检索结果-南通市图书馆

Structural Studies of 3-(1,2-O-Isopropylidene-α-D-xylosyl)-5-phenyl-1,2,4-oxadiazole

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1999年第2期10卷 117-120页

作者： Ming Long ZHANG Yu Xin CUI ling tai ma Li He Zhang Yang LU Bin ZHAO Qi tai ZHENG (The National Laboratory of Natural and Biomimetic Drugs．School of Pharmaceutical Sciences， Beijing Medical University， Beijing， 100083) (Institute of materia Me Natl. Lab. Nat. and Biomimetic Drugs School of Pharmaceutical Sciences Beijing Medical University Beijing 100083 China Institute of materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China

1、2－O－Isopropylidene－3－C－cyano－5－O－benzoyl－α－D－xylose 2 was preparedstereoselectively from 1，2－O－isopropylidene－3－oxo－5－O－benzoyl－α－D－xylose *** structure of 2was studied by two－dimensional NMR spectroscopy in conjunction with X－ray crystallography of itscorresponding 5－phenyl－1，2，4－oxadiazole isocarbonucleoside derivative 3． The absoluteconfigurations of 2 and 3，and conformation of 3 are described herein．

关键词： 5-Phenyl-1,2,4-oxadiazole isocarbonucleoside stereoselectivity NMR spectroscopy X-ray crystallography

SYNTHESIS OF DERIVATIVES OF 3-β-D-XYLOPYRANOSYL-1,2,4-OXADIAZOLES

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1992年第8期3卷 597-600页

作者： ling Jiao DONG Li LI ling tai ma Li He ZHANG School of Pharmaceutical Sciences,Beijing Medical University,Beijing 100083

The synthesis of derivatives of 3-β-D-xylopyranosyl-1,2,4-oxadiazoles is accomplished by condensing protected β-D-xylopyranosyl amidoxime with acid anhydrides or various substituted benzoyl chlorides in good *** structures of now derivatives were identified by spectra and elemental analysis. The stability of 1,2,4-oxadiazole ring and mechanism of cyclization were. investigated.

关键词： D-XYLOPYRANOSYL-1,2,4-OXADIAZOLES SYNTHESIS OF DERIVATIVES OF 3 台五

The Citron homology domain of maP4Ks improves outcomes of traumatic brain injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling Zhong Wenjiao tai Meng-Lu Liu Shuaipeng ma Tianjin Shen Yuhua Zou Chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(maP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of maP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of maP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding maP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting maP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-ling Shi Quan-Hong ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Synthesis of 5-Substituted-3-[(2’R,4’R)-4’-Hydroxy-2’-hydroxymethyltetrahydrofuran-4’-yl]-1,2,4-oxadiazoles and Their Epimers

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2001年第4期17卷 407-414页

作者： WU Wei-dong ma ling-tai ZHANG Li-he National Laboratory of Natural and Biomimetic Drugs School ofPharmaceutical SciencesPeking UniversityBeijing 100083P.R.China

The syntheses of 5-substituted-3-[( 2’ R, 4’ R)-4 ’ -hydroxy-2 ’ -hydroxymethyltetra-hydrofuran-4’ -yl]D-1 ,2, 4-oxadiazoles and their epimers were accomplished with the aid of th construction of 1,2, 4-oxadiazoles by condensation of O-acylated cyanohydrins with hydroxylamine via intramolecular transacylation and subsequent cyclization.

关键词： Nucleoside analogue 1,2,4-Oxadiazole Transacylation

Effect of strain-gradients of surface micro-beams on frequency-shift of a quartz crystal resonator under thickness-shear vibrations

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2015年第5期31卷 647-652页

作者： ling-Cheng Kong Yuan-tai Hu Department of Mechanics Huazhong University of Science and Technology

With introduction of the first-order strain-gradient of surface micro-beams into the energy density function,we developed a two-dimensional dynamic model for a compound quartz crystal resonator（QCR） system,consisting of a QCR and surface micro-beam *** frequency shift that was induced by micro-beams with consideration of strain-gradients is discussed in detail and some useful results are obtained,which have important significance in resonator design and applications.

