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Site-specific deposition creates electron-rich Pd atoms for unprecedented C-H activation in aerobic alcohol oxidation

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Chinese Journal of Catalysis 2020年第8期41卷 1240-1247页

作者： Yang Yan Bin Ye Mingshu chen linfang Lu Jian Yu Yuheng Zhou Yong Wang Juanjuan Liu Liping Xiao Shihui Zou Jie Fan Department of Chemistry Zhejiang UniversityHangzhou 310027ZhejiangChina College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005FujianChina School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027ZhejiangChina College of Materials&Environmental Engineering Hangzhou Dianzi UniversityHangzhou 310036ZhejiangChina

Here,we demonstrate a photochemical strategy to site-specifically deposit Pd atoms on Au *** high-sensitivity low-energy ion scattering spectra combined with the X-ray photoelectron spectra reveal that the surface electronic structure of Pd can be continuously regulated by tailoring the Pd-to-Au molar ratio and the location of Pd atoms in Au Pd *** is revealed that electron-rich Pd atoms are considerably more active than the net Pd atoms in aerobic alcohol ***,the catalyst with the most electron-rich Pd sites(binding energy downshift:1.0 e V)exhibits an extremely high turnover frequency(~500000 h-1 vs 12000 h-1 for that with net Pd atoms)for solvent-free selective oxidation of benzyl alcohol,which is,to the best of our knowledge,the highest value ever *** studies reveal that electron-rich Pd atoms can accelerate the oxidation of benzyl alcohol by facilitating C-H cleavage,as indicated by the significant reduction in the activation energy as compared to net Pd atoms.

关键词： AuPd/TiO2 Benzyl alcohol Selective oxidation C-H activation Electronic structure

转铁蛋白受体CD71可作为脓毒症潜在的诊断及预后生物标志物

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中华危重病急救医学 2022年第2期34卷 121-126页

作者：李林芳张源源胡迎春陈睦虎西南医科大学附属医院普通外科(乳腺) 四川泸州646000 西南医科大学附属医院手术室四川泸州646000 西南医科大学附属医院急诊医学部四川泸州646000

目的通过蛋白质组学、生物信息学、酶联免疫吸附试验(ELISA)筛选脓毒症的差异表达蛋白,以期为脓毒症的诊断和预后判断寻找新的生物标志物。方法采用成组设计的实验方法,收集2019年1月至12月入住西南医科大学附属医院急诊科的脓毒症患者... 详细信息

目的通过蛋白质组学、生物信息学、酶联免疫吸附试验(ELISA)筛选脓毒症的差异表达蛋白,以期为脓毒症的诊断和预后判断寻找新的生物标志物。方法采用成组设计的实验方法,收集2019年1月至12月入住西南医科大学附属医院急诊科的脓毒症患者(脓毒症组)和同期在本院体检健康志愿者(健康对照组)的外周血标本;随机选取两组标本进行数据非依赖性采集模式(DIA)定量检测蛋白,利用生物信息分析方法对差异蛋白在转录水平进行基因本体(GO)功能富集、组间荟萃分析(Meta分析),并构建生存曲线;利用ELISA验证筛选出的指标,将数据与临床血清降钙素原(PCT)、C-反应蛋白(CRP)、血乳酸(Lac)数据共同构建受试者工作特征曲线(ROC曲线),筛选出对脓毒症证具有诊断及预后预测价值的生物标志物。结果DIA显示,脓毒症组有71个差异蛋白,6个下调、65个上调;这些差异蛋白的GO功能富集于细胞因子介导的信号通路应激反应、炎症反应、白细胞迁移等。组间Meta分析发现,转铁蛋白受体CD71表达在脓毒症组较健康对照组高〔标准化均数差(SMD)=-0.47,95%可信区间(95%CI)为-0.93~0.00,P<0.01〕,在死亡组表达较生存组高(SMD=-0.44,95%CI为-0.70~-0.18,P=0.63)。生存曲线分析显示,CD71的表达与生存预后呈负相关,低表达者生存率越高(P=0.00034)。ELISA显示,脓毒症组CD71表达较健康对照组明显升高(nmol/L:156.83±84.71比87.99±47.89,P<0.05),死亡组CD71表达较生存组明显升高(nmol/L:219.63±125.59比130.97±40.45,P<0.05)。ROC曲线分析显示:CD71预测脓毒症的ROC曲线下面积(AUC)=0.790(敏感度为65.1%,特异度为90.0%);CD71预测脓毒症患者预后的AUC=0.744(敏感度为57.1%,特异度为94.1%);提示CD71对脓毒症的诊断和预后判断能力均强,且预后判断能力优于PCT(AUC=0.547,敏感度为64.3%,特异度为55.9%)、CRP(AUC=0.594,敏感度为64.3%,特异度为61.8%)和Lac(AUC=0.540,敏感度为42.9%,特异度为82.4%)。结论CD71对脓毒症有较好的诊断和预后判断价值,具有作为脓毒症生物标志物的潜力。

