检索结果-南通市图书馆

The therapeutic effect and mechanism of human bone marrow mesenchymal stem cells transplantation in MRL/Ipr mice

在线全文

学校读者我要写书评

暂无评论

The therapeutic effect and mechanism of human bone marrow me...

腔镜辅助下经锁骨下单切口行双侧甲状腺手术体会(附18例报告)

The 8th International Congress on SLE

作者： Kang-xing Zhou ling-Yun Sun ou-yang Jin Xue-Bing Feng The Affiliated Drum Tower Hospital of Nanjing University Medical School Jiangsu China

＜正＞Purpose:To investigate the therapeutic effects and mechanism of human bone marrow mesenchymal stem cells （MSC）transplantation in MRL/lpr mice.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国内镜杂志 2014年第4期20卷 414-417页

作者：雷睿文黄湛欧林扬杨传胜卢海张凯陈卓荣广东粤北人民医院头颈乳腺外科广东韶关512000

目的探讨腔镜辅助下经锁骨下单切口行双侧甲状腺结节手术切除的可行性和治疗效果。方法 18例双侧甲状腺良性结节,取结节较大侧锁骨下切口入路,切口长约3~4cm,行腔镜辅助下甲状腺部分或全部切除。结果所有患者均手术顺利,手术时间在60~... 详细信息

目的探讨腔镜辅助下经锁骨下单切口行双侧甲状腺结节手术切除的可行性和治疗效果。方法 18例双侧甲状腺良性结节,取结节较大侧锁骨下切口入路,切口长约3~4cm,行腔镜辅助下甲状腺部分或全部切除。结果所有患者均手术顺利,手术时间在60~90min之间,出血量20~50mL,无手术并发症,术后3~4d出院,切口一期愈合。随访1~24个月,无肿瘤复发,无颈部麻木、疼痛、吞咽不适。结论严格掌握指征,腔镜辅助下经锁骨下单切口行双侧甲状腺结节手术切除是安全可行的,术后并发症少,颈部外形美观。

关键词：腔镜辅助甲状腺结节手术

HBV抗原基因修饰树突状细胞疫苗体外抗HBV的作用

在线全文

学校读者我要写书评

暂无评论

世界华人消化杂志 2006年第19期14卷 1864-1869页

作者：黄呈辉欧阳玲黄建国黎淦平江鹏飞姚集鲁深圳市宝安区中心血站研究室深圳市518101 深圳市龙华人民医院内科深圳市518109 中山大学附属第三医院感染科广东省广州市510630

目的：探讨腺病毒载体介导HBV抗原基因修饰的树突状细胞(DCs)诱导抗HBV特异性CTL反应方法：制备携带HBsAg、HBeAg和HBcAg基因的3种重组腺病毒Ad-HBs,Ad-HBe,Ad- HBc,分别转染自脐带血体外诱导培养的DCs,观察腺病毒转染DCs效率和DCs中HB... 详细信息

目的：探讨腺病毒载体介导HBV抗原基因修饰的树突状细胞(DCs)诱导抗HBV特异性CTL反应方法：制备携带HBsAg、HBeAg和HBcAg基因的3种重组腺病毒Ad-HBs,Ad-HBe,Ad- HBc,分别转染自脐带血体外诱导培养的DCs,观察腺病毒转染DCs效率和DCs中HBV抗原的表达；混合淋巴细胞反应(MLR)测定HBV抗原基因修饰DCs刺激同种异体T淋巴细胞增殖能力；乳酸脱氢酶释放法检测特异性CTL细胞对HepG_222．1．5靶细胞的杀伤能力．结果：腺病毒载体能够高效介导HBV三个抗原基因在DCs中表达,90%以上DCs表达示踪基因EGFP,且DCs细胞形态完整：感染后72 h HBsAg和HBeAg含量分别为0．919和0．328(吸光度A值)．MLR实验显示,HBV抗原基因修饰DCs仍然具有刺激同种异体T细胞的增殖能力,Ad-HBs转染DCs组、Ad-HBe转染DCs组、Ad-HBc转染DCs组和未转染DCs组之间刺激T细胞的增殖水平无明显差异(F=1．194,P=0．389)；在E：T比例为2：1,10：1和25：1时,Ad-HBs转染DC组、Ad-HBe转染DCs组和Ad-HBc转染DCs组对HepG_222．1．5细胞的杀伤率均明显高于未转染DCs组(P＜0．001)；以Ad- HBc转染DC组对HepG_222．1．5细胞杀伤率最高．结论：HBV抗原基因修饰DCs疫苗具有刺激同种异体T细胞增殖能力,同时能增强抗HBV特异性CTL反应的能力,可能发展为一种新型抗病毒疫苗．

