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Toward a further understanding of bit-based division property

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Science China(Information Sciences) 2017年第12期60卷 277-279页

作者： Ling SUN Meiqin WANG Key Laboratory of Cryptologic Technology and Information Security Ministry of EducationShandong University Science and Technology on Communication Security Laboratory State Key Laboratory of Cryptology P.O.Box 5159

The division property of a multiset,which is a generalization of the integral property,was proposed by Todo[1]at EUROCRYPT 2015.Since division property can precisely depict the implicit properties between ALL and BALANCE properties,it allows us to efficiently construct integral distinguisher even if the round function of the block cipher is non-bijective,bit-oriented,and low-degree.

关键词： Toward a further understanding of bit-based division property ANF

Optical coherence tomography of the pulmonary arteries in children with congenital heart diseases:A systematic review

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Pediatric Investigation 2022年第4期6卷 264-270页

作者： Ling SUN Qiuping Jiang Yumei Xie Shushui Wang Zhiwei Zhang Department of Pediatric Cardiology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangdong Cardiovascular InstituteGuangdong Provincial Key Laboratory of South China Structural Heart DiseaseGuangzhouGuangdongChina

Importance:Optical coherence tomography(OCT)is a high-resolution intravascular imaging tool and has shown promise for providing real-time quantitative and qualitative descriptions of pulmonary vascular structures in vivo in adult pulmonary hypertension(PH),while not popular in pediatric patients with congenital heart diseases(CHD).Objective:The aim of this review is to summarize all the available evidence on the use of OCT for imaging pulmonary vascular remodeling in pediatric patients.Methods:We conducted the systematic literature resources(Cochran Library database,Medline via PubMed,EMBASE,and Web of Knowledge)from January 2010 to December 2021 and the search terms were“PH”,“child”,“children”,“pediatric”,“OCT”,“CHD”,“pulmonary vessels”,“pulmonary artery wall”.Studies in which OCT was used to image the pulmonary vessels in pediatric patients with CHD were considered for inclusion.Results:Five studies met the inclusion criteria.These five papers discussed the study of OCT in the pulmonary vasculature of different types of CHD,including common simple CHD,complex cyanotic CHD,and Williams-Beuren syndrome.In biventricular anatomy,pulmonary vascular remodeling was primarily reflected by pulmonary intima thickening from two-dimensional OCT.In single-ventricle anatomy,due to the state of hypoxia,the morphology of pulmonary vessels was indirectly reflected by the number and shape of nourishing vessels from three-dimensional OCT.Interpretation:OCT may be an adequate imaging procedure for the demonstration of pulmonary vascular structures and provide additional information in pediatric patients.

关键词： Children Congenital heart diseases Optical coherence tomography Pulmonary hypertension Pulmonary vessels

Research on the Trajectory Tracking Control of a 6-DOF Manipulator Based on Fully-Actuated System Models

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Journal of Systems Science & Complexity 2022年第2期35卷 641-659页

作者： sun Hao HUANG ling HE Liang School of Automation Harbin University of Science and TechnologyHarbin 150080China School of Software Northwestern Polytechnical UniversityXi’an 710072China

The multi-degree of freedom(muti-DOF)manipulator system is a complex control system with the strong coupling feature and high nonlinearity.In this paper,trajectory tracking control of a six-degree of freedom(6-DOF)manipulator based on fully-actuated system models and a direct parametric method is investigated.The fully-actuated system model of the 6-DOF manipulator is established by using the Denavit Hartenberg(DH)notation and Euler-Lagrange dynamics.A disturbance observer is constructed to solve the nonlinear uncertainties such as unmodeled dynamics and external disturbances.Then,a controller is designed using the direct parametric method to make the 6-DOF manipulator reach the desired position with high accuracy.After that,a switching control strategy is developed to suppress the peak value belonging to the controller.Simulation results reveal the effect of the proposed control approach.

