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BIOCELL 2020年第1期44卷 111-115页

作者： ha ABDEL maKSOUD Mk maHFOUZ mi SOLImaN Mohamed G ELhaRRIF M ABBASS ma EL-BADRY Department of Biochemistry Benha UniversityBenhaEgypt Department of Basic Medical Sciences Shaqra UniversityShaqraaSaudi Arabia

Pyrethroid esters are widely used as insecticides worldwide. In this study, we aimed to evaluate the harmful effect of deltamethrin on the male reproductive system through the assessment of reproductive hormones, inflammatorymarkers, and testicular function. To achieve our aim, eighty male 7-9-week-old, Wistar rats were taken, weighed, and divided into four experimental groups. The first group was kept as a control group, and the other three groups were given deltamethrin orally at different concentrations (0.87, 8.7, and 17.4 mg/kg body weight) for nine weeks. The resultsindicated that deltamethrin administration associated with a significant decrease in reproductive hormones, especially FSH, LH, and significant elevation in the interleukin 2 (IL2), interleukin 6 (IL6), histamine, and cortisol levels. Also, thesignificance of inhibition of sperm motility and viability, decreased testis weights, sperm count, and fructose in semen were noted. These findings clarify the harmful effect of deltamethrin on the male reproductive system by producing a significant alteration in reproductive hormones, inflammatory markers as well as testicular function.

关键词： Deltamethrin Reproductive hormones Inflammatory markers

Landscape of genomic imprinting and its functions in the mouse mammary gland

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Journal of Molecular Cell Biology 2020年第11期12卷 857-869页

作者： haibo Xu lina Zhao Xu Feng Yujie ma Wei Chen Li Zou Qin Yang Jihong Sun Hong Yu Baowei Jiao State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunming 650223China Department of Radiology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China

Genomic imprinting is an epigenetic modification of DNA,whereby gene expression is restricted to either maternally or paternally inherited *** genes(IGs)in the placenta and embryo are essential for growth regulation and nutrient ***,despite being an important nutrition delivery organ,studies on mammary gland genomic imprinting remain *** this study,we found that both the number of IGs and their expression levels decreased during development of the mouse mammary *** expression was lineage-specific and related to mammary gland development and ***-analysis of single-cell RNA sequencing data revealed that mammary gland IGs were co-expressed in a network that regulated cell sternness and differentiation,which was confirmed by our functional ***,our data indicated that IGs were essential for the self-renewal of mammary gland stem cells and IG decline was correlated with mammary gland *** together,our findings revealed the importance of IGs in a poorly studied nutrition-related organ,*** mammary gland,thus providing a reference for further studies on genomic imprinting.

关键词： imprinted gene imprinted gene network mammary gland stem cell differentiation metabolism

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油松人工林土壤微生物对结构调整的响应研究

林业科学研究 2024年第3期37卷 193-202页

作者：法蕾裴顺祥杜满义马淑敏吴莎吴迪王海霞李佳林许基煌中国林业科学研究院华北林业实验中心北京九龙山暖温带森林国家长期科研基地北京102300 中国林业科学研究院热带林业实验中心广西凭祥532600

[目的]为评估结构调整对油松人工林生态系统的影响,探索土壤微生物群落结构动态对结构调整干扰的响应机制。[方法]利用高通量测序技术,对结构调整后山西省中条山油松人工林林下土壤微生物的类群组成及多样性进行探究,分析土壤微生物群... 详细信息

[目的]为评估结构调整对油松人工林生态系统的影响,探索土壤微生物群落结构动态对结构调整干扰的响应机制。[方法]利用高通量测序技术,对结构调整后山西省中条山油松人工林林下土壤微生物的类群组成及多样性进行探究,分析土壤微生物群落的组成结构、多样性及其与环境因素的相互关系。[结果]油松人工林结构调整能够降低土壤的pH值,土壤养分含量显著低于对照样地。土壤微生物的优势菌群未发生较大的变化,土壤的优势细菌类群是变形菌门、放线菌门、酸杆菌门,而优势真菌类群为子囊菌门、担子菌门和被孢菌门。结构调整后油松人工林土壤微生物的丰富度显著增加,多样性较对照样地略有增加,但差异不显著。对结构调整前后的油松人工林微生物类群与土壤理化性质进行RDA分析,pH、总氮、土壤有机质和速效氮是驱动土壤微生物类群变化的主要因子。[结论]结构调整后的油松人工林样地仍处于恢复期,微生物类群结构与未调整样地相比具有相似性,但调整后的土壤微生物类群更为丰富,变形菌门和担子菌门的增加使得土壤中固氮菌的比例提高,土壤微生物类群向有助于有机质分解的方向转换。

