检索结果-南通市图书馆

Specific metabolic impairments indicate loss of sustained liver improvements in metabolic dysfunction-associated steatotic liver disease treatment

引用

Hepatobiliary Surgery and Nutrition 2024年第4期13卷 632-649,I0025-I0035页

作者： ling luo Junzhao Ye Shuyu Zhuo Bo Ma Weiyi Mai Xiaopei Cao Liuqin Liang Wei Wang Shiting Feng Zhi Dong Bihui Zhong Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Nutrition The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Gastroenterology The East Division of the First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Cardiology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Endocrinology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Rheumatology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Ultrasound The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Radiology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina

Background:High liver fat content(LFC)induces increased risks of both hepatic and extrahepatic progression in metabolic dysfunction-associated steatotic liver disease(MASLD),while maintaining a significant decline in magnetic resonance imaging-based proton density fat fraction(MRI-PDFF)(≥30%decline relative to baseline)without worsening fibrosis results in improved histological severity and ***,the factors associated with the loss of sustained responses to treatment remain unclear,and we aim to identify ***:Consecutive treatment-naïve MASLD patients between January 2015 and February 2022,with follow-up until April 2023,were included in this prospective cohort *** quantified by MRI-PDFF and liver stiffness measurements(LSM)determined by two-dimensional shear wave elastography(2D-SWE)were evaluated at weeks 0,24 and ***-PDFF response was defined as a≥30%relative decline in PDFF values,and LSM response was defined as a≥1 stage decline from ***:A total of 602 MASLD patients were *** the 303 patients with a 24-week MRI-PDFF response and complete follow-up of 48 weeks,the rate of loss of MRI-PDFF response was 29.4%,and multivariable logistic regression analyses showed that 24-week insulin resistance(IR),still regular exercise and caloric restriction after 24 weeks,and the relative decline in LFC were risk factors for loss of MRI-PDFF *** of LSM response at 48 weeks occurred in 15.9%of patients,and multivariable analysis confirmed 24-week serum total bile acid(TBA)levels and the relative decline in TBA from baseline as independent *** significant association was found at 48 weeks between loss of MRI-PDFF response and loss of LSM ***:MASLD patients with IR and high TBA levels are at higher risks of subsequent diminished sustained improvements of steatosis and fibrosis,respectively.

关键词： Metabolic dysfunction-associated steatotic liver disease(MASLD) loss of response magnetic resonance imaging-based proton density fat fraction response(MRI-PDFF response) liver stiffness measurements response(LSM response)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

疫情下的美国大学远程中文教学

引用

东南大学学报（哲学社会科学版） 2021年第S2期23卷 167-172页

作者：罗玲 The City University of New York Modern Languages DepartmentNew York10007

新冠疫情的出现,让人们改变了工作学习的节奏和日常的生活习惯,远程教学也应运而生。本文通过疫情期间远程中文教学的实践体验,全面介绍目前美国大学中文教学的实际情况,如:教学方式的改变,教学内容的增减,教学软件和辅助工具的选择和应... 详细信息

新冠疫情的出现,让人们改变了工作学习的节奏和日常的生活习惯,远程教学也应运而生。本文通过疫情期间远程中文教学的实践体验,全面介绍目前美国大学中文教学的实际情况,如:教学方式的改变,教学内容的增减,教学软件和辅助工具的选择和应用,分析各种教学方式的特点以及利与弊,分享在实际远程教学过程中的成功与不成功的经验,并对未来中文教学的发展提出展望和思考。

关键词：远程教学新冠疫情中文教学教学形式教学软件

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A New Viewpoint of Improving the Competitive Power of the City-The Entrepreneurial City

引用

Ecological Economy 2005年第3期1卷 74-78页

作者： luo ling Teng Shaoxia Yan Jun Regional Economy and City Management Research Center Southwest Jiaotong UniversityChingdu610031P.R.China. Dept.of Foreign Languages Sichuan University of Science ＆ Engineering

In resent years the entrepreneurial city is a ne w popular concept in the field of the economy and the development of the western cities At present the scholars of our country just begin to research about it. This essay tries to analyze the connotation and the function of the entrepreneurial city, and also analyzes the function and the mechanism of the improvement of the Competitiveness of the city.

