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Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease

World Journal of Gastroenterology 2017年第18期23卷 3356-3366页

作者： Natalia Pedersen Dorit Vedel Ankersen Maria Felding Henrik Wachmann Zsuzsanna Végh line molzen Johan Burisch Jens Rikardt Andersen Pia Munkholm Department of Gastroenterology Slagelse Hospital Gastroenterology Unit North Zealand Hospital Department of Nutrition Exercise and SportsUniversity of Copenhagen Department of Statistics First Department of Medicine Semmelweis University

AIM To investigate the effect of a low-FODMAP diet on irritable bowel syndrome(IBS)-like symptoms in patients with inflammatory bowel disease(IBD).METHODS This was a randomised controlled open-label trial of patients with IBD in remission or with mild-to-moderate disease and coexisting IBS-like symptoms(Rome III) randomly assigned to a Low-FODMAP diet(LFD) or a normal diet(ND) for 6 wk between June 2012 andDecember 2013. Patients completed the IBS symptom severity system(IBS-SSS) and short IBD quality of life questionnaire(SIBDQ) at weeks 0 and 6. The primary end-point was response rates(at least 50-point reduction) in IBS-SSS at week 6 between groups; secondary end-point was the impact on quality of life. RESULTS Eighty-nine patients, 67(75%) women, median age 40, range 20-70 years were randomised: 44 to LFD group and 45 to ND, from which 78 patients completed the study period and were included in the final analysis(37 LFD and 41 ND). There was a significantly larger proportion of responders in the LFD group(n = 30, 81%) than in the ND group(n = 19, 46%);(OR = 5.30; 95%CI: 1.81-15.55, P < 0.01). At week 6, the LFD group showed a significantly lower median IBSSSS(median 115; inter-quartile range [IQR] 33-169) than ND group(median 170, IQR 91-288), P = 0.02. Furthermore, the LFD group had a significantly greater increase in SIBDQ(median 60, IQR 51-65) than the ND group(median 50, IQR 39-60), P < *** In a prospective study, a low-FODMAP diet reduced IBS-like symptoms and increased quality of life in patients with IBD in remission.

关键词：煽动性的肠疾病基于万维网的管理急躁的肠症候群 Low-FODMAP 饮食

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Injury and protection of spiral ganglion neurons

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Chinese Medical Journal 2024年第6期137卷 651-656页

作者： Beilei Duan Kevin A.Peng line Wang Department of Otorhinolaryngology Head and Neck SurgeryBeijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Neurotology House ClinicLos AngelesCA 90017USA

Cochlear spiral ganglion neurons(SGNs)are bipolar ganglion cells and are the first neurons in the auditory transduction *** transmit complex acoustic information from hair cells to second-order sensory neurons in the cochlear nucleus for sound *** to SGNs causes largely irreversible hearing impairment because these neurons are highly differentiated cells and cannot regenerate,making treatment of sensorineural hearing loss(SNHL)arising from SGN injury *** exposed to ototoxic drugs or damaging levels of noise or when there is loss of neurotrophic factors(NTFs),aging,and presence of other factors,SGNs can be irreversibly damaged,resulting in *** has been found that NTFs and stem cells can induce regeneration among dead spiral ganglion *** this paper,we summarized the present knowledge regarding injury,protection,and regeneration of SGNs.

关键词： Spiral ganglion Injury Protection Auditory hair cell Ototoxic drugs Aminoglycosides Presbycusis

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A global analysis of the introduction pathways and characteristics associated with non-native fish species introduction, establishment, and impacts

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Ecological Processes 2024年第2期 16-31页

作者： Camille Bernery Céline Bellard Franck Courchamp Sébastien Brosse Boris Leroy CNRS Agro Paris Tech Ecologie Systématique Evolution Université Paris-Saclay Unité Biologie des Organismes et Ecosystèmes Aquatiques (BOREA UMR 8067) Muséum National d’Histoire Naturelle Sorbonne Universités Université de Caen Normandie Université des Antilles CNRS IRD Laboratoire évolution & Diversité Biologique (EDB UMR5174) Université Paul Sabatier-Toulouse 3 CNRS IRD UPS

Background The invasion success of introduced freshwater fishes is influenced by many factors, including ecological, species, and socioeconomic characteristics. Most studies that document the importance of these characteristics are conducted at local scales and/or focus on a single step of the invasion process. In this study, we aim to determine the species characteristics, ecological characteristics, and socioeconomic characteristics of non-native freshwater fish invasions. Our assessment was done at the global scale and considers all three steps of the invasion(i.e., introduction, establishment, and impact). For this purpose, we applied generalized linear models to 20 variables collected for 307 non-native species and modeled them as a function of ecological characteristics(i.e., environmental features), species traits(i.e., functional and morphological), and socioeconomic characteristics(i.e., human use and introduction pathways). We considered the number of countries in which each species was introduced, established, or had ecological impacts as a proxy of invasion step success. We also explored the specifics of species introduced through the aquaculture and the ornamental fish trade *** We found that non-native freshwater fishes with broad diets, high parental care, and multiple introduction pathways are the most widely introduced and established worldwide. The number of countries with impacts reported was best explained by the type of introduction pathway(i.e., aquaculture or fisheries). Moreover, among non-native species introduced through aquaculture, those belonging to Cypriniformes and having broad diets were the most widely introduced and established species. In contrast, the species introduced through the ornamental fish trade pathway belonged to various taxonomic orders but were mainly native to tropical *** Considering several types of factors is important when analyzing the invasion success of freshwater fish and disentang