关键词：油松人工林结构调整目标树经营土壤微生物微生物群落结构

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Soil properties and corn(Zea mays L.)production under manure application combined with deep tillage management in solonetzic soils of Songnen Plain,Northeast China

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Journal of Integrative Agriculture 2016年第4期15卷 879-890页

作者： MENG Qing-feng LI Da-wei ZhaNG Juan ZHOU Lian-ren ma Xian-fa WANG Hong-yan WANG Guang-cheng School of Resources and Environment Northeast Agricultural UniversityHarbin 150030P.R.China Center of Zhaozhou County on Popularization of Agricultural Technology zhaozhou 166400P.R.China

Poor soil structure and nutrients, excessive exchangeable Na＋, high pH as well as low enzyme activities are common in the solonetz, and significantly restrict corn （Zea mays L.） production. Cattle manure application combined with deep tillage is an important management practice that can affect soil physico-chemical properties and enzyme activities as well as corn yield in the solonetz. Field experiments were carried out in a randomized complete block design comprising four treatments： Corn with conventional tillage was used as a control, and corn with manure application combined with deep tillage as well as film mulching and aluminium sulfate were used as the experimental treatments, respectively. The relationship between corn yield and measured soil properties was determined using stepwise regression analysis. manure application combined with deep tillage management was more effective than conventional tillage for increasing corn yield and for improving soil properties in the solonetz. The highest corn yield was obtained in the treatments with manure application＋deep tillage＋plastic film mulching （11 472 and 12 228 kg ha-l）, and increased by 38 and 43% comparing with the control treatment （8 343 and 8 552 kg ha-1） both in the 2013 and 2014 experiments, respectively. Using factor analysis, three factors were obtained, which represented soil fertility status, soil saline-alkaline properties and soil structural properties both in the 2013 and 2014 experiments, respectively. manure and deep tillage management resulted in two distinct groups of soil properties：（1） soils with manure application combined with deep tillage and （2） soils with conventional tillage. Stepwise regression analysis showed that corn yield was significantly and positively correlated to urease and available P, as well as negatively correlated to pH, electrical conductivity （EC）, exchange sodium percentage （ESP）, and bulk density （Pb）. We concluded that Pb was dominant factor for corn yield on the b

关键词： cattle manure deep tillage corn yield solonetz

Examining residual spatial correlation in variation partitioning of beta diversity in a subtropical forest

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Journal of Plant Ecology 2019年第4期12卷 636-644页

作者： Ke Cao Xiangcheng mi Liwen Zhang haibao Ren mingjian Yu Jianhua Chen Jintun Zhang Keping ma Key Laboratory of Biodiversity Sciences and Ecological Engineering Ministry of EducationCollege of Life SciencesBeijing Normal UniversityBeijing 100875China State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of Sciences20 NanxingcunXiangshanBeijing 100093China Key Laboratory of Coastal Zone Environmental Processes Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China College of Life Sciences Zhejiang UniversityHangzhou 310058China College of Chemistry and Life Sciences Zhejiang Normal UniversityJinhua 321004China

Aims The relative roles of ecological processes in structuring beta diver-sity are usually quantified by variation partitioning of beta diversity with respect to environmental and spatial variables or gamma ***,if important environmental or spatial factors are omitted,or a scale mismatch occurs in the analysis,unaccounted spatial correlation will appear in the residual errors and lead to re-sidual spatial correlation and problematic *** Multi-scale ordination(MSO)partitions the canonical ordination results by distance into a set of empirical variograms which charac-terize the spatial structures of explanatory,conditional and residual variance against *** these variance components can be used to diagnose residual spatial correlation by checking assump-tions related to geostatistics or regression *** this paper,we first illustrate the performance of MSO using a simulated data set with known properties,thus making statistical issues *** then test for significant residual spatial correlation in beta diversity analyses of the Gutianshan(GTS)24-ha subtropical forest plot in eastern *** Findings Even though we used up to 24 topographic and edaphic variables mapped at high resolution and spatial variables representing spa-tial structures at all scales,we still found significant residual spatial correlation at the 10 m×10 m quadrat *** invalidated the analysis and inferences at this *** also show that MSO pro-vides a complementary tool to test for significant residual spatial correlation in beta diversity *** results provided a strong argument supporting the need to test for significant residual spatial correlation before interpreting the results of beta diversity analyses.

