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Exploring behavioral traits over different contexts in four species of Australian funnel-web spiders

Current Zoology 2023年第6期69卷 766-774页

作者： linda Hernandez Duran David Thomas Wilson Tasmin Lee Rymer College of Science and Engineering James Cook UniversityP.O.Box 6811CairnsQLD 4870Australia Centre for Tropical Environmental and Sustainability Sciences James Cook UniversityCairnsQLD 4870Australia Centre for Molecular Therapeutics Austr alian Institute for Tropical Health and MedicineJames Cook UniversityCairnsQLD 4878Australia

Australian funnel-web spiders are arguably the most venomous spiders in the world,with much research focusing on this aspect of their ***,other aspects related to their life history,ecology and behaviour have been *** the first time,we assessed *** risk-taking behaviour,aggressiveness and activity in the contexts of predation,conspecific tolerance and exploration of a new territory in four species of Australian funnel-web spiders:two are closely related,Hadronyche valida and ***,and two have overlapping distributions but occupy different habitats,*** and Atrax *** also compared behaviors between *** the species level,we found that *** showed consistency in risk-taking behavior when exposed to a predator stimulus,aggressiveness against conspecifics,and exploration of a new *** contrast,in the other species,only *** showed repeatability in the context of exploration of a new *** results suggest that some behavioral traits are likely more flexible than others,and that the repeatability of behaviors may be species-specific in *** we compared species,we found differences in risk-taking behavior and *** study provides novel insights to understanding variation in behavioral traits within and between species of funnel-web spiders,suggesting that some behavioral traits are likely context and/or species dependent,as a result of their evolutionary *** findings provide key insights for understanding the ecological role of behavior and venom deployment in venomous animals,and a greater understanding of behavior in these medically significant and iconic spiders thatareof conservation concern.

关键词： arachnids behavior ecological contexts flexibility mygalomorphae repeatability

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In silico docking analysis of beta-defensin 20 against cation channel sperm-associated protein 1–4 to predict its role in the sperm maturation

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Asian Journal of Andrology 2023年第4期25卷 528-532页

作者： Luluk Yunaini linda Erlina Fadilah Fadilah Dwi Ari Pujianto Doctoral Program for Biomedical Sciences Faculty of MedicineUniversitas IndonesiaJakarta 10430Indonesia Department of Medical Biology Faculty of MedicineUniversitas IndonesiaJakarta 10430Indonesia Department of Medical Chemistry Faculty of MedicineUniversitas IndonesiaJakarta 10430Indonesia Bioinformatics Core Facilities Indonesia Medical Education and Research Institute(IMERI)Faculty of MedicineUniversitas IndonesiaJakarta 10430Indonesia

Beta-defensin 20(DEFB20)is widely expressed in the epididymis with gene features involved in epididymal sperm ***,the action mechanism and function of DEFB20 in sperm maturation are still *** of the important roles of beta-defensin is the ion channel *** cation channel sperm-associated protein(CatSper)alpha is an ion channel protein found on the sperm *** study aimed to investigate the interaction between DEFB20 and CatSper1–4 protein in relation to the sperm maturation *** sequences were obtained from the National Center for Biotechnology Information(NCBI).Protein modeling and validation were carried out by using the Robetta modeling server and the Ramachandran plot *** web server was used for the docking *** results revealed a natural interaction between DEFB20 and CatSper1–*** interaction occurred at the cation channel(close to the casein kinase II),ion transport protein,and kinase c phosphorylation of the CatSper1–4 active *** DEFB20 region interacting with CatSper2–4 was the beta-defensin domain,while with CatSper1 was the non-beta-defensin *** on the analysis,DEFB20 may interact with CatSperαsubunits,particularly CatsSper1,to affect ion channel activity during sperm maturation.

关键词： CatSper DEFB20 docking sperm maturation

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Optical neuroimaging:advancing transcranial magnetic stimulation treatments of psychiatric disorders

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Visual Computing for Industry,Biomedicine,and Art 2022年第1期5卷 268-278页

作者： Shixie Jiang linda L.Carpenter Huabei Jiang Department of Psychiatry and Behavioral Sciences Stanford University School of MedicinePalo Alto CA 94305USA Department of Psychiatry and Human Behavior Butler HospitalAlpert Medical School of Brown UniversityProvidence RI 02903USA Department of Medical Engineering University of South FloridaTampa FL 33613USA

