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CAEFusion: A New Convolutional Autoencoder-Based Infrared and Visible Light Image Fusion Algorithm

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Computers, Materials & Continua 2024年第8期80卷 2857-2872页

作者： Chun-Ming Wu Mei-ling ren Jin Lei Zi-Mu Jiang Key Laboratory of Modern Power System Simulation and Control&renewable Energy Technology Ministry of EducationSchool of Electrical EngineeringNortheast Electric Power UniversityJilin132012China School of Electrical Engineering Northeast Electric Power UniversityJilin132012China School of Electronic Information Engineering Bozhou UniversityBozhou236800China

To address the issues of incomplete information,blurred details,loss of details,and insufficient contrast in infrared and visible image fusion,an image fusion algorithm based on a convolutional autoencoder is *** region attention module is meant to extract the background feature map based on the distinct properties of the background feature map and the detail feature map.A multi-scale convolution attention module is suggested to enhance the communication of feature *** the same time,the feature transformation module is introduced to learn more robust feature representations,aiming to preserve the integrity of image *** study uses three available datasets from TNO,FLIR,and NIR to perform thorough quantitative and qualitative trials with five additional *** methods are assessed based on four indicators:information entropy(EN),standard deviation(SD),spatial frequency(SF),and average gradient(AG).Object detection experiments were done on the M3FD dataset to further verify the algorithm’s performance in comparison with five other *** algorithm’s accuracy was evaluated using the mean average precision at a threshold of 0.5(mAP@0.5)*** experimental findings show that CAEFusion performs well in subjective visual and objective evaluation criteria and has promising potential in downstream object detection tasks.

关键词： Image fusion deep learning auto-encoder(AE) infrared visible light

Rough surface of copper-bearing titanium alloy with multifunctions of osteogenic ability and antibacterial activity

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Journal of Materials Science & Technology 2020年第13期47卷 130-139页

作者： Hui Liu Rui Liu Ihsan Ullah Shuyuan Zhang Ziqing Sun ling ren Ke Yang Institute of Metal Research Chinese Academy of Sciences72 Wenhua RoadShenyang110016China School of Materials Science and Engineering University of Science and Technology of China96 Jinzhai RoadHefei230026China Institute of Molecular Medicine State Key Laboratory of Oncogenes and Related GenesRenji Hospital160 Pujian RoadShanghai220127China

Implant-related infection and early bone integration are the main risk factors of implants for long-term service,to overcome these difficulties,SLA-TiCu surface was prepared by sandblasting and large-grits etching(SLA)treatment on a novel antibacterial titanium-copper alloy(TiCu),which is the most prevalent surface treatment with micro/submicron hierarchical structures to titanium-based *** of SLA-TiCu surface on the adhesion,proliferation,apoptosis and differentiation of MC3T3-E1 cells as well as the antibacterial activity against a common orthopedic pathogen(Staphylococcus aureus)were *** to the following surfaces:sandblasting and large-grits etched pure titanium(SLATi),mechanically ground pure titanium and TiCu alloy(M-Ti and M-TiCu),these results indicated that SLA-TiCu surface obviously enhanced the bone-related gene expressions(alkaline phosphates(ALP),collagen typeⅠ(COLⅠ),Runt-related transcription factor 2(RUN x 2),and osteopontin(OPN)).Moreover,SLA-TiCu surface could maintain a sustainable release of Cu2+ions and effectively inhibited the viability of *** study demonstrated that SLA-TiCu surface possessed multifunctional characteristics of improved osteogenic ability and antibacterial activity,making it promising as a novel implant material for hard tissue repairs such as orthopedics and dental implants.

关键词： Titanium Copper Roughness surface Osteogenesis Antibacterial

Functionalized TiCu/TiCuN coating promotes osteoporotic fracture healing by upregulating the Wnt/β-catenin pathway

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Regenerative Biomaterials 2023年第1期10卷 126-139页

作者： Jia Tan ling ren Kai Xie Lei Wang Wenbo Jiang Yu Guo Yongqiang Hao Department of Orthopaedic Surgery Shanghai Key Laboratory of Orthopaedic ImplantsShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Clinical and Translational Research Center for 3D Printing Technology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Institute of Metal Research Chinese Academy of SciencesShenyang 110000China Musculoskeletal Tumor Center Peking University People’s HospitalBeijing 100044China

Osteoporosis results in decreased bone mass and insufficient osteogenic *** titanium alloy implants have insufficient osteoinductivity and delayed/incomplete fracture union can occur when used to treat osteoporotic *** ions have good osteogenic activity,but their dose-dependent cytotoxicity limits their clinical use for bone *** this study,titanium alloy implants functionalized with a TiCu/TiCuN coating by arc ion plating achieved a controlled release of copper ions in vitro for 28 *** coated alloy was co-cultured with bone marrow mesenchymal stem cells and showed excellent biocompatibility and osteoinductivity in vitro.A further exploration of the underlying mechanism by quantitative real-time polymerase chain reaction and western blotting revealed that the enhancement effects are related to the upregulation of genes and proteins(such as axin2,β-catenin,GSK-3β,p-GSK-3β,LEF1 and TCF1/TCF7)involved in the Wnt/β-catenin *** vivo experiments showed that the TiCu/TiCuN coating significantly promoted osteoporotic fracture healing in a rat femur fracture model,and has good in vivo biocompatibility based on various staining *** study confirmed that TiCu/TiCuN-coated Ti promotes osteoporotic fracture healing associated with the Wnt *** the coating effectively accelerates the healing of osteoporotic fractures and improves bone quality,it has significant clinical application prospects.