关键词： beta analysis residual spatial correlation spatial scale canonical ordination multi-scale ordination variation partitioning

Multi-stemming strategies of Quercus glauca in an evergreen broad-leaved forest: when and where

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Journal of Plant Ecology 2020年第6期13卷 738-743页

作者： mide Rao Duo Ye Jianhua Chen Jian Ni Xiangcheng mi mingjian Yu Keping ma Johannes H.C.Cornelissen College of Chemistry and Life Sciences Zhejiang Normal UniversityJinhua 321004China Department of Ecological Science Faculty of ScienceVrije Universiteit AmsterdamDe Boelelaan 10851081 HV AmsterdamThe Netherlands State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China College of Life Sciences Zhejiang UniversityHangzhou 310058China

Aims Multi-stemming supports plants’resilience to disturbances and then contributes to soil stabilization and forest function,especially in mountain *** questions remain about(i)the ontogenetic phase at which multiple stems can occur,(ii)how habitat drivers affect multi-stemming and(iii)whether ontogenetic phase and habitat drivers *** asked these questions for Quercus glauca(ring-cupped oak),the dominant species and sprouter across large warm-temperate areas of Asia;its multi-stemmed trees reflect individual survival,population regeneration and forest ecosystem *** In a 5-ha permanent plot of subtropical evergreen broad-leaved forest in eastern China,we examined the temporal patterns and spatial distribution of multi-stemmed trees of *** within 99 quadrats of 20 m×20 *** Findings There were three temporal modes for multi-stemming among the *** trees and most of them appeared to produce multiple stems from an early *** disturbances related to slope convexity appear to be the main drivers of multi-stemming of ***,the closer to the ridge,the earlier the multi-stemming ***,also for other woody species in other forests and climate zones,ontogeny and environmental drivers promoting disturbance(not only geomorphology,but also extreme weather events,soil drought,fire),as well as soil fertility,need to be considered in combination to better understand multi-stemming and its consequences for community structure.

关键词： life history strategy multi-stemmed trees ontogenetic phase persistence Quercus glauca topography

根际低氧对不同抗性猕猴桃幼苗生长和内源激素的影响

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园艺学报 2009年第2期36卷 163-170页

作者：米银法马锋旺马小卫西北农林科技大学园艺学院陕西杨凌712100 河南科技大学林学院河南洛阳471003

采用水培通氮低氧胁迫法,研究猕猴桃幼苗生长量及叶、根内源激素脱落酸(ABA)、赤霉素(GA3)、吲哚乙酸(IAA)和玉米素核苷(ZR)对低氧胁迫的响应。结果表明:低氧胁迫下猕猴桃幼苗生长受到抑制,植株鲜、干样质量均低于对照,美味猕猴桃生长... 详细信息

采用水培通氮低氧胁迫法,研究猕猴桃幼苗生长量及叶、根内源激素脱落酸(ABA)、赤霉素(GA3)、吲哚乙酸(IAA)和玉米素核苷(ZR)对低氧胁迫的响应。结果表明:低氧胁迫下猕猴桃幼苗生长受到抑制,植株鲜、干样质量均低于对照,美味猕猴桃生长受影响相对较小;低氧胁迫下美味猕猴桃和中华猕猴桃叶内ABA分别较对照增加289.2%和412.9%,根内ABA含量分别增加188.5%和177.4%;叶内IAA含量先升高后下降,6d达峰值时美味猕猴桃和中华猕猴桃分别比对照增加87.3%和61.4%,根内IAA含量变化与叶类似,4d达峰值时分别比对照增加90.4%和59.6%;叶和根内GA3和ZR含量随胁迫时间延长而降低,低氧胁迫8d时,美味猕猴桃和中华猕猴桃幼苗叶内GA3分别比对照降低56.5%和79.0%;根内降低33.1%和55.1%,叶内ZR分别对比照降低70.5%和86.1%,根内降低46.9%和71.3%;低氧胁迫下,猕猴桃幼苗根和叶内IAA/ABA、ZR/ABA、GA3/ABA比值均呈现下降趋势。

关键词：猕猴桃幼苗低氧胁迫内源激素

miR-124 Modulates Gefitinib Resistance through SNAI2 and STAT3 in Non-small Cell Lung Cancer

