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Outcome of the efficacy of Chinese herbal medicine for functional constipation:A systematic review and meta-analysis

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World Journal of Clinical Cases 2022年第15期10卷 4856-4877页

作者： Zipan Lyu Yibo Fan Yang Bai Tao Liu linda LD Zhong Hui-Feng Liang Teaching and Research Division School of Chinese MedicineHong Kong Baptist UniversityHong Kong SAR 99977China Department of Cardiology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Digestive Endoscope Center Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China The Institute for Science Technology and HumanitiesShanghai University of Traditional Chinese MedicineShanghai 201203China

BACKGROUND Functional constipation(FC)is a common and chronic gastrointestinal disease and its treatment remains *** To evaluate the efficacy and safety of Chinese herbal medicine(CHM)on efficacy rate,global symptoms,bowel movements and the Bristol Stool Scale score in patients with FC by summarizing current available randomized controlled trials(RCTs).METHODS RCTs with CHM to treat FC were identified by a systematic search of six databases from inception to October 20,*** independent reviewers assessed the quality of the included articles and extracted ***-analyses were performed to odds ratio(OR),mean differences(MD)and 95%confidence interval(CI)using random-effects *** analyses and sensitivity analyses were used to explore and interpret the sources of *** funnel plot,Begg’s test and Egger’s test were used to detect publication *** Ninety-seven studies involving 8693 patients were included in this *** was significantly associated with a higher efficacy rate(OR:3.62,95%CI:3.19-4.11,P<0.00001)less severe global symptoms(OR:4.03,95%CI:3.49-4.65,P<0.00001)compared with control treatment,with the low heterogeneity between studies(I2=0%,P=0.76).CHM was also associated with more frequent bowel movements(MD 0.83,95%CI:0.67-0.98,P<0.00001),a lower score on the Bristol Stool Scale(OR:1.63,95%CI:1.15-2.32,P<0.006),and a not significant recurrence rate(OR:0.47,95%CI:0.22-0.99,P=0.05).No serious adverse effects of CHM were *** In this meta-analysis,we found that CHM may have potential benefits in increasing the number of bowel movements,improving stool characteristics and alleviating global symptoms in FC ***,a firm conclusion could not be reached because of the poor quality of the included *** trials with higher quality are required.

关键词： Functional constipation Chinese herbal medicine Efficacy Systematic review Meta-analysis

Plant conservation in Australia:Current directions and future challenges

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Plant Diversity 2017年第6期39卷 348-356页

作者： linda Broadhurst David Coates CANBR CSIRO National Research Collections Australia Department of Biodiversity Conservation and Attractions

Australia is a large, old and flat island continent that became isolated following the breakup of the Gondwanan super continent. After more than 40-50 M years of independent evolution, approx. 600,000-700,000 species now call Australia home. More than 21,000 of these species are plants, with at least84% of these being endemic. Plant taxa are protected, conserved and managed under a range of legislation at the State-and Territory-level as well as Federally for matters of national significance. This can create issues of misalignment among threatened species lists but generally there is co-operation among conservation agencies to reduce misalignments and to manage species irrespective of jurisdictional borders. Despite significant investment in programs designed to assist the recovery of Australian biodiversity, threatened plants in particular appear to be continuing to decline. This can be attributed to a range of factors including major threatening processes associated with habitat loss and invasive species,lack of public awareness of the cultural and socio-economic value of plant conservation, and our relatively poor understanding of basic species taxonomy and biology, especially for those species that have specific interactions with pollinators, symbionts and herbivores. A recent shift in Federally-based conservation programs has been to identify 30 key plant species for recovery through the setting of measurable targets, improving the support provided to recovery teams and encouraging industry,business and philanthropy to support conservation actions.

