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Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration

NANO-MICRO LETTERS 2025年第1期17卷 1-51页

作者： Wang, Xiao Zeng, Jia Gan, Donglin ling, kun He, Mingfang Li, Jianshu Lu, Yongping Guangyuan Cent Hosp Sci & Technol Innovat Ctr Biomed Mat & Clin Res Guangyuan Key Lab Multifunct Med Hydrogel Guangyuan 628000 Peoples R China Nanjing Normal Univ Jiangsu Collaborat Innovat Ctr Biomed Funct Mat Sch Chem & Mat Sci Jiangsu Key Lab Biofunct Mat Nanjing 210023 Peoples R China Sichuan Univ Coll Polymer Sci & Engn State Key Lab Polymer Mat Engn Chengdu 610065 Peoples R China

Recent advances in the combined delivery platform that integrate nano-/microscale carriers and with 3D hydrogel network for bone regeneration are *** strategies for bioactive molecules delivery involving nanoparticles, nanosheets, and microspheres, along with extra stimuli such as near-infrared light, temperature changes, ultrasonication, and inflammatory conditions, are *** prospects and challenges for the clinical translation and the development of nano-/microscale incorporated hydrogel-based delivery platform are discussed. Bioactive molecules have shown great promise for effectively regulating various bone formation processes, rendering them attractive therapeutics for bone regeneration. However, the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in vivo. Hydrogels have emerged as ideal carriers to address these challenges, offering the potential to prolong retention times at lesion sites, extend half-lives in vivo and mitigate side effects, avoid burst release, and promote adsorption under physiological conditions. This review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration, encompassing applications in cranial defect repair, femoral defect repair, periodontal bone regeneration, and bone regeneration with underlying diseases. Additionally, this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery, carrier-assisted delivery, and sequential delivery. Finally, this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

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COVID-19 in children and the importance of COVID-19 vaccination

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World Journal of Pediatrics 2021年第5期17卷 462-466页

作者： Feng-Xia Xue kun-ling Shen Department of Respiratory Medicine Beijing Children's HospitalChina National Clinical Research Center of Respiratory DiseasesNational Center for Children's HealthCapital Medical UniversityBeijing 100045China

As of August 30,2021,COVID-19 has caused more than 216 million infections and 4.49 million deaths worldwide,with 0.58 million new cases[1].Because the COVID-19 vaccine is distributed gradually and widely,the development of the global epidemic has been prevented to some extent,but the emergence of SARS-CoV-2 variants makes us *** alpha(B.1.1.7),beta(B.1.351),gamma(P.1)and delta(B.1.617)strains have been named variants of concern by the WHO[2].The SARS-CoV-2 variants have increased in transmissibility and virulence,leading to higher morbidity and mortality.

关键词： COV milli delta

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Diagnosis and treatment of 2019 novel coronavirus infection in children: a pressing issue

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World Journal of Pediatrics 2020年第3期16卷 219-221页

作者： kun-ling Shen Yong-Hong Yang China National Clinical Research Center for Respiratory Diseases BeijingChina Department of Respiratory Medicine Beijing Children's HospitalCapital Medical UniversityBeijingChina National Center for Children's Health BeijingChina Beijing Pediatric Reasearch Institute BeijingChina

The viral pneumonia in Wuhan City,China has spread around *** virus has been proven to be a novel coronavirus (named as "2019-nCoV") by World Health Organization (WHO).2019-nCoV belongs to beta-coronavirus *** January 30,2020,WHO re-evaluated the potential effects of 2019-nCoV infection in global public health,and declared this epidemic as a "Public Health Emergency of International Concern (PHEIC)".

关键词： China. treatment belongs

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Numerical Studies of Estimation of Fracture Parameters for Mismatched Welded Joints with HAZ Cracks

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Journal of Iron and Steel Research International 2015年第9期22卷 846-851页

作者： kun ling Zheng-dong WANG Fu-zhen XUAN Key Laboratory of Pressure Systems and Safety Ministry of EducationEast China University of Science and Technology

An idealized tri-material assumption is established to describe the constitutive relationship of mismatched welded joints by considering the influence of heat affected zone（HAZ）.The fracture parameters Jand C＊are estimated for mismatched welded joints with HAZ cracks by finite element analysis with ABAQUS.A middle crack tension（M（T））specimen is utilized in the analysis for different material properties and geometries of the *** influence of mechanical property and geometry on the fracture parameters Jand C＊of the specimen is discussed for the welded joints with HAZ *** results suggest that the HAZ property is a significant factor in the estimation of Jand C＊for the mismatched welded joint with HAZ crack.

