检索结果-南通市图书馆

Goat casein hydrolysates alleviated insomnia in mice via modulating the level of neurotransmitters and the composition of gut microbiota

引用

Food Science and Human Wellness 2024年

作者： ling mo Huijuan Jing Xiaojing Du Chaochao Zhao Yintao Lin Jie Li Hongxin Wang State Key Laboratory of Food Science and Technology Jiangnan University Sweet Inn (Guangzhou) Technology Development Co. Ltd School of Public Health Guilin Medical University School of Food Science and Technology Jiangnan University

Insomnia is associated with neurotransmitters and intestinal dysbiosis. Though studies have demonstrated the ameliorative effects of milk hydrolysates on insomnia， the underlying mechanisms require further exploration. In this study， we investigated how papain hydrolysates of goat casein (CPH) and whey protein (WPH) affected mice’s sleeplessness. Here， we show that CPH effectively improved the total sleep time in 12 h and restoring neurotransmitters (5-hydroxytryptamine (5-HT)， γ-aminobutyric acid (GABA)， dopamine (DA)， and norepinephrine (NE)) in mice. Further gut microbiota analysis revealed a significant increase in the relative abundance of Helicobacter and Escherichia-Shigella and a decrease in the relative abundance of Lactobacillus in the insomnia model mice (model). Compared to the model group， both CPH and WPH significantly increased the relative abundance of Akkermansia and Lactobacillus while lowering the relative abundance of Helicobacter and Escherichia-Shigella. Notably， while diazepam (DZP) increased mouse sleep duration， it also increased the relative abundance of Colidextribacter， Parasutterella， Muribaculaceae， and Prevotella. Additionally， the gene expression and protein expression of GABAAreceptor， cAMP-response element binding protein (CREB)， and brain-derived neurotrophic factor (BDNF) were upregulated in the hypothalamus. We also discovered a link between intestinal gut microbiota and neurotransmitters. Overall， our results suggest that goat milk hydrolysates， especially CPH， can effectively improve insomnia， providing a theoretical basis for further experimentation and individualized designs.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

胃早期分化型管状腺癌黏膜下层浸润的危险因素分析

引用

中国实用医药 2024年第1期19卷 24-27页

作者：覃俊富莫凌山黄学广西医科大学第八附属医院消化内科 537100

目的探讨胃早期分化型管状腺癌黏膜下层浸润的危险因素。方法回顾性分析经病理证实的行内镜黏膜下剥离术(ESD)治疗的140例胃早期分化型管状腺癌患者的临床资料,共148处病灶。根据浸润深度将胃早期分化型管状腺癌病灶分为黏膜内浸润(123... 详细信息

目的探讨胃早期分化型管状腺癌黏膜下层浸润的危险因素。方法回顾性分析经病理证实的行内镜黏膜下剥离术(ESD)治疗的140例胃早期分化型管状腺癌患者的临床资料,共148处病灶。根据浸润深度将胃早期分化型管状腺癌病灶分为黏膜内浸润(123处)和黏膜下层浸润(25处)。统计分析患者的基线特征,对胃早期分化型管状腺癌黏膜下层浸润进行单因素及多因素Logistic回归分析。结果140例患者中男性113例(80.71%),女性27例(19.29%),年龄为34~91岁,中位年龄为68(61,73)岁。140例患者共有148处病灶,病灶长径为1.5~95 mm,长径中位数为16(8,26.5)mm;浸润深度:局限在黏膜层(黏膜内浸润)123处(83.11%),黏膜下层浸润25处(16.89%),其中浸润至黏膜下层浅层16处,浸润至黏膜下层深层9处。高分化管状腺癌75处,高中分化管状腺癌61处,中分化管状腺癌12处。单因素分析表明,黏膜内浸润与黏膜下层浸润的性别、年龄、病灶位置、内镜下形态、黏液表型、免疫组化P53阳性及Ki67>50%表达情况比较,差异无统计学意义(P>0.05);黏膜内浸润与黏膜下层浸润的病灶长径≥2 cm、组织学有中分化成分的占比比较,差异有统计学意义(P<0.05)。将单因素分析有意义的结果病灶长径≥2 cm、组织学有中分化成分,进一步行多因素Logistic回归分析表明:病灶长径≥2 cm[OR=2.808,95%CI=(1.050,7.508),P=0.040<0.05]、组织学有中分化成分[OR=6.080,95%CI=(1.937,19.086),P=0.002<0.05]是胃早期分化型管状腺癌黏膜下层浸润的独立危险因素。结论胃早期分化型管状腺癌中病灶长径≥2 cm、组织学具有中分化成分者易出现黏膜下层浸润。

