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Journal of Behavioral and Brain s.ience 2014年第6期4卷 268-283页

作者： linda s. st-pierre Michael A. Pers.nger Behavioural Neuros.ience Program Laurentian University Sudbury Canada

Prepubes.ent female rats.treated with the atypical neuroleptic acepromazine but not ketamine, prazos.n, or doxepin, after lithium/pilocarpine-induced s.izures.gradually became obes. over their lifetimes.if s.ontaneous.s.izures.developed. Mild increas.s.in weight gain were induced when prepuberal females.were given pilocarpine and acepromazine while being expos.d briefly (1.5 hr) to a frequency-modulated magnetic field known to induce s.izures. Weekly (1.5 hr) expos.res.to phys.ologically-patterned magnetic fields.over 36 wks.had no effect on weight gain while continuous.peris.izure expos.re to 50 Hz fields.above about 1 μT facilitated mild weight gains.and protracted aggres.ion. Perinatal expos.re to a very weak, a 7 Hz magnetic field or a nitric oxide inhibitor retarded the weight gain induced by the obes.ty procedure. Thes. res.lts.indicate that s.nergis.s.during a s.ngle epis.de between neuronal electrical lability and pharmacological s.ates.can initiate a proces. of weight gain that progres.es.to extreme obes.ty. We s.gges. that at leas. a component of the global “epidemic of obes.ty” could be related to a s.nergis. between the ins.dious.emergence of amplitude modulations.within biologically compatible electromagnetic frequencies.from the proliferation of communication s.s.ems.and the pervas.ve utilization of pharmacology to treat trans.ent dis.rders.of ontogeny within the human population.

关键词： Obes.ty Drug-Induce Obes.ty Weak Magnetic Fields Drug-Magnetic Field s.nergis.s

Is.There a Geomagnetic Component Involved with the Determination of G?

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International Journal of Geos.iences 2014年第4期5卷 450-452页

作者： Michael A. Pers.nger linda s. st-pierre Laurentian Univers.ty Sudbury Canada

We compared the s.all quantitative changes.(range) in G over repeated meas.res.(days. with recently improved methods.of determinations.and thos. recorded over 20 years.ago. The range in the Newtonian cons.ant of gravitation G is.us.ally in the order of 400 ppm as.reflected in experimentally-determined values. The moderate s.rength negative correlation between daily fluctuations.in G, in the range of 3 × 10-3 of the average value, and an index of global geomagnetic activity reported by Vladimirs.y and Bruns.in 1998 was.als. found for the daily fluctuations.in the angular deflection θ (in arcs.conds. and geomagnetic activity within 24 hr for the Quinn et al. 2013 data. A temporal coupling between increas.s.of geomagnetic activity in the order of 10-9 T with decreas.s.in G in the order of 10-14 m3·kg-1·s.2 could s.gges. a recondite s.ared s.urce of variance. The energy equivalence for this.change in G and geomagnetic activity within 1 L of water is.~3 × 10-14 J.

关键词： Gravitational Cons.ant Variations Geomagnetic Activity Energy Convergence Electromagnetic-Gravitational Interactions

Abs.nce of Quantitative Improvement in Neurops.chological Profiles.in Patients.Who Exhibit Moderate Brain Impairment: Comparis.ns.of Cros.-s.ctional and Longitudinal Data (1 through 4 Years.Pos.-Injury)

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Journal of Behavioral and Brain s.ience 2013年第2期3卷 225-238页

作者： s.ndra G. Tiller linda s. st-pierre Michael A. Pers.nger Clinical Neurops.chology Laboratory Department of Psychology and Behavioural Neuroscience Program Laurentian University Sudbury Canada

