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Cellular metabolism: A key player in cancer ferroptosis

Cancer Communications 2024年第2期44卷 185-204页

作者： Xianjie Jiang Qiu Peng mingjing Peng linda Oyang Honghan Wang Qiang Liu Xuemeng Xu Nayiyuan Wu Shiming Tan Wenjuan Yang Yaqian Han Jinguan Lin Longzheng Xia Yanyan Tang Xia Luo Jie Dai Yujuan Zhou Qianjin Liao Hunan Key Laboratory of Cancer metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunanP.R.China Public Service Platform of Tumor Organoids Technology ChangshaHunanP.R.China Department of Head and Neck Surgery Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunanP.R.China Hengyang medical School University of South ChinaHengyangHunanP.R.China

Cellular metabolism is the fundamental process by which cells maintain growth and *** produces energy,furnishes raw materials,and intermedi-ates for biomolecule synthesis,and modulates enzyme activity to sustain normal cellular *** metabolism is the foundation of cellular life processes and plays a regulatory role in various biological functions,including pro-grammed cell *** is a recently discovered form of iron-dependent programmed cell *** inhibition of ferroptosis plays a crucial role in tumorigenesis and tumor ***,the role of cellular metabolism,particularly glucose and amino acid metabolism,in cancer ferroptosis is not well ***,we reviewed glucose,lipid,amino acid,iron and sele-nium metabolism involvement in cancer cell ferroptosis to elucidate the impact of different metabolic pathways on this ***,we provided a detailed overview of agents used to induce cancer *** explained that the metabolism of tumor cells plays a crucial role in maintaining intracellu-lar redox homeostasis and that disrupting the normal metabolic processes in these cells renders them more susceptible to iron-induced cell death,resulting in enhanced tumor cell *** combination of ferroptosis inducers and cel-lular metabolism inhibitors may be a novel approach to future cancer therapy and an important strategy to advance the development of treatments.

关键词： cancer therapy cellular metabolism ferroptosis inducer ferroptosis

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Risk profiling in patients undergoing penile prosthesis implantation

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Asian Journal of Andrology 2020年第1期22卷 8-14页

作者： linda m Huynh mohamad m Osman Faysal A Yafi Department of Urology University of CaliforniaIrvine Medical CenterOrangeCA 92868USA

Penile prosthesis implantation is the gold standard of surgical therapy for patients with medication-refractory erectile ***,this umbrella definition includes significant heterogeneity and associated risk profiles that should be candidly discussed and addressed *** associated with operative success and patient satisfaction are often surgery specific;however,risk profiling via patient selection,preoperative optimization,proper device selection,and intraoperative consideration are highly *** examples of common risk profiles include comorbidity(ies)such as cardiovascular disease,diabetes mellitus,prior abdominal surgery,Peyronie's disease,and psychological risk ***,integration of surgeon-and patient-amenable characteristics is key to decreasing risk of infection,complication,and need for ***,patient risk profiling provides a unique context for proper device selection and evidence-based intraoperative considerations.

关键词： patient selection penile prosthesis risk factors

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利妥昔单抗联合GDP方案治疗非霍奇金淋巴瘤患者的效果及对免疫功能的影响

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临床医学研究与实践 2024年第23期9卷 38-41页

作者：钟林达河南科技大学第一附属医院血液内科河南洛阳471000

目的探讨利妥昔单抗联合吉西他滨+顺铂+地塞米松(GDP)方案治疗非霍奇金淋巴瘤患者的效果及对免疫功能的影响。方法选取2020年3月至2022年8月我院收治的106例非霍奇金淋巴瘤患者,根据治疗方案不同将其分为对照组(53例)和观察组(53例)。... 详细信息

目的探讨利妥昔单抗联合吉西他滨+顺铂+地塞米松(GDP)方案治疗非霍奇金淋巴瘤患者的效果及对免疫功能的影响。方法选取2020年3月至2022年8月我院收治的106例非霍奇金淋巴瘤患者,根据治疗方案不同将其分为对照组(53例)和观察组(53例)。对照组采用GDP方案治疗,观察组在对照组基础上加用利妥昔单抗治疗。比较两组的治疗效果。结果观察组的疾病控制率(DCR)为96.23%,高于对照组的84.91%,差异具有统计学意义(Pm(Igm)、补体C3、补体C4、血管内皮生长因子(VEGF)及胸苷激酶-1(TK-1)水平均低于对照组,差异具有统计学意义(P0.05)。结论利妥昔单抗联合GDP方案治疗非霍奇金淋巴瘤患者效果显著,可改善免疫功能,降低血清肿瘤标志物水平,且用药安全性高。

关键词：非霍奇金淋巴瘤利妥昔单抗免疫功能

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ICD-11精神与行为障碍分类在中国的工作进展

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中华精神科杂志 2015年第2期48卷 126-127页

