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Characterization and map-based cloning of miniature2-m1, a gene controlling kernel size in maize

Journal of Integrative Agriculture 2020年第8期19卷 1961-1973页

作者： GUAN Hai-ying DONG Yong-bin LU Shou-ping LIU Tie-shan HE Chun-mei LIU Chun-xiao LIU Qiang DONG Rui WANG Juan LI Yu-ling QI shi-jun WANG Li-ming Maize Research Institute Shandong Academy of Agricultural Sciences/National Engineering Laboratory of Wheat and Maize/Key Laboratory of Biology and Genetic Improvement of Maize in Northern Yellow-Huai River PlainMinistry of AgricultureJinan 250100P.R.China College of Agronomy Henan Agricultural University/Collaborative Innovation Center of Henan Grain Crops/National Key Laboratory of Wheat and Maize Crop ScienceZhengzhou 450046P.R.China

Kernel development plays an important role in determining kernel size in *** we present the cloning and characterization of a maize gene,nitrate transporter1.5(NRT1.5),which controls small kernel phenotype by playing an important role in kernel development.A novel recessive small kernel mutant miniature2-m1(mn2-m1)was isolated from self-pollinated progenies of breeding *** mutant spontaneously showed small kernel character arresting both embryo and endosperm development at an early stage after *** 21 polymorphic SSR markers,the mn2-m1 locus was limited to a 209.9-kb interval using 9176 recessive individuals of a BC1 segregating population from mn2-m1/*** one annotated gene was located in this 209.9 kb region,Zm00001 d019294,which was predicted to encode nitrate transporter1.5(NRT1.5).Allelism tests confirmed that mn2-m1 was allelic to miniature2-m2(mn2-m2)and miniature2-710 B(mn2-710 B).The mn2-m1 and mn2-m2 alleles both had nucleotide deletions in the coding region resulting in premature termination,and the mn2-710 B allele had some missence *** localization showed that Miniature 2(MN2)is localized in the plasma *** real-time PCR(qRT-PCR)analysis revealed that the expression of MN2 and some genes involved in the basal endosperm transfer layer(BETL)and embryo surrounding region(ESR)development were affected in mn2-m1 *** results suggested that MN2 plays an important role in maize seed development.

关键词： miniature2-m1 nitrate transporter1.5 frame shift mutation allelism tests subcellular localization

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网络环境下价值链会计实时控制研究

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中国管理信息化 2008年第16期11卷 34-37页

作者：盛巧玲广东金融学院继续教育学院广州510521

价值链管理思想的产生使传统的会计环境发生了改变,对传统的会计控制理论和实践提出了挑战。本文在分析价值链会计实时控制的基本问题的基础上,对价值链会计实时控制的特征进行了剖析,提出了运用现代信息技术构建网络环境下价值链会计... 详细信息

价值链管理思想的产生使传统的会计环境发生了改变,对传统的会计控制理论和实践提出了挑战。本文在分析价值链会计实时控制的基本问题的基础上,对价值链会计实时控制的特征进行了剖析,提出了运用现代信息技术构建网络环境下价值链会计实时控制系统的策略。

关键词：价值链价值链会计实时控制

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Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-Liang Li Ming-sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu shi Jia-Rui Li Guang Yang Hai-Bin shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

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中医外治法历史源流与现代研究进展

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南京中医药大学学报 2022年第11期38卷 990-999页

作者：王鹏沈劼施圣杰王元彪南京中医药大学中医药文献研究所江苏南京210023 江西省皮肤病专科医院江西南昌330001

在回顾中医外治法历史源流的基础上,从理论、技术、临床等方面梳理现代外治法的发展现状,主要体现在新学说的提出、外用中药在剂型与应用方式上的改进、外治器具的革新及临床“内病外治”适用范围的拓宽,并对目前该领域研究中存在的问... 详细信息

在回顾中医外治法历史源流的基础上,从理论、技术、临床等方面梳理现代外治法的发展现状,主要体现在新学说的提出、外用中药在剂型与应用方式上的改进、外治器具的革新及临床“内病外治”适用范围的拓宽,并对目前该领域研究中存在的问题提出思考,展望未来研究趋势。