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2016年第6期36卷 839-845页

作者： fa-yong HU Xiao-nian CAO Qin-zi XU Yu DENG Sen-yan LAI Jing ma Jun-bo HU Cancer Research Institute Tongji HospitalHuazhong University of Science and Technology Department of Thoracic Surgery Tongji HospitalHuazhong University of Science and Technology Department of Respiratory and Critical Care Medicine Tongji HospitalHuazhong University of Science and Technology

Gefitinib is used as a first-line treatment for advanced non-small cell lung cancer（NSCLC）.Unfortunately,most NSCLC patients inevitably develop gefitinib resistance during *** addition to EGFR mutation status,the mechanisms involved are largely *** this study,we showed that mi R-124,a tumor suppressor,was significantly down-regulated in gefitinib-resistant NSCLC patients and cell lines compared with gefitinib-sensitive patients and cell *** addition,the mi R-124 depletion induced gefitinib resistance,and mi R-124 overexpression sensitized gefitinib-resistant cells to *** analysis revealed that mi R-124 decreased SNAI2 and STAT3 expression by directly targeting their 3＇UTRs and that knocking down SNAI2 or STAT3 partly reversed the gefitinib resistance induced by mi R-124 *** data demonstrate that the mi R-124 plays a new critical role in acquired resistance to gefitinib and that the manipulation of mi R-124 might provide a therapeutic strategy for reversing acquired gefitinib resistance.

关键词： miR-124 non-small cell lung cancer gefitinib-resistance SNAI2 STAT3

水体溶解性有机质与重金属影响机理的研究进展

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环境科技 2024年第2期37卷 62-67页

作者：刘小兰宋志鑫宋刚福唐文忠米晓曹玉婷王汉卿马轩华北水利水电大学环境与市政工程学院河南郑州450046 中国科学院生态环境研究中心北京100085

溶解性有机质(DOM)是水体中最活跃的组分,可与金属离子发生吸附、络合、氧化还原等一系列反应,影响金属离子在水环境中的迁移转化。DOM的主要成分为腐殖质,而富里酸(fa)和胡敏酸(ha)为腐殖质中占比最高的2种成分,占DOM总量的40%~60%。DO... 详细信息

溶解性有机质(DOM)是水体中最活跃的组分,可与金属离子发生吸附、络合、氧化还原等一系列反应,影响金属离子在水环境中的迁移转化。DOM的主要成分为腐殖质,而富里酸(fa)和胡敏酸(ha)为腐殖质中占比最高的2种成分,占DOM总量的40%~60%。DOM与重金属离子的相互作用一般用稳定常数表示其形成的络合物的稳定性,对重金属离子的吸附量和吸附率会受到pH值、温度、反应时间等多种环境因素的影响。在调研大量国内外文献基础上,综述了DOM与重金属离子相互作用机制及其影响的研究进展。

关键词：溶解性有机质富里酸胡敏酸重金属相互作用

Phosphate imbalance conducting by BPs-based cancer-targeting phosphate anions carrier induces necrosis

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Chinese Chemical Letters 2021年第4期32卷 1550-1554页

作者： Chunmeng ma Jinlong Zhang Yuan Zhang Chen ma minrui ma fanpeng Ran Xiaoyan Liu haixia Zhang College of Chemistry and Chemical Engineering.Lanzhou University Lanzhou 730000China

As a vital nutrient closely related to the cance r-cells proliferation,phosphate anions have been paid great attention as a promising anticancer ***,the transport of phosphate anions depends on a protein transport system which is regulated by ion homeostasis ***,we designed a reactive anionic nanocarrier based on black phosphorus nanosheets(BPs)and artesunate(ART),which could enter cells through endocytosis to generate phosphate anions,avoiding the regulation of cell *** ionic nanocarrier was coated by polydopamine to defend BPs and ART and functionalized by folate(fa)and hyaluronic acid(ha)for targeting *** the anchoring groups fa/ha targeted the carrier into cells,polydopamine coating decomposed to expose ART for further generating reactive oxygen species(ROS)in cancer cell microenvironment,providing oxidation ***,ROS generated by ART makes BPs decompose to phosphate anions with effectively speed,giving rise to the destruction of ion homeostasis to induce necro sis and inhibit the proliferation for cancer *** consequence,this research provides novel idea and direction for the ionic carriers and tumor therapeutics.

关键词： Phosphate anions carrier Black phosphorus nanosheets Artesunate Phosphate imbalance Necrosis