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Rapid tooth movement through distraction osteogenesis of the periodontal ligament in dogs

Chinese Medical Journal 2008年第5期121卷 455-462页

作者： ai Hong XU Qing-feng LU Hong-fei Mai Zhi-hui AN ai-qun LIU Guo-ping Department of Stomatology Affiliated Hospital Guangzhou Sun Yat-sen University Third Guangdong 510630 China

Background Animal models are needed for the study of rapid tooth movement into the extraction socket through distraction osteogenesis of the periodontal ligament. Methods Modified distraction devices were placed on eight dogs between the first and third mandibular premolars on the left sides; similar placement of traditional straight wise appliances on the right sides served as the control. The experimental distractors were activated （0.25 mm/d） twice a day and the control devices were activated （100 g） for two weeks with consolidation periods at weeks two, three, six, and ten. Two dogs were sacrificed at each consolidation time point; rates and patterns of tooth movement, loss of anchorage, and periapical films were evaluated, and the affected premolars and surrounding periodontal tissues were decalcified and examined histologically. General observations, X-ray periapical filming and histology examination were performed. Results Distal movement （（3.66±0.14） mm） measured two weeks after modified distraction exceeded that achieved using the traditional device （（1.15±0.21） mm; P 〈0.05）. Loss of anchorage was minimally averaged （0.34±0.06） mm and （0.32±0.07） mm in the experimental and control sides, respectively. By radiography, apical and lateral surface root resorptions on both sides were minimal. Alveolar bone lesions were never evident. Fibroblasts were enriched in periodontal ligaments and bone spicules formed actively along directions of distraction. Conclusions The canine model is suitable for the study of rapid tooth movement through distraction osteogenesis of the periodontal ligament. The technique accelerates tooth movement, periodontal remodeling, alveolar bone absorption, and may induce fibroblast formation, as compared to the traditional orthodontic method, without adversely affecting root absorption, bone loss, tooth mobility and anchorage loss.

关键词： animal model distraction osteogenesis periodontal ligament rapid tooth movement bone formation

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Solution‑Processed Transparent Conducting Electrodes for Flexible Organic Solar Cells with 16.61% Efficiency

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Nano-Micro Letters 2021年第3期13卷 39-52页

作者： Juanyong Wan Yonggao Xia Junfeng Fang Zhiguo Zhang Bingang Xu Jinzhao Wang Ling ai Weijie Song Kwun Nam Hui Xi Fan Yongfang Li Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201People’s Republic of China School of Physics and Electronics Science Engineering Research Center of Nanophotonics and Advanced InstrumentMinistry of EducationEast China Normal UniversityShanghai 200241People’s Republic of China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitution of ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Nanotechnology Center Institute of Textiles and ClothingThe Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077People’s Republic of China Department of Material Science and Engineering Hubei UniversityWuhan 430062People’s Republic of China State Key Laboratory of Organic/Inorganic Composites Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoAvenida da UniversidadeTaipaMacao SAR 999078People’s Republic of China

Nonfullerene organic solar cells(OSCs)have achieved breakthrough with pushing the efficiency exceeding 17%.While this shed light on OSC commercialization,high-performance flexible OSCs should be pursued through solution ***,we report a solution-processed flexible OSC based on a transparent conducting PEDOT:PSS anode doped with trifluoromethanesulfonic acid(CF3SO3H).Through a low-concentration and low-temperature CF3SO3H doping,the conducting polymer anodes exhibited a main sheet resistance of 35Ωsq−1(minimum value:32Ωsq−1),a raised work function(≈5.0 eV),a superior wettability,and a high electrical *** high work function minimized the energy level mismatch among the anodes,hole-transporting layers and electron-donors of the active layers,thereby leading to an enhanced carrier *** solution-processed flexible OSCs yielded a record-high efficiency of 16.41%(maximum value:16.61%).Besides,the flexible OSCs afforded the 1000 cyclic bending tests at the radius of 1.5 mm and the long-time thermal treatments at 85°C,demonstrating a high flexibility and a good thermal stability.

