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Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial

World Journal of Hepatology 2019年第3期11卷 305-317页

作者： Kylie Russell Han-Guang Zhang Lyn K GillANders Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan lindsay d plank Nutrition Services Auckland City Hospital department of Surgery University of Auckland New Zealand Liver Transplant Unit Auckland City Hospital Human development and Health Faculty of Medicine University of Southampton NIHR Southampton Biomedical Research Centre University Hospital Southampton NHS Foundation Trust and University of Southampton

BACKGROUNd Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver *** To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver *** Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STd) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POd) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POd 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until *** A total of 32 patients(17 IMN and 15 STd) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POd 1, 3, 5 and 7(P d in the IMN group(P = 0.017 for POd7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STd group(P = 0.087). Median hospital st

关键词： Liver cancer Partial hepatectomy Fish oil Arginine Nutritional status Inflammation

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二甲双胍治疗妊娠糖尿病：机体成分和代谢结局，子代7-9岁时的随访结果（MiGTOFU）

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英国医学杂志中文版 2018年第9期21卷 536-536页

作者：张贝(译) 巩纯秀(校) 北京儿童医院

目的：比较妊娠糖尿病（GdM）妇女在怀孕期间随机分为二甲双胍（±胰岛素）治疗组或胰岛素治疗组治疗后7-9岁子代的机体成分和代谢的随访结果。设计及方法：通过人体测持、生物电阻抗分析（BIA）、双能X线吸收测量（dXA）。

关键词：新陈代谢糖尿病格机后代身体

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Incorporating conceptual and interpretation uncertainty to mineral prospectivity modelling

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Geoscience Frontiers 2019年第4期10卷 1383-1396页

作者： J.N.Burkin M.d.lindsay S.A.Occhipinti E.-J.Holden Centre for Exploration Targeting School of Earth SciencesThe University of Western Australia

Prospectivity analyses are used to reduce the exploration search space for locating areas prospective for mineral *** scale of a study and the type of mineral system associated with the deposit control the evidence layers used as proxies that represent critical ore genesis *** particular,knowledge-driven approaches(fuzzy logic)use a conceptual mineral systems model from which data proxies represent the critical *** typically vary based on the scale of study and the type of mineral system being *** analyses utilising interpreted data to represent proxies for a mineral system model inherit the subjectivity of the interpretations and the uncertainties of the evidence layers used in the *** the case study presented,the prospectivity for remobilised nickel sulphide(NiS)in the west Kimberley,Western Australia,is assessed with two novel techniques that objectively grade interpretations and accommodate alternative mineralisation *** targets are then identified and supplied with a robustness assessment that reflects the variability of prospectivity value for each location when all models are *** first technique grades the strength of structural interpretations on an individual line-segment *** are obtained from an objective measure of feature evidence,which is the quantification of specific patterns in geophysical data that are considered to reveal underlying *** structures are weighted in the prospectivity model with grading values correlated to their feature *** technique allows interpreted features to contribute prospectivity proportional to their strength in feature evidence and indicates the level of associated stochastic *** second technique aims to embrace the systemic uncertainty of modelling complex mineral *** this approach,multiple prospectivity maps are each generated with different combinations of confidence values applied

关键词： Prospectivity Confidence Uncertainty Multiple models Mineral exploration Nickel

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Seed value influences cache pilfering rates by desert rodents

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Integrative Zoology 2019年第1期14卷 75-86页

作者： Stephen B.VANdER WALL lindsay A.dIMITRI William S.LONGLANd Joseph d.M.WHITE department of Biology and Program in Ecology Evolution and Conservation BiologyUniversity of NevadaRenoUSA USdA Agricultural Research ServiceRenoNevadaUSA department of Biological Sciences University of Cape TownCape TownRepublic of South Africa

Some rodents gather and store *** many seeds they gather and how they treat those seeds is largely determined by seed traits such as mass,nutrient content,hardness of the seed coat,presence of secondary compounds,and germination *** their consumption and dispersal of seeds,rodents act as agents of natural selection on seed traits,and those traits influence how rodents *** seeds that are scatter-hoarded by rodents are pilfered,or stolen,by other rodents,and seed traits also likely influence pilfering rates and seed fates of pilfered *** clarify coevolutionary relationships between rodents and the plants that they disperse,one needs to understand the role of seed traits in rodent foraging *** compared how the seeds of 4 species of plants that are dispersed by scatter-hoarding animals and that differ in value(singleleaf piñon pine,Pinus monophylla;desert peach,Prunus andersonii;antelope bitterbrush,Purshia tridentata;Utah juniper,Juniperus osteosperma)were pilfered and recached by *** hundred artificial caches of the 4 seed species(25 per species)were prepared,and removal by rodents was *** pilfered high-value seeds more rapidly than the other *** peach seeds,which contain toxic secondary compounds,were more frequently *** low value seeds like Utah juniper and antelope bitterbrush were pil-fered more slowly and were sometimes left at cache sites,and seeds of the latter species were transported shorter distances to new cache *** background density of seeds also appeared to influence the relative value of seeds.

