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Neuroimmunology and Neuroinflammation 2017年第12期4卷 263-271页

作者： lindsay H.Burns Hoau-Yan Wang Pain Therapeutics Inc. AustinTX 78731USA Department of Physiology Pharmacology and NeuroscienceCity University of New York School of MedicineNew YorkNY 10031USA. Department of Biology and Neuroscience Graduate School of the City University of New YorkNew YorkNY 10031USA.

Alzheimer's disease (AD) is a neurodegenerative disease with proteopathy characterized by abnormalities in amyloid beta (Aβ) and tau proteins. Defective amyloid and tau propagate and aggregate, leading to eventual amyloid plaques and neurofibrillary tangles. New data show that a third proteopathy, an altered conformation of the scaffolding protein filamin A (FLNA), is critically link.d to the amyloid and tau pathologies in AD. Altered FLNA is pervasive in AD brain and without apparent aggregation. In a strik.ng interdependence, altered FLNA is both induced by Aβ and required for two prominent pathogenic signaling pathways of Aβ. Aβ monomers or small oligomers signal via the α7 nicotinic acetylcholine receptor (α7nAChR) to activate k.nases that hyperphosphorylate tau to cause neurofibrillary lesions and formation of neurofibrillary tangles. Altered FLNA also enables a persistent activation of toll-lik.-receptor 4 (TLR4) by Aβ, leading to excessive inflammatory cytok.ne release and neuroinflammation. The novel AD therapeutic candidate PTI-125 binds and reverses the altered FLNAconformation to preventAβ's signaling via α7nAChR and aberrant activation of TLR4, thus reducing multiple AD-related neuropathologies. As a regulator of Aβ's signaling via α7nAChR and TLR4, altered FLNA represents a novel AD therapeutic target.

关键词： Proteopathy hyperphosphorylation α7 nicotinic acetylcholine receptor toll-lik. receptor 4 neuroinflammation PTI-125

A Ring-Cavity Diode Laser

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Journal of Modern Physics 2020年第8期11卷 1236-1244页

作者： Jianing Han lindsay Hutcherson k.ori Munek.ne Steven Shettlesworth Physics Department University of South Alabama Mobile AL USA

In this article, we report on a ring-cavity diode laser configuration, which has more features compared to the standing-wave external-cavity diode lasers. First, a transmission grating will be used, and the ring-cavity laser output will be the zero-order output from the transmission grating. Therefore, unlik. the standing-wave external cavity diode lasers, the output direction of this ring-cavity laser does not depend on the laser's frequency. Second, since it is a ring-cavity laser, it can avoid the local heating caused by the antinodes of the standing-wave lasers. Moreover, because this ring-cavity will allow the laser beam to pass the transmission grating two times, it is expected that this will ultimately result in a narrower linewidth compared to the external-cavity standing-wave lasers with the same cavity length.

关键词： PACS Numbers: 07.05.Fb 42.15.Eq 42.55.Px

Extensive Spinal Epidural Abscess: Cord Compression with Permanent Neurological Defects

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Surgical Science 2023年第8期14卷 557-564页

作者： Evan Cohen Melissa Zahl lindsay Hock.Michael Olshansk. Montefiore St. Luk.’s Cornwall Hospital Newburgh NY USA Touro College of medicine Middletown NY USA

Spinal epidural abscesses (SEA) are considerably rare and tend to present over two to five vertebral segments. Occasionally, there will be two or more noncontiguous areas of pyogenic collections [1]. Minimal cases have been reported to span the entire vertebral column;a meta-analysis estimates that 1% of all SEA are holospinal [2]. The triad of presenting symptoms includes fever, back.pain (often midline), and neurologic defects [1] [2] [3]. Early detection is identified as a critical aspect of improved outcomes. Cases that do not present in this manner or with other mask.ng symptoms can lead to delayed diagnosis, thus delaying treatment. In the event of cord compression, the occurrence of neurologic defects increases. Time from the onset of clinical manifestations to the operating room is crucial in reversing symptoms [2]. This article seek. to review a case of a 65-year-old male that presented to the emergency department (ED) due to a falling second to weak.ess and thigh pain. On presentation, he was also noted to have rhabdomyolysis causing acute k.dney injury (Ak.) with tubular necrosis. The patient was admitted to the hospital with a complex history of progressive leg weak.ess, pain in the lower back. incontinence, and elevated white blood cell count. Days into the admission, a magnetic resonance imaging (MRI) study was performed, which revealed a continuous posterior SEA from C4 to S2 with anterior mass effect causing spinal cord compression. Emergency neurosurgery was scheduled for laminectomies in the cervical, thoracic and lumbar spine to drain the abscess. Evaluation of this complex medical course, surgical approach to drainage of an incessant spinal column abscess, and sustained neurologic defects will be discussed.

