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World Journal of Emergency Medicine 2020年第1期11卷 48-53页

作者： Shao-xi Chen Karren Fan ling-pong leung Accident and Emergency Department University of Hong Kong-Shenzhen Hospital

Dear editor,China is the most populated country and the second economic entity *** Kong and Shenzhen are two adjacent cities in southern China,with similar environmental,cultural,ethnic groups,and economic *** both have a very interesting turning point in their destiny,leading to a miraculous economic ***,their government structure and health care system are totally different.[1]This is a vivid example of Deng Xiaoping’s formulation of the principle of“one country,two systems”.

关键词： editor turning totally

Performance of a prehospital trauma diversion system in Hong Kong, China

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Chinese Journal of Traumatology 2015年第3期18卷 137-140页

作者： Tak-Wai Lui Kit-ling Fan ling-pong leung Department of Medidne Queen Mary Hospital Hong Kong China Emergency Medicine Unit Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China

Purpose:To evaluate the performance of a prehospital trauma diversion system in Hong Kong, China.Methods:A retrospective analysis of prospectively collected data in the trauma registry of Queen Mary Hospital, Hong Kong from 1 January 2009 to 31 December 2013 was done. All adult patients aged 18 years or above, either primarily or secondarily diverted to Queen Mary Hospital according to the trauma patient diversion protocol, were recruited. Need for trauma center level of care was based on a consensus-based criterion standard published in 2014. Performance of the protocol in terms of over-diversion and under-diversion was determined.Results:A total of 209 patients were included for analysis. About 30% of the patients required trauma center level of care. The most common reason was the need for vascular, neurologic, abdominal, thoracic, pelvic, spine or limb-conserving surgery within 24 h of presentation. The over-diversion rate and under-diversion rate were 69.6% and 19.7% respectively.Conclusion:The trauma patient diversion protocol currently in use in Hong Kong is not accurate enough. Further revision and refinement is needed.

关键词：引水系统创伤性能香港中国神经系统流协议患者

Comparison of two emergency medical services in Beijing and Hong Kong, China

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Chinese Medical Journal 2019年第11期132卷 1372-1374页

作者： Fei Shao Kit-ling Fan Colin Robertson Marcus Ong Nan Liu ling-pong leung Reynold leung Chun-Sheng Li Departm ent of Emergency Medicine Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Accident and Emergency Department The Hong Kong University-Shenzhen Hospital Shenzhen Guangdong 518053 China Accident and Emergency Medicine and Surgery University of Edinburgh Scotland UK Department of Emergency Medicine Singapore General Hospital Singapore Health Services Research Centre Singapore Health Services Singapore Emergency Medicine Unit Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China

To Out-of-hospital cardiac arrest (OHCA) is a major issue in emergency care worldwide. The incidence of OHCA is estimated to be 50 to 60 per 100,000 persons *** advances in treatment and technology, survival following OHCA remains low. There are multiple factors affecting the survival outcome. The type of emergency medical service (EMS) system is likely to be one of them. In Asia, the EMS structure and its service capability in terms of dispatch, airway management, and medications vary widely between communities. This study aimed to evaluate the survival outcomes of OHCA in Beijing and Hong Kong (HK), China and the effect of the type of EMS system on the survival outcomes for patients with OHCA.

关键词： Extrahospital cardiac arrest (ohca) cardiac arrest emergency medical service

An Uncommon Potentially Fatal Complication in a Patient without Predisposing Factor Following Oral Bowel Preparation Commonly Used for Colonoscopy

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Open Journal of Emergency Medicine 2016年第1期4卷 6-10页

作者： Iris Wai Sum Li ling pong leung Sik Hon Tsui Queen Mary Hospital Hospital Authority Hong Kong China Emergency Medicine Unit Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China Department of Accident & Emergency Queen Mary Hospital Hospital Authority Hong Kong Special Administrative Region Hong Kong China

We described the case report of a patient presented with no known predisposing factor, generalized malaise with vomiting, locked jaw, perioral paraesthesia, carpopedal spasm and a positive Chvostek’s sign which resulted from severe electrolyte disturbance at 5 hours after use of oral sodium phosphate solution (NaPO4) as bowel preparation for colonoscopy. On presentation, she developed hyperphosphatemia and symptomatic hypocalcaemia with serum phosphate of 1.84 mmol/L and adjusted calcium level 1.67 mmol/L respectively. Her symptoms subsided after immediate intravenous calcium gluconate followed by oral calcium supplement. The electrolyte disturbances were normalized with an uneventful clinical course. The potentially fatal complications of sodium phosphate solution which commonly prescribed as bowel preparation for conventional colonoscopy could develop though previously reported as uncommon in patients without predisposing factors, and should not be overlooked. Urgent assessment and immediate correction of electrolyte disturbances are needed. Recommendations on patient selection of use of sodium phosphate to minimize risk of developing adverse events are needed to incorporate in clinical protocols.