关键词：早期胃癌管状腺癌浸润深度危险因素

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于STM32小型四旋翼飞行器硬件系统设计与实现

引用

工业控制计算机 2024年第5期37卷 150-152页

作者：莫玲龙顺宇蒋冠东刘世杰海南热带海洋学院海洋信息工程学院海南三亚572022

小型四旋翼飞行器因其独特的飞行性能和便携性能受到消费市场越来越多的关注。为实现四旋翼飞行器可控且稳定的飞行,提出了一种基于STM32F411控制器结合小功率电机的硬件系统设计方案。采用惯性测量组件MPU9250和气压传感器FBM320检测... 详细信息

小型四旋翼飞行器因其独特的飞行性能和便携性能受到消费市场越来越多的关注。为实现四旋翼飞行器可控且稳定的飞行,提出了一种基于STM32F411控制器结合小功率电机的硬件系统设计方案。采用惯性测量组件MPU9250和气压传感器FBM320检测飞行控制系统的姿态高度;采用ESP8266无线透传、NRF24L01收发模块与指挥控制系统进行信息交互;针对外部电源903052锂电池进行分模块化的电路设计;基于动力组件的数学模型可预估飞行续航时间等。经实测结果表明,该硬件系统性能稳定、安全可靠,满足小型四旋翼飞行器基本功能需求。

关键词： STM32F411 四旋翼飞行器惯性测量气压反馈姿态控制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Atomically precise Au_(25)(GSH)_(18)nanoclusters versus plasmonic Au nanocrystals:Evaluating charge impetus in solar water oxidation

引用

Chinese Chemical Letters 2023年第6期34卷 195-199页

作者： Qiao-ling mo Xiao-Cheng Dai Yang Xiao Fang-Xing Xiao College of Materials Science and Engineering Fuzhou UniversityNew CampusMinhou 350108China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China

Atomically precise metal nanoclusters(NCs)have been deemed as an emerging class of metal nanomaterials owing to fascinating size-dependent physicochemical properties,discrete energy band structure,and quantum confinement effect,which are distinct from conventional metal nanoparticles(NPs).Nevertheless,metal NCs suffer from photoinduced self-oxidative aggregation accompanied by in-situ transformation to metal NPs,markedly reducing the photosensitization of metal NCs.Herein,maneuvering the generic instability of metal NCs,we perform the charge transport impetus comparison between atomically precise metal NCs and plasmonic metal NPs counterpart obtained from in-situ self-transformation of metal NCs in photoelectrochemical(PEC)water splitting reaction.For conceptual demonstration,we proposed two quintessential heterostructures,which include TNTAs-Au_(25)heterostructure fabricated by electrostatically depositing glutathione(GSH)-protected Au_(25)(GSH)_(18)NCs on the TiO_(2)nanotube arrays(TNTAs)substrate,and TNTAs-Au heterostructure constructed by triggering self-transformation of Au_(25)(GSH)_(18)NCs to plasmonic Au NPs in TNTAs-Au_(25)via calcination.The results indicate that photoelectrons produced over Au_(25)NCs are superior to hot electrons of plasmonic Au NPs in stimulating the interracial charge transport toward solar water oxidation.This is mainly ascribed to the significantly accelerated carrier transport kinetics,prolonged carrier lifespan,and substantial photosensitization effect of Au_(25)NCs compared with plasmonic Au NPs,resulting in the considerably enhanced PEC water splitting performance of TNTAs-Au_(25)relative to plasmonic TNTAs-Au counterpart under visible light irradiation.Our work would provide important implications for rationally designing atomically precise metal NCsbased photosystems toward solar energy conversion.

关键词： Metal nanoclusters Surface Plasmon resonance Interfacial charge transfer Photoelectrochemical water splitting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于OBE理念的食品卫生与营养学专业实践教学改革的探索与思考

引用

创新创业理论研究与实践 2024年第10期7卷 30-33页

作者：李晶晶王钦莫玲桂中玉桂林医学院公共卫生学院桂林医学院后勤管理处

为提高地方医学院校食品卫生与营养学专业人才的岗位胜任力和培养质量，基于成果导向教育（Outcome-Based Education, OBE）理念，按照专业认证与工作岗位的要求，构建“三层次六结合”的实践教学体系，即“基础技能训练—综合能力训练... 详细信息

为提高地方医学院校食品卫生与营养学专业人才的岗位胜任力和培养质量，基于成果导向教育（Outcome-Based Education, OBE）理念，按照专业认证与工作岗位的要求，构建“三层次六结合”的实践教学体系，即“基础技能训练—综合能力训练—创新创业训练”三层次递进的教学模式，将实践教学与学科竞赛、创新创业训练计划项目、科研项目、教改项目、毕业设计、毕业实习相结合，提升实践教学的综合性、创新性和科研性。

