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Optoelectronics Letters 2024年

作者： LI Wenqiang WU Min LI Weijun HAO Meilan YU lina AnnLab， Institute of Semiconductors， Chinese Academy of Sciences School of Electronic， Electrical and Communication Engineering & School of Integrated Circuits， University of Chinese Academy of Sciences Beijing Key Laboratory of Semiconductor Neural Network Intelligent Sensing and Computing Technology

In recent years， machine learning (ML) techniques have been shown to be effective in accelerating the development process of optoelectronic devices. However， as "black box" models， they have limited theoretical interpretability. In this work， we leverage symbolic regression (SR) technique for discovering the explicit symbolic relationship between the structure of the optoelectronic Fabry-Perot (FP) laser and its optical field distribution， which greatly improving model transparency compared to ML. We demonstrated that the expressions explored through SR exhibit lower errors on the test set compared to ML models which suggests that the expressions have better fitting and generalization capabilities.

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Targeting a disintegrin and metalloprotease(ADAM)17-CD122 axis enhances CD8^(+)T cell effector differentiation and anti-tumor immunity

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3097-3111页

作者： lina Sun Anjun Jiao Haiyan Liu Renyi Ding Ning Yuan Biao Yang Cangang Zhang Xiaoxuan Jia Gang Wang Yanhong Su Dan Zhang Lin shi Chenming Sun Aijun Zhang Lianjun Zhang Baojun Zhang Department of Pathogenic Microbiology and Immunology School of Basic Medical SciencesXi’an Jiaotong UniversityXi’anShaanxi 710061China Institute of Infection and Immunity Translational Medicine InstituteXi’an Jiaotong University Health Science CenterXi’anShaanxi 710061China Key Laboratory of Environment and Genes Related to Diseases Ministry of EducationXi’anShaanxi 710061China Xi’an Key Laboratory of Immune Related Diseases Xi’anShannxi 710061China Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy Cancer InstituteXuzhou Medical UniversityXuzhouJiangsuChina Department of Pediatrics Qilu Hospital of Shandong UniversityJinanChina National Key Laboratory of Immunity and Inflammation Suzhou Institute of Systems MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeSuzhou 215123 JiangsuChina Key Laboratory of Synthetic Biology Regulatory Elements Suzhou Institute of Systems MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeSuzhou 215123 JiangsuChina

CD8^(+)T cell immune responses are regulated by multi-layer networks,while the post-translational regulation remains largely *** ectodomain shedding is an important post-translational process orchestrating receptor expression and signal transduction through proteolytic cleavage of membrane ***,by targeting the sheddase A Disintegrin and Metalloprotease(ADAM)17,we defined a post-translational regulatory mechanism mediated by the ectodomain shedding in CD8^(+)T *** and proteomic analysis revealed the involvement of post-translational regulation in CD8^(+)T cells.T cellspecific deletion of ADAM17 led to a dramatic increase in effector CD8^(+)T cell differentiation and enhanced cytolytic effects to eliminate pathogens and ***,ADAM17 regulated CD8^(+)T cells through cleavage of membrane ***17 inhibition led to elevated CD122 expression and enhanced response to IL-2 and IL-15 stimulation in both mouse and human CD8^(+)T ***,inhibition of ADAM17 in CD8^(+)T cells improved the efficacy of chimeric antigen receptor(CAR)T cells in solid *** findings reveal a critical post-translational regulation in CD8^(+)T cells,providing a potential therapeutic strategy of targeting ADAM17 for effective anti-tumor immunity.

关键词： immunity stimulation involvement

Ideological and Political Exploration of Academic Continuing Education Professional Diploma in Medical Imaging

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IJLAI Transactions on Science and Engineering

IJLAI Transactions on Science and Engineering 2024年第2期2卷 74-80页

作者： Lin Sun Haitong Wang Kai Wang lina Zhang Chao Yang The First Affiliated Hospital of Dalian Medical University No.150 Lianhe RoadXigang DistrictDalian CityLiaoning Province 116000China Dalian Medical University 9 West Section of Lvshun South RoadDalian CityLiaoning Province116044China

