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Genes & Diseases 2023年第1期10卷 18-21页

作者： Eva Gijbels Kevin De Muynck Bart Vanderborght Tim Meese Filip Van Nieuwerburgh Aude Vanlander Frederik Berrevoet Bart Hendrikx Anne Hoorens Hans Van Vlierberghe Mathieu Vinken lindsey devisscher Department of Pharmaceutical and Pharmacological Sciences Vrije Universiteit Brussel1090 BrusselsBelgium Gut-Liver Immunopharmacology Unit Basic and Applied Medical SciencesLiver Research Centre GhentFaculty of Medicine and Health SciencesGhent University9000 GhentBelgium Hepatology Research Unit Internal Medicine and PaediatricsLiver Research Centre GhentFaculty of Medicine and Health SciencesGhent University9000 GhentBelgiumd Lab of Pharmaceutical Biotechnology Ghent University9000 GhentBelgium NXTGNT Ghent University9000 GhentBelgium Department of HPB Surgery and Liver Transplantation Ghent University Hospital9000 GhentBelgium Department of Pathology Ghent University Hospital9000 GhentBelgium Hepatology Research Unit Internal Medicine and PaediatricsLiver Research Centre GhentFaculty of Medicine and Health SciencesGhent University9000 GhentBelgium

Cholelithiasis-induced cholestasis is one of the most common causes of hospitalization due to gastrointestinal disease,yet considerable knowledge gaps exist in the pathogenesis of this *** can partially be explained by inadequate characterization of experimental cholestasis ***,we compared the transcriptional profile of commonly used mouse models for obstructive cholestasis and benchmarked them to human disease to identify the model(s)best suited for cholelithiasis-induced cholestasis research and to uncover conserved mechanisms involved in human and murine cholestasis.

关键词： cholestasis obstructive pathogenesis

Gender disparities and woman-specific trends in Barrett’s esophagus in the United States:An 11-year nationwide populationbased study

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World Journal of Methodology 2025年第1期15卷 60-71页

作者： Karina Fatakhova Faisal Inayat Hassam Ali Pratik Patel Attiq Ur Rehman Arslan Afzal Muhammad Sarfraz Shiza Sarfraz Gul Nawaz Ahtshamullah Chaudhry Rubaid Dhillon Arthur Dilibe Benjamin Glazebnik lindsey Jones Emily Glazer Division of Gastroenterology and Hepatology Mather Hospital and Zucker School of Medicine at Hofstra UniversityPort JeffersonNY 11777United States Department of Internal Medicine Allama Iqbal Medical CollegeLahorePunjab 54550Pakistan Division of Gastroenterology and Hepatology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Division of Gastroenterology and Hepatology Geisinger Wyoming Valley Medical CenterWilkes-BarrePA 18711United States Department of Internal Medicine East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal Medicine St.Dominic's HospitalJacksonMS 39216United States Department of Gastroenterology Hepatologyand NutritionCleveland Clinic FoundationClevelandOH 44195United States Department of Internal Medicine Mather Hospital and Hofstra University ZuckerSchool of MedicinePort JeffersonNY 11777United States

BACKGROUND Barrett's esophagus(BE)is a known premalignant precursor to esophageal adenocarcinoma(EAC).The prevalence rates continue to rise in the United States,but many patients who are at risk of EAC are not *** practice guidelines include male gender as a predisposing factor for BE and *** population-based clinical evidence regarding female gender remains *** To study comparative trends of gender disparities in patients with BE in the United *** A nationwide retrospective study was conducted using the 2009-2019 National Inpatient Sample(NIS)*** with a primary or secondary diagnosis code of BE were *** major outcome of interest was determining the gender disparities in patients with *** analysis for respective outcomes for females was also reported to ascertain any time-based *** We identified 1204190 patients with BE for the study *** the included patients,717439(59.6%)were men and 486751(40.4%)were *** mean age was higher in women than in men(67.1±0.4 vs 66.6±0.3 years,P<0.001).The rate of BE per 100000 total NIS hospitalizations for males increased from 144.6 in 2009 to 213.4 in 2019(P<0.001).The rate for females increased from 96.8 in 2009 to 148.7 in 2019(P<0.001).There was a higher frequency of obesity among women compared to men(17.4%vs 12.6%,P<0.001).Obesity prevalence among females increased from 12.3%in 2009 to 21.9%in 2019(P<0.001).A lower prevalence of smoking was noted in women than in men(20.8%vs 35.7%,P<0.001).However,trend analysis showed an increasing prevalence of smoking among women,from 12.9%in 2009 to 30.7%in 2019(P<0.001).Additionally,there was a lower prevalence of alcohol abuse,Helicobacter pylori(***),and diabetes mellitus among females than males(P<0.001).Trend analysis showed an increasing prevalence of alcohol use disorder and a decreasing prevalence of *** and diabetes mellitus among women(P<0.001).CONCLUSION The prevalence of BE among

