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Efficient Synthesis of 3,5,6,8-Tetrahydro-4H-thiopyrano[4′,3′:4,5]· thieno[2,3-d]pyrimidin-4-ones via an Iminophosphorane

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Chemical Research in Chinese Universities 2010年第1期26卷 60-65页

作者： LI Wen-jing LIU Min FENG ling-ling DING Ming-wu Key Laboratory of Pesticide ＆ Chemical Biology of Ministry of Education Central China Normal University Wuhan 430079 P. R. China

3,5,6,8-Tetrahydro-4H-thiopyrano[4＇,3＇：4,5]thieno[2,3-d]pyrimidin-4-ones（7） were synthesized via the base catalytic reactions of amines or phenols with carbodiimides（5）, which were obtained from the aza-Wittig ... 详细信息

关键词： 3,5,6,8-Tetrahydro-4H-thiopyrano[4',3':4,5]thieno[2,3-d]pyrimidin-4-one Aza-Wittig reaction Carbodii- mide Isocyanate

Penicillin G acylase-responsive near-infrared fluorescent probe:Unravelling biofilm regulation and combating bacterial infections

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Chinese Chemical Letters 2024年第11期35卷 423-429页

作者： Yang Liu Leilei Zhang Kaixuan Liu ling-ling wu Hai-Yu Hu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing Key Laboratory of Active Substance Discovery and Druggability EvaluationInstitute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Antibiotic resistance poses a critical threat to human healthcare,largely driven by bacterial *** biofilms resist the immune system and antibiotics,rendering enclosed microbial cells 10-1000times more antibiotic-resistant than planktonic cells,leading to severe ***,there is an urgent need to develop innovative tools for investigating biofilm regulators and devising novel antibacterial *** this study,we developed Cy-NEO-PA,a near-infrared(NIR)fluorescent probe responsive to penicillin G acylase(PGA),with bacteria-targeting *** probe was designed to visualize the influence of environmental factors on biofilm formation in Acinetobacter baumannii(***).Our findings demonstrated that glucose suppressed PGA production,leading to enhanced biofilm formation,whereas phenylacetic acid(PAA)stimulated PGA production and inhibited biofilm formation in *** observations highlight the remarkable capability of Cy-NEO-PA to accurately measure PGA dynamics,shedding light on the critical role of PGA in biofilm ***,Cy-NEO-PA exhibited excellent biocompatibility,potent reactive oxygen species(ROS)generation,efficient photothermal conversion,and bacteria-targeting abilities,making it a promising agent for combating bacterial infections and promoting wound healing through photothermal(PTT)/photodynamic(PDT)*** discoveries emphasize the significant role of PGA in antibacterial therapy and offer valuable insights for the design of effective strategies targeting PGA to combat biofilm-associated infections.

关键词： Penicillin G acylase Phototherapy Biofilm regulation Wound healing Photothermal Photodynamic

Surface functionalized Pt/SnNb_(2)O_(6)nanosheets for visible-light-driven the precise hydrogenation of furfural to furfuryl alcohol

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Journal of Energy Chemistry 2022年第3期31卷 566-575,I0015页

作者： Yingzhang Shi Huan Wang Zhiwen Wang Cheng Liu Mingchuang Shen Taikang wu ling wu State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou UniversityFuzhou 350116FujianChina State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of ScienceFuzhou 350002FujianChina

Photocatalytic upgrading of renewable biomass is a promising way to relieve energy crisis and environmental ***,low photocatalytic efficiency and uncontrollable selectivity still limit its ***,ultrathin SnNb_(2)O_(6)nanosheets with high dispersed Pt nanoparticles(Pt/SN)were successfully developed as an efficient photocatalyst for the precise hydrogenation of furfural(FUR)to furfuryl alcohol(FOL)under visible light irradiation and exhibited the high conversion of FUR(99.9%)with the high selectivity for FOL(99.9%).It was revealed that SN with only 4.1 nm thickness possess good separation ability of photo-generated carriers and abundant surface Lewis acid sites(Nb^(5+))which would selectively chemisorb and activate FUR molecules via the Nb···O=C ***,Pt nanoparticles would gather photo-generated electrons for greatly promoting the generation of active H species to support the hydrogenation of FUR to *** synergistic effects between SnNb_(2)O_(6)nanosheets and Pt nanoparticles remarkably facilitate the photocatalytic performance for *** work not only confirms the great potential of ultrathin nanosheet photocatalyst with functional metal sites for precise upgrading of biomass but also provides an in-depth view to understand the surface/interface interaction between reactant molecules and surface sites of a photocatalyst.