关键词：食品卫生与营养专业实践教学 OBE 应用型人才 “三层次六结合” 地方医学院校

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

隔制附子艾灸百会穴在智力发育迟缓康复护理中的应用

引用

现代医药卫生 2024年第13期40卷 2233-2237页

作者：乔秋艳刘芳坚莫玲杨再婷柳州市妇幼保健院儿童康复科广西柳州545001

目的观察隔制附子艾灸百会穴中医护理结合综合康复训练及常规康复护理对智力发育迟缓患儿的临床效果。方法选取2022年2-12月在该科门诊就诊或住院诊断为智力发育迟缓的120例患儿作为研究对象,将其分为观察组和对照组,各60例。对照组... 详细信息

目的观察隔制附子艾灸百会穴中医护理结合综合康复训练及常规康复护理对智力发育迟缓患儿的临床效果。方法选取2022年2-12月在该科门诊就诊或住院诊断为智力发育迟缓的120例患儿作为研究对象,将其分为观察组和对照组,各60例。对照组给予综合康复训练及常规康复护理,观察组在对照组基础上予隔制附子艾灸百会穴中医护理。观察2组患儿治疗前后Gesell智力发育诊断量表(GDS)各能区发育商(DQ)、儿童综合功能评定表各项目分值变化情况,以及临床疗效。结果 2组患儿治疗后GDS各能区DQ均有提高,观察组适应性行为、大运动、精细动作、语言、个人-社交行为得分分别为(67.92±11.69)、(61.88±13.20)、(63.50±13.20)、(57.35±11.91)、(57.87±11.89)分,均高于对照组的(46.70±18.15)、(49.85±17.78)、(48.25±16.69)、(37.78±13.46)、(42.35±14.20)分,且组内治疗前后比较,差异均有统计学意义(P<0.05)。儿童综合功能评定表各项目分值均有提高,观察组认知功能、言语功能、运动能力、自理动作、社会适应得分分别为(10.98±3.61)、(12.12±4.08)、(18.81±5.42)、(11.83±6.03)、(8.87±3.14)分,均高于对照组的(5.29±1.65)、(6.58±3.20)、(15.30±5.42)、(5.11±4.09)、(6.11±1.79)分,且组内治疗前后比较,差异均有统计学意义(P<0.05)。观察组GDS总有效率[91.7%(55/60)]高于对照组[76.7%(46/60)],儿童综合功能评定总有效率[93.3%(56/60)]也优于对照组[80.0%(48/60)],差异均有统计学意义(P<0.05)。结论隔制附子艾灸百会穴结合综合康复训练及常规康复护理治疗智力发育迟缓疗效确切。

关键词：智力发育迟缓制附子艾灸康复护理

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research Progress on a Novel Duck Flavivirus Disease

引用

Agricultural Biotechnology 2014年第3期3卷 25-29页

作者： Sufang LV Guangjun GUO Feng LI ling mo Zhiqiang SHEN Shandong Binzhou Animal Science & Veterinary Medicine Academy Shandong Lvdu Bio-industry Co. Ltd.

A severe egg-drop disease caused by the infection of a novel duck flavivirus outbroke successively in many provinces in southeastern China since 2010.It was identified as a duck Tembusu virus（DTMUV）and named by Chinese Association of Animal Science and Veterinary Medicine in the first symposium on waterfowl disease control,which was presumed to be a mosquito-borne flavivirus of the Ntaya virus subgroup in the genus Flavivirus,family Flaviviridae.Currently,a large number of studies have been conducted on the epidemiology,clinical symptoms and pathological changes,etiology,and rapid diagnoses of the virus.The disease remains a constant threat to the duck industry.In order to provide reference for subsequent in-depth study,in this paper,research progress on the disease was summarized based on previous studies.Furthermore,the potential infection or asymptomatic infection in humans should be evaluated as soon as possible.

关键词： Duck Duck flavivirus Research progress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

热带岛屿流域水生态评价理论研究与实践——以海南岛为例

引用

中国环境科学 2024年第6期44卷 3334-3341页

作者：王明阳王立成莫凌穆晓东马字伟王赛陈晓璐刘川王丽陈力可符有利王瑞仙海南省环境科学研究院海南海口570228 国家环境保护化学品生态效应与风险评估重点实验室海南基地海南海口570228 海南大学南海海洋资源利用国家重点实验室海南海口570228

为系统科学评估海南流域的水生态现状,本研究以海南岛为例,进行了热带岛屿流域水生态评价理论研究和实践.研究基于相关成果和流域突出水生态问题,构建了水生生物､水生境､水环境和水资源共11项指标的评价体系,综合利用专家打分和层次分... 详细信息