关键词： Barrett’s esophagus Gender disparity Epidemiological trends Esophageal adenocarcinoma Screening endoscopy Female gender Risk factors

Trait allometries generate super-honesty in Anolis dewlaps and may underlie sexual dimorphism

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Integrative Zoology 2017年第2期12卷 97-111页

作者： Maria PETELO lindsey SWIERK Department of Biology University of Hawaiʻi at MānoaHonoluluUSA Las Cruces Biological Station Organization for Tropical StudiesSan VitoCoto BrusCosta Rica School of Forestry and Environmental Studies Yale UniversityNew HavenConnecticutUSA

Whether or not sexually selected traits consistently exhibit positive allometry(*** disproportionately large in larger individuals)is an ongoing *** models and exceptions to this rule suggest that the underlying drivers of sexual trait allometry are ***,we compare allometries of sexual and non-sexual traits of a species(Anolis aquaticus)within a well-studied lizard genus to test the competing hypotheses that sexual traits are,or are not,defined by positive *** further consider the relationships of trait functions,which are relatively well understood in the genus Anolis,and allometry to identify potential drivers of allometric *** particular,we explore how trait allometries interact to influence total organism function and generate sexual *** quantified size(of targeted traits)and color of a sexual signal(the dewlap)in Anolis aquaticus in the *** dewlap conveyed information relevant to intra-sexual combat and exhibited positive ***,our results suggest that using single-trait allometries as indicators of past selection provides only an incomplete understanding of trait *** the function of positive allometry in some individual sexual signals(*** conveying“super-honest”information)may be straightforward,we illustrate how scaling relationships interact synergistically to influence the function of phenotypes and propose avenues for future research.

关键词： Anolis[Norops]aquaticus color morphology reproductive strategy scaling

Microsurgical vasovasostomy

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Asian Journal of Andrology 2013年第1期15卷 44-48页

作者： lindsey Herrel Wayland Hsiao Emory University Department of Urology Atlanta GA 30322 USA

Up to 6% of men who have undergone vasectomy will ultimately elect for reversal in the form of vasovasostomy or vasoepididymostomy for various reasons. Vasovasostomy performed to regain fertility is a technique that has undergone numerous advances during the last century, including the use of microsurgical equipment and principles to construct a meticulous anastomosis, it is important during vasovasostomy to ensure good blood supply to the anastomosis as well as to build as a tension-free anastomosis. Visual inspection to ensure healthy mucosa and inner muscularis as well as atraumatic handling of tissues is helpful. With vasovasostomy, it is essential to creat a watertight anastomosis to prevent secondary scar formation. The microdot technique of vasovasostomy allows for markedly discrepant lumens to be brought together more precisely. Thereby, the planning is separated from suture placement, which prevents dog-ears and avoids subsequent leaks. In the age of in vitro fertilization （IVF）/intracytoplasmic sperm injection （ICSI）, it becomes even more important to clarify outcomes after vasectomy reversals, as patients now have a choice between surgical sperm retrieval coupled with IVF/ICSI versus vasectomy reversal. Little data on long-term outcomes for vasectomy reversals exist. Therefore, further research in this field needs to evaluate the rate of late failures and the predictors of late failures.

关键词： male infertility microsurgery vasectomy vasectomy reversal vasovasostomy

Verification and validation of hearing aids:Opportunity not an obstacle

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Journal of Otology 2016年第2期11卷 57-62页

作者： lindsey E.Jorgensen University of South Dakota Department of Communication Sciences and Disorders

Verification and validation are objective and subjective measurements of hearing aid function. Many studies have provided rationales for performing these measurements as necessary for hearing aid practitioners to provide the highest level of care. Several researchers have suggested that completing these measurements as part of routine clinical care will reduce the number of return visits, reduce the number of aids returned for credit, and increase patient satisfaction. The purpose of this review article is to provide background, method and rationale for practitioners to use these measurements to improve their practice of hearing healthcare.