关键词： Solution-processed transparent conducting electrode Flexible organic solar cell PEDOT:PSS Trifluoromethanesulfonic acid doping Solution processing

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Landscape Pattern Evolution Processes of Alpine Wetlands and Their Driving Factors in the Zoige Plateau of China

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Journal of Mountain Science 2013年第1期10卷 54-67页

作者： Bai Jun-hong LU Qiong-qiong WANG Jun-jing ZHAO Qing-qing OUYANG Hua DENG Wei LI ai-nong State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal University Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Institute of Mountain Hazards and Environment Chinese Academy of Sciences

Zoige Plateau wetlands are located in the northeastern corner of the Qinghai-Tibet *** landscape pattern evolution processes in the Zoige Plateau and their driving factors were identified by analyzing the dynamic changes in landscape modification and conversion and their dynamic rates of alpine wetlands over the past four *** results showed that the landscape conversion between wetlands and non-wetlands mainly occurred during the period from 1966 to *** marsh wetland area converted from lake and river wetlands was larger because of swamping compared to other wetland ***,the larger area of marsh wetlands was also converted to lake wetlands more than other types of *** modification processes mainly occurred among natural wetland landscapes in the first three *** conversions were observed between wetland and nonwetland landscapes(i.e.,forestland,grassland,and other landscapes) in the Zoige *** natural wetland landscapes such as river,lake and marsh wetlands showed a net loss over the past four decades,whereas artificial wetland landscapes(i.e.,paddy field and reservoir and pond wetlands) showed a net *** annual dynamic rate of the whole wetland landscape was 0.72%,in which the annual dynamic rate of river wetlands was the highest,followed by lake wetlands,while marsh wetlands had the lowest dynamic *** integrated landscape dynamic rate showed a decreasing trend in the first three *** changes in wetland landscape patterns were comprehensively controlled by natural factors and human activities,especially human activities play an important role in changing wetland landscape patterns.

关键词： Zoige Plateau Alpine wetland Landscape pattern Modification Conversion Driving factors

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蛋白酶抑制剂DUBs-IN-1抑制马立克病病毒在鸡细胞内的增殖

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中国兽医学报 2024年第8期44卷 1622-1628页

作者：艾馨许家翠谢佳良马浩原于凯刘洺丞王馨悦林俊彦高旭延边大学农学院吉林延吉133400 吉林大学动物科学学院吉林长春130062

接种疫苗是防御鸡马立克病的主要手段,但疫苗不能扼制马立克病病毒(MDV)的感染、增殖、传播以及毒力增强,因此,抑制MDV在鸡细胞内的增殖是增强疫苗防御效果的重要手段。本研究以MDV编码的大被膜蛋白MDV049为靶点,应用泛素探针从蛋白酶... 详细信息

接种疫苗是防御鸡马立克病的主要手段,但疫苗不能扼制马立克病病毒(MDV)的感染、增殖、传播以及毒力增强,因此,抑制MDV在鸡细胞内的增殖是增强疫苗防御效果的重要手段。本研究以MDV编码的大被膜蛋白MDV049为靶点,应用泛素探针从蛋白酶抑制剂库中筛选出一种化合物DUBs-IN-1,可抑制MDV049的酶活性。分子对接分析发现,DUBs-IN-1可以与MDV049的催化活性中心袋口处的7个残基互作,阻止泛素底物与活性中心的CYS98结合,进而抑制MDV049酶的活性。应用CEF细胞病变(CPE)模型研究发现,0.35、0.70μmol/L的DUBs-IN-1可显著抑制MDV所致的CPE,定量分析揭示DUBs-IN-1可显著抑制MDV在CEF细胞内的增殖(P<0.01)。应用感染MDV的鸡进行动物水平的研究发现,使用80和150μg/kg的DUBs-IN-1每日给药处理,DUBs-IN-1可显著抑制MDV在鸡T细胞内的增殖(P<0.01)。总之,本研究发现蛋白酶抑制剂DUBs-IN-1通过竞争性抑制方式抑制MDV049酶活性,并有效抑制MDV在鸡细胞内增殖,这一发现为研发抗MDV的药物奠定了理论基础。

关键词：马立克病病毒蛋白酶抑制剂 DUBs-IN-1 CEF MDV049

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Further Analysis of the Function of AtBHLH29 in Regulating the Iron Uptake Process in Arabidopsis thaliana

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Journal of Integrative Plant Biology 2006年第1期48卷 75-84页