关键词： Conservation Plant Australia Threatened species Recovery

Prospective observational study to assess the validity of the functional disability score in patients with blepharospasm,hemifacial spasm and synkinesis treated with botulinum toxin injection

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Annals of Eye Science 2023年第3期8卷 41-47页

作者： linda O.Okafor Aaron Jamison Maribel Favor Raman Malhotra Corneoplastic Unit Queen Victoria HospitalEast GrinsteadUK

Background:Benign essential blepharospasm(BEB),aberrant facial nerve degeneration and hemifacial spasm(HFS)are all examples dystonia which,though not life-threatening,can have a significant impact on patient quality of *** need for reliable self-rating surveys to monitor functional disability is *** Blepharospasm Disability Index(BSDI)is already a widely utilised and validated selfrating score for blepharospasm whilst the functional disability score(FDS)requires further *** principle aim of this study is to repeat validation of the FDS against the BSDI,which has been validated by several groups since its original description but only in patients with ***:A randomised blinded prospective cohort study was conducted at a single unit on 38 patients with BEB,aberrant facial nerve degeneration and *** were blinded to complete the FDS followed by the BSDI or the BSDI followed by the FDS with a 30-minute ***:Both the FDS and BSDI were found to be reliable with high internal consistency and test-retest *** scales were also found to be moderately correlated with the Jankovic disease severity ***:This study is the first to use the FDS as a rating scale in patients with HFS and aberrant facial nerve *** is also the first study to formally validate the FDS as an acceptable rating scale for patients with dystonia and in particular it provides validation for its use in patients with HFS and aberrant facial nerve degeneration.

关键词： Blepharospasm botulinum toxin(BoNT) dystonia

An Index-Based Approach to Assess Social Vulnerability for Hamburg, Germany

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International Journal of Disaster Risk Science 2023年第5期14卷 782-794页

作者： Malte von Szombathely Franziska S.Hanf Janka Bareis linda Meier Jürgen Oßenbrügge Thomas Pohl Institute for Geography Center for Earth System Research and SustainabilityUniversität Hamburg20146HamburgGermany Meteorological Institute Center for Earth System Research and SustainabilityUniversität Hamburg20146HamburgGermany Institute for Geography Universität Hamburg20146HamburgGermany Research Unit for Sustainability and Climate Risks Center for Earth System Research and SustainabilityUniversität Hamburg20144HamburgGermany

In this study,we set out to develop a new social vulnerability index(SVI).In doing so,we suggest some conceptual improvements that can be made to existing methodical approaches to assessing social *** make the entanglement of socio-spatial inequalities visible,we are conducting a small-scale study on heterogeneous urban development in the city of Hamburg,*** kind of high-resolution analysis was not previously available,but is increasingly requested by political decision *** can thus show hot spots of social vulnerability(SV)in Hamburg,considering the effects of social welfare,education,and *** doing so,we defined SV as a contextual concept that follows the recent shift in discourse in line with the Intergovernmental Panel on Climate Change’s(IPCC)concepts of risk and *** SVI consists of two subcomponents:sensitivity and coping *** areas of Hamburg were identified using satellite information and merged with the social data units of the *** with high SVI are distributed over the entire city,notably in the district of Harburg and the Reiherstieg quarter in Wilhelmsburg near the Elbe,as well as in the densely populated inner city areas of Eimsbüttel and *** a map at a detailed scale,our SVI can be a useful tool to identify areas where the population is most vulnerable to climate-related *** conclude that an enhanced understanding of urban social vulnerability is a prerequisite for urban risk management and urban resilience planning.

关键词： Climate change adaptation Hamburg Risk approach Social vulnerability Social vulnerability index

A clinical pathway for integrative medicine in the treatment of functional constipation in Hong Kong,China

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Journal of Integrative Medicine 2023年第6期21卷 550-560页

作者： Dong-jue Wei Hui-juan Li Zi-pan Lyu Ai-ping Lyu Zhao-xiang Bian linda LD Zhong School of Chinese Medicine Hong Kong Baptist UniversityHong KongChina School of Biological Sciences Nanyang Technological University637551Singapore