Transcranial magnetic stimulation(TMS)has been established as an important and effective treatment for various psychiatric ***,its effectiveness has likely been limited due to the dearth of neuronavigational tools for targeting purposes,unclear ideal stimulation parameters,and a lack of knowledge regarding the physiological response of the brain to TMS in each psychiatric *** optical imaging modalities,such as functional near-infrared spectroscopy and diffuse optical tomography,are promising tools for the study of TMS optimization and functional targeting in psychiatric *** possess a unique combination of high spatial and temporal resolutions,portability,real-time capability,and relatively low *** this mini-review,we discuss the advent of optical imaging techniques and their innovative use in several psychiatric conditions including depression,panic disorder,phobias,and eating *** further investment and research in the development of these optical imaging approaches,their potential will be paramount for the advancement of TMS treatment protocols in psychiatry.

关键词： Optical imaging Functional near-infrared spectroscopy Diffuse optical tomography Transcranial magnetic stimulation Major depressive disorder Panic disorder Phobia Bulimia nervosa Psychiatric disorders

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Integration of Wind and PV Systems Using Genetic-Assisted Artificial Neural Network

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Intelligent Automation & Soft Computing 2023年第2期35卷 1471-1489页

作者： E.Jessy Mol M.Mary linda Ponjesly College of Engineering NagerkovilKanyakumari629003India

The prominence of Renewable Energy Sources(RES)in the process of power generation is exponentially increased in the recent days since these sources assist in minimizing the environmental contamination.A grid-tied DFIG(Doubly Fed Induction Generator)based WECS(Wind Energy Conversion System)is introduced in this work,in which a Landsman converter is implemented to impro-vise the output voltage of PV without anyﬂuctuations.A novel GA(Genetic Algorithm)assisted ANN(Artiﬁcial Neural Network)is employed for tracking the Maximum power from *** the rotor and grid side controllers,the for-mer is implemented by combining the statorﬂux with d-q reference frame and the latter is realized by the PI *** proposed approach delivers better per-formance in the compensation of real and reactive power along with the DC link voltage *** controlling mechanism is veriﬁed in both MATLAB and experimental bench setupby using an emulated wind turbine for the concurrent control of DC link potential,active and reactive *** source current THD is observed as 1.93%and 2.4%for simulation and hardware implementation respectively.

关键词： Wind energy converter double fed induction generator ﬁeld oriented control GA-ANN MPPT DC-link voltage control

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Harmonics Mitigation Using MMC Based UPFC and Particle Swarm Optimization

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Intelligent Automation & Soft Computing 2023年第3期35卷 3429-3445页

作者： C.Gnana Thilaka M.Mary linda Ponjesly College of Engineering Nagercoil629003India

The application of non-linear loads in the power electronic device causes serious harmonic issues in the power system since it has the intrinsic prop-erty of retrieving harmonic current and reactive power from Alternating Current(AC)supply that leads to voltage *** maintain a reliable powerﬂow in the power system,an innovative Uniﬁed Power Flow Converter(UPFC)is uti-lized in this proposed *** conventional series converter is replaced with the Modular Multilevel Converter(MMC)that improves the power handling capability and achieves higher modular level with minimized *** shunt compensator assists in minimizing the voltageﬂuctuations and maximizing the voltage stability under different load *** Direct Quadrature(DQ)theory is utilized in this study to separate the harmonic components by generating reference frame *** Proportional Integral(PI)controller aids in maintain-ing the direct current potential difference in the constant mode whereas the Pulse Width Modulation(PWM)generator helps in delivering optimized output to the *** gain parameters of PI controller are optimized with the aid of employ-ing Particle Swarm Optimization(PSO).The entire work is validated using MATLAB simulink and the obtained outcomes proves that this new UPFC is highly beneﬁcial in minimizing the distortions with reduced Total Harmonic Distortion(THD)of 2.21%.

关键词： UPFC PI controller PSO MMC DQ theory STATCOM

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Perfluoroalkyl acid transformation and mitigation by nNiFe-activated carbon nanocomposites in steady-state flow column studies

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Journal of Environmental Sciences 2023年第5期127卷 678-687页

作者： Mahsa Modiri-Gharehveran Younjeong Choi Jenny E.Zenobio linda S.Lee Department of Agronomy Purdue UniversityWest LafayetteIN 47907USA Interdisciplinary Ecological Sciences&Engineering Purdue UniversityWest LafayetteIN 47907USA