关键词： CD71 脓毒症患者转铁蛋白受体外周血标本荟萃分析急诊科 Meta分析生物标志物

严重创伤患者急诊预后预测模型及评分工具的构建

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中华急诊医学杂志 2022年第5期31卷 592-597页

作者：李林芳胡化刚徐峰邱兰峰陈都李小勤苏州大学苏州医学院护理学院苏州215006 苏州大学附属第一医院急诊科苏州215006

目的利用严重创伤患者的生理指标构建急诊预后预测模型及评分工具,对其临床应用效果进行验证,为创伤患者在急诊的早期病情评估提供参考。方法本研究是回顾性研究,采用整群抽样法,收集2019年9月至2020年11月于苏州大学附属第一医院急诊... 详细信息

目的利用严重创伤患者的生理指标构建急诊预后预测模型及评分工具,对其临床应用效果进行验证,为创伤患者在急诊的早期病情评估提供参考。方法本研究是回顾性研究,采用整群抽样法,收集2019年9月至2020年11月于苏州大学附属第一医院急诊科就诊的符合纳入排除标准的严重创伤患者资料,根据患者的预后按7:3的比例根据预后情况分层随机分配为建模组与验证组。对建模组的资料进行Logistic回归分析构建预后预测模型,并将预测模型转化为简易评分工具,通过验证组和为期2个月的前瞻性数据验证对其应用效果进行评价。并将本研究构建的简易评分工具预测效能与目前临床使用的修正创伤评分(revised trauma score,RTS)和损伤严重度评分(injury severity score,ISS)比较。结果本研究最终纳入863例患者资料,其中建模组604例,验证组259例。模型共纳入收缩压、脉搏血氧饱和度、意识状态(AVPU评分)3项指标,其预测严重创伤患者急诊死亡的受试者操作曲线下面积(the area under receiver operating cure,AUC)为0.938。模型简化评分工具的AUC为0.933,最佳截断值为5分,敏感度86.7%,特异度94.2%;验证组的AUC为0.885,敏感度83.3%,特异度93.7%;前瞻性验证的AUC为0.919,敏感度100%,特异度76.7%。RTS和ISS的AUC分别为0.800和0.833,RTS的AUC低于本研究构建简化评分工具(P<0.05)。结论本预测模型及简化评分工具对严重创伤患者急诊预后的预测效能优于RTS,具有较高的分辨度,适合急诊医护工作者对严重创伤患者病情严重程度的评估。

关键词：严重创伤急诊预后预测模型评分工具

Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of cerebral venous sinus thrombosis

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Stroke & Vascular Neurology 2020年第2期5卷 152-158页

作者： Yuhua Fan Jian Yu Hongbing chen Jian Zhang Jiangang Duan Dapeng Mo Wenhao Zhu Bo Wang Fubing Ouyang Yicong chen linfang Lan Jinsheng Zeng Chinese Stroke Association Stroke Council CVST Guideline Writing Committee Department of Neurology The First Affiliated HospitalSun Yat-sen UniversityGuangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological DiseasesNational Key Clinical Department and Key Discipline of NeurologyGuangzhouChina Department of Neurology and Department of Emergency Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Interventional Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina 不详