Objective:Functional constipation(FC)is a common intestinal disease *** the presence of criteria such as Roman IV,there is no standardized diagnosis and treatment algorithm in Hong Kong that combines both Western and Chinese medicine *** study integrates current effective and safe diagnosis and treatment methods for FC and provides a clear and scientific pathway for clinical professionals and ***:A systematic search of the PubMed,Cochrane Library,and China National Knowledge Infrastructure databases was performed from their inception to June 30th,2022,collecting the current evidence about the efficacious integrative management for *** organized a meeting of professionals in fields relevant to treatment and management of FC to develop a consensus agreement on clinical pathway ***:We developed a clinical pathway for the treatment of FC based on the most recent published guidelines and consultation with *** pathway includes a hierarchy of recommendations for every step of the clinical process,including clinical intake,diagnostic examination,recommended labs,diagnostic flowchart,and guidance for selection of therapeutic ***:This pathway establishes clinical standards for the diagnosis and treatment of FC using Chinese medicine and Western medicine;it will help to provide high-quality medical services in Hong Kong for patients with FC.

关键词： Functional constipation Clinical pathway Hong Kong Integrative medicine

Cold Plasma:A Potential Alternative for Rice Grain Postharvest Treatment Management in Malaysia

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Rice science 2022年第1期29卷 1-15页

作者： Mohd Fadthul Ikmal MISNAL Norizah REDZUAN Muhamad Nor Firdaus ZAINAL Norhayati AHMAD Raja Kamarulzaman RAJA IBRAHIM linda AGUN School of Mechanical Engineering Faculty of EngineeringUniversiti Teknologi MalaysiaJohor Bahru 81310JohorMalaysia Department of Physics Faculty of ScienceUniversiti Teknologi MalaysiaJohor Bahru 81310JohorMalaysia

Use of pesticides,herbicides and fertilizers is among the techniques to control insect pests and fungal ***,the technique is the major contributor to severe environmental implications in terms of air,water and soil ***,variable inconsistency becomes an important issue in the implementation of inclined bed dryers,leading to significant rice grain *** plasma technology has been widely proposed as a potential alternative for rice grain postharvest treatment management due to the presence of generated ionised gas that eventually produces reactive oxygen species or reactive nitrogen *** species are used to decontaminate foodborne pathogens,mycotoxins and bacterial *** review explores the current literature regarding cold plasma treatment technology,focusing on its efficiency as the microbial decontamination medium and insect pest mortality medium,and on the enhancement functional,nutritional and cooking properties,especially in rice *** studies have successfully demonstrated the ability of cold plasma treatment to significantly reduce the microbial count of foodborne pathogens,detoxify mycotoxins,and control seedborne rice seedling bacterial *** studies have also proved that the implementation of cold plasma technology in postharvest management should be seriously considered for improving rice grain quantity and quality in Malaysia.

关键词： rice grain postharvest management cold plasma microbial decontamination bacterial control

A functional paradigm for evaluating culture： An example with cetaceans

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Current Zoology 2012年第2期58卷 271-286页

作者： Alison linda GREGGOR Department of Psychology University of California 3210 Tolman Hall Berkeley CA 94720-1650 USA

Nonhuman culture was first considered in nonhuman primates because they are genetically similar to humans. However, evolution is not progressive and therefore many species may occupy niches that favor socially transmitted, group specific behavior. Not surprisingly, evidence for culture has accrued in several taxonomic groups, including cetaceans. If culture is an adaptation, it is imperative we understand the factors that favor its formation. Understanding the evolutionary origin of culture will allow for a wider range of species to be studied, including those that are difficult to test in the laboratory. I propose a broad-based functional paradigm for evaluating nonhuman culture; based on the idea that while not all cultural behaviors may garner fitness benefits to the individual, the ecological and social environments in which cultural behaviors evolved must have favored the physical attributes and social learning capabilities that allow for cultural formation. Specifically this framework emphasizes the relationships between social learning, ecology, social systems, and biology in relation to culture. I illustrate the utility of the functional paradigm with evidence from the ceteacean group, while setting the stage for a stringent species by species analysis. By means of contextualizing culture, the Functional Paradigm can evaluate a species’ potential to exhibit culture and can investigate potentially cultural behaviors [Current Zoology58 (2): 271–286, 2012].

