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Danish cohort of monozygotic inflammatory bowel disease twins: Clinical characteristics and inflammatory activity

World Journal of Gastroenterology 2016年第21期22卷 5050-5059页

作者： Frederik Trier Moller lina knudsen Marcus Harbord Jack Satsangi Hannah Gordon Lene Christiansen Kaare Christensen Tine Jess Vibeke Andersen Research Unit for Molecular Diagnostics Hospital of Southern Jutland Institute of Regional Health Research University of Southern Denmark Division of Epidemiology and Disease Surveillance Statens Serum Institut Department of Gastro-enterology Chelsea and Westminster Hospital Centre for Molecular Medicine University of Edinburgh Western General Hospital Danish Ageing Research Centre Institute of Public Health University of Southern Denmark Department of Clinical Medicine University of Aalborg

AIM: To describe the establishment of a Danish inflammatory bowel diseases (IBD) twin cohort with focus on concordance of treatment and inflammatory ***: We identified MZ twins, likely to be discordant or concordant for IBD, by merging information from the Danish Twin Register and the National Patient Register. The twins were asked to provide biological samples, questionnaires, and data access to patient files and public registries. Biological samples were collected via a mobile laboratory, which allowed for immediate centrifugation, fractionation, and storage of samples. The mean time from collection of samples to storage in the -80 °C mobile freezer was less than one hour. The diagnoses where validated using the Copenhagen diagnostic ***: We identified 159 MZ IBD twin pairs, in a total of 62 (39%) pairs both twins agreed to participate. Of the supposed 62 IBD pairs, the IBD diagnosis could be confirmed in 54 pairs. The cohort included 10 concordant pairs, whereof some were discordant for either treatment or surgery. The 10 concordant pairs, where both pairs suffered from IBD, included eight CD/CD pairs, one UC/UC pair and one UC/IBDU pair. The discordant pairs comprised 31 UC, 5 IBDU (IBD unclassified), and 8 CD discordant pairs. In the co-twins not affected by IBD, calprotectin was above 100 μg/g in 2 participants, and above 50 μg/g in a further 5 ***: The presented IBD twin cohorts are an excellent resource for bioinformatics studies with proper adjustment for disease-associated exposures including medication and inflammatory activity in the co-twins.

关键词： Digestive system diseases Inflammatory bowel diseases Crohn’ s disease Ulcerative colitis Epidemiologic studies Twins Biobank

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Novel understanding of ABC transporters ABCB1/MDR/P-glycoprotein, ABCC2/MRP2, and ABCG2/BCRP in colorectal pathophysiology

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World Journal of Gastroenterology 2015年第41期21卷 11862-11876页

作者： Vibeke Andersen Katrine Svenningsen lina Almind knudsen Axel Kornerup Hansen Uffe Holmskov Allan Stensballe Ulla Vogel Molecular Diagnostic and Clinical Health Research Unit Hospital of Southern Jutland Institute of Regional Health Research-Centre S?nderjylland University of Southern Denmark Medical Department Regional Hospital Viborg Experimental Animal Models University of Copenhagen Department of Cancer and Inflammation Research University of Southern Denmark Department of Health Science and Technology Aalborg University National Research Centre for the Working Environment

AIM: To evaluate ATP-binding cassette(ABC) transporters in colonic pathophysiology as they had recently been related to colorectal cancer(CRC) development. METHODS: Literature search was conducted on Pub Med using combinations of the following terms: ABC transporters, ATP binding cassette transporter proteins, inflammatory bowel disease, ulcerative, colitis, Crohns disease, colorectal cancer, colitis, intestinal inflammation, intestinal carcinogenesis, ABCB1/P-glycoprotein(P-gp/CD243/MDR1), ABCC2/multidrug resistance protein 2(MRP2) and ABCG2/breast cancer resistance protein(BCRP), Abcb1/Mdr1 a, abcc2/Mrp2, abcg2/Bcrp, knock-out mice, tight junction, membrane lipid function. RESULTS: Recently, human studies reported thatchanges in the levels of ABC transporters were early events in the adenoma-carcinoma sequence leading to CRC. A link between ABCB1, high fat diet and gut microbes in relation to colitis was suggested by the animal studies. The finding that colitis was preceded by altered gut bacterial composition suggests that deletion of Abcb1 leads to fundamental changes of hostmicrobiota interaction. Also, high fat diet increases the frequency and severity of colitis in specific pathogenfree Abcb1 KO mice. The Abcb1 KO mice might thus serve as a model in which diet/environmental factors and microbes may be controlled and investigated in relation to intestinal inflammation. Potential molecular mechanisms include defective transport of inflammatory mediators and/or phospholipid translocation from one side to the other of the cell membrane lipid bilayer by ABC transporters affecting inflammatory response and/or function of tight junctions, phagocytosis and vesicle trafficking. Also, diet and microbes give rise to molecules which are potential substrates for the ABC transporters and which may additionally affect ABC transporter function through nuclear receptors and transcriptional regulation. Another critical role of ABCB1 was suggested by the finding that ABCB1 expr

关键词： ATP-binding cassette transporters Colorectal cance

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表面波纹度及粗糙度对微气体轴承性能的影响

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润滑与密封 2023年第4期48卷 104-111页

作者：李祥张小青司丽娜田斌北京工商大学人工智能学院北京100048 北方工业大学机械与材料工程学院北京100144

为了探究表面粗糙度、表面波纹度以及两者同时存在时对气体滑块轴承润滑性能的影响,采用分形函数表征粗糙表面,正弦曲线表征表面波纹度,代入适用于任意努森数的超薄气膜润滑Reynolds方程,得到同时考虑表面形貌特征及稀薄效应的润滑方程... 详细信息

为了探究表面粗糙度、表面波纹度以及两者同时存在时对气体滑块轴承润滑性能的影响,采用分形函数表征粗糙表面,正弦曲线表征表面波纹度,代入适用于任意努森数的超薄气膜润滑Reynolds方程,得到同时考虑表面形貌特征及稀薄效应的润滑方程,并采用有限差分法进行求解。结果表明:在轴承不发生碰磨的情况下,轴承表面粗糙度值越大,气膜压力越高,轴承承载力也越高;表面波纹度的幅值、相位角、周期对轴承性能均有较大影响,相位角φ=3π/4附近、波纹周期在0.4及0.8附近时承载力较大;对于复合形貌表面,表面粗糙度可以弥补表面波纹度可能带来的气膜压力及承载力损失,轴承数越大,效果越明显;表面粗糙度对压力中心影响较小,而波纹度对压力中心的影响较大。

关键词：微气体轴承表面粗糙度分形函数表面波纹度稀薄效应

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