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Retinal Vascular Imaging Application in Women’s Reproductive Health:Clinical Implications and Future Directions

Maternal-Fetal Medicine 2024年第2期6卷 92-96页

作者： Beth Shi Yu lim ling-Jun li Yong Loo lin School of Medicine National University of SingaporeSingapore 117597Singapore Department of Obstetrics&Gynaecology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119228Singapore Global Centre for Asian Women’s Health Human Potential Translational Research ProgrammeYong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore NUS Bia-Echo Asia Centre for Reproductive Longevity and Equality(ACRLE) Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117456Singapore Singapore Eye Research Institute Singapore National Eye CentreSingapore 168751Singapore

Over the past two decades,population-based studies employing semiautomatic computer-assisted programs have uncovered associations between retinal microvascular features and various systemic *** the recognition of retinal imaging in cardiometabolic health grows,there is increasing evidence supporting its application in women’s health,particularly during the reproductive *** review aims to summarize the indications of retinal imaging in women’s health and intergenerational health,where suboptimal retinal imaging has been found to mirror pathological systemic changes,such as suboptimal hemodynamic circulation,inflammation,endothelial dysfunction,oxidative stress,and hypoxia in *** from Singapore Growing Up in Singapore Towards Healthy Outcomes and Singapore Preconception Study of Long-Term Maternal and Child Outcomes cohorts have reported serial changes in retinal conventional microvascular features(e.g.,retinal arteriolar narrowing,retinal venular widening)and retinal geometric microvascular features(e.g.,sparse fractal dimension,enlarged branching angle,and increased curvature tortuosity)during the preconception and antenatal *** morphological abnormalities were found to be related to female fertility,maternal antenatal health conditions,postnatal maternal cardiometabolic health,and intergenerational health in the *** the compelling evidence of the ability to detect microvascular changes through noninvasive methods at an early stage,retinal imaging holds the potential to facilitate timely interventions,mitigate the progression of complications,and prevent adverse pregnancy *** ahead,the convergence of artificial intelligence and advanced imaging techniques heralds a promising era in women’s health research and clinical practice.

关键词： Retinal vascular imaging Reproductive health

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Constructing S-scheme charge separation in cobalt phthalocyanine/oxygen-doped g-C_(3)N_(4) heterojunction with enhanced photothermal-assisted photocatalytic H_(2) evolution

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Rare Metals 2024年第1期43卷 198-211页

作者： Wei-Long Shi Zheng Xu Yu-Xing Shi ling-ling li Jia-lin Lu Xin-Hai Sun Xin Du Feng Guo Chang-Yu Lu School of Material Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003JiangsuChina College of Chemistry Zhengzhou UniversityZhengzhou 450001China School of Water Resource and Environment Hebei Province Key Laboratory of Sustained Utilization and Development of Water RecourseHebei Center for Ecological and Environmental Geology ResearchHebei Geo UniversityShijiazhuang 050031China

Hydrogen acquisition from solar energy is an effective way to address energy crisis,which makes the development of efficient photocatalysts become the main direction of scientific ***,cobalt phthalocyanine/oxygen-doped g-C_(3)N_(4)(CoPc/OCN) S-scheme heterojunction photocatalyst was designed by coupling multi-step calcination with solvothermal method for enhanced photothermal-assisted photocatalytic H_(2) *** multistep calcined g-C_(3)N_(4) is easier for O-doping formation,and the ethanol solvothermal strategy is utilized to enhance the dispersion of CoPc on OCN nano sheet surface and forms sufficient S-scheme heterojunction through *** addition,the active sites and excellent photothermal properties of CoPc itself further improve the integrated photocatalytic activity of CoPc/OCN S-scheme *** optimal photocatalytic hydrogen evolution rate of CoPc/OCN S-scheme heterojunction photocatalyst reached 9.56 mmol·g^(-1)·h^(-1),which is 2.69 and 1.23 times higher than that of CN and OCN,*** work provides a valuable design idea and scheme for enhancing the multi-factor co-assisted photocatalytic H_(2) evolution performance.