关键词：乙型肝炎病毒抗原树突状细胞 T淋巴细胞细胞毒性腺病毒载体

Drawing-upsetting-extrusion-clinching of high-strength steel and aluminum alloy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2023年第10期30卷 1974-1986页

作者： ling-feng Luo Shang-yu Huang Mei yang Jian-hua Hu Bing ou School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070HubeiChina Hubei Engineering Research Center for Green Precision Material Forming Wuhan University of TechnologyWuhan 430070HubeiChina Shanghai Technician School Shanghai 200437China

To realize good point connection between high-strength steel and aluminum alloy,a process of drawing-upsetting-extrusion-clinching was ***,the sheets were drawn;then,the bottom of the protrusion part was extruded,forming the necessary initial interlock;and finally,the protrusion part was reverse press clinched,forming a certain height of the clinched *** DP980 high-strength steel and A15083 aluminum alloy as the connection objects and using the method of numerical simulation combined with experimental test,the mold was made,and the experiment was carried out on the basis of numerical *** experimental results proved the feasibility of the process and the effectiveness of the numerical *** simulation and experimental results show that the necessary interlock in the drawing-upsetting-extrusion stage is the premise of effective *** relative protrusion height should be around 55.6%after *** best comprehensive mechanical properties measured by strength test were shear resistance of 2644 N,fatigue life of 24,535 times and peel resistance of 1522 *** failure analysis,the relationship between the interlock Tu and the neck thickness Tn of the joint with the best comprehensive mechanical properties was established as Tu=*** design method of die and process parameters when the sheet thickness changes was researched by numerical *** results show that the clearance between the punch and the die and the bottom thickness are directly proportional to the sheet thickness,and the drawing depth is directly proportional to the punch radius.

关键词： Clinching High-strength steel Aluminum alloy Process parameter Joint strength

New two-layer Ruddlesden-Popper cathode materials for protonic ceramics fuel cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Advanced Ceramics 2021年第5期10卷 1052-1060页

作者： Yihan ling Tianming GUO yangyang GUO yang yang Yunfeng TIAN Xinxin WANG Xuemei ou Peizhong FENG School of Materials Science and Physics China University of Mining and TechnologyXuzhou 221116China

New two-layer Ruddlesden-Popper(RP)oxide La_(0.25)Sr_(2.75)FeNiO_(7-δ)(LSFN)in the combination of Sr_(3)Fe_(2)O_(7-δ) and La_(3)Ni_(2)O_(7-δ) was successfully synthesized and studied as the potential active single-phase and composite cathode for protonic ceramics fuel cells(PCFCs).LSFN with the tetragonal symmetrical structure(IMmmm)is confinned,and the co-existence of Fe^(3+)/Fe^(4+) and Ni^(3+)/Ni^(2+) couples is demonstrated by X-ray photoelectron spectrometer(XPS)*** LSFN conductivity is apparently enhanced after Ni doping in Fe-site,and nearly three times those of Sr_(3)Fe_(2)O_(7-δ),which is directly related to the carrier concentration and conductor ***,anode supported PCFCs using LSFN-BaZr_(0.1)Ce_(0.7)Y_(0.2)O_(3-δ)(LSFN-BZCY)composite cathode achieved high power density(426 mW·cm^(-2) at 650℃)and low electrode interface polarization resistance(0.26Ω·cm^(2)).Besides,distribution of relaxation time(DRT)function technology was further used to analyse the electrode polarization *** observed three peaks(Pl,P2,and P3)separated by DRT shifted to the high frequency region with the decreasing temperature,suggesting that the charge transfer at the electrode-electrolyte interfaces becomes more difficult at reduced *** results demonstrate that new two-layer RP phase LSFN can be a promising cathode candidate for PCFCs.

关键词： protonic ceramics fuel cells(PCFCs) Ruddlesden-Popper(RP)phase single-phase cathode distribution of relaxation time(DRT)function charge transfer

Fatal ventricular arrhythmias after osimertinib treatment for lung adenocarcinoma: a case report

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2023年第3期20卷 242-246页

作者： Gui-Gao GUO Xin LUO Ke ZHU ling-ling LI yang-Fan ou Cardiovascular Department Zhuzhou Hospital Affiliated to Xiangya School of MedicineCentral South UniversityZhuzhouHunanChina

Osimertinib,a third-generation epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKIs),is approved globally as the first-line treatment for patients with EGFR mutations(EGFRm:Ex19del/L858R)and T790M resistance mutations in advanced non-small cell lung cancer(NSCLC).[1−3]With its widespread use,the cardiotoxicity of osimertinib has been of great *** to the *** and Drug Administration Adverse Events Reporting System(FAERS),the main cardiac-related adverse events with EGFR-TKIs are heart failure,QT prolongation,atrial fibrillation,acute myocardial infarction and pericardial effusion,and osimertinib has a higher incidence of QT prolongation,heart failure and atrial fibrillation than other EGFR-TKIs.

