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Functional role of anion channels in cardiac diseases

Acta Pharmacologica Sinica 2005年第3期26卷 265-278页

作者： LuisLHLIU NathanBOZEAT ZMaggieHUANG SunnyYXIANG lindaye JosephRHUME Center of Biomedical Research Excellence Department of Pharmacology School of Medicine University of Nevada Reno Nevada 89557-0270 USA Center of Biomedical Research Excellence Department of Pharmacology School of Medicine University of Nevada Reno Nevada 89557-0270 USA Center of Biomedical Research Excellence Department of Pharmacology School of Medicine University of Nevada Reno Nevada 89557-0270 USA Center of Biomedical Research Excellence Department of Pharmacology School of Medicine University of Nevada Reno Nevada 89557-0270 USA Center of Biomedical Research Excellence Department of Pharmacology School of Medicine University of Nevada Reno Nevada 89557-0270 USA Center of Biomedical Research Excellence Department of Pharmacology School of Medicine University of Nevada Reno Nevada 89557-0270 USA

In comparison to cation (K+,Na+,and Ca2+) channels,much less is currentlyknown about the functional role of anion （Cl-） channels in cardiovascular physiol-ogy and *** the past 15 years,various types of Cl-currentshave been recorded in cardiac cells from different species including *** Cl-channels described to date may be encoded by five different Cl-chan-nel genes:the PKA- and PKC-activated cystic fibrosis tansmembrane conduc-tance regulator （CFTR）,the volume-regulated CLC-2 and CIC-3,and the Ca2+-activated CLCA or *** studies using multiple approaches toexamine the functional role of Cl-channels in the context of health and diseasehave demonstrated that Cl-channels might contribute to:1) arrhythmogenesis inmyocardial injury;2) cardiac ischemic preconditioning;and 3) the adaptive re-modeling of the heart during myocardial hypertrophy and heart ***,anion channels represent very attractive novel targets for therapeutic approachesto the treatment of heart *** evidence suggests that Cl-channels,like cation channels,might function as a multiprotein complex or functional *** the post-genome era,the emergence of functional proteomics has necessitateda new paradigm shift to the structural and functional assessment of integrated Cl-channel multiprotein complexes in the heart,which could provide new insight intoour understanding of the underlying mechanisms responsible for heart diseaseand protection.

关键词： anion channel cardiovascular system physiology heart disease blood pressure

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CYSTIC FIBROSIS TRANSDUCTANCE REGULATOR IS INVOLVED IN MOUSE HEART ISCHEMIC PRECONDITIONING

CYSTIC FIBROSIS TRANSDUCTANCE REGULATOR IS INVOLVED IN MOUSE...

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中国药理学会第八次全国代表大会暨全国药理学术会议

作者：陈红 ConorMcGuckin lindaye SusanTamowski PaulScowen Department of Pharmacology Second Military Medical University Shanghai China Center of Biomedical Research Excellence Department of Pharmacology University of Nevada School of Medicine Reno NV USA

Background: There are some evidence suggest that cystic fibrosistransmembrane conductance regulator (CFTR), a chloride channel, may beinvolved in ischemic preconditioning (IPC). We used isolated heartperfusion preparation from wild-type (WT) and CFTR knockout mice (CFTR-/-)to test whether activation of CFTR plays a role in early IPC. Methods:Hearts were isolated from WT mice (8 weeks of age) and perfused in theLangendorff mode. The hearts were subjected to 30 min global ischemiafollowed by 40 min reperfusion (Ischemia control), or three cycles of 5

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