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“湘江之花”,长沙,湖南,中国

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世界建筑 2024年第4期 28-29页

作者： line+studio line+建筑事务所

长沙“湘江之花”是位于湘江畔的城市会客厅。设计以可动主体空间灵活应对周边环境,既有效规避观景视线的遮挡,也避免其本身对沿岸其他建筑的视线遮挡。建筑整体模拟花瓣的仿生形象和花瓣开合的动态效果,在动力机械装置带动下“花瓣”... 详细信息

长沙“湘江之花”是位于湘江畔的城市会客厅。设计以可动主体空间灵活应对周边环境,既有效规避观景视线的遮挡,也避免其本身对沿岸其他建筑的视线遮挡。建筑整体模拟花瓣的仿生形象和花瓣开合的动态效果,在动力机械装置带动下“花瓣”向外展开,“花蕊”观光厅跃升,实现绽放。“湘江之花”以工业装置的设计与建造路径,在数字化模型、仿真技术、智能建造等新技术支撑下,打破传统建筑的维度限制,实现整体可动的动态建筑。

关键词：数字化模型动态效果仿真技术动力机械动态建筑设计与建造湘江

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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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Risk Factors for Cardiovascular Disease among Hotel Workers, Bohicon, Benin

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Occupational Diseases and Environmental Medicine 2024年第2期12卷 130-141页

作者： Mênonli Adjobimey Rose Mikponhoué Eméline Gbaguidi Esdras Hountohotegbè Hélène Sacca Paul Ayélo Vikkey Antoine Hinson Unité de Recherche et d&#8217Enseignement en Sant&#233 au Travail et Environnement FSS Cotonou Cotonou Benin Service de Santé au Travail du Centre National Hospitalier Universitaire de Pneumo Phtisiologie de Cotonou Cotonou Benin Laboratoire d’ Epid&#233miologie des Maladies Chroniques et Neurologiques FSS Cotonou Benin

Introduction: Non-communicable diseases (NCDs) are on the increase in several sectors of activity. The aim of the study was to determine the frequencies of cardiovascular risk factors (CVRF) and factors associated with hypertension among hotel workers in the city of Bohicon. Methods: This was a descriptive and analytical cross-sectional study conducted in the period from December 2018 to January 2019. The variables studied were sociodemographic, occupational, anthropometric and behavioral. Participant recruitment was exhaustive. A standardized questionnaire inspired by the STEPS-WHO questionnaire was used for data collection. After the descriptive analysis, a bivariate analysis was performed using Pearson’s Chi-square test or Fisher’s test at the 5% threshold. Results: A total of 101 workers, 53 (52.47%) of them male, participated in the study. The mean age was 30.60 ± 8.20 years, with extremes of 18 and 55 years. The frequencies of the main risk factors were: 68.32% sitting position > 6 hours/day;38.61% shift work;21.78% high psychological demand, 82.18% low decision latitude, 24.75% low social support, 21.78% occupational stress;7 (6.93%) harmful alcohol consumption;6.93% tobacco consumption;48.51% insufficient physical activity;98.02% insufficient fruit and vegetable consumption;59.41% overweight;14.85% HTA. Factors associated with hypertension were: sex, age and marital status. Conclusion: Occupational factors need to be taken into account when assessing CVRFs. NCD control programs are needed in all sectors of activity. A larger study is needed in the hotel sector.

关键词： FDRCV Occupational Factors Hypertension Hotels Benin

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微地形大理洱海小邑庄生态驿站

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室内设计与装修 2024年第2期 44-48页

作者： line+建筑事务所 line+建筑事务所

大理洱海生态廊道的建设工程旨在构建健康的水陆缓冲带和生态屏障,并拓宽居民、游客与洱海的互动界面。面对苍山洱海、古朴村落的原生环境,设计试图以地景建筑的方式最低程度介入,以“锚固与悬浮”回应建筑与土地的关系,对话环境;以“... 详细信息

大理洱海生态廊道的建设工程旨在构建健康的水陆缓冲带和生态屏障,并拓宽居民、游客与洱海的互动界面。面对苍山洱海、古朴村落的原生环境,设计试图以地景建筑的方式最低程度介入,以“锚固与悬浮”回应建筑与土地的关系,对话环境;以“低技与低碳”回应地方性与当代建造的关系,创新经验;以“开放与包容”回应公共建筑与人的关系,构筑日常性的活动平台。

关键词：创新经验建设工程日常性缓冲带原生环境生态廊道微地形生态屏障

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西藏远古氏族“格茹”考——基于《格茹父系的起源》研究

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西藏研究 2024年第1期 34-40,155,156页