关键词： Symptomatic Hypocalcaemia Hyperphosphatemia Sodium Phosphate Solution Bowel

Ecology and risks of the global plastisphere as a newly expanding microbial habitat

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The Innovation 2024年第1期5卷 49-58页

作者： Changchao Li Michael RGillings Chao Zhang Qinglin Chen Dong Zhu Jie Wang Kankan Zhao Qicheng Xu Polly Hangmei leung Xiangdong Li Jian Liu ling Jin Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina Environment Research Institute Shandong UniversityQingdao 266237China State Key Laboratory of Marine Pollution City University of Hong KongKowloon TongHong KongChina ARC Centre of Excellence in Synthetic Biology Faculty of Science and EngineeringMacquarie UniversitySydneyNSW 2109Australia Key Laboratory of Urban Environment and Health Ningbo Urban Environment Observation and Research StationInstitute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation College of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100193China Institute of Soil and Water Resources and Environmental Science College of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization Nanjing Agricultural UniversityNanjing 210095China Department of Health Technology and Informatics and Research Institute for Future Food The Hong Kong Polytechnic UniversityKowloonHong KongChina Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China

Plastic offers a new niche for microorganisms,the *** everincreasing emission of plastic waste makes it critical to understand the microbial ecology of the plastisphere and associated ***,we present a global fingerprint of the plastisphere,analyzing samples collected from freshwater,seawater,and terrestrial *** plastisphere assembles a distinct microbial community that has a clearly higher heterogeneity and a more deterministically dominated assembly compared to natural *** coexistence patterns—loose and fragile networks with mostly specialist linkages among microorganisms that are rarely found in natural habitats—are seen in the *** microbiomes generally have a great potential to metabolize organic compounds,which could accelerate carbon *** involved in the nitrogen cycle are also altered in the plastisphere,especially in freshwater plastispheres,where a high abundance of denitrifiers may increase the release of nitrite(aquatic toxicant)and nitrous oxide(greenhouse gas).Enrichment of animal,plant,and human pathogens means that the plastisphere could become an increasingly mobile reservoir of harmful *** findings highlight that if the trajectory of plastic emissions is not reversed,the expanding plastisphere could pose critical planetary health challenges.

关键词： reservoir mostly habitat

Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice

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Chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea ling-Yu Kan Ben Chung-Lap Chan Grace Gar-Lee Yue LI Pei-ting Sharon Sze-Man Hon HUANG Dan-qi Miranda Sin-Man Tsang Clara Bik-San Lau Ping-Chung leung Chun-Kwok Wong Institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina China-Australia International Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(P<0.05),altered the hypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(P<0.05).4HF-doxorubicin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

A potentially life-threatening complication of university orientation activities

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World Journal of Emergency Medicine 2012年第1期3卷 71-73页

作者： ling pong leung Accident & Emergency Department Queen Mary Hospital

BACKGROUND:This case report describes a university student who participated in an orientation activity and developed exertional ***:With prompt intravenous volume expansion started in the accident and emergency department,he made an uneventful recovery despite a marked elevation of creatine *** risk factors of developing exertional rhabdomyolysis were *** based on these risk factors were made to the organizers of such orientation ***:He was discharged on day *** follow-up on day 8 after presentation at the accident and emergency department,the CK level was 46 000 U/L and it fell to 2600 U/L in another *** follow-up 3 weeks after the incident,he remained well without ***:For the clinicians,once rhadbomyolysis is suspected or diagnosed,intravenous fluid therapy with a crystalloid should be initiated as soon as possible to prevent the occurrence of acute renal faiure.

