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High mobility group box 1 levels as potential predictors of asthma severity

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Chinese Medical Journal 2023年第13期136卷 1606-1608页

作者： Shuanglan Xu Weihua Liu Liuchao Zhang Quan He Chenhui Ma Jingxian Jiang Sheng Ye Linyang Ge Zi Chen linfu zhou Department of Respiratory and Critical Care Medicine The First Affiliated HospitalNanjing Medical UniversityNanjingJiangsu 210029China Institute of Integrative Medicine Nanjing Medical UniversityNanjingJiangsu 210029China 不详

To the Editor:Asthma is an abnormal chronic inflammatory disease characterized by the involvement of a complex network of cells.Barrier epithelial cells(ECs)represent the first line of defense and express pattern recognition receptors to recognize type-2 cell-mediated immune insults.An exaggerated abnormal barrier function or inadequate immune response may contribute to the pathophysiology of asthma.

关键词： asthma involvement severity

Computed tomography-identified phenotypes of small airway obstructions in chronic obstructive pulmonary disease

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Chinese Medical Journal 2021年第17期134卷 2025-2036页

作者： Tao Li Hao-Peng zhou Zhi-Jun zhou Li-Quan Guo linfu zhou Department of Respiratory and Critical Care Medicine The First Affiliated HospitalNanjing Medical UniversityNanjingJiangsu 210029China Department of Respiratory Medicine Xuzhou First People’s HospitalXuzhouJiangsu 221116China Department of Medicine Jiangsu University School of MedicineZhenjiangJiangsu 212013China Institute of Radio Frequency&Optical Electronics-Integrated Circuits School of Information and EngineeringSoutheast UniversityNanjingJiangsu 210096China Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of SciencesSuzhouJiangsu 215163China Institute of Integrative Medicine Nanjing Medical UniversityNanjingJiangsu 210029China

Chronic obstructive pulmonary disease(COPD)is a heterogeneous disease characteristic of small airway inflammation,obstruction,and emphysema.It is well known that spirometry alone cannot differentiate each separate component.Computed tomography(CT)is widely used to determine the extent of emphysema and small airway involvement in COPD.Compared with the pulmonary function test,small airway CT phenotypes can accurately reflect disease severity in patients with COPD,which is conducive to improving the prognosis of this disease.CT measurement of central airway morphology has been applied in clinical,epidemiologic,and genetic investigations as an inference of the presence and severity of small airway disease.This review will focus on presenting the current knowledge and methodologies in chest CT that aid in identifying discrete COPD phenotypes.

关键词： Chronic obstructive pulmonary disease Small airway obstruction Computed tomography Phenotype Pulmonary function test

Stem cell therapy for chronic obstructive pulmonary disease

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Chinese Medical Journal 2021年第13期134卷 1535-1545页

作者： Yun-Tian Chen Kang Miao linfu zhou Wei-Ning Xiong Department of Pulmonary and Critical Care Medicine Shanghai Ninth People's HospitalShanghai Jiaotong University School of MedicineShanghai 200011China Department of Pulmonary and Critical Care Medicine Key Laboratory of Pulmonary Diseases of Health MinistryKey Cite of National Clinical Research Center for Respiratory DiseaseWuhan Clinical Medical Research Center for Chronic Airway DiseasesTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Respiratory and Critical Care Medicine The First Affiliated HospitalNanjing Medical UniversityNanjingJiangsu 210029China

Chronic obstructive pulmonary disease(COPD),characterized by persistent and not fully reversible airflow restrictions,is currently one of the most widespread chronic lung diseases in the world.The most common symptoms of COPD are cough,expectoration,and exertional dyspnea.Although various strategies have been developed during the last few decades,current medical treatment for COPD only focuses on the relief of symptoms,and the reversal of lung function deterioration and improvement in patient^quality of life are very limited.Consequently,development of novel effective therapeutic strategies for COPD is urgently needed.Stem cells were known to differentiate into a variety of cell types and used to regenerate lung parenchyma and airway structures.Stem cell therapy is a promising therapeutic strategy that has the potential to restore the lung function and improve the quality of life in patients with COPD.This review summarizes the current state of knowledge regarding the clinical research on the treatment of COPD with mesenchymal stem cells(MSCs)and aims to update the understanding of the role of MSCs in COPD treatment,which may be helpful for developing effective therapeutic strategies in clinical settings.