关键词：功能评估人文化鲸类动物功能模式非人灵长类动物社会环境进化起源实验室测试

Factors that affect heart rate variability following acute resistance exercise:A systematic review and meta-analysis

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Journal of Sport and Health Science 2022年第3期11卷 376-392页

作者： Sajith U.Marasingha-Arachchige JacoboÁ.Rubio-Arias Pedro E.Alcaraz linda H.Chung UCAM Research Center for High Performance Sport Catholic University of MurciaMurcia 30107Spain LFE Research Group Department of Health and Human PerformanceFaculty of Physical Activity and Sport Science-INEFUniversidad Politécnica de MadridMadrid 28040Spain Faculty of Sport Catholic University of MurciaMurcia 30107Spain

Background:There is controversial evidence regarding the effect of acute resistance exercise(ARE) on heart rate variability(HRV) parameters,which indicates the activities of the cardiac autonomic nervous *** aim of this study was to perform a systematic review and meta-analysis of the literature on the effect of ARE on HRV parameters and identify its possible moderating ***:The PubMed-Medline,Web of Science,SPORTDiscus,and Cochrane Library databases were *** Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA) declaration was followed,and the methodological quality of the studies was *** level of significance was set at p≤***-six studies met the inclusion *** effect analyses between pre-and post-test interventions demonstrated an increase in normalized units low frequency(p <0.001;standardized mean difference(SMD)=0.78;95% confidence interval(95%CI):0.46-1.11) and low frequency/high frequency ratio(p <0.001;SMD=0.82;95%CI:0.64-0.99) and a decrease in standard deviation of the normal-to-normal(NN)interval(p <0.001;SMD=-0.58;95%CI:-0.85 to-0.30),root mean square of the successive differences(p <0.001;SMD=-1.01;95%CI:-1.29 to-0.74),and normalized units high frequency(p <0.001;SMD:-1.08;95%CI:-1.43 to-0.73) following ARE in healthy individuals range:15 ± 1 to 48 ± 2 years;mean ± SD).Results:There were differences between the subgroups in the number of sets used in an exercise(p=0.05) for root mean square of the successive differences,as well as for exercise intensity(p=0.01) and rest between sets(p=0.05) for normalized units high ***,there were differences between the subgroups in training volume for root mean square of the successive differences(p=0.01),normalized units high frequency(p=0.003) and normalized units low frequency(p=0.02).Conclusion:Overall,there was a withdrawal of cardiac parasympathetic and activation of cardiac sympathetic modulations following ARE,and th

关键词： Cardiac Parasympathetic Sympathetic

Current status of disparity in liver disease

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World Journal of Hepatology 2022年第11期14卷 1940-1952页

作者： Tomoki Sempokuya Josh Warner Muaataz Azawi Akane Nogimura linda L Wong Division of Gastroenterology and Hepatology Department of Internal MedicineUniversity of Nebraska Medical CenterOmahaNE 68198United States Department of Internal Medicine University of Nebraska Medical CenterOmahaNE 68198United States Division of Gastroenterology and Hepatology Sanford Center for Digestive HealthSioux Falls 57105SDUruguay Department of Public Health Nagoya City University Graduate School of Medical SciencesNagoya 467-8601AichiJapan Division of Psychiatry and Cognitive-Behavioral Medicine Nagoya City University Graduate School of Medical SciencesNagoya 467-8601AichiJapan Department of Surgery John A.Burns School of MedicineUniversity of Hawaii at ManoaHonoluluHI 96813United States

Disparities have emerged as an important issue in many aspects of healthcare in developed countries and may be based on race,ethnicity,sex,geographical location,and socioeconomic *** liver disease specifically,these potential disparities can affect access to care and outcome in viral hepatitis,chronic liver disease,and hepatocellular *** in hepatologists and medical providers versed in liver disease may amplify these disparities by compromising early detection of liver disease,surveillance for hepatocellular carcinoma,and prompt referral to subspecialists and transplant *** the United States,continued efforts have been made to address some of these disparities with better education of healthcare providers,use of telehealth to enhance access to specialists,reminders in electronic medical records,and modifying organ allocation systems for liver *** review will detail the current status of disparities in liver disease and describe current efforts to minimize these disparities.

关键词： Disparity Transplant Race Age Gender Hepatitis