关键词： nitride-titanium-copper orthopaedic implant osteogenesis osteointegration osteoporotic fractures

In vitro insights into the role of copper ions released from selective laser melted CoCrW-xCu alloys in the potential attenuation of inflammation and osteoclastogenesis

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Journal of Materials Science & Technology 2020年第6期41卷 56-67页

作者： Yanjin Lu Xiongcheng Xu Chunguang Yang ling ren Kai Luo Ke Yang Jinxin Lin Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350001China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Stomatology Fujian Medical UniversityFuzhou 350001China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

In this study,the CoCrW-x Cu alloys(x=2,3 and 4 wt%)were fabricated using selective laser melting(abbreviated as Co-2 Cu,Co-3 Cu and Co-4Cu)with the purpose of reducing the inflammation responses and the activity of *** metal ions releasing test showed that when the Cu content was less than 4 wt%,the releasing amount of Co and Cr ions was very small;however,when 4 wt%Cu was added in the CoCrW based alloy,the quantity of Co ions was significantly elevated with respect to the other groups due to the segregation of precipitates in the matrix;the Cu2+ion quantity of the Co-2Cu,Co-3Cu and Co-4Cu alloys were 0.05,0.09 and 0.27 g/(L cm2)after 7 d immersion,respectively;the RT-q PCR and ELISA data indicated that the expression levels of the pro-inflammatory cytokines(TNF-αand IL-6)were down-regulated in the Co-3Cu and Co-4Cu groups,whereas the expression level of the anti-inflammatory cytokine(IL-10)was up-regulated in all CoCrW-x Cu alloys;meanwhile,the Cu-containing CoCrW alloys significantly down-regulated the expression of the NF-B signal pathway in a Cu content-dependent manner,and the downstream transcription factors of NF-B signal pathway including NFATc1,TRAP and Cath-K were also down-regulated via potentially manipulating the NF-B signal *** comprehensive consideration,it is considered that the Co-3Cu alloy is a potential material for self-alleviating inflammatory responses.

关键词： Osteoclast Selective laser melting Macrophage Cu-bearing biomedical alloy Biocompatibility

Ultrafine-grained Ti6Al7Nb-xCu alloy with ultrahigh strength and exceptional biomedical properties

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Journal of Materials Science & Technology 2023年第33期164卷 68-78页

作者： Yi Li Hai Wang Konrad Koenigsmann Hui Liu Shuyuan Zhang ling ren Ke Yang Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China University of Chicago ChicagoIL 60637USA Binzhou Institute of Technology Shandong Key Laboratory of Advanced Aluminum Materials and TechnologyBinzhou 256606China

Grain refinement has been found to be able to improve the strength of metals without reducing their plasticity or *** this work,ultrafine-grained Ti6Al7Nb-xCu(x=0,3 wt%,6 wt%,9 wt%)alloys were fabricated based on the clinically used Ti6Al7Nb alloy via Cu alloying fabrication strategy combined with dynamic recrystallization(DRX)from martensite during hot *** results indicate that Cu alloying is not only effective in reducing the width of martensite laths after quenching in theβphase region but also increases the nucleation rate of DRX during the high-temperature ***,the Ti2Cu phase that precipitates from the matrix can pin the grain boundaries and inhibit their growth during the high-temperature *** optimal Cu concentration of Ti6Al7Nb-xCu alloy is determined to be 6 wt%,and the optimal deformation temperature is determined to be 750°*** this Cu content and deformation temperature,the grain size is only 270 nm,the tensile strength is up to 1266±10 MPa,and the elongation is 17%.Compared with the commercial Ti6Al7Nb alloy,the ultrafine-grained Ti6Al7Nb-6Cu alloy has better overall mechanical properties,good biocompatibility,and unique antibacterial *** work provides a theoretical basis for fabricating the new antibacterial titanium-based alloys with high strength.