关键词： Direct parametric approach fully-actuated system manipulator nonlinear disturbance observer trajectory tracking

Broad strategies for neutralizing SARS-CoV-2 and other human coronaviruses with monoclonal antibodies

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Science China(Life Sciences) 2023年第4期66卷 658-678页

作者： Zhiyang ling Chunyan Yi Xiaoyu sun Zhuo Yang Bing sun State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

Antibody therapeutics and vaccines for coronavirus disease 2019(COVID-19)have been approved in many countries,with most being developed based on the original strain of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).SARS-CoV-2 has an exceptional ability to mutate under the pressure of host immunity,especially the immune-dominant spike protein of the virus,which is the target of both antibody drugs and vaccines.Given the continuous evolution of the virus and the identification of critical mutation sites,the World Health Organization(WHO)has named 5 variants of concern(VOCs):4 are previously circulating VOCs,and 1 is currently circulating(Omicron).Due to multiple mutations in the spike protein,the recently emerged Omicron and descendent lineages have been shown to have the strongest ability to evade the neutralizing antibody(NAb)effects of current antibody drugs and vaccines.The development and characterization of broadly neutralizing antibodies(bNAbs)will provide broad strategies for the control of the sophisticated virus SARS-CoV-2.In this review,we describe how the virus evolves to escape NAbs and the potential neutralization mechanisms that associated with bNAbs.We also summarize progress in the development of bNAbs against SARS-CoV-2,human coronaviruses(CoVs)and other emerging pathogens and highlight their scientific and clinical significance.

关键词： antibody therapy broad neutralizing antibody human coronaviruses SARS-CoV-2

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Light(Science & Applications) 2024年第2期13卷 333-346页

作者： Yifan sun Qian Li ling-Jun Kong Xiangdong Zhang Key Laboratory of advanced optoelectronic quantum architecture and measurements of Ministry of Education Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of Technology100081BeijingChina

Compared with electrical neural networks,optical neural networks(ONNs)have the potentials to break the limit of the bandwidth and reduce the consumption of energy,and therefore draw much attention in recent years.By far,several types of ONNs have been implemented.However,the current ONNs cannot realize the acceleration as powerful as that indicated by the models like quantum neural networks.How to construct and realize an ONN with the quantum speedup is a huge challenge.Here,we propose theoretically and demonstrate experimentally a new type of optical convolutional neural network by introducing the optical correlation.It is called the correlated optical convolutional neural network(COCNN).We show that the COCNN can exhibit“quantum speedup”in the training process.The character is verified from the two aspects.One is the direct illustration of the faster convergence by comparing the loss function curves of the COCNN with that of the traditional convolutional neural network(CNN).Such a result is compatible with the training performance of the recently proposed quantum convolutional neural network(QCNN).The other is the demonstration of the COCNN’s capability to perform the QCNN phase recognition circuit,validating the connection between the COCNN and the QCNN.Furthermore,we take the COCNN analog to the 3-qubit QCNN phase recognition circuit as an example and perform an experiment to show the soundness and the feasibility of it.The results perfectly match the theoretical calculations.Our proposal opens up a new avenue for realizing the ONNs with the quantum speedup,which will benefit the information processing in the era of big data.

关键词： process quantum convolution

Jigsaw puzzle of SARS-CoV-2 RBD evolution and immune escape

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Cellular & Molecular Immunology 2022年第7期19卷 848-851页

作者： Chunyan Yi Xiaoyu sun Zhiyang ling Bing sun State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China School of Life Science and Technology ShanghaiTech University100 Haike RoadShanghai 201210China

The outbreak of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which causes coronavirus disease 2019(COVID-19),has posed a tremendous threat to global health,resulting in over 510 million infections and at least 6.23 million deaths worldwide as of early May 2022.Extensive efforts to fight against the SARS-CoV-2 pandemic have accelerated the research and clinical development of various vaccines and neutralizing antibodies(NAbs)[1,2].However,SARS-CoV-2 has an exceptional ability to mutate and evade the human immune system,which highlights the surveillance of SARS-CoV-2 evolution to anticipate and facilitate a timely response to new variants that could impact viral transmissibility and the efficacy of vaccines and antibody therapies[3].

关键词： acute respiratory evolution

Paleomagnetic constraints on Paleogene-Neogene rotation and paleo-stress in the northern Qaidam Basin

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Science China Earth Sciences 2022年第12期65卷 2385-2404页

作者： Ling SUN Junliang JI Bingshuai LI Xingbo LI Wujun WU Kexin ZHANG Hubei Key Laboratory of Critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China School of Earth Sciences East China University of TechnologyNanchang 330013China Jiangsu Oilfield Company SinopecYangzhou 225009China Research Institute of Petroleum Exploration and Development-Northwest PetroChinaLanzhou 730020China Institute of Geological Survey China University of GeosciencesWuhan 430074China