关键词：中医外治法理论源流中药外用内病外治发展现状

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竹屑袋料栽培香菇试验

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广西农学报 2022年第4期37卷 22-26页

作者：石志辉覃培升桂林市灵川县恩泽食用菌专业合作社广西桂林541209 广西大学广西南宁530022

【目的】利用废弃的毛竹竹屑进行袋料香菇栽培实验研究,筛选竹屑栽培香菇优良配方。【方法】设置A、B、C、D、E共5组实验,其中A组为对照组,将香菇品种“庆科212”接种在5组不同竹屑配方培养基中进行栽培,记录菌丝和香菇子实体生长情况... 详细信息

【目的】利用废弃的毛竹竹屑进行袋料香菇栽培实验研究,筛选竹屑栽培香菇优良配方。【方法】设置A、B、C、D、E共5组实验,其中A组为对照组,将香菇品种“庆科212”接种在5组不同竹屑配方培养基中进行栽培,记录菌丝和香菇子实体生长情况和计算各生长阶段的生物转化率,探究不同竹屑添加量对香菇生长的影响。【结果】实验结果表明,B、C、D、E组菌丝正常吃料和出菇,但菌丝生长期比对照组A稍长。对照组A鲜菇总产量高达239.44 kg,生物学转化率为88.68%,比B、C、D、E组高,但与其中D组配方香菇总产量224.99 kg,生物学转化率为83.33%差异不显著。【结论】利用袋料中添加30%的竹屑时,能有效降低企业生产成本,提高香菇种植的经济效益与生态效益,适宜规模化推广应用。

关键词：袋料香菇竹屑配方筛选

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西藏八宿、左贡和芒康两栖爬行动物多样性调查报告

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动物学杂志 2022年第2期57卷 236-246页

作者：石胜超石秀东姚忠祎齐银江建平中国科学院成都生物研究所成都610041 中国科学院大学北京100049 西藏生态安全屏障生态监测站网芒康生态站昌都854500

于2019年8月至2020年7月调查了西藏生态安全屏障生态监测站网芒康生态站所辖3县(八宿、左贡和芒康)的两栖爬行动物多样性。本次调查共计布设155条样线,海拔区间为2270~4610 m。调查结果显示,该地区两栖动物共计有8种,隶于4科5属;爬行动... 详细信息

于2019年8月至2020年7月调查了西藏生态安全屏障生态监测站网芒康生态站所辖3县(八宿、左贡和芒康)的两栖爬行动物多样性。本次调查共计布设155条样线,海拔区间为2270~4610 m。调查结果显示,该地区两栖动物共计有8种,隶于4科5属;爬行动物7种,隶于3科4属。其栖息地共有5种植被类型,Shannon-Weiner多样指数表征其中两栖爬行动物多样性由高到低为:灌丛、针叶林、阔叶林、针阔叶混交林、草甸。在垂直分布方面,两栖动物分布海拔区间为2280~4350 m,爬行动物分布海拔区间为2270~3470 m,爬行动物分布海拔整体上低于两栖动物。在动物区系组成方面,多数两栖动物为广布种及古北界物种,而爬行动物中多数为东洋界物种。本次调查共记录到国家Ⅱ级重点保护野生动物3种:帆背龙蜥(Diploderma vela)、巴塘龙蜥(***)和滑腹龙蜥(***)。调查结果显示,干热河谷地带物种多样性较高,且具多个区域特有物种,亟待进行保护地规划和建设。此外,本文记述了西藏自治区爬行动物分布1新记录种——乡城原矛头蝮(Protobothrops xiangchengensis)。

关键词：两栖动物爬行动物西藏物种多样性分布新记录种

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Influence of cryogenic permanent magnet undulator motion error on magnetic field error and radiation intensity loss

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Radiation Detection Technology and Methods 2018年第1期2卷 200-206页

作者： Shu-Chen Sun Wei-Fan sheng Hui-Hua Lu Xiao-Yu Li Shu-Tao Zhao ling-ling Gong Wan Chen Zhi-Qiang Li Lei Zhang Yu-Feng Yang Xiang-Zhen Zhang Ya-Jun Sun Laboratory of Particle Acceleration Physics&Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Science Beijing 100049China

A cryogenic permanent magnet undulator prototype designed for Chinese High Energy Photon Source Test Facility(HEPSTF)at Institute of High Energy Physics is constructed and now *** precision of girders is a significant parameter to guarantee gap error so as to avoid phase error and radiation intensity *** order to study and minimize girder parallelism errors,RADIA and SPECTRA are used to calculate qualified motion *** Modules and single motor closed-loop feedback are designed to compensate the *** field is finally tuned to reach *** of the study and analysis will be presented in this paper.