关键词： Biomass conversion Hydrogenation of furfural Two-dimensional materials Sn2NbO6 nanosheet Pt nanoparticle Photocatalysis

Covalent triazine-based frameworks confining cobalt single atoms for photocatalytic CO_(2) reduction and hydrogen production

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Journal of Materials Science & Technology 2022年第21期116卷 41-49页

作者： Guocheng Huang Guiyun Lin Qing Niu Jinhong Bi ling wu Department of Environmental Science and Engineering Fuzhou UniversityMinhouFujian 350108China State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou UniversityMinhouFujian 350108China

Single-atom catalysts(SACs)have emerged as an advanced frontier in heterogeneous catalysis due to their potential to maximize the atomic ***,covalent triazine-based frameworks(CTFs)confining cobalt single atoms(Co-SA/CTF)photocatalysts have been synthesized and used for efficient CO_(2) reduction and hydrogen production under visible light *** resulted Co-SA/CTF demonstrate excellent photocatalytic activity,with the CO and H2 evolution rates reaching 1665.74μmol g^(−1) h^(−1) and 1293.18μmol g^(−1) h^(−1),respectively,far surpassing those of Co nanoparticles anchored CTF and pure CTF.A variety of instrumental analyses collectively indicated that Co single atoms sites served as the reaction center for activating the adsorbed CO_(2) molecules,which significantly improved the CO_(2) reduction ***,the introduction of Co single atoms could accelerate the separation/transfer of photogenerated charge carriers,thus boosting the photocatalytic *** study envisions a novel strategy for designing efficient photocatalysts for energy conversion and showcases the application of CTFs as attractive support for confining metal single atoms.

关键词： Covalent triazine-based frameworks Co single atoms Photocatalysis CO_(2)reduction Hydrogen evolution

The facile insertion of β-keto sulfones to arynes:The direct preparation of polysubstituted ortho-keto benzyl sulfones

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Chinese Chemical Letters 2008年第6期19卷 631-633页

作者： Jian Xue Lu ling wu Xian Huang Department of Chemistry Zhejiang University （Campus Xixi） Hangzhou 310028 PR China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 PR China

One novel carbon-carbon bond insertion reaction of arynes has been developed. By this reaction β-keto sulfones can insert the triple bond of arynes to prepare polysubstituted ortho-keto benzyl sulfones.

关键词： arynes Insertion reaction C-C bonds β-Keto sulfones

Effect of Bu-Zhong-Yi-Qi-Tang on deficiency of N-glycan/nitric oxide and islet damage induced by streptozotocin in diabetic rats

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World Journal of Gastroenterology 2009年第14期15卷 1730-1737页

作者： xiao-Qiu Liu ling wu Xue-Jun Guo Pi-Wei Institute Guangzhou University of Traditional Chinese Medicine Guangzhou 510405 Guangdong Province China Laboratory Animal Research Center Guangzhou University of Traditional Chinese Medicine Guangzhou 510405 Guangdong Province China

AIM: To investigate the effect of Bu-Zhong-Yi-Qi-Tang (Decoction for Reinforcing Middle Jiao and Replenishing Qi) on deficiency of N-glycan/nitric oxide (NO) and islet damage induced by injecting two medium doses of streptozotocin (STZ). METHODS: Diabetes was induced by intraperitoneal injection of STZ at 55 mg/kg on day 1 and day 8. Islet damage was evaluated using a scoring system. Nitrite, nitrate, α-mannosidase and amylase activities were measured by colorimetry. N-glycan patterns of amylase were determined with lectin [ConA, pisum sativum agglutinin (PSA), peanut agglutinin (PNA), and lens culinaris agglutinin (LCA)] affinity precipitation method. RESULTS: Severe islet necrosis and mild islet atrophy were observed in diabetic rats. The number and size ofislets, the activities of α-mannosidase, amylase and nitrite were decreased, while the binding of PNA and LCA to amylase was increased. All of which were improved after treatment with Bu-Zhong-Yi-Qi-Tang. Islet damage was significantly correlated with nitrite, nitrate, α-mannosidase, amylase and the binding of LCA, PNA, and PSA to ***: STZ-induced islet damage is related to N-glycan deficiency in proteins by blocking α-mannosidase activity and no deficiency, accumulation of unfolded proteins, and endoplasmic reticulum stress and activation of cellular signals, all of which are improved after treatment with Bu-Zhong-YiQi-Tang.

