检索结果-南通市图书馆

New insights into the cell-and tissue-specificity of glucocorticoid actions

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第2期18卷 269-278页

作者： linda Quatrini Sophie Ugolini Department of Immunology IRCCS Bambino GesùChildren’s HospitalRomeItaly Aix Marseille Univ CNRSINSERMCentre d’Immunologie de Marseille-LuminyMarseilleFrance

Glucocorticoids(GCs)are endogenous hormones that are crucial for the homeostasis of the organism and adaptation to the external *** of their anti-inflammatory effects,synthetic GCs are also extensively used in clinical ***,almost all cells in the body are sensitive to GC *** a result,these mediators have pleiotropic effects,which may be undesirable or detrimental to human ***,we summarize the recent findings that contribute to deciphering the molecular mechanisms downstream of glucocorticoid receptor *** also discuss the complex role of GCs in infectious diseases such as sepsis and COVID-19,in which the balance between pathogen elimination and protection against excessive inflammation and immunopathology needs to be tightly *** understanding of the cell type-and context-specific actions of GCs from the molecular to the organismal level would help to optimize their therapeutic use.

关键词： Glucocorticoids inflammation immune response

A functional paradigm for evaluating culture： An example with cetaceans

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2012年第2期58卷 271-286页

作者： Alison linda GREGGOR Department of Psychology University of California 3210 Tolman Hall Berkeley CA 94720-1650 USA

Nonhuman culture was first considered in nonhuman primates because they are genetically similar to humans. How- ever, evolution is not progressive and therefore many species may occupy niches that favor socially transmitted, group specific behavior. Not surprisingly, evidence for culture has accrued in several taxonomic groups, including cetaceans. If culture is an ada- ptation, it is imperative we understand the factors that favor its formation. Understanding the evolutionary origin of culture will allow for a wider range of species to be studied, including those that are difficult to test in the laboratory. I propose a broad-based functional paradigm for evaluating nonhuman culture; based on the idea that while not all cultural behaviors may garner fitness benefits to the individual, the ecological and social environments in which cultural behaviors evolved must have favored the physical attributes and social learning capabilities that allow for cultural formation. Specifically this framework emphasizes the relationships between social learning, ecology, social systems, and biology in relation to culture. I illustrate the utility of the func- tional paradigm with evidence from the ceteacean group, while setting the stage for a stringent species by species analysis. By means of contextualizing culture, the Functional Paradigm can evaluate a species＇ potential to exhibit culture and can investigate potentially cultural behaviors

关键词： Nonhuman culture Social learning Evolutionary fimction Cetaceans

Using dogs for tiger conservation and research

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2010年第4期5卷 390-396页

作者： linda L.KERLEY Zoological Society of London Regent’s Park LondonUK

This paper is a review of the history,development and efficacy of using dogs in wildlife studies and considers the use of dogs in the research and conservation of wild tigers(Panthera tigris Linnaeus,1758).Using scat detection dogs,scent-matching dogs,law enforcement detection dogs and protection dogs are proven methods that can be effectively used on *** methods all take advantage of the dog’s extremely evolved sense of smell that allows them to detect animals or animal byproducts(often the focus of tiger studies).Dogs can be trained to communicate this information to their handlers.

关键词： conservation detection dogs scats surveys tigers

Evolution of an Eocene–Oligocene Saline Lake Depositional System and Its Controlling Factors, Jianghan Basin, China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Earth Science 2014年第6期25卷 959-976页

作者： Chunju Huang linda Hinnov State Key Laboratory of Biogeology and Environmental Geology School of Earth SciencesChina University of Geosciences Department of Earth and Planetary Sciences Johns Hopkins University

The Upper Eocene–Lower Oligocene Qianjiang Formation of the Jianghan Basin in central China consists of a 4700-m-thick lacustrine succession, containing 1800 m of halite deposits. The maximum thickness of the formation is 4700 m, and includes 1800 m of halite. We have identified eight third-order depositional sequences based on pinch-out and onlap stratigraphic patterns in 2-D and 3-D seismic data and well logs. The basin evolved from a deep to shallow under-filled lake during the Eocene–Oligocene interval. The main rock types are dark mudstones, halite, and siltstone/sandstone in the depocenter, and alternating mudstone and gypsum in shallower areas. The vertical succession indicates a strong sedimentary cyclicity. Depositional facies indicate the presence of two lake system types. Halite developed in a saline lake system, whereas clastic sediments were deposited in freshwater lake systems. The alternating sediment types indicate that the basin cycled repeatedly between saline and freshwater lake systems. This cyclicity was caused by availability of accommodation space that was controlled by a combination of climate change, tectonic subsidence and sediment supply; notably, the highest frequency cycles occurred at Milankovitch timescales controlled by the Earth＇s orbital variations. The cyclic halite plays an important role in generating and preserving oil in the Qianjiang Formation of the Qianjiang depression.