关键词： Spinal Epidural Abscess Holospinal Abscess Cauda Equina Spinal Compression

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对外汉语中级综合教材对比分析

对外汉语中级综合教材对比分析

作者： lindsay Sullivan（苏林溪）辽宁师范大学

学位级别：硕士

本论文对《文化中文》和《桥梁:实用汉语中级教程》(以下简称《桥梁》)进行了对比分析。前者是汉语作为外语的中级综合教材,后者是汉语作为第二语言的中级综合教程。近年来,学者们认为在汉语做外语和汉语作为第二语言的教材中,应当把语... 详细信息

本论文对《文化中文》和《桥梁:实用汉语中级教程》(以下简称《桥梁》)进行了对比分析。前者是汉语作为外语的中级综合教材,后者是汉语作为第二语言的中级综合教程。近年来,学者们认为在汉语做外语和汉语作为第二语言的教材中,应当把语言与文化内容相结合。《文化中文》与《桥梁》这两套教材都体现了上述趋势。但是,两者却以不同的方式将语言和文化相结合。《文化中文》的对象是把汉语作为外语来学习的在美国的学生。《文化中文》以不同的文化项目构成一系列的话题而每一单元的话题是以文化为中心的。它所选择的话题都属于中国文化遗产的范畴,以学生容易接受的方式介绍中国某些重要的文化特色。相比之下,《桥梁》则采用不同的方式介绍中国文化。《桥梁》针对的教学对象是在中国的外国留学生。这套教材的很多课文选自中国文学作品,当然课文编撰者对所选的内容进行了删改取舍。其中有些课文的原作者在中国文学历史上就有很重要的地位。本论文对这两套教材中的某些课文与课后练习进行对比分析,笔者希望通过这些对比来说明这两套教材是如何将语言和文化结合起来的。本论文对这两套教材在把语言和文化结合起来的优点与不足分别进行了对比分析。本论文的第二章讨论了每套教材的优点,而在第三章里则讨论各自的不足之处。在第四章,笔者对将来的教材编写者提出了一些建议,主张他们编写的教材不仅能够帮助中级汉语水平学习者更好地学习语言,也期望他们所选择的教材能帮助语言学习者掌握更多的文化知识。

关键词：对外汉语中级综合教材语言教学文化项目

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统计学:二十一世纪的挑战和机遇(Ⅳ)

数理统计与管理 2005年第6期24卷 119-126页

作者： Bruce lindsay Jon k.ttenring David Siegmund 缪柏其中国科学技术大学统计与金融系安徽合肥230026

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关键词：统计学二十一世纪统计教育教育系统短缺问题教师队伍统计教学再教育

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统计学:二十一世纪的挑战和机遇(Ⅲ)

数理统计与管理 2005年第5期24卷 112-125页

作者： Bruce lindsay Jon k.ttenring David Siegmund 缪柏其单位不详

统计学作为一门学科，它的一个显著特征就是它与整个自然科学、社会科学和技术的相互作用。这一节主要阐述统计学在广泛的领域内对于人类提高认识所起的作用。

关键词：统计学二十一世纪自然科学相互作用社会科学

Recent Advances in the Small Mammal Biostratigraphy and Magnetostratigraphy of Lanzhou Basin

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Chinese Science Bulletin 1999年第S1期44卷 105-118页

作者： LawrenceJ.FLYNN Will DOWNS NeilOPDYk. HUANGk.inian Everett lindsay Peabody Museum Harvard University Cambridge MA 02138 USA Bilby Research Center Northern Arizona University Flagstaff AZ 86011 USA Department of Geology University of Florida Gainesville FL 32611 USA Department of Geosciences University of Arizona Tucson AZ 85721. USA

