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Polycystic ovary syndrome: Pathways and mechanisms for possible increased susceptibility to COVID-19

World Journal of Clinical Cases 2021年第12期9卷 2711-2720页

作者： Ioannis Ilias Spyridon Goulas lina zabuliene Department of Endocrinology Elena Venizelou HospitalAthens GR-11521Greece Department of Gastroenterology Unit Elena Venizelou HospitalAthens GR-11521Greece Institute of Clinical Medicine Faculty of MedicineVilnius UniversityVilnius LT-03101Lithuania

In 75%of women with polycystic ovary syndrome(PCOS),insulin action is *** obesity,visceral adipose tissue becomes dysfunctional:Chronic inflammation is favored over storage,contributing to the development of metabolic ***,metabolic syndrome(MetSy)and non-alcoholic fatty liver disease(NAFLD)apparently share common pathogenic factors;these include abdominal adiposity,excess body weight and insulin *** in the gut microbiome have been noted in women with PCOS compared to controls;these may lead to deterioration of the intestinal barrier,increased gut mucosal permeability and immune system activation,hyperinsulinemia and glucose intolerance,which hamper normal ovarian function and follicular development(all being hallmarks of PCOS).It has been proposed that PCOS may entail higher susceptibility to coronavirus disease 2019(COVID-19)via its associated comorbidities(NAFLD,obesity,MetSy and alterations in the gut microbiome).Studies have found an association between acute respiratory distress syndrome(seen in severe cases of COVID-19)and the intestinal ***,apparently,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can gain entry to the gastrointestinal tract via locally-expressed angiotensin converting enzyme type 2 *** body weight is associated with more severe COVID-19 and increased *** robust links between SARS-CoV-2 infection and PCOS/NAFLD/gut microbiome/metabolic consequences are yet to be confirmed,it seems that strategies for adapting the intestinal microbiome could help reduce the severity of COVID-19 in women with PCOS with or without NAFLD,MetSy or obesity.

关键词： Adipose tissue Obesity Polycystic ovaries SARS-CoV-2 COVID-19 Human

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Epinephrine also acts on beta cells and insulin secretion

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World Journal of Clinical Cases 2024年第9期12卷 1712-1713页

作者： lina zabuliene Ioannis Ilias Faculty of Medicine Vilnius UniversityVilnius LT-03101Lithuania Department of Endocrinology “Hippokration”General HospitalAthens GR-11527Greece

In a recent review examining neurotransmitter modulation of insulin secretion,the significant impact of epinephrine was not *** primary action involves inhibiting insulin release via alpha-adrenergic receptors,thereby reducing the response to insulin secretion stimulators,through the activation of K+channels and resulting in membrane hyperpolarization in beta cells.

关键词： Epinephrine Insulin Islets Glucose Human

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Pandemic and precocious puberty-a Google trends study

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World Journal of Methodology 2023年第1期13卷 1-9页

作者： Athanasios Tselebis lina zabuliene Charalampos Milionis Ioannis Ilias Department of Psychiatry “Sotiria”General Chest Diseases HospitalAthens GR-11527Greece Faculty of Medicine Vilnius UniversityVilnius LT-03101Lithuania Department of Endocrinology Elena Venizelou General and Maternity HospitalAthens GR-11521Greece

BACKGROUND Recent publications from several countries have reported that more young people(mainly girls)are experiencing precocious puberty(PP)/menarche during the coronavirus disease 2019 pandemic compared to the *** variation is attributed to the stress of confinement,lack of exercise,obesity and disturbed sleep patterns.A common feature of the relevant papers,however,is the small number of reported cases of *** have shown that searches for diseases on the internet also reflect to some extent the epidemiology of these *** To estimate,through internet searches for PP,any changes in the epidemiology of *** We assessed in Google Trends searches for 21 PP-related terms in English internationally(which practically dwarf searches in other languages),in the years ***,we assessed local searches for selected terms,in English and local languages,in countries where a rise in PP has been *** were collected in Relative Search Volumes format and analyzed using Kendall’s Tau test,with a statistical significance threshold of P<*** Internationally,searches for three PP-related terms showed no noticeable change over the study period,while searches for eight terms showed a *** increase was found over time in searches for nine PP-related *** the 17 searches in English and local languages,in countries where a rise in PP has been reported,5 showed a significant increase over *** Over the study period,more than half of the search terms showed little change or *** discrepancy between internet searches for PP and the reported increase in the literature is *** would be expected that a true increase in the incidence of PP would also be aptly reflected in Google *** our findings are valid,the literature may have been *** known secular trend of decreasing age of puberty may also have played a role.

关键词： Data collection Epidemiology Puberty Human Methods Trends

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Artificial night light and thyroid cancer

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World Journal of Methodology 2024年第1期14卷 87-93页

作者： Athanasios Tselebis Eftychia Koukkou Charalampos Milionis lina zabuliene Argyro Pachi Ioannis Ilias Department of Psychiatry “Sotiria”General Chest Diseases HospitalAthens GR-11527Greece Department of Endocrinology Diabetes and MetabolismElena Venizelou General HospitalAthens GR-11521Greece Faculty of Medicine Vilnius UniversityVilnius LT-03101Lithuania

BACKGROUND The occurrence of thyroid cancer(TC)has increased in recent *** to outdoor artificial light at night(ALN)is associated with an increased risk of *** To investigated the impact of ALN,as a significant environmental pollutant,on TC incidence *** The assessment involved analyzing satellite ALN data in conjunction with TC incidence data[adjusted standardized rate(ASR)],while considering the quality of cancer registries(QCR),gross domestic product(GDP)per person,and health expenditure per person(HEP)for each *** Results indicated a correlation between higher ASR and ALN exposure percentages,particularly in countries with higher GDP or HEP quartiles(all P0.10).CONCLUSION The findings suggest a potential link between higher GDP and adverse health conditions,serving as possible risk factors for TC,rather than a direct association with *** include the use of cross-sectional data,temporal misalign ment,and reliance on ALN as a socioeconomic *** is proposed that light pollution might be connected to a lifestyle conducive to ***,the presence of higher GDP/HEP could enhance access to diagnostic resources,potentially facilitating TC diagnosis and inclusion in cancer registries.

关键词： Lighting Human Epidemiology Thyroid Cancer

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