关键词： Chronic obstructive pulmonary disease Mesenchymal stem cells Clinical trial Inflammation

Sialic acid-binding immunoglobulin-like lectin 9 as a potential therapeutic target for chronic obstructive pulmonary disease

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Chinese Medical Journal 2021年第7期134卷 757-764页

作者： Zi Chen Shuang-Lan Xu Lin-Yang Ge Jin Zhu Tao Zheng zhou Zhu linfu zhou Department of Respiratory and Critical Care Medicine The First Affiliated HospitalNanjing Medical UniversityNanjingJiangsu 210029China Epidemiological Department Huadong Medical Institute of BiotechniquesNanjingJiangsu 210002China Department of Pediatrics and Department of Molecular Microbiology and Immunology Brown University Warren Alpert Medical SchoolProvidenceRI 02912USA.

Chronic obstructive pulmonary disease(COPD)has become the third-leading cause of death worldwide,which is a severe economic burden to the healthcare system.Chronic bronchitis is the most common condition that contributes to COPD,both locally and systemically.Neutrophilic inflammation predominates in the COPD airway wall and lumen.Logically,repression of neutrophilia is an essential fashion to COPD treatment.However,currently available anti-neutrophilic therapies provide little benefit in COPD patients and may have serious side effects.Thus,there is an urgent need to explore an effective and safe anti-neutrophilic approach that might delay progression of the disease.Sialic acid-binding immunoglobulin-like lectin(Siglec)-9 is a member of the Siglec cell surface immunoglobulin family.It is noteworthy that Siglec-9 is highly expressed on human neutrophils and monocytes.Ligation of Siglec-9 by chemical compounds or synthetic ligands induced apoptosis and autophagic-like cell death in human neutrophils.Furthermore,administration of antibody to Siglec-E,mouse functional ortholog of Siglec-9,restrained recruitment and activation of neutrophils in mouse models of airway inflammation in vivo.Given the critical role that neutrophils play in chronic bronchitis and emphysema,targeting Siglec-9 could be beneficial for the treatment of COPD,asthma,fibrosis,and related chronic inflammatory lung diseases.

关键词： Sialic acid-binding immunoglobulin-like lectin-9(Siglec-9) Siglec-E Neutrophils Chronic obstructive pulmonary disease

Artificial intelligence-powered remote monitoring of patients with chronic obstructive pulmonary disease

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Chinese Medical Journal 2021年第13期134卷 1546-1548页

作者： Xuying Li Hao-Peng zhou Zhi-Jun zhou Nan Du Er-Heng Zhong Ke Zhai Nathan Liu linfu zhou Stanford Center for Professional Development Stanford UniversityPalo AltoCA 94305USA Department of Medicine Jiangsu University School of MedicineZhenjiangJiangsu 212013China Institute of Radio Frequency&Optical Electronics-Integrated Circuits School of Information and EngineeringSoutheast UniversityNanjingJiangsu 210096China Wenjing Technologies Shanghai 200020China Dawnlight Technologies Palo AltoCA 94304USA Department of Respiratory and Critical Care Medicine The First Affiliated HospitalNanjing Medical UniversityNanjingJiangsu 210029China

Chronic obstructive pulmonary disease(COPD)has recently become the third leading cause of death following heart disease and cancer.Acute exacerbation of COPD(AECOPD)can be prevented by early detection of deterioration... 详细信息

关键词： obstructive Acute death

Association between socioeconomic status and chronic obstructive pulmonary disease in Jiangsu province, China: a population-based study

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Chinese Medical Journal 2021年第13期134卷 1552-1560页