关键词： Micro-beams Strain-gradient Quartz crystal resonator Frequency shift

The 2022 record-breaking high temperature in China:Sub-seasonal stepwise enhanced characteristics,possible causes and its predictability

在线全文

学校读者我要写书评

暂无评论

Advances in Climate Change Research 2023年第5期14卷 651-659页

作者： Yuan-Yuan ma Yi-Ting CHEN Xiao-Xue HU Qian-Rong ma tai-Chen FENG Guo-ling FENG Di ma Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China School of Physical Science and Technology Yangzhou UniversityYangzhou 225127China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China School of Atmospheric Sciences Key Laboratory of Tropical Atmosphere-Ocean SystemMinistry of EducationSun Yat-sen UniversityZhuhai 519082China Southern marine Science and Engineering Guangdong Laboratory Zhuhai 519082China

In the summer of 2022,an unprecedented and long-lasting high temperature swept central-eastern China,causing significant societal ***,the sub-seasonal characteristics,causes and predictability of this extreme high temperature event are not well *** on the locations,intensities and causes of the high temperature,we divided it into three stages:early(13 June-3 July),sustained(4-28 July),and enhancement(29 July-30 August)*** high temperature during the early stage mainly occurred in north-central China with an anomaly of 2.5℃compared with climatology(1981-2010),while the last two stages occurred in the middle and lower Yangtze River Basin with anomalies of 2.8 and 3.8℃*** high temperature during the three stages were all regulated by the strengthening and westward extension of the western Pacific subtropical high(WPSH)but involved different physical *** the early stage,it was mainly caused by the anticyclones over the Mongolia and Northwest Pacific and enhanced by the minor impact of *** the sustained stage it was influenced by relatively more stronger WPSH and South Asia high(SAH)and the relatively minor impact of the anticyclone over the north-western South *** the enhancement stage,the high temperature was mainly caused by a combination of the record-breaking WPSH and SAH and the strong European blocking ***,the exceptionally powerful WPSH was well correlated with the sea surface temperature gradient induced by the developing La Niñ*** ECMWF and NCEP models reasonably predicted the location and intensity of the high temperature in the early stage,but poorly predicted that in the sustained and enhancement stages partly because of the failure prediction of the WPSH's enhancement and westward *** ECMWF model's more accurate prediction of the WPSH may contribute to its better forecasting of the heatwaves.

关键词： High temperature Sub-seasonal characteristics Western Pacific subtropical high La Niña development phase Predictability

Novel Fréchet-type dendritic BINOL ligands and their applications in Ti(IV) complex catalyzed asymmetric addition of diethylzinc to aldehydes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2007年第12期18卷 1487-1489页

作者： Liang Yin Chao Feng Wang Huan ling Wang Rong Li Jian tai ma College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 China

New Frechet-type dendritic BINOL ligands bearing several BINOL units at the periphery have been successfully synthesized. The （dendritic BINOL） Ti（IV） complexes were proved to be efficient catalysts for the enantioselective addition of diethylzinc to aromatic aldehydes. Moreover, these ligands could be quantitatively recovered and reused at least five times without a loss of the yield and enantioselectivity.

关键词： Asymmetric catalysis BINOL Aldehydes

Recovery and separation of rare earth elements by molten salt electrolysis

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and materials 2021年第6期28卷 899-914页

作者： tai-qi Yin Yun Xue Yong-de Yan Zhen-chao ma Fu-qiu ma Mi-lin Zhang Gui-ling Wang Min Qiu Yantai Research Institute&Graduate School Harbin Engineering UniversityYantai 264006China College of Science Heihe UniversityHeihe 164300China Zhongkexin Engineering Consulting(Beijing)Co. LtdBeijing 100039China

With the increasing demand of rare earth metals in functional materials,recovery of rare earth elements(REEs)from secondary resources has become important for the green economy *** salt electrolysis has the advantages of low water consumption and low hazardous waste during REE *** review systematically summarizes the separation and electroextraction of REEs on various reactive electrodes in different molten *** also highlights the relationship between the formed alloy phases and electrodeposition parameters,including applied potential,current,and ion ***,the feasibility of using LiF–NaF–KF electrolyte to recover REEs is evaluated through thermodynamic *** related to REE separation/recovery the choice of electrolyte are discussed in detail to realize the low-energy and high current efficiency of practical applications.

关键词： rare earth element molten salt reactive electrode electrochemical separation