关键词： Hearing aids Verification Real-ear measurements Probe-microphone measurements Satisfaction

THREE BAYS ESTUARY(BARNSTABLE,CAPE COD)WATERSHED RESTORATION PL AN:A GREEN INFRASTRUCTURE APPROACH

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Journal of Green Building 2016年第2期11卷 22-38页

作者： Scott Horsley Erin Perry lindsey Counsell Horsley Witten Group Inc. Cape Cod Commission Three Bays Preservation Inc

This paper presents an approach described as“non-traditional”for restoring water quality and ecosystem services that have been degraded as a result of excess *** focuses on emerging technologies often referred to as green *** technologies may provide cost effective alternatives to traditional,gray infrastructure such as sewering and is likely to provide significant co-benefits including the creation of local jobs,the preservation of real estate values,and habitat *** paper focuses on the Three Bays estuary on Cape Cod to illustrate the benefits and potential of green infrastructure *** Three Bays estuary is presented as a case study and as a representative example of implementation of the broader Cape Cod Water Quality Management Plan Update(208 Plan Update)-a nationally-recognized watershed planning project designed to provide a pathway for the fifteen towns of Cape Cod to achieve compliance with Section 208 of the Clean Water *** Three Bays estuary and embayment system is a scenic Cape Cod bay that hosts sailing,kayaking,swimming and shellfishing and is located in the Town of *** is comprised of three primary segments that include West Bay,North Bay and Cotuit ***-systems include Prince Cove that flows into North Bay,the Narrows that flows between North Bay and Cotuit Bay and Eel Pond that flows into East Bay(see Figure 1).The Massachusetts Estuaries Project(MEP)is a state-sanctioned watershedmodeling project that assesses the conditions of the state’s estuaries and required restoration *** technical report(2006)indicates that the water quality of the Three Bays system has resulted in seriously degraded to moderately degraded *** system is listed as an impaired water body on the US Environmental Protection Agency(EPA)303d list of impaired *** approved Total Maximum Daily Load(TMDL)for nitrogen has been established for the *** assessment is supported by more recent em

关键词： water quality green infrastructure ecosystem services stormwater management floating constructed wetlands nitrogen management permeable reactive barriers urine diversion technology

Advances in human stem cell therapies:pre-clinical studies and the outlook for central nervous system regeneration

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Neural Regeneration Research 2021年第4期16卷 614-617页

作者： lindsey H.Forbes Melissa R.Andrews Medical Research Council Centre for Reproductive Health The Queen’s Medical Research InstituteUniversity of EdinburghEdinburghUK School of Biological Sciences University of SouthamptonSouthamptonUK

Cell transplantation has come to the forefront of regenerative medicine alongside the discovery and application of stem cells in both research and clinical *** are several types of stem cells currently being used for pre-clinical regenerative therapies,each with unique characteristics,benefits and *** brief review will focus on recent basic science advancements made with embryonic stem cells and induced pluripotent stem *** embryonic stem cells and induced pluripotent stem cells provide platforms for new neurons to replace dead and/or dying cells following *** to their capacity for reprogramming and differentiation into any neuronal type,research in preclinical rodent models has shown that embryonic stem cells and induced pluripotent stem cells can integrate,survive and form connections in the nervous system similar to de novo *** forward however,there are some limitations to consider with the use of either stem cell ***,embryonic stem cells are not an ideal source of cells,genetically,induced pluripotent stem cells are not ideal in terms of personalized treatment for those with certain genetic diseases the latter of which may guide regenerative medicine away from personalized stem cell based therapies and into optimized stem cell ***,the potential of these stem cells in central nervous system regenerative therapy is only beginning to be *** example,through genetic modification,stem cells serve as ideal platforms to reintroduce missing or downregulated molecules into the nervous system to further induce regenerative *** this review,we highlight the limitations of stem cell based therapies whilst discussing some of the means of overcoming these limitations.

关键词： cell transplantation central nervous system regeneration embryonic stem cells induced pluripotent stem cells spinal cord injury

Crosstalk Complexities between Auxin, Cytokinin, and Ethylene in Arabidopsis Root Development： From Experiments to Systems Modeling, and Back Again

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Molecular Plant 2017年第12期10卷 1480-1496页

作者： Junli Liu Simon Moore Chunli Chen Keith lindsey Department of Biosciences Durham University South Road Durham DH1 3LE UK College of Life Science and Technology Huazhong Agricultural University Wuhan 430070 China These authors contributed equally to this article.