关键词： N-Giycan Nitric oxide Diabetic rats Isletdamage Alpha mannosidase Bu-Zhong-Yi-Qi-Tang

Modeling Method and Control Strategy for Hose-Drogue Aerial Refueling System

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第2期35卷 371-382页

作者： wu ling Sun Yongrong Huang Bin Liu Jianye Navigation Research Center Nanjing University of Aeronautics and Astronautics Nanjing 210016 P. R. China Department of Automation of Nanhang Jincheng College Nanjing 211156 P. R. China

Conventional method for hose-drogue model of aerial refueling system is known to be complex due to the flexible body of *** as reported,drogues are unstable in atmospheric turbulence,which greatly decreases docking success *** paper proposes a dynamic model for a hose-drogue aerial refueling system based on Kane equation and rigid multi-body dynamics,and analyzes its ***,the nonlinear dynamic model is linearized at the equilibrium point and simplified from full order to 2 nd *** on the simplified 2 nd order model,active control strategies,including proportion integral derivative(PID)and liner quadratic regulator(LQR)control laws,are designed to inhibit the pendulum movement of drogue due to,atmospheric *** simulation results show the significant correctness of the proposed dynamic model by steady-state drag and balance position of drogue when the tanker flights under different ***,the steady state position error varies within 1 cm,thanks to either controller,when the drogue suffers from moderate-level atmospheric ***,the PID controller exhibits better control effect and higher control precision than LQR controller.

关键词： aerial refueling dynamic modeling hose drogue Kane equation proportion integral derivative(PID)control liner quadratic regulator(LQR)

Phase Conjugation of Squeezed Light

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Chinese Physics Letters 1993年第4期10卷 220-222页

作者： LI Shiqun wu ling-An Department of Applied Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaBeijing 100080

Phase conjugation in degenerate four-wave mixing with a squeezed input beam is *** show that the phase conjugate mode is always super-Poissonian and never squeezed,but the combination mode may be squeezed to an extent... 详细信息

关键词： wave squeezed conjugate

SYNTHESIS OF CHIRAL CONJUGATED POLYBINAPHTHYLS BY SONOGASHIRA REACTION

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Chinese Journal of Polymer Science 2006年第3期24卷 273-279页

作者：成义祥 ling-wu Chen Xiao-wei Zou Jin-feng Song College of Chemistry and Chemical Engineering Nanjing University Nanjing 210093 China

Chiral polymers P-1 and P-2 were synthesized by the polymerization of （R）-3,3＇-diiodo-2,2＇-bisbutoxy-1,1＇- binaphthyl （M- 1 ） with 2,5-di（4-ethynylphenyl）- 1,3,4-oxadiazole （M-3） and （R）-3,3＇-diethylnyl-2,2＇-bisbutoxy- 1,1 ＇-binaphthyl （M-2） with 1,2-di（4-bromophenyl）acetylene （M-4） under Sonogashira reaction, respectively. Both monomers and polymers were analyzed by NMR, MS, FT-IR, UV-Vis spectroscopy, DSC-TGA, fluorescence spectroscopy, GPC and CD spectroscopy. CD spectra of P-1 and P-2 are similar due to the same chiral center units and main chain structure. The long wavelengths CD effect of P-1 and P-2 can be regarded as the more extended conjugated structure and a highly rigid backbone in the polymer chain. Polymers have strong blue fluorescence due to the efficient energy migration from the extended n-electronic structure of the polymers to the chiral binaphthyl core and are expected to provide understanding of the relationship between molecular structure and fluorescent property of the chiral polymers.

关键词： (R)-BINOL Chiral conjugated polymer Sonogashira reaction Fluorescence.