In alignment with the 20th National Congress of the Communist Party of China’s commitment to establish a healthier nation,the focus on healthcare strategically prioritizes human *** necessitates redefining medical service ***,the training of medical students and continuing education is *** recent years,the notion of incorporating“ideological and political education within the curriculum”is becoming more explicit,especially within university talent *** paper,exploring the unique attributes of professional medical imaging student training and continuing education,proposes the innovative model of“3+4+2”ideological and political education at the First Affiliated Hospital of Dalian Medical *** introduces a new system of“school-family-society”tripartite co-education,a new mechanism of“party committee-functional departments-teaching and research office-teachers”four-level linkage,and a novel approach of“party branch-teaching and research office”dual-wheel drive,integrating value shaping,knowledge imparting,and ability *** goal is to nurture Party talents and educate patriots,thereby enhancing the effectiveness of“comprehensive education”and bolstering the construction of new medical sciences.

关键词： Curriculum ideological and political Medical imaging Imaging technology Academic continuing education Medical education

一种用于天基低轨卫星网络边缘计算的GA-DDPG卸载算法

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工程科学学报 2024年第2期46卷 343-353页

作者：史栋元王丽娜北京科技大学计算机与通信工程学院通信工程系北京100083

低轨卫星网络是第六代移动通信系统(6G)网络的重要组成部分,弥补了地面基站覆盖的盲区.由于星上计算能力和电池容量受限,导致任务出现时延长和能耗高的问题,因此在低轨卫星网络中引入边缘计算,边缘计算的一项关键技术就是计算卸载.针对... 详细信息

低轨卫星网络是第六代移动通信系统(6G)网络的重要组成部分,弥补了地面基站覆盖的盲区.由于星上计算能力和电池容量受限,导致任务出现时延长和能耗高的问题,因此在低轨卫星网络中引入边缘计算,边缘计算的一项关键技术就是计算卸载.针对计算卸载过程中星间环境动态变化和高维动作空间的问题,提出一种基于遗传算法(GA)和深度确定性策略梯度(DDPG)的天基低轨卫星网络边缘计算卸载算法——GA-DDPG算法.卫星边缘计算环境的不断变化会导致DDPG奖励稀疏和探索性不足,将GA引入到DDPG算法中,首先,利用GA的选择算子使DDPG算法能够适应不断变化的卫星环境;然后,针对动作空间维度变大导致DDPG算法收敛不稳定的问题,利用GA种群的多样化探索和种群的冗余提升DDPG算法收敛的稳定性.仿真结果表明,GA-DDPG卸载算法能够降低天基低轨卫星网络计算负载,且时延和能耗均低于DDPG卸载算法和GA卸载算法.与DDPG卸载算法相比,GA-DDPG卸载算法还能提升收敛速度和稳定性.

关键词：低轨卫星边缘计算任务卸载遗传算法深度强化学习星间链路

SlBEL11 regulates flavonoid biosynthesis,thus fine-tuning auxin efflux to prevent premature fruit drop in tomato

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Journal of Integrative Plant Biology 2024年第4期66卷 749-770页

作者： Xiufen Dong Xianfeng Liu lina Cheng Ruizhen Li Siqi Ge Sai Wang Yue Cai Yang Liu Sida Meng Cai-Zhong Jiang Chun-Lin shi Tianlai Li Daqi Fu Mingfang Qi Tao Xu College of Horticulture Shenyang Agricultural UniversityShenyang 110866China Collaborative Innovation Center for Efficient and Green Production of Agriculture in Mountainous Areas of Zhejiang Province College of Horticulture ScienceZhejiang A&F UniversityHangzhou 311300China Key Laboratory for Quality and Safety Control of Subtropical Fruits and Vegetables Collaborative Innovation Center for Efficient and Green Production of Agriculture in Mountainous Areas of Zhejiang ProvinceMinistry of Agriculture and Rural AffairsCollege of Horticulture ScienceZhejiang A&F UniversityHangzhou 311300China Key Laboratory of Protected Horticulture of Ministry of Education Shenyang 110866China Crops Pathology and Genetic Research Unit United States Department of Agriculture Agricultural Research ServiceWashingtonDC 20250USA Department of Plant Sciences University of CaliforniaDavisCA 95616USA AngENOVO Oslo 0753Norway Laboratory of Fruit Biology College of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China