作者：戴云飞肖泽萍赵敏王振徐一峰谢斌 Geoffrey m.reed 上海交通大学医学院附属精神卫生中心 200030 世界卫生组织精神卫生和物质滥用部门

ICD-10是当前国际上应用最普遍的诊断系统,WHO成员国采用ICD系统来确立卫生服务的准入资格,制订相关的政策和法规,同时卫生专业人员以ICD为基础,对健康状况形成相应的概念、提供治疗和评估疗效.目前,WHO正在开展ICD-10的修订工作,并计划... 详细信息

ICD-10是当前国际上应用最普遍的诊断系统,WHO成员国采用ICD系统来确立卫生服务的准入资格,制订相关的政策和法规,同时卫生专业人员以ICD为基础,对健康状况形成相应的概念、提供治疗和评估疗效.目前,WHO正在开展ICD-10的修订工作,并计划在2017年正式颁布实施ICD-11[1].WHO精神卫生和物质滥用部门对发展ICD-11精神与行为障碍分类这一章节提供技术支持和指导,其中包括一系列涉及全球范围的测试和活动,这对于ICD-11精神与行为障碍分类可能的变化具有深远的意义.

关键词：精神卫生行为障碍分类 ICD-10 中国卫生专业人员 ICD系统诊断系统

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Projection on Segre varieties and determination of holomorphic mappings between real submanifolds Dedicated to Professor Sheng GONG on the occasion of his 75th birthday

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Science China mathematics 2006年第11期49卷 1611-1624页

作者： BAOUENDI m S EBENFELT Peter ROTHSCHILD linda P Department of mathematics University of California at San Diego La JollaCA 92093-0112USA

It is shown that a germ of a holomorphic mapping sending a real-analytic generic submanifold of finite type into another is determined by its projection on the Segre variety of the target manifold. A necessary and sufficient condition is given for a germ of a mapping into the Segre variety of the target manifold to be the projection of a holomorphic mapping sending the source manifold into the target. An application to the biholomorphic equivalence problem is also given.

关键词： Segre variety, generic submanifold, Segre mappings, finite type, biholomorphic equivalence.

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糠醛渣增强粗甘油基聚氨酯泡沫性能的研究

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林产化学与工业 2024年第1期44卷 65-73页

作者：付凯阎振丽李梦雨陈玮张琳达常春郑州大学化工学院河南郑州450001 车用生物燃料技术国家重点实验室河南南阳473000 河南省生物基化学品绿色制造重点实验室河南濮阳457000 河南省杰出外籍科学家工作室河南郑州450001

采用一锅法将生物柴油副产物粗甘油(CG)转化为生物基多元醇(CG-polyol),并以糠醛渣(FR)为增强填料,共混发泡制备出一种FR增强生物基聚氨酯(PU/FR)泡沫复合材料。通过对PU/FR泡沫的结构形貌、热稳定性、发泡时间、密度和压缩强度进行表征... 详细信息

采用一锅法将生物柴油副产物粗甘油(CG)转化为生物基多元醇(CG-polyol),并以糠醛渣(FR)为增强填料,共混发泡制备出一种FR增强生物基聚氨酯(PU/FR)泡沫复合材料。通过对PU/FR泡沫的结构形貌、热稳定性、发泡时间、密度和压缩强度进行表征,探究了糠醛渣粒径(0.25 mm、 0.09 mm样品分别标记为FR60和FR180)和添加量对PU/FR泡沫性能的影响。结果表明:通过热转化法合成的CG-polyol酸值为1.9 mg/g、羟值为406 mg/g、黏度为1 092 mPa·s,该多元醇适合用于制备PU泡沫。FR的加入延长了发泡时间,最大上升时间和不粘时间分别由未添加时的29和31 s提高到37和39 s,泡孔结构更加完整,泡孔尺寸减少,破碎现象明显减少。FR添加量≤5%时,可有效提高泡沫的密度和压缩强度;当添加量相同时,FR180填料对泡沫的性能提升更显著;当FR180添加量为5%时制备的PU/FR180-5泡沫复合材料的压缩强度达到最大为0.153 3 mPa,相比未添加FR的泡沫提高了28.1%,此时密度为0.051 0 g/cm~3,导热系数为0.032 8 W/(m·K),复合材料的综合性能较好。同时FR的添加可适当提高PU泡沫材料的热稳定性,相比未添加FR的泡沫的最大热解速率温度(T_(max))453℃,PU/FR180-5泡沫的T_(max)达到463℃。

关键词：糠醛渣粗甘油高值化聚氨酯泡沫

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Integration of Wind and PV Systems Using Genetic-Assisted Artificial Neural Network

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Intelligent Automation & Soft Computing 2023年第2期35卷 1471-1489页

作者： E.Jessy mol m.mary linda Ponjesly College of Engineering NagerkovilKanyakumari629003India

The prominence of Renewable Energy Sources(RES)in the process of power generation is exponentially increased in the recent days since these sources assist in minimizing the environmental contamination.A grid-tied DFIG(Doubly Fed Induction Generator)based WECS(Wind Energy Conversion System)is introduced in this work,in which a Landsman converter is implemented to impro-vise the output voltage of PV without anyﬂuctuations.A novel GA(Genetic Algorithm)assisted ANN(Artiﬁcial Neural Network)is employed for tracking the maximum power from *** the rotor and grid side controllers,the for-mer is implemented by combining the statorﬂux with d-q reference frame and the latter is realized by the PI *** proposed approach delivers better per-formance in the compensation of real and reactive power along with the DC link voltage *** controlling mechanism is veriﬁed in both mATLAB and experimental bench setupby using an emulated wind turbine for the concurrent control of DC link potential,active and reactive *** source current THD is observed as 1.93%and 2.4%for simulation and hardware implementation respectively.