The consensus view among geologists is that the Lanzhou Basin sequence of sedimentscontains the Oligocene/Miocene boundary, but where this occurs is unk.own. Indeed, this is thecrux of the issues concerning mid-Tertiary paleontology in Asia: what fauna corresponds with thistime? What turnover events or distinctive taxa signal the beginning of the Miocene epoch? Oncek.own, this will be of broad usefulness because vertebrate-bearing deposits are widespread in Asiaand can be used to date basin sediments. Lanzhou and other basins permit a means of correlating tothe time scale by using fauna and paleomagnetic data locally, and ultimately radiometric data fromdistant localities, to develop a precise biochronology. Herein, we summarize faunal constraints,primarily those of small mammal taxa, on correlation of the Lanzhou magnetozone sequence to themagnetic time scale. We conclude that the lower part of the Xianshuihe Formation contains theOligocene/Miocene boundary, and that the top of the formation, both in the south and north partsof the basin, is middle Miocene in age. Rodents from lower white sand units of the XianshuiheFormation, correlate to the Xiejia assemblage of the Xining Basin, Qinghai Province, and are early,but not earliest, Miocene age. The implication for rodent faunas of the epoch boundary is that theyretained a mainly "Oligocene" composition, and that other presumed late Oligocene assemblagesmay be, in fact, early Miocene in age. The Lanzhou appearance of Proboscidea is 19-18 Ma, asexpected.

关键词： Oligocene Miocene Gansu China biostratigraphy biochronology paleomagnetsim

Obesity Appears to Impact Male Fertility by Degrading Overall Semen Quality Rather than Individual Semen Parameters

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Open Journal of Obstetrics and Gynecology 2014年第15期4卷 917-923页

作者： Joseph Petty Sami Jabara Samuel Prien lindsay Penrose Department of Animal and Food Sciences Texas Tech University Lubbock USA Department of Obstetrics and Gynecology Texas Tech University Health Sciences Center Lubbock USA

Obesity has become a well-recognized medical issue. However its exact role in male infertility remains unclear. The objective of the current study was to determine if an increase inBMIis associated with an increase in semen parameter abnormalities and if this relationship was influenced by other patient activities. Charts were reviewed for one hundred and thirty-three male patients who had also undergone a complete initial office face to face interview, as part of an infertility evaluation and a semen analysis. As part of standard patient care, all patients answered a detailed questionnaire regarding demographics, exposures, medical and reproductive history as part of their infertility evaluation. Patients were grouped according toBMIas normal (20 - 24 k./m2), overweight (25 - 30 k./m2), or obese (>30 k./m2). Semen analysis parameters analyzed included: morphology, volume, concentration, percent motility, and agglutination. While some parameters suggested trends, results were similar between the normal, overweight, and obeseBMI, for concentration (P= 0.18), volume (P = 0.845), motility (P = 0.06);% Positive agglutination: 12%, 7%, 7%?(P = 0.668) and % normal morphology (P = 0.083). Unlik. a number of previous studies, results indicate that there is no statistically significant association betweenBMIand any of the individual semen parameters tested. Raw data suggested a trend for decreasing concentration with increasingBMI. Further, data also suggested equal numbers of oligospermics in each group. However, when the data look.d at globally rather than on the effects on individually parameters (total number of normal motile sperm cells—NMS), functional sperm cells decreased with increasing BMI. None of these factors appeared to be affected by other patient factors. Collectively these data suggest that obesity has a multifactorial effect on male fertility;possibly due to relationships with the hormone cascade, body composition and potentially testis temperature regulati

关键词： Body Mass Index Obesity Semen Analysis Sperm Morphology

Wind Power Uncertainty and Power System Performance

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Engineering（科研） 2013年第10期5卷 41-51页

作者： C. lindsay Anderson Judith B. Cardell Departmentof Biological and Environmental Engineering Cornell University Ithaca USA Pick.r Engineering Program and Department of Computer Science Smith College Northampton USA

The penetration of wind power into global electric power systems is steadily increasing, with the possibility of 30% to 80% of electrical energy coming from wind within the coming decades. At penetrations below 10% of electricity from wind, the impact of this variable resource on power system operations is manageable with historical operating strategies. As this penetration increases, new methods for operating the power system and electricity mark.ts need to be developed. As part of this process, the expected impact of increased wind penetration needs to be better understood and quantified. This paper presents a comprehensive modeling framework. combining optimal power flow with Monte Carlo simulations used to quantify the impact of high levels of wind power generation in the power system. The impact on power system performance is analyzed in terms of generator dispatch patterns, electricity price and its standard deviation, CO2 emissions and amount of wind power spilled. Simulations with 10%, 20% and 30% wind penetration are analyzed for the IEEE 39 bus test system, with input data representing the New England region. Results show that wind power predominantly displaces natural gas fired generation across all scenarios. The inclusion of increasing amounts of wind can result in price spik. events, as the system is required to dispatch down expensive demand in order to maintain the energy balance. These events are shown to be mitigated by the inclusion of demand response resources. Benefits include significant reductions in CO2 emissions, up to 75% reductions at 30% wind penetration, as compared to emissions with no wind integration.

关键词： Wind Power Power System Operations Variable Energy Resources Demand Response