A total of 127 adult patients.who had s.s.ained an impact of s.gnificant mechanical energy to their s.ulls.during motor vehicle incidents.were given thorough neurops.chological, cognitive and pers.nality as.es.ments.between 0.5 years.and 4 years.after the event. Cros.-s.ctional analys.s.indicated no s.atis.ically s.gnificant objective changes.in patients.as.a function of yearly intervals. However there was.s.rong evidence of s.gnificant deterioration of neurops.chological proficiency and efficiency between 0.3 to 1.0 years.after the injury. A s.bs.t (n = 20) of patients.who dis.layed moderately s.vere neurops.chological impairment when as.es.ed about 1 year after the injury s.owed no s.atis.ically s.gnificant changes.when reas.es.ed about 1.5 years.later (2.5 years.after the brain trauma). Thes. res.lts.challenge the traditional concept of “recovery” following a traumatic brain injury and indicate that ins.dious.proces.es.that advers.ly affect neurocognitive capacity may emerge 0.5 years.after the trauma. Pos.-hoc analys.s.indicated that the occurrence of uncons.ious.es. or its.duration at the time of the injury minimally affected the magnitude of s.bs.quent indices.of neurops.chological impairment but influenced the incidence of electroencephalographic theta activity during the years.following the injury.

关键词： TBI Neurops.chological Impairment Tes.-Retes. Reliability Pers.nality Electroencephalographic Indicators

An ethically guided preclinical device for phenotyping H_(2)production in laboratory rodents

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Animal Models.and Experimental Medicine 2024年第4期7卷 553-561页

作者： Victor Pas.al-Mous.ellard Emilie Boucher s.éphane Tanguy Philippe Cinquin pierre-Alain Barraud ChloéDavin Cordélia s.lomez-Ihl Dalil Hannani François.Boucher Jean-pierre Alcaraz Univers.ty Grenoble Alpes CNRSUMR 5525VetAgro SupGrenoble INPTIMCGrenobleFrance

Background:Dihydrogen(H_(2))is.produced endogenous.y by the intes.inal microbiota through the fermentation of diet *** the pas. few years.numer-ous.s.udies.have demons.rated the s.gnificant therapeutic potential of H_(2)in various.pathophys.ological contexts.making the characterization of its.production in labora-tory s.ecies.of major preclinical ***:This.s.udy propos.s.an innovative s.lution to accurately monitor H_(2)pro-duction in free-moving rodents.while res.ecting animal welfare *** devel-oped device cons.s.ed of a wire rodent cage placed ins.de an airtight chamber in which the air quality was.maintained,and the H_(2)concentration was.continuous.y *** the airtightnes. and efficiency of the s.s.ems.us.d to control and maintain air quality in the chamber were checked,tes.s.were carried out on rats.and mice with different metabolic phenotypes.over 12 min to 1-h experiments.and repeatedly.H_(2)production rates.HPR)were obtained us.ng an eas. calculation algorithm bas.d on a firs.-order moving ***:HPR in hyperphagic Zucker rats.was.found to be twice as.high as.in control Wis.ar rats.res.ectively,2.64 and 1.27 nmol.s.(−1)per *** addition,the inges.ion of inulin,a dietary fiber,s.imulated H_(2)production in *** were 0.46 nmol.s.(−1)for animals.under control diet and 1.99 nmol.s.(−1)for animals.under inulin ***:The propos.d device coupled with our algorithm enables.fine analys.s.of the metabolic phenotype of laboratory rats.or mice with regard to their endogenous.H_(2)production.

关键词： hydrogen therapy laboratory rodents microbiota molecular hydrogen noninvas.ve monitoring device

Endos.opic treatment of biliopancreatic pathology in patients.with Whipple's.pancreaticoduodenectomy s.rgical variants. Les.ons.learned from s.ngle-balloon enteros.opy-as.is.ed ERCP

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Hepatobiliary & Pancreatic Dis.as.s.International 2024年第5期23卷 509-514页

作者： Rodrigo Garcés.Durán Laurent Monino pierre H Deprez Hubert Pies.evaux Tom G Moreels Department of Gas.roenterology and Hepatology Universitécatholique de LouvainCliniques Universitaires Saint-LucAvenue Hippocrates 101200 BrusselsBelgium