关键词： desert rodents food storage granivory pilfering scatter-hoarding seed dispersal seed traits

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Assessing the impact of conceptual mineral systems uncertainty on prospectivity predictions

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Geoscience Frontiers 2022年第6期13卷 182-207页

作者： Mark d lindsay Agnieszka M.Piechocka Mark W Jessell Richard Scalzo Jeremie Giraud Guillaume Pirot Edward Cripps Commonwealth Scientific and Industrial Research Organisation Mineral Resources Australian Resources Research CentreWA 6151Australia Mineral Exploration Cooperative Research Centre Centre for Exploration TargetingSchool of Earth SciencesThe University of Western AustraliaPerthWA 6009Australia ARC Centre for data Analytics for Resources and Environments(dARE) Perth and SydneyAustralia University of Sydney School of Mathematics and StatisticsSydneyAustralia Universitéde Lorraine GeoRessourcesCNRS54000 NancyFrance The University of Western Australia Department of Mathematics and StatisticsPerthAustralia

The past two decades have seen a rapid adoption of artificial intelligence methods applied to mineral exploration. More recently, the easier acquisition of some types of data has inspired a broad literature that has examined many machine learning and modelling techniques that combine exploration criteria,or ’features’, to generate predictions for mineral prospectivity. Central to the design of prospectivity models is a ’mineral system’, a conceptual model describing the key geological elements that control the timing and location of economic mineralisation. The mineral systems model defines what constitutes a training set, which features represent geological evidence of mineralisation, how features are engineered and what modelling methods are used. Mineral systems are knowledge-driven conceptual models, thus all parameter choices are subject to human biases and opinion so alternative models are ***, the effect of alternative mineral systems models on prospectivity is rarely compared despite the potential to heavily influence final predictions. In this study, we focus on the effect of conceptual uncertainty on Fe ore prospectivity models in the Hamersley region, Western Australia. Four important considerations are tested.(1) Five different supergene and hypogene conceptual mineral systems models guide the inputs for five forest-based classification prospectivity models model.(2) To represent conceptual uncertainty, the predictions are then combined for prospectivity model comparison.(3)Representation of three-dimensional objects as two-dimensional features are tested to address commonly ignored thickness of geological units.(4) The training dataset is composed of known economic mineralisation sites(deposits) as ’positive’ examples, and exploration drilling data providing ’negative’sampling locations. Each of the spatial predictions are assessed using independent performance metrics common to AI-based classification methods and subjected to geological pl

关键词： Uncertainty Modelling Prospectivity Economic geology Geological plausibility Forest-based classification

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development and application of feature engineered geological layers for ranking magmatic,volcanogenic,and orogenic system components in Archean greenstone belts

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Geoscience Frontiers 2024年第2期15卷 251-273页

作者： R.M.Montsion S.Perrouty M.d.lindsay M.W.Jessell R.Sherlock Mineral Exploration Research Centre Harquail School of Earth SciencesGoodman School of MinesLaurentian UniversitySudburyOntario P3E 2C6Canada Centre for Exploration Targeting School of Earth SciencesThe University of Western Australia35 Stirling HighwayCrawley 6009Australia Commonwealth Scientific and Industrial Research Organization Mineral Resources26 Dick Perry AveKensingtonWA 6151Australia ARC Centre for data Analytics for Resources and Environments(dARE) Perth and SydneyAustralia

