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中国临床药理学杂志 2024年第9期40卷 1371-1371页

作者： PALMIERI C linden H BIRRELL S N 王超群

雄激素受体在雌激素受体阳性乳腺癌中具有抑制肿瘤的作用。本研究评估了enobosarm(一种口服选择性雄激素受体调节剂)在雌激素受体(ER)阳性、人类表皮生长因子受体2(HER2)阴性和雄激素受体(AR)阳性疾病的妇女中的活性和安全性。

关键词：激素受体阳性晚期乳腺癌抑制肿瘤 G200 平行设计

First-principles search of hot superconductivity in La-X-H ternary hydrides

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npj Computational Materials 2022年第1期8卷 1-8页

作者： Simone Di Cataldo Wolfgang von der linden Lilia Boeri Institute of Theoretical and Computational Physics Graz University of TechnologyNAWI Graz8010GrazAustria Dipartimento di Fisica Sapienza Universitàdi Roma00185RomaItaly Centro Ricerche Enrico Fermi Via Panisperna89a00184RomaItaly

Motivated by the recent claim of hot superconductivity with critical temperatures up to 550 K in La + x hydrides,we investigate the high-pressure phase diagram of compounds that may have formed in the experiment,using first-principles calculations for evolutionary crystal structure prediction and *** from the hypothesis that the observed T_(c) may be realized by successive heating upon a pre-formed LaH_(10) phase,we examine plausible ternaries of lanthanum,hydrogen and other elements present in the diamond anvil cell: boron,nitrogen,carbon,platinum,gallium,*** find that only boron and,to a lesser extent,gallium form metastable superhydride-like structures that can host high-T_(c) superconductivity,but the predicted T_(c)’s are incompatible with the experimental *** results indicate that,while the claims of hot superconductivity should be reconsidered,it is very likely that unknown H-rich ternary or multinary phases containing lanthanum,hydrogen,and possibly boron or gallium may have formed under the reported experimental conditions,and that these may exhibit superconducting properties comparable,or even superior,to those of currently known hydrides.

关键词： hydrides boron superconductivity

Endocrine impact of Helicobacter pylori:Focus on ghrelin and ghrelin o-acyltransferase

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World Journal of Gastroenterology 2011年第10期17卷 1249-1260页

作者： Penny L Jeffery Michael A McGuckin Sara K linden Mucosal Diseases Program Mater Medical Research InstituteMater Health Services Mucosal Immunobiology and Vaccine Center Sahlgrenska AcademyUniversity of Gothenburg

Ghrelin is predominantly produced by the gastric enteroendocrine cell compartment and is octanoylated by the recently discovered ghrelin o-acyltransferase （GOAT） before secretion into the bloodstream. This octanoylation is essential for many of the biological properties of ghrelin including appetite stimulation and anti-inflammatory properties as only the acylated form of ghrelin binds to the ghrelin receptor, the growth hormone secretagogue receptor （GHS-R）. Given the gastric location of ghrelin production, it is perhaps not surprising that insult to the gastric mucosa affects circulating ghrelin levels in humans. Helicobacter pylori （H. pylon） infects more than fifty percent of the world＇s population and once established within the gastric mucosa, can persist for life. Infection is associated with chronic gastritis, gastric atrophy and ulceration, reduced appetite and a lower body mass index （BMI）. The large majority of studies investigating levels of circulating ghrelin and ghrelin expression in the stomach in patients with H. pylori infection indicate that the bacterium has a negative impact on ghrelin production and/or secretion. Eradication of infection restores ghrelin, improves appetite and increases BMI in some studies, however, a causative relationship between H. pylori-associated serum ghrelin decline and food intake and obesity has not been established. Most studies measure total ghrelin in the circulation although the measurement of the ratio of acyl/total ghrelin gives a clearer indication that the ghrelin acylation process is altered during infection and atrophy. GOAT is essential for the production of biologically-active, acyl ghrelin and the impact of H. pylori on GOAT expression and activity will be highly informative in the future.

