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Apoptosis and the target genes of microRNA-21

Chinese Journal of Cancer 2011年第6期30卷 371-380页

作者： lindsey E.becker Buscaglia Department of Biochemistry and Molecular Biology School of MedicineUniversity of Louisville

MicroRNA-21(miR-21) is frequently up-regulated in cancer and the majority of its reported targets are tumor *** functional suppression,miR-21 is implicated in practically every walk of oncogenic life:the promotion of cell proliferation,invasion and metastasis,genome instability and mutation,inflammation,replicative immortalization,abnormal metabolism,angiogenesis,and evading apoptosis,immune destruction,and growth *** particular,miR-21 is strongly involved in *** this article,we reviewed the experimentally validated targets of miR-21 and found that two thirds are linked to intrinsic and/or extrinsic pathways of cellular *** suggests that miR-21 is an oncogene which plays a key role in resisting programmed cell death in cancer cells and that targeting apoptosis is a viable therapeutic option against cancers expressing miR-21.

关键词：细胞凋亡 microRNA 靶基因程序性细胞死亡肿瘤抑制基因致癌基因 miR 微RNA

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MicroRNAs in NF-κB signaling

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Journal of Molecular Cell Biology 2011年第3期3卷 159-166页

作者： Xiaodong Ma lindsey E.becker Buscaglia Juanita R.Barker Yong Li Department of Biochemistry and Molecular Biology School of MedicineUniversity of Louisville319 Abraham Flexner WayLouisvilleKY 40202USA

Nuclear factor κB(NF-κB)is a transcriptional factor that regulates a battery of genes that are critical to innate and adaptive immunity,cell proliferation,inflammation,and tumor ***(miRNAs)are short RNA molecules of 20-25 nucleotides in length that negatively regulate gene expression in animals and plants primarily by targeting 3′untranslated regions of *** this work,we review the convergence of miRNAs and NF-κB signaling and dysregulation of miRNAs and NF-κB activation in human diseases,particularly in *** function of miR-146,miR-155,miR-181b,miR-21,and miR-301a in NF-κB activation and their impact on tumorigenesis are *** that over 1000 human miRNAs have been identified,rendering miRNAs one of the most abundant classes of regulatory molecules,deciphering their biological function and pathological contribution in NF-κB dysregulation is essential to appreciate the complexity of immune systems and to develop therapeutics against cancer.

关键词： microRNA NF-κB cancer

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The dichotomy of p53 regulation by noncoding RNAs

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Journal of Molecular Cell Biology 2014年第3期8卷 198-205页

作者： Qipan Deng lindsey becker Xiaodong Ma Xiaoming Zhong Ken Young Kenneth Ramos and Yong Li Department of Biochemistry and Molecular Biology School of Medicine University of Louisville 319 Abraham Flexner Way Louisville KY 40202 USA Department of Cardiology Huaihe Hospital of Henan University Kaifeng 475000 China Department of Hematopathology The University of Texas MD AndersonCancer Center Houston TX 77030 USA School of Life Science and Technology ShanghaiTech University Shanghai 200031 Cl~ina

The p53 tumor suppressor gene is the most frequently mutated gene in cancer. Significant progress has been made to discern the im- portance of p53 in coordinating cellular responses to DNA damage, oncogene activation, and other stresses. Noncoding RNAs are RNA molecules functioning without being translated into proteins. In this work, we discuss the dichotomy of p53 regulation by noncoding RNAs with four unconventional questions. First, is overexpression of microRNAs responsible for p53 inactivation in the absence of p53 mutation？ Second, are there somatic mutations in the noncoding regions of the p53 gene？ Third, is there a germline mutant in the non- coding regions of the p53 gene that predisposes carriers to cancer？ Fourth, can p53 activation mediated by a noncoding RNA mutation cause cancer？ This work highUghts the prominence of noncoding RNAs in p53 dysregutation and tumorigenesis.

关键词： noncoding RNA p53 activation mutation 3'UTR poiymorphism ribosomopathies

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