关键词： enterpriser entrepreneurial city Competitive Power of the City

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

采用扩展π演算的测试用例生成方法

引用

计算机工程与设计 2016年第11期37卷 2985-2991页

作者：罗玲西南电子技术研究所四川成都610036

针对时间相关并发系统的测试问题,提出一种采用扩展π演算p-π的测试用例生成方法。采用p-π为时间相关并发系统建模,由p-π的操作规则构造出系统模型的时间相关标记迁移系统,基于时间相关标记迁移系统和用例规约生成测试用例,测试用例... 详细信息

针对时间相关并发系统的测试问题,提出一种采用扩展π演算p-π的测试用例生成方法。采用p-π为时间相关并发系统建模,由p-π的操作规则构造出系统模型的时间相关标记迁移系统,基于时间相关标记迁移系统和用例规约生成测试用例,测试用例的生成满足执行动作覆盖准则、路径覆盖准则和时间约束覆盖准则,给出测试用例的选择策略。基于网上订票系统的分析结果表明,该方法能够为时间相关并发系统有效地生成测试用例,通过p-π的验证方法,保证了产生的测试用例的正确性。

关键词： π演算进程代数测试用例基于模型的测试形式化模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

采用随机Petri网的嵌入式机载软件可靠性检测

引用

计算机工程与应用 2019年第1期55卷 233-240页

作者：罗玲西南电子技术研究所航空部成都610036

针对嵌入式机载软件设计中存在的典型缺陷问题,结合嵌入式机载软件任务调度特性,提出采用随机Petri网对嵌入式机载软件设计进行仿真验证的可靠性检测方法,以提高嵌入式机载软件设计的可靠性。该方法采用随机Petri网对嵌入式机载软件系... 详细信息

针对嵌入式机载软件设计中存在的典型缺陷问题,结合嵌入式机载软件任务调度特性,提出采用随机Petri网对嵌入式机载软件设计进行仿真验证的可靠性检测方法,以提高嵌入式机载软件设计的可靠性。该方法采用随机Petri网对嵌入式机载软件系统行为建模,并给出典型缺陷的检测策略和判定准则,然后通过对Petri网模型进行仿真验证,检测系统是否存在此类设计缺陷;并给出了软件设计的运行流程的仿真验证算法,以支持对相应设计的可靠性检测。通过与其他可靠性检测方法的比较,表明了该方法的有效性。

关键词：随机Petri网(PN) 软件可靠性嵌入式机载软件

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

雌孕激素对ALI大鼠Ⅱ型肺泡上皮细胞ENaC表达的影响

引用

吉林大学学报（医学版） 2012年第5期38卷 836-840,F0002页

作者：罗玲王导新重庆医科大学附属第二医院呼吸内科重庆400010

目的:研究雌孕激素对急性肺损伤(ALI)大鼠Ⅱ型肺泡上皮细胞钠通道(ENaC)表达的影响,探讨雌孕激素促进肺泡内液体清除的机制。方法:雌性未成年SD大鼠40只,随机分为正常对照组、ALI模型组、雌孕激素联合治疗A组和雌孕激素联合治疗B组,正... 详细信息