Aim Cerebral venous sinus thrombosis(CVST)is a less common cerebrovascular disease that predominantly affects young *** incidence of CVST is 2-5/10000000/year,accounting for 0.5%-1%of all *** reduce mortality and morbidity associated with CVST,Chinese Stroke Association commissioned the authors to write the current guideline on the management of *** PubMed(MEDLINE),CNKI and Wanfang database were searched for studies related to CVST from 1 January 1990 to 31 July *** were synthesised by evidence *** recommendation was fully discussed by the writing group members and reviewed by Chinese Stroke Association Stroke Fellow *** of evidence grading algorithm of Chinese Stroke Association was used to grade each *** This guideline mainly focuses on the diagnostic evaluation,therapeutic strategies and secondary prevention of ***/CTV and MRI/MRV are recommended in the initial imaging evaluation of patients with suspected *** therapy with low-molecular weight heparin should be initiated in patients with CVST *** the acute stage,warfarin is recommended for 3-6 months to prevent the recurrence of CVST and other venous thromboembolic *** The guideline summarises the current evidence regarding the management of CVST,and provides references for diagnosis,treatment and secondary prevention of CVST in China.

关键词： prevention tables initiated

Chemical fingerprint analysis of Gentianae Radix et Rhizoma by high-performance liquid chromatography

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Acta Pharmaceutica Sinica B 2012年第1期2卷 46-52页

作者： Baozhong Duan Jianyong Hu linfang Huang Xianying Yang Fuying chen Institute of Medicinal Plant Development Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China College of Pharmaceutical Sciences Dali UniversityDali 671000China Dali Institute for Food and Drug Control Dali 671000China

Gentianae Radix et Rhizoma(also called "Longdan" in Chinese)is commonly used for eliminating damp-heat and quenching the fire of liver and gall bladder in traditional Chinese *** this study,a novel and reliable method using high-performance liquid chromatography(HPLC)was developed both for quantitative analysis of four bioactive compounds(loganic acid,swertiamarin,gentiopicroside and sweroside)and chemical fingerprint analysis of "Longdan".In quantitative analysis,four compounds showed good regressions(R^(2)>40.9987)within the test ranges and the recovery of the method was in the range 97.61-102.49%.In fingerprint analysis,ten characteristic peaks were selected to evaluate the similarities of the crude drugs,and the HPLC chromatograms of twenty samples from different regions of China showed similar *** results demonstrated that the combination of the quantitative and chromatographic fingerprint analyses offered an efficient way to evaluate the quality consistency of Gentianae Radix et Rhizoma.

关键词： Gentianae Radix et Rhizoma Loganic acid Swertiamarin Gentiopicroside Sweroside HPLC Quantitative determination Fingerprint Quality control

Identifying Osmunda japonica and its adulterants by chloroplast DNA

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Identifying Osmunda japonica and its adulterants by chloropl...

RING finger 138 deregulation distorts NF-κB signaling and facilities colitis switch to aggressive malignancy

2013年中国药学大会暨第十三届中国药师周

作者： SiHao Zheng linfang Huang Shilin chen Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College

Three chloroplast barcodes （psbA-trnH, rbcL and matK） were firstly tested to differentiate O. japonica from its adulterants. The result shown that psbA-trnH exhibited better performance in terms of amplification, sequencing, genetic distance divergence and variation, and three barcodes could identify O. japonica and its adulterants respectively. The psbA-trnH region obtained smaller overlap than rbcL and matK, and owned bigger interspecific divergence. Based on psbA-trnH sequences, a pair of primers was designed to identify O. japonica specifically. In Conclusion, psbA-trnH was more optimal barcode for authenticating O. japonica. DNA barcoding could accurately identify O. japonica and its adulterants.