关键词： Photothermal Photocatalytic H_(2)evolution Cobalt phthalocyanine Oxygen-doped g-C_(3)N_(4) Sscheme heterojunction

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LaMnO_(3)/Co_(3)O_(4) nanocomposite for enhanced triethylamine sensing properties

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Journal of Rare Earths 2024年第4期42卷 733-742页

作者： Jian Zhang Yanping Chen ling li Xue Chen Wenya An Xiujuan Qian Yuye Tao School of Science Shandong Jianzhu UniversityJinan250100China

LaMnO_(3) modified Co_(3)O_(4) nanocomposites were prepared by simple hydrothermal method co mbined with sol-gel *** gas sensitivity properties of pure Co_(3)O_(4) and LaMnO_(3)/Co_(3)O_(4) with different composite proportions are *** is found that 0.6-LMO/Co_(3)O_(4) sensor has higher sensitivity to triethylamine(TEA)than pure Co_(3)O_(4) sensor,which is improved by 9.27 *** the working temperature is reduced from 150 to 130℃.Besides,it has excellent gas selectivity and *** improvement of the gas sensitivity of LaMnO_(3)/Co_(3)O_(4) sensor may be due to the fact that LaMnO_(3) is an effective catalyst,and the catalytic performance perhaps is beneficial to improving the sensing *** addition,the formation of p-p heterojunctions may be the key factor to improve the gas sensing *** work provides a new Co_(3)O_(4)-based gas sensing material for the detection of TEA.

关键词： Gas sensing Co_(3)O_(4) LaMnO_(3) Triethylamine Rareearths

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Regulating Signal Pathway Triggers Circular Reactive Oxygen Species Production to Augment Oxidative Stress with Enzyme-Activated Nanoparticles

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CCS Chemistry 2024年第3期6卷 693-708页

作者： Benkai Bao Qiong Yuan Qian Feng ling li Meiqi li Yanli Tang Key Laboratory of Analytical Chemistry for life Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid ChemistryMinistry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’anShaanxi Province 710119

Regulating antioxidative stress pathways to augment oxidative stress and enhance antitumor therapy is highly desirable but very ***,we initiated a multifunctional nanoparticle to regulate the Keap1-Nrf2 antioxidative stress pathway to promote cancer cell *** OPFV-SnMP@GE11 nanoparticles were assembled by enzyme-activated OPFV-TLQ,tin mesoporphyrin(SnMP),and ***-SnMP@GE11 accumulated at tumor sites through specific targeting with ***-TLQ was specifically reduced to a photosensitizer OPFVNH2 by endocellular NAD(P)H:quinone oxidoreductase 1(NQO1).Under irradiation,OPFV-NH2 greatly produced reactive oxygen species(ROS)through a type I mechanism,which activated the Keap1-Nrf2 signal pathway and enhanced the transcription of NQO1,resulting in a continuous and explosive generation of ***,SnMP inhibited the activity of heme oxygenase-1(HO-1),further depressing antioxidative *** strategy provides insight into the regulation of the signal pathway to amplify oxidative stress,paving the way to studying the molecular mechanisms of cellular activities to enhance cancer therapy.

关键词： Keap1-Nrf2 pathway enzyme-activated probe reactive oxygen species oxidative stress antitumor therapy

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Multi-performance evaluation of high-throughput accelerated corrosion test for high-strength low-alloy 921A steel

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Journal of Iron and Steel Research(International) 2024年第5期31卷 1260-1278页

作者： Cong-cong Du Ming-hua Qin Zhan-fang Wu Dong-ling li Lei Zhao Xiang-yang li Hai-zhou Wang Beijing Advanced Innovation Center for Materials Genome Engineering National Center for Materials Service SafetyUniversity of Science and Technology BeijingBeijing100083China China Iron and Steel Research Institute Group Co. Ltd.Beijing100081China Beijing Advanced Innovation Center for Materials Genome Engineering Central Iron and Steel Research InstituteBeijing100081China