关键词： Motion precision test Cryogenic permanent magnet undulator Phase error Radiation intensity

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乌梅丸治疗神志疾病研究进展

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中国中医药现代远程教育 2023年第10期21卷 192-195页

作者：宗非凡史玲山东中医药大学针灸推拿学院山东济南250000 山东省威海市中医院神志病科山东威海264200

社会调查发现,神志病的发病率逐年增高,西方医学治疗本病多使用抗抑郁类及镇静安眠类药物,该类药物不良反应(成瘾性、抗药性等)明显,大多数患者不能接受且不能遵医嘱长时间服药,故疗效欠佳。乌梅丸为治疗厥阴病的名方,通过查阅相关文献... 详细信息

社会调查发现,神志病的发病率逐年增高,西方医学治疗本病多使用抗抑郁类及镇静安眠类药物,该类药物不良反应(成瘾性、抗药性等)明显,大多数患者不能接受且不能遵医嘱长时间服药,故疗效欠佳。乌梅丸为治疗厥阴病的名方,通过查阅相关文献,发现乌梅丸治疗神志疾病效果明显,此文从乌梅丸的药物现代机制及厥阴病病机出发,对乌梅丸治疗神志疾病做系统的研究论述,以期能更好地指导临床治疗。

关键词：乌梅丸现代药理神志病厥阴病综述

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Infant cholestasis patient with a novel missense mutation in the AKR1D1 gene successfully treated by early adequate supplementation with chenodeoxycholic acid: A case report and review of the literature

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World Journal of Gastroenterology 2018年第35期24卷 4086-4092页

作者： Hui-Hui Wang Fei-Qiu Wen Dong-ling Dai Jian-She Wang Jing Zhao Kenneth DR Setchell Li-Na shi Shao-Ming Zhou Si-Xi Liu Qing-Hua Yang Gastroenterology Department Shenzhen Children’s Hospital Center for Pediatric Liver Diseases Children’s Hospital of Fudan University Department of Pathology and Laboratory Medicine Cincinnati Children’s Hospital Medical Center My Genostics Incorporation Konggang Industrial Park

Steroid 5β-reductase [aldo-keto reductase family 1 member D1(AKR1D1)] is essential for bile acid biosynthesis. Bile acid deficiency caused by genetic defects in AKR1D1 leads to life-threatening neonatal hepatitis and cholestasis. There is still limited experience regarding the treatment of this disease. We describe an infant who presented with hyperbilirubinemia and coagulopathy but normal bile acid and γ-glutamyltransferase. Gene analysis was performed using genomic DNA from peripheral lymphocytes from the patient, his parents, and his elder brother. The patient was compound heterozygous for c.919C>T in exon 8 and exhibited a loss of heterozygosity of the AKR1D1 gene, which led to an amino acid substitution of arginine by cysteine at amino acid position 307(p.R307C). Based on these mutations, the patient was confirmed to have primary 5β-reductase deficiency. Ursodeoxycholic acid(UDCA) treatment did not have any effect on the patient. However, when we changed to chenodeoxycholic acid(CDCA) treatment, his symptoms and laboratory tests gradually improved. It is therefore crucial to supplement with an adequate dose of CDCA early to improve clinical symptoms and to normalize laboratory tests.

关键词： Aldo-keto reductase family 1 member D1 Cholestasis Congenital bile acid synthesis defect Gene mutation

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高密派诗人的文化品格

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山东师范大学学报（人文社会科学版） 2005年第5期50卷 21-25页

作者：石玲山东师范大学齐鲁文化研究中心山东济南250014

高密派是清代乾隆时期出现于山左地区、主要由寒士诗人组成的诗歌流派,主要代表人物有“高密三李”等。该诗派追步中晚唐之张籍和贾岛,极力强调诗人人格的傲岸,倡导“风雅”和“气骨”,提倡用心苦吟,以沉实瘦硬对抗诗坛“涂饰柔腻”的... 详细信息

高密派是清代乾隆时期出现于山左地区、主要由寒士诗人组成的诗歌流派,主要代表人物有“高密三李”等。该诗派追步中晚唐之张籍和贾岛,极力强调诗人人格的傲岸,倡导“风雅”和“气骨”,提倡用心苦吟,以沉实瘦硬对抗诗坛“涂饰柔腻”的风气。它产生于传统文化的重镇,在价值观念和人格追求上皆体现了以儒家思想为基础的传统文化,同时也打上了地域文化的烙印。

关键词：高密诗派寒士诗人文化品格

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