Background: Endos.opic treatment of biliopancreatic pathology is.challenging due to s.rgically altered anatomy after Whipple's.pancreaticoduodenectomy. This.s.udy aimed to evaluate the feas.bility and s.fety of s.ngle-balloon enteros.opy-as.is.ed endos.opic retrograde cholangiopancreatography(s.E-ERCP) to treat biliopancreatic pathology in patients.with Whipple's.pancreaticoduodenectomy s.rgical variants. Methods. We retros.ectively analyzed 106 s.E-ERCP procedures.in 46 patients.with Whipple's.variants. Technical and clinical s.cces. rates.and advers. events.were evaluated. Res.lts. Biliary s.E-ERCP was.performed in 34 patients.and pancreatic s.E-ERCP in 17, including 5 with both indications. From a total of 106 s.E-ERCP procedures. 76 were biliary indication with technical s.cces. rate of 68/76(90%) procedures.and clinical s.cces. rate of 30/34(88%) patients. Mild advers. event rate was.8/76(11%), without s.rious.advers. events. From a total of 106 s.E-ERCP procedures. 30 were pancreatic indication with technical s.cces. rate of 24/30(80%) procedures. P = 0.194 vs. biliary s.EERCP) and clinical s.cces. rate of 11/17(65%) patients. P = 0.016 vs. biliary s.E-ERCP). Mild advers. event rate was.6/30(20%)( P = 0.194 vs. biliary s.E-ERCP), without s.rious.advers. events. After s.E-ERCP failure, endos.opic ultras.und-guided drainage, percutaneous.drainage and redo s.rgery were alternative therapeutic options. Conclus.ons. Biliopancreatic pathology after Whipple's.pancreaticoduodenectomy variants.can be treated us.ng s.E-ERCP without s.rious.advers. events. Technical and clinical s.cces. rates.are high for biliary indications. whereas.clinical s.cces. rate of pancreatic indications.is.s.gnificantly lower. s.E-ERCP can be cons.dered as.firs.-line treatment option in this.patient group with s.rgically altered anatomy.

关键词： Enteros.opy Endos.opic retrograde cholangiopancreatography Pancreaticoduodenectomy s.rgically altered anatomy Whipple’s.procedure

Decompos.tion mechanis.s.of nuclear-grade cationic exchange res.n by advanced oxidation proces.es.s.atis.ical molecular fragmentation model and DFT calculations

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Journal of Environmental s.iences 2024年第1期135卷 433-448页

作者： Xiang Meng pierre Dés.s.uelles.Lejin Xu Department of Nuclear Engineering and Technology School of Energy and Power EngineeringHuazhong University of Science&TechnologyWuhan 430074China CNRs Laboratoire de Physique des Gaz et des PlasmasUniversitéParis-SaclayOrsay 91405France s.ate Key Laboratory of Coal Combus.ion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The treatment and dis.os.l of radioactive was.e are pres.ntly facing great *** ion exchange res.ns.have become a focus.of attention due to their high production and s.rious.environmental *** this.paper,a s.mplified model of cationic exchange res.n is.propos.d,and the degradation proces.es.of cationic res.n monomer initiated by hydroxyl radicals.·OH)are clarified by combining s.atis.ical molecular fragmentation(s.F)model and dens.ty functional theory(DFT)*** prediction of active s.tes.indicates.that the s.O bonds.and the C-s.bond of the s.lfonic group are more likely to react during the *** meta-pos.tion of the s.lfonic group on the benzene ring is.the mos. active s.te,and the benzene ring without the s.lfonic group has.a certain *** C11-C14 and C17-C20 bonds.on the carbon s.eleton,are the mos. eas.ly *** is.als. found that dihydroxy addition and elimination reactions.play a major role in the proces. of des.lfonation,carbon s.eleton cleavage and benzene ring *** decompos.tion mechanis.s.found through the combination of phys.cal models.and chemical calculations.provide theoretical guidance for the treatment of complex polycyclic aromatic hydrocarbons.

关键词： Cationic exchange res.n s.atis.ical molecular fragmentation model Dens.ty functional theory Hydroxyl radical Decompos.tion mechanis.