关键词： mismatched welded joint tri-material assumption heat affected zone(HAZ) J-integral C*parameter

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Wave-activity relation containing wave-basic flow interaction based on decomposition of general potential vorticity

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Chinese Physics B 2021年第4期30卷 648-657页

作者： Na Li ling-kun Ran Bao-Feng Jiao Key Laboratory of Cloud-Precipitation Physics and Severe Storms(LACS) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Nanjing University of Information Science and Technology Nanjing 210044China University of the Chinese Academy of Sciences Beijing 100049China

On the basis of the general potential vorticity theorem(GPV),a new wave-activity relation is derived in an ageostrophic and nonhydrostatic dynamic *** the Reynolds average is taken,the wave-activity relation shares an exchange term with the equation of the basic-state ***,the two equations are capable of presenting the dynamic process of the wave-basic flow *** the E-P flux theory which can only be used in large-scale atmosphere,the corresponding derivation provides a useful tool to analyze the feedback of waves to basic states and the forcing of basic states to waves simultaneously,and it can be used in mesoscale systems,such as heavy rainfall *** theory was initially applied to the landfalling Typhoon Mujigae(2015) by assigning the scalar φ to the generalized potential temperature(GPT).The results showed that the newly-derived wave-activity density is able to describe the wave activities associated with strong precipitation in Typhoon Mujigae(2015),including the eyewall and spiral ***,the interaction between the basic-state vortex and mesoscale waves denoted by the exchange term between basic-state GPV and wave-activity density mainly occurs in the eyewall in Typhoon Mujigae(2015).A comparison of the exchange term with other forcing terms in the newly-derived wave-activity relation indicates that the basic state-wave interaction plays a significant role in enhancing wave activities in the high-precipitation *** a magnitude analysis of the interaction term,it is found that the strong interaction between basic-state vortex and mesoscale waves is mainly attributed to two factors:the vertical vorticity intensity of the basic-state vortex and the averaged perturbation advection of perturbation GPT which is an exchange between the basic-state GPT and perturbation GPT.

关键词： wave-activity density basic state-wave interaction wave-activity relation

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Simulation of a torrential rainstorm in Xinjiang and gravity wave analysis

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Chinese Physics B 2018年第5期27卷 573-580页

作者： Rui Yang Yi Liu ling-kun Ran Yu-Li Zhang Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

We used a weather research and forecasting model to simulate a torrential rainstorm that occurred in Xinjiang,China during June 16–17,*** model successfully simulated the rainfall area,precipitation intensity,and changes in *** identified a clear wave signal using the two-dimensional fast Fourier transform method;the waves propagated westwards,with wavelengths of 45–20 km,periods of 50–120 min,and phase velocities mainly concentrated in the-25 m/s to-10 m/s *** results of wavelet cross-spectral analysis further confirmed that the waves were gravity waves,peaking at 11:00 UTC,June 17,*** gravity wave signal was identified along 79.17–79.93°E,81.35–81.45°E and 81.5–81.83°*** gravity waves detected along 81.5–81.83°E corresponded well with precipitation that accumulated in 1 h,indicating that gravity waves could be considered a rainstorm precursor in future precipitation forecasts.

关键词： gravity wave rainstorm spectral analysis methods weather research and forecasting model

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Diagnosis of deformation-derived ascending areas in a rainband

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Atmospheric and Oceanic Science Letters 2018年第4期11卷 300-306页

作者： LI Na RAN ling-kun GAO Shou-Ting Key Laboratory of Cloud-Precipitation Physics and Severe Storms Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Plateau Atmosphere and Environment Key Laboratory of Sichuan Province SichuanChina

This paper demonstrates that,for a moist baroclinic frontal system,the large-value deformation belt in the low-level atmosphere overlaps with *** precisely describe the relationship between deformation and heavy precipitation,deformation is introduced into the nongeostrophic Q^#-vector.Q^#is then decomposed into three parts:the divergence-related term,the vorticity-related term,and the deformation-related *** calculating the divergence of Q#and its components,it is found that in strong ascending areas within precipitation regions the nongeostrophic Q^#-vector divergence shows strong negative *** deformational component can contribute about 68%to these negative *** verifies that strong deformation in a precipitating atmosphere is favorable for the development of convection and *** addition,by calculating the correlation coefficients between the Q^#-vector(including its components)divergence and vertical motions,it is also found that the Q^#-vector divergence shows higher correlation with vertical motion within the precipitation belt and lower correlation in the non-precipitation areas,which indicates a larger contribution of Q^#to vertical motion when precipitation occurs and implies an effect of Q^#to the precipitation distribution or spatial *** the three components of the Q^#-vector,the correlation coefficients between the deformational component and vertical motion are the most similar in pattern to that of the correlation coefficients between the Q#-vector and vertical motion,which further reflects the important contribution of deformation to the large spatial variability of precipitation.