关键词： saline lake depositional sequence Eocene Oligocene Milankovitch cycle Jianghan Basin Qianjiang Formation

Updates in diagnosis and management of pancreatic cysts

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第34期27卷 5700-5714页

作者： linda S Lee Division of Gastroenterology Hepatology and EndoscopyBrigham and Women's HospitalBostonMA 02115United States

Incidental pancreatic cysts are commonly encountered with some cysts having malignant *** most common pancreatic cystic neoplasms include serous cystadenoma,mucinous cystic neoplasm and intraductal papillary mucinous *** stratifying pancreatic cysts is important in deciding whether patients may benefit from endoscopic ultrasound(EUS)or surgical *** should be reserved for patients with malignant cysts or cysts at high risk for developing malignancy as suggested by various risk features including solid mass,nodule and dilated main pancreatic *** may supplement magnetic resonance imaging findings for cysts that remain indeterminate or have concerning features on *** cyst fluid markers including carcinoembryonic antigen,glucose,amylase,cytology,and DNA markers help distinguish mucinous from nonmucinous *** review will guide the practicing gastroenterologist in how to evaluate incidental pancreatic cysts and when to consider referral for EUS or *** presumed low risk cysts,surveillance strategies will be *** pancreatic cysts requires an individualized approach that is directed by the various guidelines.

关键词： Pancreatic cyst Intraductal papillary mucinous neoplasm Endoscopic ultrasound-guided fine needle aspiration Serous cystadenoma Surveillance Carcinoembryonic antigen

Special Issue Introduction-The Whitefly Bemisia tabaci Species Complex and Begomoviruses:Research Progress and Future Prospects

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2012年第2期11卷 171-175页

作者： linda L Walling Department of Botany and Plant Sciences Center for Plant Cell Biology University of California Riverside 92521-0124USA

The whitefly Bemisia tabaci species complex and the begomoviruses they transmit are devastating agricultural pests *** the rapid and further inva-sions by some members of the whitefly species complex into new regions,... 详细信息

关键词： Special Issue Introduction-The Whitefly Bemisia tabaci Species Complex and Begomoviruses

Exercise and oncology:The role of physical activity in disease prevention and health promotion

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2023年第6期12卷 651-652,F0003页

作者： Zan Gao linda Trinh School of Kinesiology University of MinnesotaMinneapolisMN 55455USA Department of Kinesiology Recreationand Sport StudiesThe University of TennesseeKnoxvilleTN 37996USA Faculty of Kinesiology&Physical Education University of TorontoTorontoON M5S 2W6Canada

The field of exercise-oncology has evolved significantly over the past 30 *** studies have examined the role of structured exercise interventions—often incorporating aerobic or resistance training at moderate-to-vigorous intensities,sometimes in conjunction with multi-modal strategies—for individuals living with and beyond cancer.

关键词： prevention promotion oncology

Neoadjuvant chemoradiation therapy and pathological complete response in rectal cancer

在线全文

学校读者我要写书评

暂无评论

Gastroenterology Report 2015年第4期3卷 277-288,I0001页

作者： linda Ferrari Alessandro Fichera Division of General Surgery Department of SurgeryUniversity of Washington Medical CenterSeattleWashington 98195USA

The management of rectal cancer has evolved significantly in the last few *** improvements in local disease control were achieved in the 1990s,with the introduction of total mesorectal excision and neoadjuvant *** 1 evidence has shown that,with neoadjuvant chemoradiation therapy(CRT)the rates of local recurrence can be lower than 6%and,as a result,neoadjuvant CRT currently represents the accepted standard of *** approach has led to reliable tumor down-staging,with 15–27%patients with a pathological complete response(pCR)—defined as no residual cancer found on histological examination of the *** who achieve pCR after CRT have better long-term outcomes,less risk of developing local or distal recurrence and improved *** all these reasons,sphincter-preserving procedures or organ-preserving options have been suggested,such as local excision of residual tumor or the omission of surgery *** local recurrence rate has been stable at 5–6%with this multidisciplinary management method,distal recurrence rates for locally-advanced rectal cancers remain in excess of 25%and represent the main cause of death in these *** this reason,more recent trials have been looking at the administration of full-dose systemic chemotherapy in the neoadjuvant setting(in order to offer early treatment of disseminated micrometastases,thus improving control of systemic disease)and selective use of radiotherapy only in non-responders or for low rectal tumors smaller than 5 cm.

关键词： rectal cancer neoadjuvant chemoradiation therapy pathological complete response

Hemipteran and dipteran pests: Effectors and plant host immune regulators

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2016年第4期58卷 350-361页

作者： Isgouhi Kaloshian linda L.Walling Institute of Integrative Genome Biology and Center for Plant Cell Biology University of California Department of Nematology University of California Department of Botany and Plant Sciences University of California

Hemipteran and dipteran insects have behavioral,cellular and chemical strategies for evading or coping with the host plant defenses making these insects particularly destructive pests worldwide. A critical component of a host plant＇s defense to herbivory is innate immunity. Here we review the status of our understanding of the receptors that contribute to perception of hemipteran and dipteran pests and highlight the gaps in our knowledge in these early events in immune signaling. We also highlight recent advances in identification of the effectors that activate pattern-triggered immunity and those involved in effector-triggered immunity.

关键词： Aphids effectors endosymbionts Hessian fly planthoppers resistance genes