目的:研究雌孕激素对急性肺损伤(ALI)大鼠Ⅱ型肺泡上皮细胞钠通道(ENaC)表达的影响,探讨雌孕激素促进肺泡内液体清除的机制。方法:雌性未成年SD大鼠40只,随机分为正常对照组、ALI模型组、雌孕激素联合治疗A组和雌孕激素联合治疗B组,正常对照组颈静脉注入生理盐水(***-1),后3组经颈静脉注入油酸(***-1)建立ALI模型,其中雌孕激素联合A、B组分别在油酸注入前12和36h皮下注射不同比例的雌孕激素混合液0.1mL(A组1∶1 000,B组1∶200)。建模后6h处死大鼠,测定肺湿重/干重比值,计算肺系数,观察肺组织病理改变,测定肺组织匀浆中α-ENaC、β-ENaC和γ-ENaC mRNA及蛋白的表达水平。结果:①与正常对照组比较,ALI模型组肺湿重/干重比值及肺系数增加,差异有统计学意义(P<0.01);与ALI模型组比较,雌孕激素联合治疗组肺湿重/干重比值及肺系数下降,以A组明显,差异有统计学意义(P<0.05)。②ALI模型组大鼠出现明显肺水肿、出血及炎性细胞浸润;与模型组比较,联合治疗组大鼠肺水肿、出血及炎性细胞浸润较轻,A组稍明显。③与正常对照组比较,ALI组α-ENaC和γ-ENaC mRNA及蛋白表达水平明显降低,差异有统计学意义(P<0.01);与ALI模型组比较,联合治疗组α-ENaC和γ-ENaC mRNA及蛋白表达水平有增加,以A组增加明显,差异有统计学意义(P<0.05)。结论:雌孕激素可以通过增加ALI大鼠Ⅱ型肺泡上皮细胞α-ENaC和γ-ENaC mRNA及蛋白的表达水平,促进肺泡内液体的清除。

关键词：雌激素孕激素钠通道急性肺损伤急性呼吸窘迫综合征

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

科研课题组的层次结构差异与领导创造力

引用

科学学研究 2006年第A02期24卷 508-511页

作者：罗玲玲东北大学科学技术与社会研究中心辽宁沈阳110004

论述科研课题组客观存在着不同层次结构的差异,这种差异与创造力的关系对科研管理和创造力评估都具有重要意义。分析不同层次的课题组中领导所起的作用。认为课题组长的创造力是团体创造力的核心指标;大科学需要懂得管理文化创新的领导... 详细信息

论述科研课题组客观存在着不同层次结构的差异,这种差异与创造力的关系对科研管理和创造力评估都具有重要意义。分析不同层次的课题组中领导所起的作用。认为课题组长的创造力是团体创造力的核心指标;大科学需要懂得管理文化创新的领导;处于不同层次科研课题组的领导需要具有不同的能力。最后,提出有利于团体创造力发挥的领导胜任对策。

关键词：团体创造力科研管理课题组制领导创造力层次结构

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Case Report of Inflammatory Disseminated Superficial Porokeratosis: An Eruptive Pruritic Papular Variant of Porokeratosis

引用

International Journal of Dermatology and Venereology 2021年第4期4卷 257-259页

作者： ling-ling luo Hao Chen Xue-Si Zeng Pan-Gen Cui Department of Dermatology Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Department of Pathology Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China

Introduction: Eruptive pruritic papular porokeratosis (EPPP) is a rare variant of porokeratosis. Several cases of this varient of porokeratosis had been ***, we reported an old man with this rare kind of porokeratosis which is often eruptive and *** report: A 72 years-old Chinese man presented to our hospital with intensively pruritic papular lesions on his trunk and limbs. Physical examination showed numerous scattered keratotic papules measuring 35 mm in diameter on his trunk and extremities. Some coalesced into anannular lesion with a slightly raised peripheral red rim. A tissue biopsy revealed the presence of a cornoid lamella. The patient was diagnosed with EPPP. After 3-months’ treatment of antihistamines and topical steroid agents, the lesions and the pruritus were ***: EPPP predominantly happens in an old male demographic. Patients with EPPP often develop pruritic papules spread on the body with or without preexisting typical porokeratosis lesions, and the lesions can subside within few months, leaving small brown spots or annular lesions. EPPP has the unique histological characteristic of porokeratosis cornoid lamella. The mechanism of EPPP is still unknown. It is important for clinicians to be aware of a disseminated pruritic papules as a manifestation of ***: The lesion of porokeratosis can be manifested as eruptive papules with intensive itch. When a patient develops eruptive pruritic papules, it is necessary to consider the possibility of EPPP. Histopathology is necessary for diagnosis.

关键词： porokeratosis pruritus case report

来源：

维普期刊数据库

同方期刊数据库评论