为系统科学评估海南流域的水生态现状,本研究以海南岛为例,进行了热带岛屿流域水生态评价理论研究和实践.研究基于相关成果和流域突出水生态问题,构建了水生生物､水生境､水环境和水资源共11项指标的评价体系,综合利用专家打分和层次分析法计算了评价指标权重,并采用水生态环境质量综合评价指数(WEQI)对南渡江､昌化江和万泉河等海南岛典型流域开展水生态现状评价实践.结果表明:南渡江､昌化江和万泉河干流水生态为良好水平(63.77~71.57分),4座水库为一般水平(41.50~59.55分),水生生物是水生态提升的首要制约项,人为活动是水生态破坏的主要原因,水库还受生态需水量的限制.本研究构建的热带岛屿水生态评价体系可为当地水生态监测和评价提供科学依据.

关键词：热带岛屿流域水生态海南

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Productivity and the Survival Rate after Winter Management of Seven Tropical Forage Accessions in Subtropical Region of China

引用

Agricultural Sciences 2017年第5期8卷 451-464页

作者： Chengxin He ling mo Yuqing Huang Zhongfeng Zhang Michael Hare Danjuan Zen Gaozhong Pu Guangxi Key Laboratory of Plant Conservation and Restoration Ecology in Karst Terrain Guangxi Institute of Botany CAS Guilin China Faculty of Agriculture Ubon Ratchathani University Ubon Ratchathani Thailand

Forage production and quality of five tropical grass accessions (Guimu-1 hybrid elephant grass (PG1), Mulato II (M II), Ubon paspalum (PU), hybrid elephant grass (PH) and Reyan 11 paspalum (PR11)) and two tropical legume accessions (Reyan 5 stylo (SR5) and Ubon stylo (SU)) were evaluated in a field experiment in a subtropical area with hot summers and cold winters in Guangxi, China. Three forage stubble cover managements: no cover (CK), dry mass cover (MC) and plastic cover (PC) were applied at the end of the summer period to evaluate cold tolerance and accession survival over the winter. Photosynthesis measurements were taken from the forages in mid-summer. The results showed that PG1 accession produced significantly higher dry matter yields (67.0 t·ha-1) than the other grass and legume accessions. Legume accessions SU and SR5 produced much less dry matter (6.4 - 7.2 t·ha-1) compared to the grasses. M II, PU and PR11 contained the largest proportion of leaf. PG1 and PH showed good cold tolerance (survival rate >85%) under -1°C conditions without any cover management. PR11 had better cold tolerance than PU. M II exhibited very poor winter survival under no cover and with massive cover, and only survived well under plastic cover. The two stylo accessions died completely under all winter cover management treatments. In the growing season, under a given photosynthesis photon flux density (PPFD) = 1500 μmol m-2 s-1, the net photosynthesis rate Pn of all the seven accessions was above 28 μmol m-2 s-1, of which hybrid elephant grass and M II were above 42 μmol m-2 s-1. Though these 7 tropical accessions yielded high production in the grow season, stylo and M II are sensitive to cold in subtropical region of Guangxi. The result suggests that PG1 and PU are good accessions and can be used as productive perennial pasture, while stylo and M II are simply considered as annual one. Additionally, if paspalum was trained in cool region before being introduced to subtropical region, it may present both productivity and enhanciv

关键词： Cold Tolerance Production Photosynthesis Tropical Grasses Winter

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research Progress in Prevention and Treatment of Bacterial Diseases by Traditional Chinese Medicine

引用

Agricultural Biotechnology 2016年第4期5卷 38-41页

作者： Sufang LYU Guangjun GUO ling mo Feng LI Feng WEI Bingmei DONG Zhiqiang SHEN Shandong Binzhou Animal Science & Veterinary Medicine Insitute Shandong Binzhou Research Development and Promotion Center for Livestock and Poultry Propolis Vaccine Binzhou 256600 China Shandong Lvdu Bio-industry Company. LTD Binzhou 256600 China

Recently, antibiotics have been widely used to resist various bacterial diseases in livestock breeding, which generated more superbacteria with resistance. Food safety problems, such as animal drug residues are urgent to be solved. Traditional Chinese medicines are traditional treasures of China, which attract more and more attention in the prevention and treatment of bacterial diseases because of their abundant advantages including improving immunologic function of or-ganisms, antibacterial, antivirus, antitumor, anti-inflammatory and improving animal performance. The advantages of traditional Chinese medicines, such as low toxicity, low residual, green and safe, conform to food safety requirements. The using condition of traditional Chinese medicines in main bacterial diseases of animals was reviewed in the paper, thus to provide a reference for livestock production.

关键词： Traditional Chinese medicine Livestock Bacterial diseases Research progress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：