关键词： Appetite Ghrelin Ghrelin o-acyltransferase Helicobacterpylori Infection Inflammation Obesity

PHOTOCURING STUDY OF NEW DENTAL RESINS BASED ON MULTIFUNCTIONAL ACRYLIC ISOCYANURATE BY PHOTOCALORIMETRY

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Chinese Journal of Polymer Science 1999年第5期17卷 411-415页

作者：聂俊 L.A.linden J.F.Rabek Institute of Photographic Chemistry Chinese Academy of Sciences Beijing 100101 China Department of Dental Biomaterials Science Karolinska Institute S14104 Huddinge Stockholm

Photocuring of new dental resins composed of tri(2-hydroxyethyl) isocyanurate triacrylate (THITA) alone and its mixtures with trimethylolpropane triacrylate (TMPTA) or pentaerythritol triacrylate (PETA) initiated by camphorquinone/amine system was studied by photocalorimetry. Among several different amines as coinitiators, 2-ethyl-4-dimethylaminobenzoate (AM-3), N,N-dimethylbenzylamine (AM-5) and 2,4,6-[tri(dimethylaminomethyl)]phenol (AM-6) are most effective. Upon irradiation, photopolymerization can occur immediately and no induction period appears in N-2 nor in air. Comparing the THITA/TMPTA and THITA/PETA mixtures, the parameters of photopolymerization and hardness of photocured samples show a small difference and only change slightly with varying molar ratios of mixture. In the presence of inorganic filler, the hardness of photocuring resins is almost the same as that for commercial products.

关键词： multifunctional acrylates photocuring dental resin network

The impact of prehospital blood sampling on the emergency department process of patients with chest pain:a pragmatic non-randomized controlled trial

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World Journal of Emergency Medicine 2023年第4期14卷 257-264页

作者： Johan L.van Nieuwkerk M.Christien van der linden Rolf J.Verheul Merel van Loon-van Gaalen Marije Janmaat Naomi van der linden Emergency Department Haaglanden Medical Centre&Emergency Medical Services Haaglandenthe Hague 2501 CBthe Netherlands Research and Development Haaglanden Medical Centrethe Hague 2501 CKthe Netherlands Laboratory Services Haaglanden Medical Centrethe Hague 2501 CKthe Netherlands Emergency Department Haaglanden Medical Centrethe Hague 2501 CKthe Netherlands Faculty of Health University of Applied Sciences LeidenLeiden 2300 AJthe Netherlands Faculty of Technology Policy and ManagementDelft University of TechnologyDelft 2628 BXthe Netherlands

BACKGROUND:In patients with chest pain who arrive at the emergency department(ED)by ambulance,venous access is frequently established prehospital,and could be utilized to sample *** blood sampling may save time in the diagnostic *** this study,the association of prehospital blood draw with blood sample arrival times,troponin turnaround times,and ED length of stay(LOS),number of blood sample mix-ups and blood sample quality were ***:The study was conducted from October 1,2019 to February 29,*** patients who were transported to the ED with acute chest pain with low suspicion for acute coronary syndrome(ACS),outcomes were compared between cases,in whom prehospital blood draw was performed,and controls,in whom blood was drawn at the *** analyses were used to assess the association of prehospital blood draw with the time ***:Prehospital blood draw was performed in 100 *** 406 patients,blood draw was performed at the *** blood draw was independently associated with shorter blood sample arrival times,shorter troponin turnaround times and decreased LOS(P0.05).CONCLUSION:For patients with acute chest pain with low suspicion for ACS,prehospital blood sampling is associated with shorter time intervals,while there were no significant differences between the two groups in the validity of the blood samples.

关键词： Blood specimen collection Crowding Emergency medical services Troponin

In-silico synthesis of lowest-pressure high-T_(c) ternary superhydrides

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npj Computational Materials 2022年第1期8卷 1119-1125页

作者： Roman Lucrezi Simone Di Cataldo Wolfgang von der linden Lilia Boeri Christoph Heil Institute of Theoretical and Computational Physics Graz University of TechnologyNAWI Graz8010GrazAustria Dipartimento di Fisica Sapienza Universitàdi Roma00185RomeItaly Enrico Fermi Research Center Via Panisperna 89 A00184RomeItaly

We report the theoretical prediction of two high-performing hydride superconductors BaSiH_(8)and SrSiH_(8).They are thermodynamically stable above pressures of 130 and 174 GPa,respectively,and metastable below *** anharmonic phonon calculations,we determine the minimum pressures of dynamical stability to be around 3 GPa for BaSiH8 and 27 GPa for SrSiH_(8),and using the fully anisotropic Migdal-Eliashberg theory,we predict Tc’s around 71 and 126 K,*** also introduce a method to estimate the lowest pressure of synthesis,based on the calculation of the enthalpy barriers protecting the BaSiH_(8)Fm3¯m structure from decomposition at various *** kinetic pressure threshold is sensibly higher than the one based on dynamic stability,but gives a much more rigorous limit for synthesizability.