The ongoing contamination of groundwater with per-and polyfluoroalkyl substances(PFAS)has resulted in a global and rapidly growing interest in PFAS groundwater *** technologies that lead to PFAS destruction are often limited by not addressing all PFAS,being energy-intensive or not being suited for in-situ *** developed nNiFeactivated carbon(AC)nanocomposites and demonstrated varying degrees of PFAS reduction and fluoride generation with these nanocomposites in batch reactors for several *** we explore nNiFe-AC’s effectiveness to transform perfluoroalkyl acid acids(PFAAs)under steady-state flow(0.0044 to 0.15 mL/min)in nNiFe-AC:sand packed *** experiments included,two perfluorooctane sulfonate(PFOS)in deionized water and two PFAA mixtures in deionized water or bicarbonate buffer containing five perfluoroalkyl carboxylates(PFCAs,C5-C9)and three perfluoroalkyl sulfonates(PFSAs,C4,C6 and C8)at temperatures of 50 or 60℃ were *** transformation was similar in PFOS-only and PFAA mixture column ***,%PFAA transformation under flow conditions exceeded what we observed previously in batch reactors with up to 53%transformation of a PFAA mixture with∼8%*** chain PFAS dominated the PFAAs transformed and a bicarbonate matrix appeared to reduce overall *** breakthrough was slower than predicted from only sorption due to transformation;some longer chain PFAS like PFOS did not ***,nNiFe-AC technology with both in-situ and ex-situ potential application was shown to be a plausible part of a treatment train needed to address the ongoing challenge for cleaning up PFAS-contaminated waters.

关键词： PFAAs PFAS Zero valent iron Nanoparticles Remediation Groundwater

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Determination of multiple drugs of abuse in human urine using dispersive liquid–liquid microextraction and capillary electrophoresis with PDA detection

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Forensic Sciences Research 2022年第2期7卷 265-271页

作者： Liang Meng Shuhai Ye Yilin Wu linda You Department of Forensic Science Fujian Police CollegeFuzhouChina Institute of Forensic Science Fujian Provincial Public Security DepartmentFuzhouChina

A new method was developed for pre-concentration and determination of multiple drugs of abuse in human urine using dispersive liquid–liquid microextraction(DLLME)and capillary electrophoresis(CE)with photodiode array *** method was based on the formation of tiny droplets of an organic extractant in the prepared sample solution using water-immiscible organic solvent(chloroform)dissolved in water-miscible organic dispersive solvent(isopropyl alcohol).The organic phase,which extracted eight drugs of abuse from the prepared urine solution,was separated by *** sedimented phase was transferred into a small volume CE auto-sampler vial with 10μL of 1%HCl methanol solution and evaporated to *** residue was reconstituted in lidocaine hydrochloride(internal standard)aqueous solution and introduced by electrokinetic injection into *** the optimum conditions,acceptable linear relationship was observed in the range of 3.0–500 ng/mL with the correlation coefficient(r)of 0.9982–0.9994 for spiked urine *** limit of detection(LOD)(S/N=3)was estimated to be 1.0 ng/mL.A recovery of 75.7%–90.6%was obtained for spiked *** mean relative error(MRE)was within±7.0%and the relative standard deviation(RSD)was less than 6.9%.The proposed DLLME-CE procedure offers an alternative analytical approach for the sensitive detection of drugs of abuse in real urine samples.

关键词： Forensic sciences forensic toxicology dispersive liquid-liquid microextraction capillary electrophoresis drugs of abuse urine sample

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Isolation and identification of an isomeric sildenafil analogue as an adulterant in an instant coffee premix

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Forensic Sciences Research 2022年第2期7卷 290-298页

作者： Ahmad Yusri Mohd Yusop linda Xiao Shanlin Fu Centre for Forensic Science University of Technology SydneyUltimoAustralia Pharmacy Enforcement Division Ministry of HealthSelangorMalaysia

The proliferation of adulterated health foods and beverages in the market demands a comprehensive analytical strategy to identify the adulterants,particularly those of isomeric phosphodiesterase 5(PDE5)*** instant coffee premix(ICP)purchased from an online retailer was flagged for suspected adulteration through PDE5 inhibition *** ICP was then analysed using suspected-target and non-targeted screenings of a liquid chromatography-quadrupole time-of-flight mass *** on these findings,a PDE5 inhibitor initially assigned as compound X was isolated from the ICP by employing a liquid chromatography-diode array detection before its structural elucidation with liquid chromatography-ultraviolet(LC-UV)spectroscopy and nuclear magnetic resonance(NMR)*** suspected-target screening matched the protonated molecule([MþH]þ)precursor ion of compound X at m/z 499.2310 with two suspected analytes that are structural isomers of one *** fragmentation patterns of compound X were comparable to those analogues in the dithiocarbodenafil group through the non-targeted *** findings,complemented by the LC-UV and NMR spectroscopy data,together with the chromatographic separation of related structural isomers,conclude the identity of compound *** our best knowledge,this is the first study to report the presence of 3,5-dimethylpiperazinyl-dithiodesmethylcarbodenafil in an ICP sample.