Auxin regulates flower and fruit abscission,but how developmental signals mediate auxin transport in abscission remains ***,we reveal the role of the transcription factor BEL1-LIKE HOMEODOMAIN11(SlBEL11)in regulating auxin transport during abscission in tomato(Solanum lycopersicum).SlBEL11 is highly expressed in the fruit abscission zone,and its expression increases during fruit *** of SlBEL11 expression by RNA interference(RNAi)caused premature fruit drop at the breaker(Br)and 3d post-breaker(Br+3)stages of fruit *** and metabolome analysis of SlBEL11-RNAi lines revealed impaired flavonoid biosynthesis and decreased levels of most flavonoids,especially quercetin,which functions as an auxin transport *** suggested that SlBEL11 prevents premature fruit abscission by modulating auxin efflux from fruits,which is crucial for the formation of an auxin response ***,quercetin treatment suppressed premature fruit drop in SlBEL11-RNAi *** affinity purification sequencing(DAP-seq)analysis indicated that SlBEL11 induced expression of the transcription factor gene SlMYB111 by directly binding to its *** immunoprecipitation-quantitative polymerase chain reaction and electrophoretic mobility shift assay showed that *** MYELOBLASTOSIS VIRAL ONCOGENE HOMOLOG111(SlMYB111)induces the expression of the core flavonoid biosynthesis genes SlCHS1,SlCHI,SlF3H,and SlFLS by directly binding to their *** findings suggest that the SlBEL11-SlMYB111 module modulates flavonoid biosynthesis to fine-tune auxin efflux from fruits and thus maintain an auxin response gradient in the pedicel,thereby preventing premature fruit drop.

关键词： abscission auxin flavonoid SlBEL11 tomato

英语写作教学中作文自动评价系统反馈有效性的元分析

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中国外语 2024年第4期21卷 69-77页

作者：王利娜上海健康医学院

作文自动评价系统在国内外英语写作教学中的应用越来越广泛,但是学界对作文自动评价系统反馈能否有效促进英语写作教学却一直存在争议。本研究对国内外25项作文自动评价系统反馈实证研究进行了元分析,探究其在英语写作教学中的效果及影... 详细信息

作文自动评价系统在国内外英语写作教学中的应用越来越广泛,但是学界对作文自动评价系统反馈能否有效促进英语写作教学却一直存在争议。本研究对国内外25项作文自动评价系统反馈实证研究进行了元分析,探究其在英语写作教学中的效果及影响因素。结果显示,作文自动评价系统反馈具有中等效应,研究背景、学习者教育层次和专业、作文自动评价系统平台、评分主体以及干预次数对反馈效果均有显著影响。本研究结果对英语写作教学、作文自动评价系统反馈研究和作文自动评价系统开发具有一定的启示。

关键词：作文自动评价系统反馈元分析写作教学

进化与共生:产业化进程中我国艺术电影的制作生态

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当代电影 2024年第7期 33-39页

作者：靳丽娜中国电影艺术研究中心电影产业研究部

韩延的《我爱你!》、孔大山的《宇宙探索编辑部》、魏书钧的《河边的错误》、张律的《白塔之光》、刘伽茵的《不虚此行》等都各具特色,在获得口碑的同时也赢得了观众的青睐,我国的艺术电影似乎又迎来了新一波的发展高峰。伴随着我国电... 详细信息

韩延的《我爱你!》、孔大山的《宇宙探索编辑部》、魏书钧的《河边的错误》、张律的《白塔之光》、刘伽茵的《不虚此行》等都各具特色,在获得口碑的同时也赢得了观众的青睐,我国的艺术电影似乎又迎来了新一波的发展高峰。伴随着我国电影产业化改革的步伐加快,艺术电影的制作生态是否发生了改变?本文从2023年以来的艺术电影市场表现入手,探讨市场容量的扩张、观影人群规模的增长、差异化观影渠道的拓展对艺术电影市场表现的影响;进而从思维理念、投资扶持、制作模式三个维度发掘艺术电影制作生态的进化呈现出发行思维前置、国内资本主导、监制等主创团队推进艺术电影工业化流程的特点。

关键词：艺术电影制作生态监制工业化流程

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全向双功能太赫兹超表面器件

光学学报 2024年第3期44卷 247-259页

作者：张丽娜李九生中国计量大学太赫兹波研究所浙江杭州310018

传统太赫兹多功能超表面器件只适用于对圆极化波或线极化波进行单独操控,应用场景受到局限。针对这一问题,提出一种全向双功能太赫兹超表面用于对圆极化和线极化波进行操控。该超表面单元由4层聚酰亚胺介质以三明治形式分隔5个金属层(... 详细信息

