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SPOC模式在高校教学中的应用——以工程图学课程为例

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黑龙江高教研究 2016年第11期34卷 164-166页

作者：石玲哈尔滨工程大学机电工程学院黑龙江哈尔滨150001

分析SPOC的概念及教学特点,基于SPOC的混合式教学颠覆高校传统课堂的教学形式,弥补MOOC中的缺点与不足。文章以工程图学这门课程为例,介绍SPOC教学模式整体教学框架的设计,并将SPOC教学模式与MOOC教学模式进行对比剖析,总结出SPOC的应... 详细信息

分析SPOC的概念及教学特点,基于SPOC的混合式教学颠覆高校传统课堂的教学形式,弥补MOOC中的缺点与不足。文章以工程图学这门课程为例,介绍SPOC教学模式整体教学框架的设计,并将SPOC教学模式与MOOC教学模式进行对比剖析,总结出SPOC的应用优势。

关键词：工程图学教学模式在线课程

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论政府效能监察体系的构建

河北学刊 2007年第6期27卷 58-63页

作者：时运生河北省社会科学院社会发展研究所河北石家庄050051

中国在进行廉政建设的同时,也在进行政府效能监察工作。效能监察是监察机关为维护公共利益对监察对象存在的不尽职、不正确尽职、影响其他人尽职,乃至玩忽职守渎职失职等违法、违纪行为进行的监督检查活动。由于理论支撑滞后和相对经验... 详细信息

中国在进行廉政建设的同时,也在进行政府效能监察工作。效能监察是监察机关为维护公共利益对监察对象存在的不尽职、不正确尽职、影响其他人尽职,乃至玩忽职守渎职失职等违法、违纪行为进行的监督检查活动。由于理论支撑滞后和相对经验不足,至今没有形成公众认可的、在较大范围适用的政府效能监察体系。本文依据调查资料,分析了构建当代政府效能监察体系的实践基础,揭示了政府效能监察体系的内容结构,预测了政府效能监察的发展趋势,提出了健全和完善效能监察体系的措施。

关键词：中国政治效能监察体系构建趋势预测

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考虑破坏面转移和垃圾坝作用的边坡稳定分析

岩土工程学报 2014年第6期36卷 998-1004页

作者：施建勇雷省河海大学岩土力学与堤坝工程教育部重点实验室江苏南京210098

垃圾坝是山谷型填埋场和横向扩建填埋场中常采用的增稳措施;破坏面在衬里结构不同界面间发生转移也是被证实的规律,考虑破坏面转移和垃圾坝作用的垃圾体边坡稳定分析方法尚未见报道。通过将衬里结构中破坏面转移点作为分界点,将滑动垃... 详细信息

垃圾坝是山谷型填埋场和横向扩建填埋场中常采用的增稳措施;破坏面在衬里结构不同界面间发生转移也是被证实的规律,考虑破坏面转移和垃圾坝作用的垃圾体边坡稳定分析方法尚未见报道。通过将衬里结构中破坏面转移点作为分界点,将滑动垃圾体分成5个楔体,利用极限平衡条件建立了五楔体边坡稳定分析方法。研究结果表明,五楔体极限平衡分析方法能够分析考虑破坏面转移和垃圾坝影响的填埋体稳定性;考虑破坏面转移计算得到的安全系数低于不考虑考虑破坏面转移的计算结果,考虑破坏面转移的计算方法能够发现更危险的情况;填埋场安全系数随垃圾坝高度的增大而增大;垃圾坝的背坡有一最优坡度,垃圾坝的背坡小于这一坡度时,发生"坝背破坏"模式;垃圾坝的背坡大于这一坡度时,发生"坝底破坏"模式;最危险破坏面通过填埋场的背坡和底坡的衬里,再通过垃圾坝的坝背衬里界面或坝底。

关键词：破坏面转移垃圾坝边坡稳定分析坝背坝底

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益生元在药物递送系统中的研究进展

药学学报 2022年第7期57卷 2041-2048页

作者：任玲郑稳生何淑旺于昊杨王璐璐中国医学科学院、北京协和医学院药物研究所北京100050 北京达因高科儿童药物研究院北京101149

随着对肠道微生物研究的深入,肠道菌群对人类健康的影响受到关注,已成为当前生命科学和医学的研究热点,也被认为是疾病治疗的重要靶点。益生元可调节肠道菌群的组成和功能从而改善宿主健康。碳水化合物是最基本的益生元,其独特的理化性... 详细信息