作者： Dan-Dan Zhang Jian-Nan Liu Qing Ye Zi Chen Ling Wu Xue-Qing Peng Gan Lu Jin-Yi zhou Ran Tao Zhen Ding Fei Xu linfu zhou Department of Respiratory and Critical Care Medicine The First Affiliated HospitalNanjing Medical UniversityNanjingJiangsu 210029China Chronic Airway Disease Research Office Department of Respiratory MedicineGeriatric Hospital of Nanjing Medical UniversityNanjingJiangsu 210024China Department of Respiratory Medicine Jiangsu Province Geriatric HospitalNanjingJiangsu 210024China Nanjing Municipal Center for Disease Control and Prevention NanjingJiangsu 210037China Department of Pharmacy Geriatric Hospital of Nanjing Medical UniversityNanjingJiangsu 210024China School of Public Health Nanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Provincial Center for Disease Control and Prevention NanjingJiangsu 210009China

Background:Chronic obstructive pulmonary disease(COPD)is a common public health problem worldwide.Recent studies have reported that socioeconomic status(SES)is related to the incidence of COPD.This study aimed to investigate the association between SES and COPD among adults in Jiangsu province,China,and to determine the possible direct and indirect effects of SES on the morbidity of COPD.Methods:A cross-sectional study was conducted among adults aged 40 years and above between May and December of 2015 in Jiangsu province,China.Participants were selected using a multistage sampling approach.COPD,the outcome variable,was diagnosed by physicians based on spirometry,respiratory symptoms,and risk factors.Education,occupation,and monthly family average income(FAI)were used to separately indicate SES as the explanatory variable.Mixed-effects logistic regression models were introduced to calculate odds ratios(ORs)and 95%confidence intervals(CIs)for examining the SES-COPD relationship.A pathway analysis was conducted to further explore the pulmonary function impairment of patients with different SES.Results:The mean age of the 2421 participants was 56.63±9.62 years.The prevalence of COPD was 11.8%(95%CI:10.5%–13.1%)among the overall sample population.After adjustment for age,gender,residence,outdoor and indoor air pollution,body weight status,cigarette smoking,and potential study area-level clustering effects,educational attainment was negatively associated with COPD prevalence in men;white collars were at lower risk(OR:0.60,95%CI:0.43–0.83)of experiencing COPD than blue collars;compared with those within the lower FAI subgroup,participants in the upper(OR:0.68,95%CI:0.49–0.97)tertiles were less likely to experience COPD.Such negative associations between all these three SES indicators and COPD were significant among men only.Education,FAI,and occupation had direct or indirect effects on pulmonary function including post-bronchodilator forced expiratory volume in 1 s/forced vital capacity(FEV1/FVC),FEV1,FVC,and FEV1 perce

关键词： Socioeconomic status Family average income Smoking Air pollution Body mass index Chronic obstructive pulmonary disease

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稀见清初浙派词谱《词鹄》考论

浙江大学学报（人文社会科学版） 2024年第2期54卷 142-151页

作者：王琳夫朱惠国辽宁大学文学院辽宁沈阳110136 华东师范大学中国语言文学系上海200241

《词鹄》是《词律》《钦定词谱》两部名谱的中间环节,与清初制谱风潮中十余部著作有关,是一部具有学术史贯通属性的稀见词谱。作者孙致弥是康熙近臣,作者楼俨是《钦定词谱》的分纂官。《词鹄》实为《钦定词谱》之先声,关注宫调、严格互... 详细信息

《词鹄》是《词律》《钦定词谱》两部名谱的中间环节,与清初制谱风潮中十余部著作有关,是一部具有学术史贯通属性的稀见词谱。作者孙致弥是康熙近臣,作者楼俨是《钦定词谱》的分纂官。《词鹄》实为《钦定词谱》之先声,关注宫调、严格互校等制谱理念被《钦定词谱》继承。二人与朱彝尊等浙派词人关系极为密切,《词鹄》也反映了清初浙西词派的声律思想。谱中指出了万树“上下片互校”“以入代平”等做法的疏失,采用“分体互见”的列调方式,标注领字、标注多音字、为换韵设计专门符号,很多设计为词学史上仅见、首见,有很高的样本价值。

关键词：《词鹄》《词律》《钦定词谱》词谱浙西词派明末清初

Polymorphisms of TLR7 and TLR8 associated with risk of asthma and asthma-related phenotypes in a southeastern Chinese Han population

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Journal of Nanjing Medical University 2009年第1期23卷 25-32页