关键词： Deformation Q-vector precipitation ascending motion

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Quantitative Study of the Morphological Variations among Dzieduszyckia Populations from the Devonian Rongxian Formation,South China and their Influencing Factors

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Acta Geologica Sinica(English Edition) 2023年第6期97卷 1604-1615页

作者： LI Tong DONG Lin SUN Yuanlin YUAN Zhiwei NIE Ting ling kun Key Laboratory of Orogenic Belts and Crustal Evolution MOEPeking UniversityBeijing 100871China School of Earth and Space Science Peking UniversityBeijing 100871China

The rhynchonellide brachiopod Dzieduszyckia Siemiradzki is widely distributed in the Lower Famennian strata,and exhibits a wide range of morphological variations among populations.1272 autochthonous Devonian Rongxian Dzieduszyckia fossils were collected from three populations in South China,namely the Dazhai,Dalong,and Longmi sections.A series of quantitative morphological analyses were conducted to understand the morphological variation among populations and identify the triggers responsible for such *** results show that the Dazhai population differs significantly in morphospace from the Dalong and Longmi populations,while the latter two exhibit more similar morphological features,suggesting that geographic distribution may play a key role in affecting Dzieduszyckia *** Longmi population shows a distinct morphospace from the Dazhai population and an overlapped morphospace with the Dalong population,indicating that habitat may not be the controlling ***,the Dazhai and Dalong populations share some morphological similarities,but the Dazhai and Longmi populations occupy completely different morphospaces,indicating that evolution had a greater impact on phenotypic divergence than *** findings suggest that geographic distribution is the predominant factor influencing the morphological variation of Dzieduszyckia,while evolution and living habitat are less significant,the former of which might play a more important role.

关键词： Dzieduszyckia morphological variation geographic distribution evolution habitat NMDS

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High-temperature performance prediction of iron ore fines and the ore-blending programming problem in sintering

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International Journal of Minerals,Metallurgy and Materials 2014年第8期21卷 741-747页

作者： Bing-ji Yan Jian-liang Zhang Hong-wei Guo ling-kun Chen Wei Li School of Metallurgical and Ecological Engineering University of Science and Technology Beijing State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing R&D Center of Wuhan Iron and Steel (Group) Corporation

The high-temperature performance of iron ore fmes is an important factor in optimizing ore blending in sintering. However, the application of linear regression analysis and the linear combination method in most other studies always leads to a large deviation from the desired results. In this study, the fuzzy membership functions of the assimilation ability temperature and the liquid fluidity were proposed based on the fuzzy mathematics theory to construct a model for predicting the high-temperature performance of mixed iron ore. Comparisons of the prediction model and experimental results were presented. The results illustrate that the prediction model is more accurate and effective than previously developed models. In addition, fuzzy constraints for the high-temperature performance of iron ore in this research make the results of ore blending more comparable. A solution for the quantitative calculation as well as the programming of fuzzy constraints is also introduced.

关键词： iron ores blending sintering high temperature properties prediction programming

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Influence of Mass and Radius of Ice Crystals on Hydrometeors,Internal Energy,and Kinetic Energy:A Numeric Model Study

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Atmospheric and Oceanic Science Letters 2014年第1期7卷 49-55页

作者： RAN ling-kun QI Yan-Bin LI Na Key Laboratory of Cloud-Precipitation Physics and Severe Storms Institute of Atmospheric PhysicsChinese Academy of Sciences Jilin Weather Modification Office University of Chinese Academy of Sciences

Two cloud-scale experiments with two different ice-phase schemes were carried out for a precipitation event that occurred in eastern China in *** results were analyzed to examine the influences of the change of ice-particle mass and radius on hydrometeors,internal energy,and kinetic energy,as well as the primary factors *** was found that the ice content increases notably and the snow content decreases due to the *** is the consequence of the modulation of cloud microphysical *** particular,the Bergeron process and the accretion of snow and cloud ice are markedly *** differences of internal energy and kinetic energy between the two experiments are caused by adjustments to pressure-flux divergence,the coupling of temperature and divergence,and gravitational work,and the reason is that these three factors result in differences of local changes of internal and kinetic energy.

关键词： mass and radius of ice crystals cloud hydrometeors internal energy kinetic energy

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