Understanding how hormones and genes interact to coordinate plant growth in a changing environment is a major challenge in plant developmental biology. Auxin, cytokinin, and ethylene are three important hormones that regulate many aspects of plant development. This review critically evaluates the crosstalk between the three hormones in Arabidopsis root development. We integrate a variety of experimental data into a crosstalk network, which reveals multiple layers of complexity in auxin, cytokinin, and ethylene crosstalk. In particular, data integration reveals an additional, largely overlooked link between the ethylene and cytokinin pathways, which acts through a phosphorelay mechanism. This proposed link addresses outstanding questions on whether ethylene application promotes or inhibits receptor kinase activity of the ethylene receptors. Elucidating the complexity in auxin, cytokinin, and ethylene crosstalk requires a combined experimental and systems modeling approach. We evaluate important modeling efforts for establishing how crosstalk between auxin, cytokinin, and ethylene regulates patterning in root develop- ment. We discuss how a novel methodology that iteratively combines experiments with systems modeling analysis is essential for elucidating the complexity in crosstalk of auxin, cytokinin, and ethylene in root development. Finally, we discuss the future challenges from a combined experimental and modeling perspective.

关键词： Arabidopsis auxin cytokinin ethylene hormonal crosstalk spatiotemporal modeling

Functional genomics studies on the innate immunity of disease vectors

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Insect Science 2008年第1期15卷 15-27页

作者： Luke A. Baton lindsey Garver Zhiyong Xi George Dimopoulos W. Harry Feinstone Department of Molecular Microbiology and Immunology Malaria Research Institute Bloomberg School of Pubfic Health Johns Hopkins University Baltimore Maryland USA

The increasing availability of genome sequences and the development of highthroughput techniques for gene expression profiling and functional characterization are transforming the study of innate immunity and other areas of insect biology. Already, functional genomic approaches have enabled a quantum advance in the characterization of mosquito immune responses to malaria parasite infection, and similar high-throughput functional genomic studies of other vector-pathogen interactions can be expected in the near future. The application of microarray-based and other expression analyses provide genomewide transcriptional profiles that can be used to identify insect immune system components that are differentially regulated upon exposure to various classes of pathogens, including many important etiologic agents of human and animal diseases. The role of infection-responsive or other candidate immune genes identified through comparative genomic approaches can then be functionally characterized, either in vivo, for instance in adult mosquitoes, or in vitro using cell lines. In most insect vectors of human pathogens, germ-line transgenesis is still technically difficult and maintenance of multiple transgenic lines logistically demanding. Consequently, transient RNA interference （RNAi）-mediated gene-silencing has rapidly become the method of choice for functional characterization of candidate innate immune genes. The powerful combination of transcriptional profiling in conjunction with assays using RNAi to determine gene function, and identify regulatory pathways, together with downstream cell biological approaches to determine protein localization and interactions, will continue to provide novel insights into the role of insect innate immunity in a variety of vector-pathogen interactions. Here we review advances in functional genomics studies of innate immunity in the insect disease vectors, over the past decade, with a particular focus on the Anopheles mosquito and its respo

关键词： Anopheles genomics innate immunity insect mosquito malaria microarray,parasite Plasmodium RNA interference transcriptomics transgenesis vector

Dewlap size in male water anoles associates with consistent inter-individual variation in boldness

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Current Zoology 2019年第2期65卷 189-195页

作者： Breanna J. PUTMAN Kylee R. AZURE lindsey SWIERK Department of Ecology and Evolutionary Biology University of California Los Angeles CA 90095-1606 USA Section of Herpetology and Urban Nature Research Center Natural History Museum of Los Angeles County Los Angeles CA 90007 USA Environmental Science Department Aaniiih Nakoda College Harlem MT 59526 USA dSchool of Forestry and Environmental Studies Yale University New Haven CT 06511 USA

Male sexually selected signals can indicate competitive ability by honestly signaling fitnessrelevant traits such as condition or performance. However, behavior can also influence contest outcomes;in particular, boldness often predicts dominance rank and mating success. Here, we sought to determi ne whether male ornament size is associated with consiste nt in dividual differences in boldness in water anoles Anol is aquaticus. We measured the relative size of the dewlap, a flap of skin under the chin that is a sexually selected ornament in Anolis lizards, and tested for associations with responses to a novel and potentially risky environment: time to emerge from a refuge into an arena and number of head sea ns post-emergence. We found that in dividuals con siste ntly differed in both time to emerge and head sea nning (i.e., in dividual resp on ses were repeatable), and that dewlap size was negatively related to nu mber of head sea ns. This suggests that orname nt size could indicate male boldness if seanning represents antipredator vigilance. We found that males that had larger relative dewlaps were also in better body condition, but boldness (i.e., head scann ing) was not related to condition. Lastly, we found con siste nt d iff ere nces in behavior betwee n trials, showing that anoles were becoming habituated or sensitized to the testing arena. Overall, our study shows that in additi on to indicating con dition and perform a nee, dewlap size could also honestly indicate male boldness in Anolis lizards.

关键词： Anolis aquaticus behavioral syndrome mating success personality signal sexual selection temperament