Knowing the rotation and paleo-stress history in Qaidam Basin is a fundamental parameter to quantify the mechanism of intracontinental deformation in Tibetan Plateau.However,few studies have been conducted on tectonic rotation and stress evolution over long timescales in the Qaidam Basin.Here,we report new magnetic declination and the anisotropy of magnetic susceptibility(AMS)from a~52–7 Ma sequence of fluvial and lacustrine sediments in the Dahonggou(DHG)section in the northern Qaidam Basin.The magnetic declination revealed that the northern Qaidam Basin underwent a clockwise rotation 25.1°±8.6°during~33–17 Ma,followed by a counterclockwise rotation 16.9°±6.8°during~17–13.5 Ma.The AMS results showed that the“earliest deformation”fabrics were interrupted by the“pencil structure”fabrics in the intervals of~52–45 and~21–15 Ma.The interruption,synchronous with the marked deceleration of the India-Asia convergence rate,indicates pulse of strong tectonic compressive stress.In addition,the AMS results documented a transition in stress direction from S-N to SW-NE at~15 Ma,suggesting a kinematic shift in the northeastern TP.Our constraints on the rotation and stress from the northern Qaidam Basin support the two-stage evolution of the Altyn Tagh Fault(ATF).The fast-rate slip motion on the ATF during the early Oligocene caused the clockwise rotation in the northern Qaidam Basin;the second stage with enhanced thrusting since the middle Miocene caused extensive crustal shortening and dispersive NW-trending folds and faults in the Qaidam Basin and the northeastern TP.

关键词： Tectonic rotation Stress Anisotropy of magnetic susceptibility Paleo-Neogene Northern Qaidam Basin Tibetan Plateau

Distribution of phytoplankton community and its influence factors in an urban river network,East China

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Frontiers of Environmental Science & Engineering 2018年第6期12卷 133-144页

作者： Ling SUN Hui Wang Yuanqing Kan Shiliang Wang State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China Tianjin Key Laboratory of Animal and Plant Resistance College of Life SciencesTianjin Normal UniversityTianjin 300387China Tianjin Academy of Environmental Sciences Tianjin 300191China School of Geography and Tourism Qufu Normal UniversityRizhao 276826China

Effects of urban river conditions on phytoplankton community were investigated. Nitrate utilization and hydrodynamic condition affected phytoplankton distribution. A winter bloom was induced by abundant ammonia, tota... 详细信息

关键词： Phytoplankton composition Spatiotemporal distribution Functional groups Nitrate nitrogen Winter bloom

Differences in insomnia-related self-reported outcomes among elderly hospitalized patients

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World Journal of Psychiatry 2024年第5期14卷 686-694页

作者： Xia Ding ling-Xia Qi Dong-Yun sun Department of Gangzha General Medical Center The Affiliated Hospital of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Anesthesiology and Surgery The Affiliated Hospital of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Ophthalmic Surgery Room The Affiliated Hospital of Nantong UniversityNantong 226000Jiangsu ProvinceChina

Insomnia is among the most common sleep disorders worldwide.Insomnia in older adults is a social and public health problem.Insomnia affects the physical and mental health of elderly hospitalized patients and can aggravate or induce physical illnesses.Understanding subjective feelings and providing reasonable and standardized care for elderly hospitalized patients with insomnia are urgent issues.AIM To explore the differences in self-reported outcomes associated with insomnia among elderly hospitalized patients.METHODS One hundred patients admitted to the geriatric unit of our hospital between June 2021 and December 2021 were included in this study.Self-reported symptoms were assessed using the Athens Insomnia Scale(AIS),Generalized Anxiety Disorder Scale-7(GAD-7),Geriatric Depression Scale-15(GDS-15),Memorial University of Newfoundland Scale of Happiness(MUNSH),Barthel Index Evaluation(BI),Morse Fall Scale(MFS),Mini-Mental State Examination,and the Short Form 36 Health Survey Questionnaire(SF-36).Correlation coefficients were used to analyze the correlation between sleep quality and self-reported symptoms.Effects of insomnia was analyzed using Logistic regression analysis.RESULTS Nineteen patients with AIS≥6 were included in the insomnia group,and the incidence of insomnia was 19%(19/100).The remaining 81 patients were assigned to the non-insomnia group.There were significant differences between the two groups in the GDA-7,GDS-15,MUNSH,BI,MFS,and SF-36 items(Pling(P<0.05).Subjective well-being and quality of life were poorer in the insomnia group than in the control group.The AIS scores positively correlated with the GAD-7,GDS-15,and MFS scores in elderly hospitalized patients with insomnia(P<0.05).Logistic regression analysis showed that GDS-15≥5 was an independent risk factor for insomnia in elderly hospitalized patients(P<0.05).C

关键词： Elderly hospitalized patients Insomnia Self-reported outcomes Symptoms Subjective feelings Correlation