关键词： Forensic sciences food adulteration non-targeted screening phosphodiesterase 5 inhibitors structural isomer suspected-target screening

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Direct GHG emissions from a pilot scale MBR-process treating municipal wastewater

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Advances in Climate Change Research 2022年第1期13卷 138-145页

作者： Christian BARESEL Jingjing YANG Niclas BORNOLD Kare TJUS linda KANDERS Klara WESTLING IVL Swedish Environmental Research Institute AB Valhallavagen 81Stockholm 10031Sweden

To evaluate direct greenhouse gas emissions from Membrane Biological Reactor(MBR),measurements of nitrous oxide(N_(2)O)and methane(CH_(4))were made at a pilot-scale MBR treating municipal wastewater Measurements were conducted during two campaigns with some changes in processes,*** a pre-aeration tank in the second measurement,different distributions of aeration in the treatment line,not the same wastewater inflow rate,two types of ultrafiltration *** was found that about 0.004% and 0.07% of the total ammonium loads were emitted as N_(2)O,CH_(4) emissions were 0.026% and 0.12% of incoming TOC(0.008% and 0.04% of incoming COD)in 2014 and *** obtained N_(2)O emission values were relatively *** study suggested that a high aeration at the beginning of the treatment line may result in significantly high emissions of both N_(2)O and CH_(4).A significant change in aeration in the membrane ultrafiltration tank did not have the same *** MBR process is known for high quality effluent but have been questioned due to its higher carbon footprint due to energy *** study gave a reference case about direct GHG emissions from MBR process and provide information for the further evaluation of MBR processes.

关键词： Greenhouse gases(GHGs) Nitrous oxide(N_(2)O) Methane(CH_(4)) Membrane biological reactor(MBR)

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Clinical features and long-term outcomes of patients with colonic oligopolyposis of unknown etiology

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World Journal of Gastroenterology 2022年第48期28卷 6950-6961页

作者： Dan Feldman linda Rodgers-Fouche Stephanie Hicks Daniel C Chung Division of Gastroenterology Massachusetts General HospitalBostonMassachusetts 02114United States Center for Cancer Risk Assessment Massachusetts General HospitalBostonMassachusetts 02114United States Division of Gastroenterology and Center for Cancer Risk Assessment Massachusetts General HospitalHarvard Medical SchoolBostonMassachusetts 02114United States

BACKGROUND Colonic adenomatous polyposis of unknown etiology(CPUE)is an adenomatous polyposis phenotype that resembles Familial Adenomatous Polyposis(FAP)even though no germline pathogenic variant is *** We sought to better characterize the clinical features and outcomes in a cohort of CPUE *** This is a retrospective case series of patients 18 years old or older with adenomatous oligopolyposis(between 10-100 adenomas)and negative genetic testing,identified through the Hereditary Gastrointestinal Cancer Database at Massachusetts General Hospital,a tertiary academic referral center.A retrospective chart review was performed with a focus on demographics,alcohol and tobacco use,medication use,familial malignancy and polyp burden,genetic testing information,endoscopic surveillance data including the corresponding histopathology,colonic and extracolonic malignancies,mortality events,and their *** correlation and Pearson Chi-square test(or Fisher's exact test)were used for continuous and categorical variables *** CPUE patients were primarily male(69%)and presented for genetic counseling at 63.7 *** 2 patients(2.9%)reported a first-degree relative with *** an average surveillance period of 12.3 years,0.5 colonoscopies per year were *** developed 2.3 new adenomas per year.4(5.7%)were diagnosed with colorectal cancer(CRC)at a mean age of 66 years,and 3 were diagnosed prior to the onset of oligopolyposis.7(10%)required colectomy due to advanced dysplasia or polyp *** respect to upper gastrointestinal manifestations,1 patient had a gastric adenoma,but there were no cases of gastric or small bowel *** surveillance,10(14%)patients died at a mean age of 72,and none were due to *** CPUE is distinct from familial adenomatous polyposis(FAP)syndrome and the use of FAP surveillance guidelines may result in unnecessarily frequent upper and lower endoscopies.

关键词： Colonic polyposis of unknown etiology Multigene cancer panel Colorectal cancer Colectomy Surveillance Mortality

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