作者： Juan Zhang Hui-Fen Zhu Hui Liang Kun-Fan Liu ai-Min Zhang Hong-Qing Ling Dao-Wen Wang Institute of Genetics and Developmental Biology the Chinese Academy of Sciences Beijing 100101 China

Using T-DNA insertion and chemical mutants, two recent studies have shown that AtBHLH29, encoding a putative basic helix-loop-helix （BHLH） protein, is involved in regulating the iron uptake process in Arabidopsis thaliana. Herein, we report that RNA interference （RNai） mutants can be used to reveal more accurately the genetic function of AtBHLH29. We compared the iron deficiency responses of seven RNai strains that contained decreasing amounts of AtBHLH29transcripts. Under high iron conditions （50 μmol/L iron）, only in the most severe RNai strains （R101, R111, and R119） was plant growth significantly retarded. However, these mutants could still survive and produce seeds. This suggests that the function of AtBHLH29 is beneficial, but not absolutely essential, to plant growth when iron supply is not limiting. Under low iron conditions （less than 10 μmol/L iron）, the Rlll and R119 strains died prematurely, demonstrating that AtBHLH29 is absolutely necessary for plant survival when iron supply is restricted. The transcription of AtBHLH29 was essential for the expression of AtFRO2 （encoding the ferric chelate reductase）. In contrast, the expression of AtlRT1 （encoding the high-affinity iron transporter） was not so strongly dependent upon the transcription of AtBHLH29. By transient expression, we found that the AtBHLH29-GUS fusion protein was targeted specifically to the nucleus in plant cells. Interestingly, the nuclear localization of AtBHLH29-GUS was abolished when the four consecutive arginine residues located in the basic region of the putative AtBHLH29 protein were replaced by alanine residues by mutagenesis. The implications of our findings on further studies of the mechanism underlying the function of AtBHLH29 are discussed.

关键词： Arabidopsis AtBHLH29 basic helix-loop-helix protein iron RNA interference.

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老年男性2型糖尿病患者血糖波动与骨代谢指标及骨密度的相关性研究

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标记免疫分析与临床 2024年第8期31卷 1487-1494页

作者：陈逸青陈福华应瑞雪艾李雅代芳王萍安徽医科大学第一附属医院内分泌科安徽合肥230022 安徽省第二人民医院内分泌科安徽合肥230041

目的探讨老年男性2型糖尿病患者(T2DM)血糖波动相关指标与骨代谢指标及骨密度的相关性。方法选取2020年9月至2023年3月在安徽医科大学第一附属医院内分泌科就诊的老年男性T2DM患者252例,根据患者骨密度结果分为正常组、骨量减少组以及... 详细信息

目的探讨老年男性2型糖尿病患者(T2DM)血糖波动相关指标与骨代谢指标及骨密度的相关性。方法选取2020年9月至2023年3月在安徽医科大学第一附属医院内分泌科就诊的老年男性T2DM患者252例,根据患者骨密度结果分为正常组、骨量减少组以及骨质疏松组。所有受试者均进行临床信息的采集,同时行体格检查、实验室检查,所有受试者均进行连续72h动态血糖监测(CGM),并收集血糖波动相关指标。采用t检验或方差检验对3组患者间的一般临床资料、实验室结果进行比较;采用Pearson相关分析、多元回归分析探讨血糖波动相关指标与骨代谢指标及骨密度的相关性。结果随着骨量减少的严重程度的增加,患者的年龄、病史时间显著增加,BMI显著降低,使用GLP-1受体激动剂的患者比例在骨质疏松症组显著减少。同时骨形成指标OC、PINP以及骨吸收指标CTX、TRAP均有明显减少。血糖波动指标TIR、SDBG、CV、MAGE、MODD随着患者骨量减少的严重程度的增加而显著增加。另外,通过Pearson相关分析、多元回归分析后发现,OC与CV、MAGE、MODD呈显著独立负相关,CTX与TIR、CV、MAGE呈显著独立负相关,TRAP与MAGE呈显著独立负相关。股骨颈T值与全髋T值与MAGE呈显著独立负相关。结论本研究发现老年男性T2DM患者血糖波动和骨转换标志物、骨密度之间存在独立的负相关关系。故积极控制老年男型T2DM患者的血糖波动可能有利于骨代谢以及骨密度的改善。