关键词： High strength titanium alloy Ultrafine grain Antibacterial Dynamic recrystallization

Antibacterial Properties of Ti-6Al-4V-xCu Alloys

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Journal of Materials Science & Technology 2014年第7期30卷 699-705页

作者： ling ren Zheng Ma Mei Li Yu Zhang Weiqiang Liu Zhenhua Liao Ke Yang Institute of Metal Research Chinese Academy of Sciences Department of Orthopedic Surgery Guangzhou General Hospital of Guangzhou Military Command Research Institute of Tsinghua University in Shenzhen Shenzhen High-Tech Industrial Estate

Surgical implant-associated bacterial infection is becoming a serious clinical problem. A series of copper-bearing titanium alloy, Ti-6Al-4V-xCu （x = 1, 3, 5 wt%）, were fabricated in the present study in order to reduce the hazard of the bacterial infection problem by means of the strong antibacterial ability of Cu element. The metallography, X-ray diffraction, antibacterial ability, corrosion resistance and cytotoxicity of Ti-6Al-4V-xCu alloys were preliminarily studied with comparison to the commercial medical Ti-6Al-4V alloy. The Ti-6Al- 4V-xCu alloys showed obvious antibacterial abilities with good corrosion resistance and cytocompatibility, and the antibacterial role was enhanced with increasing Cu content, which has significant potential for clinical applications as surgical implant materials.

关键词： Ti-6Al-4V Cu-bearing titanium alloy Antibacterial property

Promoting osteointegration effect of Cu-alloyed titanium in ovariectomized rats

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Regenerative Biomaterials 2022年第1期9卷 143-155页

作者： Xiyue Zhang Hui Liu ling Li Cuishan Huang Xiangbo Meng Junzuo Liu Xueling Bai ling ren Xinluan Wang Ke Yang ling Qin Institute of Metal Research Chinese Academy of ScienceShenyang 110016PR China Translational Medicine Research Center Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenPR China Musculoskeletal Research Laboratory of Department of Orthopaedis&Traumatology The Chinese University of Hong KongHK SARPR China

Osteoporosis is a common skeletal disease making patients be prone to the osteoporotic ***,the clinical implants made of titanium and its alloys with a poor osseointegration need a long time for healing and easily to ***,a new class of Cu-alloyed titanium(TiCu)alloys with excellent mechanical properties and bio-functionalization has been *** this study,the osteoporosis modeled rats were used to study the osteointegration effect and underlying mechanism of *** results showed that after implantation for 4 weeks,TiCu alloy could promote the reconstruction of vascular network around the implant by up-regulating vascular endothelial growth factor *** 8weeks,it could further promote the proliferation and differentiation of osteoblasts,mineralization and deposition of collagens,and then significantly increasing bone mineral density around the *** conclusion,TiCu alloy would enhance the fixation stability,accelerate the osteointegration,and thus reduce the risk of aseptic loosening during the long-term implantation in the osteoporosis *** study was the first to report the role and mechanism of a Cu-alloyed metal in promoting osteointegration in osteoporosis environment,which provides a new attractive support for the improvement of future clinical applications of Cu-alloyed antibacterial titanium alloys.

关键词： copper-alloyed titanium alloy osteoporosis implant osseointegration vascularization

Recent Progress and Applications of HfO_(2)-Based Ferroelectric Memory

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Tsinghua Science and Technology 2023年第2期28卷 221-229页

作者： Xiao Liu Xiangshun Geng Houfang Liu Minghao Shao Ruiting Zhao Yi Yang Tian-ling ren Beijing National Research Center for Information Science and Technology(BNRist) School of Integrated CircuitsTsinghua UniversityBeijing 100084China

The discovery of ferroelectricity in hafnium oxide (HfO_(2)) based thin films in 2011 renewed the interest inferroelectrics. These new ferroelectrics possess completely different crystal morphology with conventional perovskiteferroelectrics, and present more robust ferroelectric properties upon aggressive scaling and compatibility withstandard integrated circuit fabrication processes. In this article, we give a brief introduction to the conventionalferroelectric memories, then review the basic properties, recent progress, and memory applications of theseHfO_(2)-based ferroelectrics.

关键词： ferroelectric memory non-volatile memory hafnium oxide fluorite structure material

Cytotoxic Effect on Osteosarcoma MG-63 Cells by Degradation of Magnesium

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Journal of Materials Science & Technology 2014年第9期30卷 888-893页

作者： Mei Li ling ren LiHua Li Peng He GuoBo Lan Yu Zhang Ke Yang Hospital of Orthopedics Guangzhou General Hospital of Guangzhou Military Command Institute of Metal Research Chinese Academy of Sciences

Biocompatible and biodegradable magnesium （Mg） based metals have attracted great interest for use in orthopedic implants and devices. Based on our previous study that Mg with and without micro-arc oxidation （MAO） coating showed obvious cytotoxic effect on tumor cells due to the increase of pH value during the degradation of Mg, this study further evaluated the cytotoxic effect of Mg and MAO coated Mg on osteosarcoma （MG-63） cells by analyzing the cell adhesion, morphology and number through observation of scanning electron microscope, as well as live/dead staining, lactate dehydrogenase （LDH） activity and 4, 6- diamidino-2-phenylindole （DAPI） assay. The results indicated that, compared to titanium, Mg could strongly inhibit the cell adherence, morphology and number of MG-63 on the surface of the naked Mg, whereas the MAO coated Mg showed relative weak cytotoxic effect on MG-63 cells, expecting that magnesium based metals with suitable coating can be designed to be applied as tumor prosthesis in the clinical practice.

关键词： Magnesium Biodegradation Osteosarcoma Cytotoxicity