关键词： Osmunda japonica identification chloroplast DNA adulterants

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2555-2567页

作者： Yalan Lu Rong Huang Jianming Ying Xingchen Li Tao Jiao Lei Guo Haitao Zhou Han Wang Amannisa Tuersuntuoheti Jianmei Liu Qichen chen Yanhong Wang Luying Su Changyuan Guo Fu Xu Ziyi Wang Yan Lu Kai Li Junbo Liang Zhen Huang Xiao chen Jinjie Yao Hanjie Hu Xiaowen cheng Yufeng Wan Xinyan chen Ning Zhang Shiying Miao Jianqiang Cai linfang Wang Changzheng Liu Wei Song Hong Zhao Department of Biochemistry and Molecular Biology State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Department of Hepatobiliary Surgery State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Gene Editing Screening and R&D of Digestive System Tumor Drugs Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of HealthBeijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijing 100021China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518116China Department of Pathology State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Clinical Laboratory the First Affiliated HospitalAnhui Medical UniversityHefei 230022China Wellcome Centre for Anti-Infectives Research(WCAIR) Division of Biological Chemistry and Drug DiscoverySchool of Life SciencesUniversity of DundeeDundee DD15EHUK

Prolonged activation of nuclear factor(NF)-кB signaling significantly contributes to the development of colorectal cancer(CRC).New therapeutic opportunities are emerging from targeting this distorted cell signaling ***,we discovered the critical role of RING finger 138(RNF138)in CRC tumorigenesis through regulating the NF-кB signaling,which is independent of its Ubiquitin-E3 ligase activity involved in DNA damage ***138^(−/−) mice were hyper-susceptible to the switch from colitis to aggressive malignancy,which coincided with sustained aberrant NF-кB signaling in the colonic ***,RNF138 suppresses the activation of NF-кB signaling pathway through preventing the translocation of NIK and IKK-Beta Binding Protein(NIBP)to the cytoplasm,which requires the ubiquitin interaction motif(UIM)*** importantly,we uncovered a significant correlation between poor prognosis and the downregulation of RNF138 associated with reinforced NF-кB signaling in clinical settings,raising the possibility of RNF138 dysregulation as an indicator for the therapeutic intervention targeting NF-кB *** the xenograft models built upon either RNF138-dificient CRC cells or the cells derived from the RNF138-dysregulated CRC patients,we demonstrated that the inhibition of NF-кB signaling effectively hampered tumor ***,our work defined the pathogenic role of aberrant NF-кB signaling due to RNF138 downregulation in the cascade events from the colitis switch to colonic neoplastic transformation and progression,and also highlights the possibility of targeting the NF-кB signaling in treating specific subtypes of CRC indicated by RNF138-ablation.

关键词： malignancy sustained finger

地震动随机性对地表加速度峰值的影响及机理研究

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岩土工程学报 2023年第S2期45卷 7-12页

作者：齐文浩陈方晓李林芳张苋凯中国地震局工程力学研究所地震工程与工程振动重点实验室黑龙江哈尔滨150080 地震灾害防治应急管理部重点实验室黑龙江哈尔滨150080

人造地震动的随机性对地表加速度峰值有重要影响。基于黑龙江地区土层剪切波速以及土体非线性统计结果建立了3个土层地震反应模型,以黑龙江地区典型基岩加速度反应谱为目标谱,每一目标谱选取400个不同的随机数人工合成400条随机地震动... 详细信息

人造地震动的随机性对地表加速度峰值有重要影响。基于黑龙江地区土层剪切波速以及土体非线性统计结果建立了3个土层地震反应模型,以黑龙江地区典型基岩加速度反应谱为目标谱,每一目标谱选取400个不同的随机数人工合成400条随机地震动加速度时程作为输入,通过土层地震反应分析得到3个经验模型共10800个地表加速度峰值结果。统计分析了每一目标谱下加速度峰值的分布特征及其差异性,并通过傅里叶谱与目标反应谱对比分析初步解释了造成这一差异性的原因。结果表明:在剖面相同,目标反应谱相同的情况下,不同随机数得到的场地地表加速度峰值存在一定差异,大致呈现正态分布;且这种差异与地表地震动傅里叶谱峰值点周期对应的该地震动目标反应谱谱值的大小呈正相关。

关键词：随机数人造地震动加速度峰值反应谱傅里叶谱

Butyrylcholinesterase inhibitory-active components in Aucklandia lappa Decne

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Butyrylcholinesterase inhibitory-active components in Auckla...