关键词： Wind energy converter double fed induction generator ﬁeld oriented control GA-ANN mPPT DC-link voltage control

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Harmonics mitigation Using mmC Based UPFC and Particle Swarm Optimization

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Intelligent Automation & Soft Computing 2023年第3期35卷 3429-3445页

作者： C.Gnana Thilaka m.mary linda Ponjesly College of Engineering Nagercoil629003India

The application of non-linear loads in the power electronic device causes serious harmonic issues in the power system since it has the intrinsic prop-erty of retrieving harmonic current and reactive power from Alternating Current(AC)supply that leads to voltage *** maintain a reliable powerﬂow in the power system,an innovative Uniﬁed Power Flow Converter(UPFC)is uti-lized in this proposed *** conventional series converter is replaced with the modular multilevel Converter(mmC)that improves the power handling capability and achieves higher modular level with minimized *** shunt compensator assists in minimizing the voltageﬂuctuations and maximizing the voltage stability under different load *** Direct Quadrature(DQ)theory is utilized in this study to separate the harmonic components by generating reference frame *** Proportional Integral(PI)controller aids in maintain-ing the direct current potential difference in the constant mode whereas the Pulse Width modulation(PWm)generator helps in delivering optimized output to the *** gain parameters of PI controller are optimized with the aid of employ-ing Particle Swarm Optimization(PSO).The entire work is validated using mATLAB simulink and the obtained outcomes proves that this new UPFC is highly beneﬁcial in minimizing the distortions with reduced Total Harmonic Distortion(THD)of 2.21%.

关键词： UPFC PI controller PSO mmC DQ theory STATCOm

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Plant conservation in Australia:Current directions and future challenges

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Plant Diversity 2017年第6期39卷 348-356页

作者： linda Broadhurst David Coates CANBR CSIRO National Research Collections Australia Department of Biodiversity Conservation and Attractions

Australia is a large, old and flat island continent that became isolated following the breakup of the Gondwanan super continent. After more than 40-50 m years of independent evolution, approx. 600,000-700,000 species now call Australia home. more than 21,000 of these species are plants, with at least84% of these being endemic. Plant taxa are protected, conserved and managed under a range of legislation at the State-and Territory-level as well as Federally for matters of national significance. This can create issues of misalignment among threatened species lists but generally there is co-operation among conservation agencies to reduce misalignments and to manage species irrespective of jurisdictional borders. Despite significant investment in programs designed to assist the recovery of Australian biodiversity, threatened plants in particular appear to be continuing to decline. This can be attributed to a range of factors including major threatening processes associated with habitat loss and invasive species,lack of public awareness of the cultural and socio-economic value of plant conservation, and our relatively poor understanding of basic species taxonomy and biology, especially for those species that have specific interactions with pollinators, symbionts and herbivores. A recent shift in Federally-based conservation programs has been to identify 30 key plant species for recovery through the setting of measurable targets, improving the support provided to recovery teams and encouraging industry,business and philanthropy to support conservation actions.

关键词： Conservation Plant Australia Threatened species Recovery

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Laboratory results of foam application testing for longwall shield dust control in a simulated environment

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International Journal of Coal Science & Technology 2021年第2期8卷 217-227页

作者： W.R.reed m.R.Shahan Y.Zheng A.mazzella CDC-NIOSH PittsburghPAUSA

There were 37 longwall faces operating in mines in the United States in *** average panel width for these longwalls was approximately 368.5 m(1209 ft).This translates to a range of approximately 170-240 shields per longwall,depending upon the width of *** movement of longwall shields is a significant contributor to respirable dust overexposures to longwall *** is expected to have the potential to reduce this shield dust *** foam is applied to the area on the roof between the coal face and the shield tip after the shearer *** this study,the longwall shield dust simulator was used to test three foam agents for their ability to control dust from longwall shield *** showed that at low-velocity ventilation(≈3.0 m/s(600 fpm))all foam agents were able to produce dust reduction levels of at least 45%.At high-velocity ventilation(≈5.1 m/s(1000 fpm)),the reductions were lower and more variable,ranging from being undeterminable for one foam agent to having 46%-63%reductions for the other two foam agents,with one instance of an increase in dust ***,the use of foam agents can provide longwall shield dust *** factors are roof coverage and the ability of foam to remain on the roof for extended time periods.

关键词： Longwall Shields Foam Respirable Dust Silica Dust

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