关键词： lung acute ventricular

在线全文

学校读者我要写书评

暂无评论

脐血采分过程中微生物污染的调查

陕西医学检验 2002年第1期17卷 16-17页

作者：胡燕芬饶美琼邹翠贤朱美玲欧阳玲深圳市宝安血站脐血库广东深圳518101

目的　探讨不同脐血采分过程中微生物污染率。方法　脐血采集按美国脐血库标准操作规程(SOP) ;6 6份脐血同时按密闭式和开放式两种操作方式进行脐血造血细胞分离处理 ;采用全新型BACTEC90 5 0细菌培养系统对分离前、后脐血进行细菌和真... 详细信息

目的　探讨不同脐血采分过程中微生物污染率。方法　脐血采集按美国脐血库标准操作规程(SOP) ;6 6份脐血同时按密闭式和开放式两种操作方式进行脐血造血细胞分离处理 ;采用全新型BACTEC90 5 0细菌培养系统对分离前、后脐血进行细菌和真菌培养。结果　脐血采集后细菌和真菌污染率分别为 3 .0 %、1 .5 % ;密闭式分离处理后细菌和真菌污染率分别增加到 6 .0 %、3 .0 % ;开放式分离处理后细菌和真菌污染率分别增加到 7.5 %和 3 .0 %。结论　脐血采分过程是导致脐血细胞微生物污染的重要原因 ,操作过程中必须严格执行消毒、隔离、灭菌技术和操作员管理制度以尽量降低污染率。

关键词：脐血采集微生物污染分离细菌真菌血库

Design of a rapid-cycling synchrotron for flash proton therapy

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2023年第10期34卷 1-11页

作者： Ying Shi Man-Zhou Zhang Lian-Hua ou-yang Zhi-ling Chen Xiu-Fang Li De-Ming Li Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China

The purpose of this study was to design a rapid-cycling synchrotron, making it capable of proton beam ultrahigh dose rate irradiation, inspired by laser accelerators. The design had to be cheap and simple. We consider our design from six aspects: the lattice, injection, extraction, space charge effects, eddy current effects and energy switching. Efficiency and particle quantity must be addressed when injected. The space charge effects at the injection could affect particles' number. The eddy current effects in the vacuum chambers would affect the magnetic field itself and generate heat, all of which need to be taken into account. Fast extraction can obtain 10^(10) protons/pulse, equal to instantaneous dose rate up to 10~7 Gy/s in a very short time, while changing various extraction energies rapidly and easily to various deposition depths. In the further research, we expect to combine a delivery system with this accelerator to realize the FLASH irradiation.

关键词： FLASH Rapid-cycling synchrotron Proton therapy

Residents'environmental conservation behaviour in the mountain tourism destinations in China:Case studies of Jiuzhaigou and Mount Qingcheng

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2017年第12期14卷 2555-2567页

作者： zhang yu-ling zhang jie zhang hong-ou zhang ruo-yang wang yang guo yong-rui wei zong-cai guangzhou institute of geography Guangzhou 510070China guangdong open laboratory of geospatial information technology and application Guangzhou 510070China school of geographic and oceanographic science nanjing universityNanjing 210046China shenzhen tourism college jinan universityShenzhen 518053China school of history culture and tourism jiangsu normal universityJiangsu Normal UniversityXuzhou 221116China school of architecture state key laboratory of subtropical building sciencesouth china university of technologyGuangzhou 510641China

This study aimed at gaining an understanding of the formation of residents' Environmental Conservation Behaviour(ECB) to promote sustainable tourism development in Chinese mountain areas. In particular, a theoretical framework was constructed by merging residents' mountain attachment and their environmental values,and awareness of environmental consequences based on the Cognition Behaviour Theory. This research sampled 642 residents with convenience sampling method in Jiuzhaigou and Mount Qingcheng, and structural equation modelling analysis was conducted to identify the relationships among the above variables. Results verified that mountain attachment affected people's awareness of environmental consequences, which then affected their *** values and mountain attachment directly and positively influenced ECB. Moreover,awareness of environmental consequences played the most prominent role in predicting ECB among all the predictors in this study. In all, this study derived several significant implications which can not only contribute to environmental management policies in tourism field but also help to improve the levels of the antecedents of residents' ECB and promote sustainable tourism development in Chinese mountain areas.

关键词： Sustainable tourism development Mountain attachment Environmental Conservation Behaviour Environmental values Cognitive Behaviour Theory