Mis.ed Pancreaticobiliary Malignancy: The Flaw of the Expedited Cholecys.ectomy

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s.rgical s.ience 2024年第7期15卷 451-464页

作者： Dylan s. Goto Laris.a Fujii-Lau linda L. Wong Department of s.rgery John A. Burns School of Medicine University of Hawaii Honolulu HI USA Department of Medicine John A. Burns School of Medicine University of Hawaii Honolulu HI USA

Background: Early cholecys.ectomy has.been recommended for patients.with acute cholecys.itis.and galls.one pancreatitis. However, patients.with pancreaticobiliary malignancy may pres.nt acutely with s.milar s.mptoms. We hypothes.ze that the diagnos.s.of thes. malignancies.may potentially be delayed as.an unintended cons.quence of expedited cholecys.ectomies. This.s.udy reviews.a cohort of patients.who underwent pancreaticoduodenectomy (PD) to identify thos. who underwent a s.parate cholecys.ectomy before their PD. Methods. We retros.ectively reviewed 162 PDs.performed between 2012 and 2022. Data collected included: demographics. dis.as. etiology and the pres.nce of cholelithias.s. We identified patients.who had a previous.cholecys.ectomy and the time elaps.d before PD as.well as.procedures.done during the interval. We reported detailed cas. s.mmaries.on thos. patients.who had a cholecys.ectomy within 1 year of PD. Res.lts. In the entire cohort, mean age was.65 years. 54% were males. and 83% had a malignant reas.n for PD. Thirty-one patients.had cholelithias.s.with 23 (14%) patients.having had previous.cholecys.ectomy. s.x patients.had cholecys.ectomy within 1 year of PD. They had the following malignancies. ampullary—3, pancreas.1, cholangiocarcinoma—1 and neuroendocrine—1. Four of thes. patients.had expedited cholecys.ectomy on their index hos.ital admis.ion and were later found to have a periampullary malignancy with further work up. Conclus.ons. Pancreaticobiliary malignancies.can be difficult to diagnos., and s.rgeons.s.ould not overlook thes. potential diagnos.s.when cons.dering expedited cholecys.ectomy. Future s.udies.in large cohorts.are needed to identify high ris. candidates.who s.ould undergo more detailed tes.ing to exclude malignancy before proceeding with cholecys.ectomy.

关键词： Cholecys.ectomy Periampullary Malignancy Pancreas.Malignancy Pancreaticoduodenectomy

Hemodynamic management of congenital diaphragmatic hernia:the role of targeted neonatal echocardiography

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World Journal of Pediatric s.rgery 2024年第2期7卷 81-89页

作者： Aimann s.rak linda Mahgoub Jos.ph Y Ting Department of Pediatrics University of AlbertaEdmontonAlbertaCanada

Congenital diaphragmatic hernia(CDH)is.a major congenital anomaly,res.lting from the herniation of abdominal contents.into the thoracic cavity,thereby impeding the proper development of the lungs.and pulmonary *** s.verity correlates.with a s.ectrum of pulmonary hypoplas.a,pulmonary hypertens.on(PHT),and cardiac dys.unction,cons.ituting the pathophys.ological triad of this.complex *** accurate diagnos.s.and effective management of PHT and cardiac dys.unction is.pivotal to optimizing patient *** neonatal echocardiography is.ins.rumental in delivering real-time data crucial for the bes.oke,pathophys.ology-targeted hemodynamic management of CDH-as.ociated PHT.

关键词： congenital targeted neonatal

Re-evaluation of recent res.arch on metabolic utilization of energy in poultry: Recommendations.for a net energy s.s.em for broilers

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Animal Nutrition 2024年第1期16卷 62-72页

作者： Jean Noblet Aye-Cho Tay-Zar s.u-Biao Wu Pairat s.ichana pierre Cozannet pierre-Andre Geraert Mingan Choct INRAE Charoen Pokphand Foods.Public Company Limited (CPF) s.hool of Environmental and Rural s.ience University of New England Adis.eo France s.A.s.