作者：尕本加德拉东知青海民族大学藏学院西宁810007 甘肃省甘南州玛曲县藏族寄宿制高级中学玛曲747300

生活在西藏西部的“■”或“■”人与川西嘉绒藏族同宗同源,两者皆是川西高原远古人群“格茹”的直系后裔。即早在吐蕃形成之前,“格茹”人西迁至青藏高原,定居于雅鲁藏布江流域并逐渐形成了后来的西藏“■”人。对藏文早期刻本文献《... 详细信息

生活在西藏西部的“■”或“■”人与川西嘉绒藏族同宗同源,两者皆是川西高原远古人群“格茹”的直系后裔。即早在吐蕃形成之前,“格茹”人西迁至青藏高原,定居于雅鲁藏布江流域并逐渐形成了后来的西藏“■”人。对藏文早期刻本文献《格茹父系的起源》进行研究,同时结合藏、汉文相关史料语境,详细考证西藏“格茹”人的起源及其早期变迁历程,深入探讨其与嘉绒藏族之间的历史渊源,可进一步探知从先秦时期到吐蕃分据割据时期,我国西南边疆各民族交往交流交融的历史,进而可论证西藏各民族为推动建构中华民族多元一体格局所做出的重要历史贡献。

关键词：远古氏族格茹嘉绒族源关系

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Nucleoredoxin-like 2 metabolic signaling impairs its potential contribution to neurodegenerative diseases

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Neural Regeneration Research 2023年第3期18卷 529-530页

作者： Mariangela Corsi Céline Jaillard Thierry Léveillard Sorbonne Université INSERMCNRSInstitut de la VisionParisFrance

Alzheimer’s disease(AD)threatens the foundations of humanity and our *** is a neurological disorder primarily affecting the elderly through memory disorders,cognitive decline,and loss of *** dramatic consequences of this late-onset disease were illustrated sensitively in Michael Haneke’s masterpiece,*** and governments have invested colossal efforts to develop a treatment for this terrible *** and in the past decade the amyloid cascade has dominated the therapeutic research on AD,but the absence of benefit for patients treated with drugs that reduce brain amyloid deposit questions the role ofβ-amyloid as a causative agent(Herrup,2021).The recent approval of aducanumab by the United States Food and Drug Administration,a drug that targetsβ-amyloid,is at the center of a scandal among clinicians and researchers,as it does not provide therapeutic benefits to patients and is listed among the breakdowns of the year 2021 by Science magazine(Voosen et al.,2021).The lack of progress in curing AD and recent therapeutic failures calls for further exploratory research.

关键词： approval consequences listed

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Epidemiological and Paraclinical Aspects of Helicobacter pylori Infection among Hepatitis B Virus Carriers in the Republic of Congo

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Open Journal of Gastroenterology 2024年第5期14卷 184-191页

作者： Jile Florient Mimiesse Monamou Nuptia Kanoha Elenga Ngala Itoua Ngaporo Clausina Ahoui Apendi Marlyse Ngalessami Mouakosso Arnaud Mongo Onkouo Mauria Ibobi Rody Stéphane Ngami Mardoché Motoula Latou Hostaud Atipo Ibara Céline Sandra Adoua Déby Gassaye Blaise Irénée Atipo Ibara Department of Gastroenterology and Internal Medicine Brazzaville University Hospital Brazzaville The Republic of Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville The Republic of Congo

Objective: Describe the epidemiological and paraclinical aspects of HP infection in hepatitis B virus carriers. Population and Method: This was a descriptive cross-sectional study running from January 1 to August 30, 2019, a period of 8 months. It took place in the Hospital Centers of the two major cities of Congo (Brazzaville and Pointe-Noire). The target population of our study consists of patients carrying HBV under antiviral treatment or not. Patients aged at least 18 years and consenting with a biological and morphological assessment were included. We did not include in our study patients taking or having taken antibiotics and/or PPIs less than 4 weeks ago. We excluded all patients who did not deposit fresh stools and those in whom stool extraction could not be done manually. The variables studied covered sociodemographic, clinical and paraclinical aspects. Data entry was done using Excel 8.0 software. Statistical analysis was carried out with SPSS 20.0 software. Results: During our study, we included 169 patients. The frequency of HPAG in the stools of HBV carriers in our study population was 63.9% (n = 109). Male patients represented 69% (n = 75) and female patients represented 31% (n = 34). The average age of the patients is 43.92 ± 13.51 years with extremes of 18 years and 80 years. Concerning profession, unemployed patients and those working in the private sector were the most represented in respectively 28.4% (n = 31) and 22.9% (n = 25) without statistical link. Households comprising between 4 - 10 people and the use of public latrines were the risk factors most represented in respectively 69% (n = 75) and 88% (n = 96) without statistical link. Clinically, hepatomegaly and signs of portal hypertension were most represented in 53% (n = 58) and 47% (n = 51). Biologically, HBV DNA was detectable in 60.5% of cases (n = 66).

关键词： Helicobacter pylori Hepatitis B Virus Congo

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