Geologically representative feature engineering is a crucial component in geoscientific applications of machine *** commonly applied feature engineering techniques used to produce input variables for machine learning apply geological knowledge to generic data science techniques,which can lead to ambiguity,geological oversimplification,and/or compounding subjective *** that utilize minimally processed input variables attempt to overcome these issues,but often lead to convoluted and uninterpretable *** address these challenges,new and enhanced feature engineering methods were developed by combining geological knowledge,understanding of data limitations,and a variety of data science *** include non-Euclidean fluid pre-deformation path distance,rheological and chemical contrast,geologically constrained interpolation of characteristic host rock geochemistry,interpolation of mobile element gain/loss,assemblages,magnetic intensity,structural complexity,host rock physical *** methods were applied to compiled open-source and new field observations from Archean greenstone terranes in the Abitibi and western Wabigoon sub-provinces of the Superior Province near Timmins and dryden,Ontario,*** feature maps represent conceptually significant components in magmatic,volcanogenic,and orogenic mineral systems.A comparison of ranked feature importance from random forests to conceptual mineral system models show that the feature maps adequately represent system components,with a few exceptions attributed to biased training data or limited constraint *** study also highlights the shared importance of several highly ranked features for the three mineral systems,indicating that spatially related mineral systems exploit the same features when *** feature importance when classifying orogenic Au mineralization in Timmins and dryden provides insights into the possible cause of contrasting endowment be

关键词： Machine learning Random forests Mineral systems Magmatic Ni-Cu-PGE Volcanogenic Massive Sulfide(VMS)Cu-Zn-Pb-Ag(-Au) Orogenic Au Abitibi Wabigoon

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developing a framework to inform scale-up success for population health interventions:a critical interpretive synthesis of the literature

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Global Health Research and Policy 2020年第1期5卷 279-289页

作者： duyen Thi Kim Nguyen lindsay McLaren Nelly d.Oelke Lynn McIntyre department of Economics Faculty of BusinessUniversity of New Brunswick100 Tucker Park RoadP.O.Box 5050Saint JohnNew Brunswick E2L 4L5Canada School of Epidemiology and Public Health Faculty of MedicineUniversity of Ottawa600 Peter Morand Crescent OttawaOntario K1G 5Z3Canada New Brunswick Health Research Foundation 10 Knowledge Park DriveFrederictonNew Brunswick E3C 2M7Canada department of Community Health Sciences Cumming School of MedicineUniversity of CalgaryTRW33280 Hospital Dr.NWCalgaryAlberta T2N 4Z6Canada O’Brien Institute for Public Health University of CalgaryTRW33280 Hospital Dr.NWCalgaryAlberta T2N 4Z6Canada School of Nursing Faculty of Health and Social DevelopmentUniversity of British Columbia3333 University WayKelownaBritish Columbia V1V 1V7Canada

Background:Population health interventions(PHIs)have the potential to improve the health of large populations by systematically addressing underlying conditions of poor health outcomes(i.e.,social determinants of health)and reducing health ***-up may be one means of enhancing the impact of effective ***,not all scale-up attempts have been *** an attempt to help guide the process of successful scale-up of a PHI,we look to the organizational readiness for change theory for a new perspective on how we may better understand the scale-up *** the change theory,our goal was to develop the foundations of an evidence-based,theory-informed framework for a PHI,through a critical examination of various PHI scale-up experiences documented in the ***:We conducted a multi-step,critical interpretive synthesis(CIS)to gather and examine insights from scale-up experiences detailed in peer-reviewed and grey literatures,with a focus on PHIs from a variety of global *** CIS included iterative cycles of systematic searching,sampling,data extraction,critiquing,interpreting,coding,reflecting,and *** relevant to innovations,complexity,and organizational readiness guided our analysis and ***:We retained and examined twenty different PHI scale-up experiences,which were extracted from 77 documents(47 peer-reviewed,30 grey literature)published between 1995 and ***,we identified three phases(i.e.,Groundwork,Implementing Scale-up,and Sustaining Scale-up),11 actions,and four key components(i.e.,PHI,context,capacity,stakeholders)pertinent to the scale-up *** guiding theories provided explanatory power to various aspects of the scale-up process and to scale-up success,and an alternative perspective to the assessment of scale-up readiness for a ***:Our synthesis provided the foundations of the Scale-up Readiness Assessment *** theoreticallyinformed and rigorous synt

关键词： Population health intervention Scale-up Framework Critical interpretive synthesis Readiness

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Surgical treatment of Lenke 5 adolescent idiopathic scoliosis: Comparison of anterior vs posterior approach

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World Journal of Orthopedics 2016年第9期7卷 553-560页

作者： Mark F Abel Anuj Singla Mark A Feger lindsay d Sauer Wendy Novicoff department of Orthopedic Surgery University of Virginia

