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Murine model to study brain,behavior and immunity during hepatic encephalopathy

World Journal of Hepatology 2014年第4期6卷 243-250页

作者： lindisley ferreira gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes Laboratório de Imunobiofotonica Department of MorphologyICBUFMGBelo Horizonte 31270-901Brazil School of Medicine UFMGBelo Horizonte 31270-901Brazil Department of Physiology ICBUFMGBelo Horizonte 31270-901Brazil Department of Morphology UFMGBelo Horizonte 31270-901Brazil Department of Biochemistry and Immunology UFMGBelo Horizonte 31270-901Brazil

AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the ***:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital *** was evaluated using prolonged prothrombin and partial thromboplastin *** parameters were measured through tail *** levels were quantified in serum and brain ***(EEG) and psychomotor activity score were performed to show brain *** edema was evaluated using magnetic resonance ***:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver *** intense hepatic neutrophil accumulation occurred in response to TAA-induced liver *** led to mice mortality and weight loss,which was associated with severe ***,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance *** agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in *** this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction ***:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment.

关键词： Hepatic encephalopathy Liver injury Thioacetamide Neurological dysfunction Neuropsychomotor abnormalities Intracranial hypertension Cerebral herniation

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Ex-Patients with COVID-19: Observations after Healing and Its Consequences*

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Open Journal of Epidemiology 2021年第1期11卷 31-36页

作者： José Humberto Cardoso Resende Aline Correia Barbosa Arley Braz gomides Daniel Asafe ferreira Rocha Gabriela Costa Santos Helena Beatriz Gonç alves Pô rto Mariana Palmeira Dias De Souza Rainy da Silva Rogério Tágara Alessandra Oliveira Kamimura Emí dio Silva Falcã o Brasileiro Alfredo Nasser University Aparecida de Goi&#226 nia GO Brazil

During the SARS-Cov-2 or COVID-19 clinical course pandemic of the coronavirus family, we observed symptoms of the respiratory tract, fever, cough, sore throat, and fatigue. The most common symptoms were loss of smell and taste and, when aggravated, it could develop into pneumonia and even death. We selected 40 former COVID-19 patients, who answered a questionnaire with questions about the symptoms and complications after they were cured and which symptoms remained or appeared after the total isolation quarantine for a specific time. Among the answers, the most cited was about “forgetting”. Another observation noted was the number of cases in children, which surprised us, considering that, at the beginning of the pandemic, the danger was more related to the elderly population and those with comorbidities.

关键词： Corona COVID Disease Infection Pandemic Pneumonia Thrombosis

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Ex-Patients with COVID-19: Observations after Healing and Its Consequences

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Open Journal of Epidemiology（流行病学期刊） 2021年第1期

作者： José Humberto Cardoso Resende Aline Correia Barbosa Arley Braz gomides Daniel Asafe ferreira Rocha Gabriela Costa Santos Helena Beatriz Gonçalves Pôrto Mariana Palmeira Dias De Souza Rainy da Silva Rogério Tágara Alessandra Oliveira Kamimura Emídio Silva Falcão Brasileiro

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