传统太赫兹多功能超表面器件只适用于对圆极化波或线极化波进行单独操控,应用场景受到局限。针对这一问题,提出一种全向双功能太赫兹超表面用于对圆极化和线极化波进行操控。该超表面单元由4层聚酰亚胺介质以三明治形式分隔5个金属层(顶层和底层椭圆金属图案、第3和第7层的金属光栅以及中间矩形金属条结构)组成。当圆极化太赫兹波入射时,该超表面结构在频率1.4 THz和1.5 THz处产生拓扑荷数l=±1、±2涡旋波束,在1.3 THz处产生l=-1四个涡旋波束和l=+2偏移涡旋波束,并且在1.5 THz处同时产生l=-1、+2叠加涡旋波束。当线极化太赫兹波从±z方向入射时,所设计的超表面在频率0.72 THz处实现透射波极化转换功能,极化转换率大于95%。研究结果表明,该超表面为实现双向多功能太赫兹波调控器件设计提供了一种创新思路。

关键词：太赫兹涡旋波束发生器极化转换多功能

中原北方宋金时期仿木构砖室墓的营建类型及技法特征刍议

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故宫博物院院刊 2024年第8期 102-117,157,158页

作者：俞莉娜北京大学中国考古学研究中心北京大学考古文博学院

本文关注中原北方宋金时期仿木构砖室墓中的砖作营造系统,从砖雕装饰、砖雕仿木构两方面的加工建造特征出发,将宋金仿木构砖室墓分为以条砖为主、部分模件化和高度模件化三种营建方式,并以桌椅和对坐装饰为例,复原讨论了不同营建方式下... 详细信息

本文关注中原北方宋金时期仿木构砖室墓中的砖作营造系统,从砖雕装饰、砖雕仿木构两方面的加工建造特征出发,将宋金仿木构砖室墓分为以条砖为主、部分模件化和高度模件化三种营建方式,并以桌椅和对坐装饰为例,复原讨论了不同营建方式下砖室墓的建造工序。作者认为,砖室墓营建方式的差异与其技术传播方式和工匠组织有关。在以条砖为主的营建方式下,砖作技术依赖口诀传播,或体现了北宋小农生产下的兼业活动的历史背景;而在高度模件化的营建方式下,砖作技术转而以摹本的形式传播,是北宋晚期及金代工匠组织形式变化的历史见证。

关键词：宋金时期仿木构砖室墓营造技术工匠组织

Uniformity Control of Scanned Beam in 300 MeV Proton and Heavy Ion Accelerator Complex at SESRI

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原子能科学技术 2024年第4期58卷 705-713页

作者： HOU Lingxiao YUAN Youjin shEN Guodong RUAN shuang LIU Jie ZHU Yunpeng WAng Geng GUO Hongliang LYU Mingbang GAO Daqing XU Zhiguo sh.ng lina YAng Jiancheng Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

In recent years,heavy ion accelerator technology has been rapidly developing worldwide and widely applied in the fields of space radiation simulation and particle ***,a very high uniformity in the irradiation area is required for the extracted ion beams,which is crucial because it directly affects the experimental precision and therapeutic ***,ultra-large-area and high-uniformity scanning are crucial requirements for spacecraft radiation effects assessment and serve as core specification for beamline terminal *** the 300 MeV proton and heavy ion accelerator complex at the Space Environment Simulation and Research Infrastructure(SESRI),proton and heavy ion beams will be accelerated and ultimately delivered to three irradiation *** order to achieve the required large irradiation area of 320 mm×320 mm,horizontal and vertical scanning magnets are used in the extraction beam ***,considering the various requirements for beam species and energies,the tracking accuracy of power supplies(PSs),the eddy current effect of scanning magnets,and the fluctuation of ion bunch structure will reduce the irradiation *** mitigate these effects,a beam uniformity optimization method based on the measured beam distribution was proposed and applied in the accelerator complex at *** the experiment,the uniformity is successfully optimized from 75%to over 90%after five iterations of adjustment to the PS *** this paper,the method and experimental results were introduced.

关键词： heavy ion accelerator beam uniformity scanning magnet MIC