随着对肠道微生物研究的深入,肠道菌群对人类健康的影响受到关注,已成为当前生命科学和医学的研究热点,也被认为是疾病治疗的重要靶点。益生元可调节肠道菌群的组成和功能从而改善宿主健康。碳水化合物是最基本的益生元,其独特的理化性质及肠道菌调节能力可在实现药物靶向递送的同时又能促进肠道健康,从而对疾病的治疗发挥积极作用。本文对不同种类的益生元及其肠道菌调节机制进行了阐述,介绍了碳水化合物类益生元在药物递送系统中的研究进展,并对其应用前景进行展望,以期为相关研究提供参考。

关键词：益生元碳水化合物肠道微生物药物递送系统肠道健康

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强化税收宏观调控职能的构想

税务与经济 2001年第1期 18-20页

作者：史玲南京经济学院财政系江苏镇江212413

当前税收宏观调控职能未能有效发挥 ,根本原因在于税制及税制结构设计不合理 ,税权划分不科学 ,同时宏观税负水平的下降及依法治税环境也不适应税收调控的需要。要充分发挥税收调控职能 ,必须在优化税制及税制结构的同时 ,合理划分税权 ... 详细信息

当前税收宏观调控职能未能有效发挥 ,根本原因在于税制及税制结构设计不合理 ,税权划分不科学 ,同时宏观税负水平的下降及依法治税环境也不适应税收调控的需要。要充分发挥税收调控职能 ,必须在优化税制及税制结构的同时 ,合理划分税权 ,并加大税收执法力度 ,努力提高税收占国民收入的比重。

关键词：税收调控流转税所得税税权划分依法治税

Mapping quantitative trait loci associated with starch paste viscosity attributes by using double haploid populations of rice (Oryza sativa L.)

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Journal of Integrative Agriculture 2020年第7期19卷 1691-1703页

作者： Tahmina SHAR sheng Zhong-hua Umed ALI Sajid FIAZ WEI Xiang-jin XIE Li-hong JIAO Gui-ai Fahad ALI SHAO Gao-neng HU shi-kai HU Pei-song TANG Shao-qing State Key Laboratory of Rice Biology/Key Laboratory of Rice Biology and Breeding Ministry of Agriculture/China National Rice Research InstituteHangzhou 310006P.R.China

The paste viscosity attributes of starch,measured by rapid visco analyzer(RVA),are important factors for the evaluation of the cooking and eating qualities of rice in breeding *** determine the genetic roots of the paste viscosity attributes of rice grains,quantitative trait loci(QTLs)associated with the paste viscosity attributes were mapped,using a double haploid(DH)population derived from Zhongjiazao 17(YK17),a super rice variety,crossed with D50,a tropic japonica ***-four QTLs,for seven parameters of the RVA profiles,were identified in three planting *** 54 QTLs were located on all of the 12 chromosomes,with a single QTL explaining 5.99 to 47.11%of phenotypic *** the QTLs identified,four were repeatedly detected under three environmental conditions and the other four QTLs were repeated under two *** of the QTLs detected for peak viscosity(PKV),trough viscosity(TV),cool paste viscosity(CPV),breakdown viscosity(BDV),setback viscosity(SBV),and peak time(PeT)were located in the interval of RM 6775-RM 3805 under all three environmental conditions,with the exception of pasting temperature(PaT).For digenic interactions,eight QTLs with six traits were identified for additivexenvironment interactions in all three planting *** epistatic interactions were estimated only for PKV,SBV and *** present study will facilitate further understanding of the genetic architecture of eating and cooking quality(ECQ)in the rice quality improvement program.

关键词： RVA profiles eating and cooking quality(ECQ) quantitative trait loci(QTL) DH population rice

Two-dimensional transition metal halide PdX_(2)(X=F,Cl,Br,I):A promising candidate of bipolar magnetic semiconductors

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Chinese Physics B 2023年第12期32卷 481-488页

作者：陈苗苗李胜世纪维霄张昌文 School of Physics and Technology Institute of SpintronicsUniversity of JinanJinan 250022China

Two-dimensional(2D)nanomaterials with bipolar magnetism show great promise in spintronic *** carriers'spin-polarized orientation in bipolar magnetic semiconductor(BMS)requires a gate voltage,but that is ***,a new method has been proposed to solve the problem of volatility by introducing a ferroelectric gate with proper band *** this paper,we predict that the PdX_(2)(X=F,Cl,Br,I)monolayers are 2D ferromagnetic BMS with dynamic stability,thermal stability,and mechanical stability by first-principles *** critical temperatures are higher than the boiling point of liquid nitrogen and the BMS characteristics are robust against external strains and electric fields for PdCl_(2) and PdBr_(2).Then,we manipulate the spin-polarization of PdCl_(2) and PdBr_(2) by introducing a ferroelectric gate to enable magnetic half-metal/semiconductor switching and spin-up/down polarization switching *** kinds of spin devices(multiferroic memory and spin filter)have been proposed to realize the spin-polarized directions of *** results demonstrate that PdCl_(2) and PdBr_(2) with BMS characters can be widely used as a general material structure for spintronic devices.