关键词： 2型糖尿病血糖波动连续动态血糖监测骨代谢指标骨密度

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新型缓释载体材料在草地贪夜蛾引诱剂中的应用

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环境昆虫学报 2024年第1期46卷 236-242页

作者：李红卫钱寅杰于艳雪赵雪晴谌爱东程志强翟俊峰中国检验检疫科学研究院植物检验与检疫研究所北京100176 吉林农业大学植物保护学院长春130118 云南省农业科学院农业环境资源研究所昆明650205

比较不同草地贪夜蛾引诱剂的田间诱集效果差异,筛选出长持效期引诱剂使用的缓释载体材料,为草地贪夜蛾的长期种群监测提供重要的理论依据。本研究首先将新型材料海藻酸钙/聚己内酯微球作为缓释载体应用于草地贪夜蛾引诱剂1,对其结构性... 详细信息

比较不同草地贪夜蛾引诱剂的田间诱集效果差异,筛选出长持效期引诱剂使用的缓释载体材料,为草地贪夜蛾的长期种群监测提供重要的理论依据。本研究首先将新型材料海藻酸钙/聚己内酯微球作为缓释载体应用于草地贪夜蛾引诱剂1,对其结构性能进行相关分析;通过田间诱集试验比较引诱剂1、引诱剂2、引诱剂3、引诱剂4、引诱剂5等五种不同草地贪夜蛾引诱剂的田间持续监测诱集效果;利用气相色谱仪定量比较两种诱集效果不同载体材料的引诱剂1(最优)、引诱剂2(最差)中所含性信息素组分的缓释能力。结果表明:新型材料海藻酸钙/聚己内酯微球的蛙卵状球形结可使草地贪夜蛾引诱剂1中信息素组分缓慢释放,室内静置2个月后该载体基本结构保持稳定;五种不同草地贪夜蛾引诱剂的持续诱捕能力对比为:引诱剂1>引诱剂5>引诱剂4>引诱剂3>引诱剂2,引诱剂1使用80 d仍然具有很强的引诱效果;通过对比诱集持续效果最优及最差的2种引诱剂1、引诱剂2所用载体的缓释性能,发现田间诱集持续效果最好的引诱剂1对草地贪夜蛾性信息素组分的缓释效果显著优于引诱剂2。海藻酸钙/聚己内酯微球作为载体材料可使草地贪夜蛾引诱剂的诱集持效期达80 d以上,可实现对草地贪夜蛾危害周期全覆盖,为持续开展草地贪夜蛾种群监测奠定了重要理论基础。

关键词：海藻酸钙/聚己内酯微球引诱剂缓释草地贪夜蛾

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Systematic Characterization of Long Non-Coding RNAs and Their Responses to Drought Stress in Dongxiang Wild Rice

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Rice science 2020年第1期27卷 21-31页

作者： QI Weidong CHEN Hongping YANG Zuozhen HU Biaolin LUO Xiangdong ai Bing LUO Yuan HUANG Yu XIE Jiankun ZHANG Fantao College of Life Sciences Jiangxi Normal UniversityNanchang 330022China Rice Research Institute Jiangxi Academy of Agricultural SciencesNanchang 330200China Cipher Gene Limited Liability Company Beijing 100080China

Long non-coding RNAs(lncRNAs) play important roles in response to various biotic and abiotic stresses. So far, systematic identification and characterization of lncRNAs have been reported in a few model plant species and major crops, but their roles in abiotic stress response have not yet been reported in common wild rice(Oryza rufipogon). Dongxiang wild rice(DXWR) possesses a high degree of drought resistance and has been well recognized as a precious genetic resource for drought resistant rice breeding. We presented the reference catalog of 1 655 novel lncRNA transcripts in DXWR using strand-specific RNA sequencing and bioinformatics approaches. Meanwhile, a total of 1092 lncRNAs were determined as differentially expressed lncRNAs under drought stress. Quantitative real-time PCR results exhibited a high concordance with RNA sequencing data, which confirmed that the expression patterns of lncRNAs based on RNA sequencing were highly reliable. Furthermore, 8 711 transcripts were predicted as target genes of the differentially expressed lncRNAs. Functional annotation analysis based on Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases showed that the target genes were significantly enriched in cellular and metabolic processes, cell part, binding and plant hormone signal transduction, as well as many other terms related to abiotic stress resistance. These results expanded our understanding of lncRNA biology and provided candidate regulators for genetic improvement of drought resistance in rice cultivars.