The corrosion behavior of high-strength low-alloy 921A steel in a simulated marine atmospheric environment was studied using a high-throughput experimental *** corrosion behavior,corrosion morphology,and corrosion products of 921A steels were analyzed using various techniques,including corrosion mass loss method,polarization curve,white-light interferometry,scanning electron microscopy,energy-dispersive spectrometry,microbeam X-ray fluorescence spectrometry,X-ray diffraction technique,and X-ray photoelectron *** test results indicated that 921A steel exhibits better corrosion resistance than Q450NQR1 steel in simulated harsh atmospheric environments,as evidenced by a lower corrosion mass loss rate throughout the corrosion *** corrosion products of both steels consisted ofα-FeOOH,Fe_(3)O_(4),andγ-FeOOH,withα-FeOOH being more prevalent in the rust layer of 921A steel than in Q450NQR1 *** inner rust layer of 921A steel also exhibited an appositional enrichment region of Cr,Ni,Mo,and V,leading to its superior corrosion resistance compared to that of Q450NQR1 *** efficacy of high-throughput accelerated corrosion experimental methods was highlighted for evaluating the corrosion resistance of steel materials in harsh environmental *** findings suggest that 921A steel exhibits better corrosion resistance compared to Q450NQR1 steel and has the potential to be more suitable in harsh marine atmospheric *** characterization of the rust layer structures and composition reveals the parallel enrichment of certain elements in the inner rust layer of 921A steel,which enhances its corrosion resistance.

关键词： Atmospheric corrosion High-throughput experimental method High-strength low-alloy steel Corrosion characteristics Rust layer Element enrichment

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Cambricon-QR:a sparse and bitwise reproducible quantized training accelerator

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High Technology Letters 2024年第1期30卷 52-60页

作者：李楠 ZHAO Yongwei ZHI Tian liU Chang DU Zidong HU Xing li Wei ZHANG Xishan li ling SUN Guangzhong School of Computer Science and Technology University of Science and Technology of ChinaHefei 230026P.R.China State Key Laboratory of Processors Institute of Computing TechnologyChinese Academy of SciencesBeijing 100086P.R.China Cambricon Tech.Ltd Beijing 100191P.R.China Institute of Software Chinese Academy of SciencesBeijing 100086P.R.China

Quantized training has been proven to be a prominent method to achieve deep neural network training under limited computational *** uses low bit-width arithmetics with a proper scaling factor to achieve negligible accuracy ***-Q is the ASIC design proposed to efficiently support quantized training,and achieves significant performance ***,there are still two caveats in the ***,Cambricon-Q with different hardware specifications may lead to different numerical errors,resulting in non-reproducible behaviors which may become a major concern in critical ***,Cambricon-Q cannot leverage data sparsity,where considerable cycles could still be squeezed *** address the caveats,the acceleration core of Cambricon-Q is redesigned to support fine-grained irregular data *** new design not only enables acceleration on sparse data,but also enables performing local dynamic quantization by contiguous value ranges(which is hardware independent),instead of contiguous addresses(which is dependent on hardware factors).Experimental results show that the accuracy loss of the method still keeps negligible,and the accelerator achieves 1.61×performance improvement over Cambricon-Q,with about 10%energy increase.

关键词： quantized training sparse accelerator Cambricon-QR

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TiO_(2)-Fe_(2)TiO_(5)heterostructure hollow spheres enable high-performance lithium-sulfur batteries via interfacial engineering

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Rare Metals 2024年第8期43卷 4006-4012页

作者： Kai-Tao liu Hong-Qiang Wang Zhuo Chen Shi-lin Zhang Ying-Ying Song Fang liu Qiao-ling li Jiao li School of Materials Science and Engineering Shandong University of TechnologyZibo 255049China College of Chemistry&Environmental Science Hebei UniversityBaoding 071002China School of Chemical Engineering Faculty of SciencesEngineering and TechnologyUniversity of AdelaideAdelaide 5005Australia School of Materials Science and Engineering Hebei University of TechnologyTianjin 300130China

The shuttle effect of lithium polysulfides between sulfur cathode and lithium anode is a notorious problem in the commercial application of lithium-sulfur ***,heterostructured TiO_(2)-Fe_(2)TiO_(5)hollow spheres were ... 详细信息

关键词： lithium sulfide (5)

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Surface quality investigation in high-speed dry milling of Ti-6Al-4V by using 2D ultrasonic-vibration-assisted milling platform

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Advances in Manufacturing 2024年第2期12卷 349-364页

作者： Jin Zhang li ling Qian-Yue Wang Xue-Feng Huang Xin-Zhen Kang Gui-Bao Tao Hua-Jun Cao College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing400044People’s Republic of China State Key Laboratory of Mechanical Transmissions Chongqing UniversityChongqing400044People’s Republic of China Aerospace Research Institute of Materials and Processing Technology Beijing100076People’s Republic of China