Different energy s.s.ems.have been propos.d for energy evaluation of feeds.for domes.ic animals. The oldes. and mos. commonly us.d s.s.ems.take into account the fecal energy los. to obtain diges.ible energy(DE), and fecal, urinary and fermentation gas.s.energy los.es.to calculate metabolizable energy(ME). In the cas. of ruminants.and pigs. the net energy(NE) s.s.em, which takes.into account the heat increment as.ociated with the metabolic utilization of ME, has.progres.ively replaced the DE and ME s.s.ems.over the las. 50 years. For poultry, apparent ME(AME) is.us.d exclus.vely and NE is.not yet us.d widely. The pres.nt paper cons.ders.s.me important methodological points.for meas.ring NE in poultry feeds.and s.mmarizes.the available knowledge on NE s.s.ems.for poultry. NE prediction equations.bas.d on a common analys.s.of three recent s.udies.repres.nting a total of 50 complete and balanced diets.fed to broilers.are propos.d; thes. equations.including the AME content and eas.ly available chemical indicators.have been validated on another s.t of 30 diets. The equations.are applicable to both ingredients.and complete diets. They rely primarily on an accurate and reliable AME value which then repres.nts.the firs. limiting predictor of NE value. Our analys.s.indicates.that NE would be a better predictor of broiler performance than AME and that the hierarchy between feeds.is.dependent on the energy s.s.em with a higher energy value for fat and a lower energy value for protein in an NE s.s.em. Practical cons.derations.for implementing s.ch an NE s.s.em from the commonly us.d AME or AMEn(AME adjus.ed for zero nitrogen balance) s.s.ems.are pres.nted. In conclus.on, there is.s.fficient information to allow the implementation of the NE concept in order to improve the accuracy of feed formulation in poultry.

关键词： Poultry Feed evaluation Net energy Energy s.s.em

Advancements.in Catalys.s.for Electrochemical Nitrate Reduction: A s.s.ainable Approach for Mitigating Nitrate Pollution: A Review

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Modern Res.arch in Catalys.s 2024年第1期13卷 1-28页

作者： Gerald D. s. Quoie Jr. Jean pierre Bavumiragira Varney Kromah s.ate Key Laboratory of Pollution Control and Res.urces.Reus. College of Environmental Science and Engineering Tongji University Shanghai China Key Laboratory of Yangtze River Water Environment Ministry of Education Tongji University Shanghai China Department of Mining Engineering College of Engineering University of Liberia Monrovia Liberia

Nitrate pollution is.of great importance in both the environmental and health contexts. neces.itating the development of efficient mitigation s.rategies. This.review provides.a comprehens.ve analys.s.of the many catalys.s.employed in the electrochemical reduction of nitrate to ammonia, and pres.nts.a viable environmentally friendly approach to addres. the is.ue of nitrate pollution. Hence, the electrochemical trans.ormation of nitrate to ammonia s.rves.the dual purpos. of addres.ing nitrate pollution in water bodies. and is.a us.ful agricultural res.urce. This.review examines.a range of catalys. materials.s.ch as.noble and non-noble metals. metal oxides. carbon-bas.d materials. nitrogen-doped carbon s.ecies. metal complexes. and s.miconductor photocatalys.s. It evaluates.catalytic efficiency, s.lectivity, s.ability, and overall proces. optimization. The performance of catalys.s.is.influenced by various.factors. including reaction conditions. catalys. s.ructure, loading techniques. and electrode interfaces. Comparative analys.s.was.performed to evaluate the catalytic activity, s.lectivity, Faradaic efficiency, current dens.ty, s.ability, and durability of the catalys.s. This.as.es.ment offers.s.gnificant pers.ectives.on the s.ructural, compos.tional, and electrochemical characteris.ics.that affect the efficacy of thes. catalys.s. thus.informing future inves.igations.and advancements.in this.domain. In addition to mitigating nitrate pollution, the electrochemical reduction of nitrate to ammonia is.in line with s.s.ainable agricultural methods. res.urce cons.rvation, and the utilization of renewable energy res.urces. This.s.udy explores.the factors.that affect the catalytic efficiency, provides.new opportunities.to addres. nitrate pollution, and promotes.the development of s.s.ainable environmental s.lutions.

关键词： Nitrate Pollution Electrochemical Reduction Ammonia s.s.ainable Farming Catalys.s