关键词： Dongxiang wild rice drought stress long non-coding RNA systematic characterization

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Characterization and enrichment of hepatic progenitor cells in adult rat liver

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World Journal of Gastroenterology 2004年第10期10卷 1480-1486页

作者： ai-LanQin Xia-QiuZhou WeiZhang HongYu Qinxie DepartmentofInfectiousDiseases RuijinHospitalShanghaiSecondMedicalUniversityShanghai200025China

aiM: To detect the markers of oval cells in adult rat liver and to enrich them for further analysis of characterization in ***: Rat model for hepatic oval cell proliferation was established with 2-acetylaminofluorene and two third partial hepatectomy (2-AAF/PH). Paraffin embedded rat liver sections from model (11 d after hepatectomy) and control groups were stained with HE and OV6, cytokeratin19 (CK19),albumin, alpha fetoprotein (AFP), connexin43, and c-kit antibodies by immunohistochemistry. Oval cell proliferation was measured with BrdU incorporation test. C-kit positive oval cells were enriched by using magnetic activated cell sorting (MACS) .The sorted oval cells were cultured in a low density to observe colony formation and to examine their characterization in vitroby immunocytochemistry and ***: A 2-AAF/PH model was successfully established to activate the oval cell compartment in rat liver. BrdU incorporation test of oval cell was positive. The hepatic oval cells coexpressed oval cell specific marker OV6, hepatocytemarker albumin and cholangiocyte-marker CK19. They also expressed AFP and connexin 43. C-kit, one hematopoietic stem cell receptor, was expressed in hepatic oval cells at high levels. By using c-kit antibody in conjunction with MACS,we developed a rapid oval cell isolation protocol. The sorted cells formed colony when cultured in vitro. Cells in the colony expressed albumin or CK19 or coexpressed both and BrdU incorporation test was positive. RT-PCR on colony showed expression of albumin and CK19 ***: Hepatic oval cells in the 2-AAF/PH model had the properties of hepatic stem/progenitor cells. Using MACS, we established a method to isolate oval cells. The sorted hepatic oval cells can form colony in vitro which expresses different combinations of phenotypic markers and genes from both hepatocytes and cholangiocyte lineage.

关键词：肝祖细胞肝脏动物模型细胞增殖肝椭圆细胞

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WC粉体对ZL102合金组织和性能影响的研究

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中国铸造装备与技术 2024年第3期59卷 46-52页

作者：贾熙杨慕尧杨继伟王泽杨军艾秀兰大连交通大学材料科学与工程学院辽宁大连116028 东北大学材料科学与工程学院辽宁沈阳110000 大连华锐重工铸业有限公司辽宁大连116028

将不同量的WC粉体加入到ZL102合金试样,利用SEM、三维视频显微镜以及拉伸试验机等表征手段,研究WC粉体对ZL102合金性能的影响。试验结果表明:随着WC粉体加入量的增加,ZL102合金的微观组织明显细化,同时合金的力学性能得到明显的改善。... 详细信息

将不同量的WC粉体加入到ZL102合金试样,利用SEM、三维视频显微镜以及拉伸试验机等表征手段,研究WC粉体对ZL102合金性能的影响。试验结果表明:随着WC粉体加入量的增加,ZL102合金的微观组织明显细化,同时合金的力学性能得到明显的改善。当WC粉体加入量为0.20%时,ZL102合金获得了相对最好的显微组织和拉伸性能。共晶硅由不均匀分布的长针状逐渐转变为短棒状或点状在晶间均匀分布,晶粒组织从大量的柱状晶向等轴晶转化;抗拉强度及拉伸断口最大凸起高度先上升后下降,延伸率变化趋势不明显,抗拉强度237 MPa,提高了10.50%;拉伸断口最大凸起高度是1558.30μm,提高了72.21%。

关键词： WC粉体 ZL102合金显微组织力学性能

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