关键词： PdX_(2)(X=F Cl Br I) bipolar magnetic semiconductors first-principles calculations

训诂与《诗经》文本阐释——以《周南·卷耳》为例

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孔子研究 2023年第6期 56-65,158页

作者：杨玲兰州大学文学院兰州730020

《诗经·周南·卷耳》主旨纷纭,其阐释分歧主要集中在“嗟我怀人,置彼周行”之“周行”的训释。经学主训“官列”,由此产生“官人说”。文学主训“道路”,于是有了“怀人说”。通过引证本书、他书、小学典籍分析考辨可知:“周行”非“... 详细信息

《诗经·周南·卷耳》主旨纷纭,其阐释分歧主要集中在“嗟我怀人,置彼周行”之“周行”的训释。经学主训“官列”,由此产生“官人说”。文学主训“道路”,于是有了“怀人说”。通过引证本书、他书、小学典籍分析考辨可知:“周行”非“周道”,无道路义。《卷耳》之“周行”如训为“道路”,诗意难通;训为“官列”,则诗意豁然,且上博简《孔子诗论》“《卷耳》,不知人”也可得妥当解释,《卷耳》的经典特质、丰富内涵和本事均可揭橥、呈现。于此可见训诂之于《诗经》文本阐释之重要。

关键词：《诗经·周南·卷耳》诗旨周行训诂阐释

Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2384-2391页

作者： Zhijian Xu Danrong shi Jian-Bao Han Yun ling Xiangrui Jiang Xiangyun Lu Chuan Li Likun Gong Guangbo Ge Yani Zhang Yi Zang Tian-Zhang Song Xiao-Li Feng Ren-Rong Tian Jia Ji Miaojin Zhu Nanping Wu Chunhui Wu Zhen Wang Yechun Xu Cheng Peng Min Zheng Junling Yang Feifei Du Junliang Wu Peipei Wang Jingshan Shen Jianliang Zhang Yong-Tang Zheng Hangping Yao Weiliang Zhu State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China Drug Discovery and Design Center Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China School of Pharmacy University of Chinese Academy of SciencesBeijing100049China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesFirst Affiliated HospitalZhejiang University School of MedicineHangzhou310003China Kunming National High-level Biosafety Research Center for Non-human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan650107China Department of Infectious Disease Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Center for Drug Safety Evaluation and Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghai201203China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan650223China Jinan Microecological Biomedicine Shandong Laboratory Jinan250117China

Effective drugs with broad spectrum safety profile to all people are highly expected to combat COVID-19 caused by *** we report that nelfinavir,an FDA approved drug for the treatment of HIV infection,is effective against SARS-CoV-2 and *** of nelfinavir could inhibit the activity of the main protease of the SARS-CoV-2(IC50=8.26μM),while its antiviral activity in Vero E6 cells against a clinical isolate of SARS-CoV-2 was determined to be 2.93μM(EC50).In comparison with vehicle-treated animals,rhesus macaque prophylactically treated with nelfinavir had significantly lower temperature and significantly reduced virus loads in the nasal and anal swabs of the *** necropsy,nelfinavir-treated animals had a significant reduction of the viral replication in the lungs by nearly three orders of magnitude.A prospective clinic study with 37 enrolled treatment-naive patients at Shanghai Public Health Clinical Center,which were randomized(1:1)to nelfinavir and control groups,showed that the nelfinavir treatment could shorten the duration of viral shedding by 5.5 days(9.0 vs.14.5 days,P=0.055)and the duration of fever time by 3.8 days(2.8 vs.6.6 days,P=0.014)in mild/moderate COVID-19 *** antiviral efficiency and clinical benefits in rhesus macaque model and in COVID-19 patients,together with its well-established good safety profile in almost all ages and during pregnancy,indicated that nelfinavir is a highly promising medication with the potential of preventative effect for the treatment of COVID-19.

关键词： drugs infected treatment