关键词： Rhadbomyolysis Acute renal faiure

Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica Sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin Ng Grace Lui Lowell ling Agnes S.Y.leung Chit Chow Siaw Shi Boon Wendy C.S.Ho Maggie Haitian Wang Renee Wan Yi Chan Albert Martin Li David Shu Cheong Hui Paul Kay Sheung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The SARS-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus SARS-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq Subgenomic RNA(sgRNA)

Utilization of the Accident & Emergency Departments by Chinese elderly in Hong Kong

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World Journal of Emergency Medicine 2015年第4期6卷 283-288页

作者： Wai Lam Yip Kit ling Fan Chun Tat Lui ling pong leung Fu Ng Kwok leung Tsui Accident & Emergency Department Queen Mary Hospital Emergency Medicine Unit The University of Hong Kong Accident & Emergency Department Tuen Mun Hospital Accident & Emergency Department Caritas Medical Centre

BACKGROUND: The epidemiological data on elderly patients attending Accident and Emergency Departments(AEDs) in Hong Kong is lacking. The study aimed to examine the epidemiology of geriatric patient visits to AEDs in Hong Kong, including demographic data and predictors of life-saving interventions(LSI) and ***: A retrospective cross-sectional study of geriatric patients older than 64 years old attending three AEDs during the year 2012, with a sample of 1 200 patient visits recruited. The data were retrieved from the medical records of the respective hospitals. Descriptive characteristics of the visits were provided. Multivariate logistic regression was performed to evaluate the predictors of LSI and hospital ***: The mean age of the patients was 79.1 years. Totally 49.7% of the patients were male. "Diseases of the respiratory system" was the commonest diagnosis in AEDs as well as that required admission. The admission rate was 56.8%. Logistic regression demonstrated that dependent activity of daily living(ADL), arrival by ambulance, and the higher number of co-morbidities were predictors of LSI, while advanced age, dependent ADL, institutionalized patients, arrival by ambulance, and higher number of co-morbidities were predictors of hospital ***: Ageing population is creating an imminent burden on the emergency service in Hong Kong. Previously unavailable epidemiological information about geriatric attendance to AEDs was described. This forms the basis for development of future studies concerning the medical services on this specific group of patients.

关键词： Elderly Geriatric Emergency department Epidemiology

Diagnostic accuracy of Focused Abdominal Sonography for Trauma in blunt abdominal trauma patients in a trauma centre of Hong Kong

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Chinese Journal of Traumatology 2012年第5期15卷 273-278页

作者： Cheung Kent Shek Wong Hay Tai leung ling pong Tsang Tat Chi leung Gilberto Ka Kit Department of Accident and Emergency Queen Mary Hospital 102 Pokfulam Road Pokfulam Hong Kong China Department of Surgery Li Ka Shing Faculty of Medicine University of Hong Kong Hong Kong China

为损伤的 ObjectiveFocused 腹的 Sonography (快) 广泛地为 intraperitoneal 的察觉被使用在受不了钝腹的损伤(蝙蝠) 的病人的免费液体。针对在指明的损伤 *** 估计这调查的诊断精确性的这研究是在在香港在一个损伤中心看见的 6 年时... 详细信息

为损伤的 ObjectiveFocused 腹的 Sonography (快) 广泛地为 intraperitoneal 的察觉被使用在受不了钝腹的损伤(蝙蝠) 的病人的免费液体。针对在指明的损伤 *** 估计这调查的诊断精确性的这研究是在在香港在一个损伤中心看见的 6 年时期上的蝙蝠病人的回顾的研究。快调查结果与剖腹术，腹的计算断层摄影术或尸体调查结果相比，它为 intraperi-toneal 的存在用作标准答案免费液体。没快有的病人或确定的测试执行了，有先存在的腹液体，在复活死了或有快调查结果的 imcomplete 文档的标准答案被排除。性能当敏感，特性，预兆的值(PV ) ，可能性的比率(LR ) 和 *** 在 302 个病人被执行，他们中的 153 个在这分析被包括，快被表示。敏感，特性，积极 PV，否定 PV，积极 LR，否定 LR 和精确性为快分别地 50.0% ， 97.3% ， 87.0% ， 84.6% ， 18.8， 0.5 和 85.0% 。快被发现在不太严重地受伤的病人和在更严重地受伤的 *** 特定的更多更敏感是在对蝙蝠病人的起始的评价的可靠调查。诊断价值能被损害的严厉快影响，职员训练被需要进一步提高它的有效使用。

关键词：诊断准确性闭合性创伤患者腹部损伤香港超音波