AIM To compare the posterior vs anterior approaches for fusion of Lenke 5 adolescent idiopathic scoliosis curves,matched for curve magnitude and for the distal level of fixation(dLOF) standardized to the third lumbar vertebrae(L3).METHOdS A prospectively collected multicenter database was used for this retrospective comparative study. Our dependent variables included sagittal and coronal radiographic measurements, number of fused vertebrae, estimated blood loss, length of hospitalization and SRS total and individual domain scores at the two-year follow-up. Subject demographics were similar for all group *** t-test was used to compare groups for all analyses at P d cases of Lenke 5 curves, a selective approach was used only 50% of the time in cases undergoing a posterior fusion. When comparing a posterior selective approach to an anterior selective approach,surgeons utilizing a posterior approach fused significantly more levels than surgeons using an anterior approach with no other significant differences in radiographic or SRS outcomes(Ant = 4.8 ± 1.0 levels vs post = 6.1 ± 1.0 levels, P dLOF was standardized to L3, the anterior approached provided significantly greater lumbar Cobb percent correction than the posterior approach(Ant = 69.1% ± 12.6% vs post =54.6% ± 16.4%, P = 0.004), with no other significant radiographic or SRS score differences between *** Surgeons treating Lenke 5c curves with a posterior instrumentation and fusion vs an anterior approach include more motion segments, even with a selective fusion. When controlled for the distal level of fixation,the anterior approach provides greater correction of the thoracolumbar curve.

关键词： Instrumentation Thoracolumbar curve Selective fusion

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Morphological Effects of Natural Products on Schizosaccharomyces pombe Measured by Imaging Flow Cytometry

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Natural Products and Bioprospecting 2014年第1期4卷 27-35页

作者： Joel Heisler lindsay Elvir Farah Barnouti Erica Charles Tom d.Wolkow Radha Pyati University of North Florida JacksonvilleFLUSA University of Coloradoat Colorado Springs Colorado SpringsCOUSA

Gaining a full understanding of the mechanisms of action of natural products as therapeutic agents includes observing the effects of natural products on cellular morphology,because abnormal cellular morphology is an important aspect of cellular transformations that occur as part of disease *** this study a set of natural products was examined in search of small molecules that influence the cylindrical morphology of fission yeast Schizosaccharomyces *** flow cytometry of large populations of *** exposed to natural products captured cell images and revealed changes in mean length and aspect ratio of *** natural products were found to alter ***’s morphology relative to control,in terms of elongating cells,shrinking them,or making them more *** results may facilitate future investigations into methods by which cells establish and maintain specific shapes.

关键词： Schizosaccharomyces pombe Morphology Natural products Imaging flow cytometry Aspect ratio Fission yeast

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A comparison of three surface roughness characterization techniques:photogrammetry,pin profiler,and smartphone-based LidAR

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International Journal of digital Earth 2022年第1期15卷 2422-2439页

作者： Zohreh Alijani Julien Meloche Alexander McLaren John lindsay Alexandre Roy Aaron Berg department of Geography Environment and GeomaticsUniversity of GuelphGuelphCanada département de Géomatique Appliquée Université de SherbrookeSherbrookeCanada département des Sciences de l’Environment Université du Québec à Trois-RivièresTrois-RivièresCanada

Surface roughness plays an important role in microwave remote *** the agricultural domain,surface roughness is crucial for soil moisture retrieval methods that use electromagnetic surface scattering or microwave radiative transfer ***,improved characterization of Soil Surface Roughness(SSR)is of considerable *** this study,three approaches,including a standard pin profiler,a LidAR point cloud generated from an iPhone 12 Pro,and a Structure from Motion(SfM)photogrammetric point cloud,were applied over 24 surface profiles with different roughness variations to measure surface *** objective of this study was to evaluate the capability of smartphone-based LidAR technology to measure surface roughness parameters and compare the results of this technique with the more common *** showed that the iPhone LidAR technology,when point cloud data is captured in a fine-resolution mode,has a significant correlation with SfM photogrammetry(R2=0.70)and a relatively close agreement with pin profiler(R2=0.60).However,this accuracy tends to be greater for random surfaces and rough profiles with row structure *** results of this study confirm that smartphone-based LidAR can be used as a cost-effective,fast,and time-efficient alternative tool for measuring surface roughness,especially for rough,wide,and inaccessible areas.

关键词： LidAR surface roughness structure from motion iPhone pin profiler

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