关键词： synthesis stability high

Markets in crypto‑assets regulation:Does it provide legal certainty and increase adoption of crypto‑assets?

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Financial Innovation 2023年第1期9卷 509-538页

作者： Tina van der linden Tina Shirazi Faculty of Law Transnational Legal StudiesVrije Universiteit Amsterdam1081 HV AmsterdamThe Netherlands Zurich Switzerland

This study discusses the European Union’s proposal for a Regulation on Markets in Crypto-Assets,now subject to formal approval by the European *** objective is to explore whether it will positively impact the adoption of crypto-assets in the financial *** use of crypto-assets is ***,some stakeholders in the financial service sector remain skeptical and hesitant to adopt assets that are yet to be defined and have an unclear legal *** regulatory uncertainty has been identified as the primary reason for the reluctant *** proposed regulation(part of the EU’s Digital Finance Strategy)aims to provide this legal certainty for currently unregulated *** study investigates whether or not the proposed regulation can be expected to have the intended effect by reviewing the proposed regulation itself,the opinions and reactions of the various stakeholders,and secondary *** reveal that such regulation will most likely not accelerate the adoption of crypto-assets in the EU financial services sector,at least not sufficiently or as *** suggestions are made to improve the proposal.

关键词： MiCA regulation Crypto-assets Legal certainty Blockchain Distributed ledger technology Utility tokens Stablecoins Asset-referenced tokens e-money tokens

Current Climate Data Rescue Activities in Australia

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Advances in Atmospheric Sciences 2016年第12期33卷 1323-1324页

作者： linden ASHCROFT Rob ALLAN Howard BRIDGMAN Joelle GERGIS Christa PUDMENZKY Ken THORNTON Centre for Climate Change Universitat Rovira i Virgili Tortosa 43500 Spain Met Office hadley Centre Exeter EX13PB United Kingdom School of Environmental and Life Sciences The University of Newcastle New South Wales 2300 Australia School of Earth Sciences The University of Melbourne Victoria 3010 Australia International Centre for Applied Climate Sciences University of Southern Queensland Toowoomba 4350 Australia Cultural Collections The University of Newcastle New South Wales 2300 Australia

1. Introduction Recovering historical instrumental climate data is crucial for identifying long-term climate variability and change, putting present climate into context and constraining future climate projections （Brunet and Jones, 2011）. In other words, to understand the future, we need to improve our understanding of the past.

关键词： over ENSO Current Climate Data Rescue Activities in Australia

Just Java /++Peter van der linden.

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Exploring attendance at emergency departments for children with non-urgent conditions in Turkey: a qualitative study of parents and healthcare staff perspectives

1996年

作者： Peter van der linden.

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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Emergency and Critical Care Medicine 2022年第2期2卷 50-60页

作者： Ahmet Butun Fiona Lynn Jennifer McGaughey Katrina McLaughlin Mark linden Faculty of Health Sciences Mardin Artuklu UniversityKampus YerleskesiArtuklu/MardinTurkey School of Nursing and Midwifery Queen’s University BelfastMedical Biology CentreBelfastNorthern Ireland School of Psychology Queen’s University BelfastDavid Keir BuildingBelfastNorthern Ireland

Background:Overcrowding in Emergency Departments(EDs)is a significant global concern with negative consequences for patients,healthcare staff,and healthcare *** use of EDs by parents of children with non-urgent conditions is associated with overcrowding,higher healthcare costs,lower quality of care,and longer waiting *** in this area has largely been conducted in high-income countries,with a dearth of work originating in middle and low-income *** aim of this study was to explore the reasons for parents attending EDs with their child for non-urgent conditions in ***:Semi-structuredinterviews wereconductedwith 13parents,15 EDstaff,and10GeneralPractitioners(GPs)in2 regions of Turkey between March and May *** were analyzed using the principles of grounded ***:The findings were classified into 5 core categories:(1)parents’feelings,knowledge,and perceived inability to provide self-care;(2)perceived limitationsofhealthcare services,system,and staff;(3)parents’preferencesforhospital andED services;(4)adverse impact on ED services;and(5)perceived needs for ***:This is the first study conducted in a middle-income country regarding parental reasons for using the ED for non-urgent *** efforts must be made to reduce unnecessary visits to the ED to better meet service user needs and to increase the satisfaction of both parents and healthcare *** findings of this study may inform healthcare providers,policymakers,healthcare staff,and researchers to design interventions in order to mitigate overcrowding in the ED.

关键词： Emergency departments Healthcare staff experiences Non-urgent Overcrowding Parent experiences Qualitative research