷 133-134页

作者： Xin-Biao Xu Chang-ling zou Key Laboratory of Quantum Information University of Science and Technology of ChinaChinese Academy of SciencesHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China

A research group from Nankai University in China has demonstrated an integrated whispering gallery mode(WGM)microcavity laser on erbium-doped thin-film lithium niobate with a pump threshold of about 200 μW and a side-mode suppression ratio exceeding 26 d B [1]. The Vernier effect is applied to realize the single-mode lasing in a photonic molecule. The work provides a feasible scheme for on-chip single-mode laser for integrated lithium niobate on insulator(LNOI) photonic circuits, and more active devices in LNOI will be developed inspired by this work.

关键词： pump mode lithium