Ultrasonic-vibration-assisted milling(UVAM)is an advanced method for the efficient and precise machining of difficult-to-machine materials in modern ***,the milling efficiency is limited because the ultrasonic vibration toolholder ER16 collet has a critical cutting ***,a 2D UVAM platform is built to ensure precision machining efficiency and improve the surface quality without changing the milling *** evaluate this 2D UVAM platform,ultrasonic-vibration-assisted high-speed dry milling(UVAHSDM)is performed to process a titanium alloy(Ti-6Al-4V)on the platform,and the milling temperature,surface roughness,and residual stresses are selected as the important indicators for performance *** results show that the intermittent cutting mechanism of UVAHSDM combined with the specific spindle speed,feed speed,and vibration amplitude can reduce the milling temperature and improve the texture of the machined *** with conventional milling,UVAHSDM reduces surface roughness and peak-groove surface profile values and extends the range of residual surface compressive stresses from−413.96 MPa to−600.18 *** excellent processing performance demonstrates the feasibility and validity of applying this 2D UVAM platform for investigating surface quality achieved under UVAHSDM.

关键词： 2D ultrasonic-vibration-assisted milling(UVAM)platform Ultrasonic-vibration-assisted high-speed dry milling(UVAHSDM) Milling temperature Surface roughness Residual stress

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Bifurcations and Spatiotemporal Patterns in the Diffusive Nutrient-Microorganism Model

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Acta Mathematicae Applicatae Sinica 2024年

作者： Ya-di WANG Hai-long YUAN Yan-ling li School of Arts and Sciences Shaanxi University of Science and Technology School of Mathematics and Statistics Xi'an Jiaotong University School of Mathematics and Information Science Shaanxi Normal University

In this paper, the diffusive nutrient-microorganism model subject to Neumann boundary conditions is considered. The Hopf bifurcations and steady state bifurcations which bifurcate from the positive constant equilibrium of the system are investigated in details. In addition, the formulae to determine the direction of Hopf and steady state bifurcations are derived. Our results show the existence of spatially homogeneous/nonhomogeneous periodic orbits and steady state solutions, which indicates the spatiotemporal dynamics of the system. Some numerical simulations are also presented to support the analytical results.

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Skeletal phenotypes and molecular mechanisms in aging mice

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ZOOLOGICAL RESEARCH 2024年第4期45卷 724-746页

作者： Guan, Qiao Zhang, Yuan Wang, Zhi-Kun liu, Xiao-Hua Zou, Jun Zhang, ling-li Shanghai Univ Sport Sch Exercise & Hlth Shanghai 200438 Peoples R China Shanghai Univ Sport Coll Athlet Performance Shanghai 200438 Peoples R China

Aging is an inevitable physiological process, often accompanied by age-related bone loss and subsequent bone-related diseases that pose serious health risks. Research on skeletal diseases caused by aging in humans is challenging due to lengthy study durations, difficulties in sampling, regional variability, and substantial investment. Consequently, mice are preferred for such studies due to their similar motor system structure and function to humans, ease of handling and care, low cost, and short generation time. In this review, we present a comprehensive overview of the characteristics, limitations, applicability, bone phenotypes, and treatment methods in naturally aging mice and prematurely aging mouse models (including SAMP6 , POLG mutant, LMNA , SIRT6 , ZMPSTE24 , TFAM , ERCC1 , WERNER , and KL/KL- deficient mice). We also summarize the molecular mechanisms of these aging mouse models, including cellular DNA damage response, senescence-related secretory phenotype, telomere shortening, oxidative stress, bone marrow mesenchymal stem cell (BMSC) abnormalities, and mitochondrial dysfunction. Overall, this review aims to enhance our understanding of the pathogenesis of aging-related bone diseases.

关键词： Aging Premature aging Mice Bone Gene knockout HUTCHINSON-GILFORD-PROGERIA SENESCENCE-ACCELERATED MOUSE AGE-RELATED-CHANGES MITOCHONDRIAL TRANSCRIPTION FACTOR NUCLEOTIDE EXCISION-REPAIR MTDNA COPY NUMBER BONE LOSS SENILE OSTEOPOROSIS MURINE MODEL DNA-DAMAGE

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