作者： Qian Zhang Fenhong Qian linfu zhou Guozhen Wei Ying Wang Zhibin Hu Guangfu Jin Jianling Bai Kaisheng Yin Department of Respiratory Medicine Affiliated Changzhou No.2 People's Hospital Nanjing Medical University Changzhou 213003 China Department of Respiratory Medicine Affiliated Jiangbing Hospital Jiangsu University Zhenjiang 212001 China Department of Respiratory Medicine First Affiliated Hospital Nanjing Medical University Nanjing 210029 China Department of Genetics Chinese National Human Genome Center at Shanghai Shanghai 201203 China Department of Epidemiology and Biostatistics Cancer Research Center Nanjing Medical University Nanjing 210029 China Department of Epidemiology and Biostatistics School of Public Health Nanjing Medical University Nanjing 210029 China

Objective： To evaluate the effects of polymorphisms in TLR7 and TLRS（as potential candidate genes） on asthma risk and asthma-related phenotypes. Methods： We consecutively recruited 318 unrelated adult asthmatic patients and 352 healthy volunteers from the same area of southeast China. Genotyping of each selected SNP was performed using multiplex PCR in conjunction with tagged array single base extension technology. We conducted case-control and case-only association studies between the selected SNPs in TLR7 and TLR8 and asthma or asthma-related phenotypes. Results： The T allele of rs5935436 SNP in TLR7 was protective from developing asthma in males （adjusted ORs = 0.126, 95% CIs = 0.016-0.995）. The CT/TT genotype of rs5935436 was less frequent in female asthmatics with allergic rhinitis （adjusted ORs = 0.18, 95% CIs = 0.04-0.90）. The homozygote AA of rs3761623 and GG of rs3764880 were positively associated with lower FEV1% and asthma severity in female asthmatics. These results were confirmed by haplotype analysis. Conclusion：TLR7 and TLR8 polymorphisms may play an important role in the pathogenesis of asthma that is gender-dependent. This could be clinically useful, both for identifying patients at risk of asthma and for preventing its occurrence.

关键词： Asthma Atopy Phenotype Polymorphism Toll-like receptors

全自动核酸提纯及实时荧光PCR系统的性能验证与评价

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医学动物防制 2024年第4期40卷 410-413页

作者：田锋党晓霞夏侯为民耿合员周林福陈程慧蒋璐蔡晓雪陈超怡史燕新疆国际旅行卫生保健中心乌鲁木齐海关口岸门诊部新疆维吾尔自治区乌鲁木齐830011 韶关海关综合技术服务中心江苏国际旅行卫生保健中心南京海关口岸门诊部浙江大学

目的评估全自动核酸提取纯化及实时荧光PCR分析系统检测新型冠状病毒核酸的性能。方法根据新型冠状病毒感染防控方案,研究购自上海生工的全自动核酸提取纯化及实时荧光PCR分析系统、2019-nCoV试剂盒、不同浓度的新型冠状病毒核酸检测标... 详细信息

目的评估全自动核酸提取纯化及实时荧光PCR分析系统检测新型冠状病毒核酸的性能。方法根据新型冠状病毒感染防控方案,研究购自上海生工的全自动核酸提取纯化及实时荧光PCR分析系统、2019-nCoV试剂盒、不同浓度的新型冠状病毒核酸检测标准品,对样品的阴阳性符合率、精密性、变异系数、最低检出限、重复性、检测时长等指标进行检测,并根据检测结果验证、评估自动核酸提取纯化及实时荧光PCR分析系统性能。结果样本的阴、阳性符合率均为100.00%,精密性阳性符合率均为100.00%,变异系数(coefficient of variation,CV)为≤5.00%,最低检出限循环阈值(cycle threshold,Ct)<43.00,阳性检出率为100.00%,重复性阴、阳性符合率均为100.00%,设备检测时长2h以内。结论根据本研究结果,该系统特异性强、重复性好,同时最低检出限和精密性均符合现场使用要求,可有效降低操作风险,且检测时长较传统PCR短,可大规模适用于口岸一线。

关键词：新型冠状病毒性能验证实时荧光PCR 系统评价