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Nanoprobes in biomedical detection

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Science China Chemistry 2016年第3期59卷 255-263页

作者： Yawei zhao Changling Zou Hongkang zhao lina zhao School of Physics Beijing Institute of Technology Beijing 100081 China Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China

Environmental problems caused by the development of nanotechnology have threatened human health. Investigating the biomedical effects of nanomaterials can help to solve these environmental safety issues. In studies on the biomedical effects of nanomaterials, several types of novel nanoscale probes that allow reliable, sensitive, accurate and rapid biomedical detection have emerged. We summarize recent developments in three categories of these nanoprobes, including noble metal nanocluster probes, carbon-based nanostructured probes, and unnatural amino acid-based probes. Besides reviewing the utility of different nanoprobes in cell imaging and protein detection, we also discuss the molecular mechanism of nanoprobe detection. Perspectives of novel nanoprobe design based on molecular details of biomedical detection are presented.

关键词： nanomaterials nanoprobes biomedical detection environmental safety

The reactive activities of natural amino acids: key principles of peptide-templated Au cluster synthesis

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Science Bulletin 2016年第22期61卷 1732-1738页

作者： Xu Li Nan Li lina zhao Department of Mechanical and Electrical Engineering North China Institute of Science and Technology Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics Chinese Academy of Sciences School of Physics Beijing Institute of Technology

Coating of gold nanoclusters with peptides is an important targeting method in biomedical ***, their synthetic method highly influences their targeting ability. Current methods often use harsh reagents and organic solvents to control morphology, which are not preferred for biomedical applications. Recently, several peptides with specific amino acid sequences have successfully been used to reduce Au ions and synthesize biocompatible peptide-covered gold particles in ***, the molecular mechanism of peptide-assisted nanocluster formation is yet unclear. Thus, reactive abilities of different amino acids should be studied to improve design of peptides with predetermined amino acid content and consequently, synthesize gold nanoclusters with improved performance. In this theoretical study, we have approximated the reactive abilities of 20 natural amino acids in their neutral state using density functional theory calculations, such as Fukui indices and HOMO/LUMO composition analysis. We have found that the top reducing agents are tryptophan, histidine, and tyrosine, and thestrongest binding can be expected from methionine and cysteine. Further study of the exact reactive sites in these high reactive amino acids provided the deep insight for the peptide design route for the targeted gold nanocluster formation.

关键词： Reactive activity Amino acid Synthesis in situ Au nanocluster DFT calculation

In situ synthesis and modification of calcium carbonate nanoparticles via a bobbling method

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Science China Chemistry 2009年第7期52卷 924-929页

作者： zhao lina FENG JingDong WANG ZiChen College of Chemistry Jilin Normal UniversitySiping 136000China Institute of Chemistry Jilin UniversityChangchun 130023China

Modified calcium carbonate (CaCO3) nanoparticles with cubic- and spindle-like configuration were synthesized in situ by the typical bobbling (gas-liquid-solid) method. The modifiers, such as sodium stearate, octadecyl dihydrogen phosphate (ODP) and oleic acid (OA), were used to obtain hydrophobic nanoparticles. The different modification effects of the modifiers were investigated by measuring the active ratio, whiteness and the contact angle. Moreover, transmission electron microscopy (TEM), X-ray diffraction (XRD) and thermogravimetry analysis (TGA analysis) were employed to characterize the obtained products. A preliminary reaction mechanism was discussed. According to the results, the active ratio of CaCO3 modified by ODP was ca. 99.9% and the value of whiteness was 97.3% when the dosage of modifiers reached 2%. The contact angle was 122.25° for the CaCO3 modified in the presence of sodium stearate, ODP and OA. When modified CaCO3 was filled into PVC, the mechanical properties of products were improved greatly such as rupture intensity, pull intensity and fuse temperature. The compatibility and affinity between the modified CaCO3 nanoparticles and the organic matrixes were greatly improved.

关键词： in situ synthesis CaCO3 nanoparticles hydrophobic modifiers mechanical properties PVC

Targeted peptide-Au cluster binds to epidermal growth factor receptor (EGFR) in both active and inactive states： a clue for cancer inhibition through dual pathways

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Science Bulletin 2018年第6期63卷 349-355页

作者： Peng Zhang Jiao Zhai Xueyun Gao Hongkang zhao Wenyong Su lina zhao School of Physics Beijing Institute of Technology Beijing 100081 China Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Department of Chemistry and Chemical Engineering. Beijing University of Technology Beijing 100124 China

The epidermal growth factor receptor （EGFR） has become an important target protein in anticancer drug development. Meanwhile, peptide-Au cluster has been proposed as potential targeted nano-drug assembled by targeting peptide. Here, we designed and synthesized a novel peptide-Au cluster as AuloPeptides to target to EGFR. We found AumPeptides could target to the natural binding sites of all EGFRs at mem- brane in both active and inactive states by molecular simulations. Its targeted ability was further verified by the co-localization and blocking experiments. We also study the configuration modifications of both active and inactive EGFRs after binding by AumPeptides. For active EGFR, the absorbed AuloPeptide5 might replace the natural ligand in EGFR endocytosis process. Then, the peptide-Au cluster in endochylema could inhibit the cancer relating enzyme activity including thioredoxin reductasel （TrxR1） and induce the oxidative stress mediated apoptosis in tumor cells. For inactive EGFR, it was retained in inactive state by Au10 Peptides binding to inhibit dimerization of EGFR for anticancer. Both pathways might be applied in anticancer drug development based on the theoretical and experimental study here.

关键词： peptide-Au cluster EGFR Targeted binding Anticancer

A Uniformly Robust Staggered DG Method for the Unsteady Darcy-Forchheimer-Brinkman Problem

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Communications on Applied Mathematics and Computation 2022年第1期4卷 205-226页

作者： lina zhao Ming Fai Lam Eric Chung Department of Mathematics The Chinese University of Hong KongHong Kong SARChina

In this paper,we propose and analyze a uniformly robust staggered DG method for the unsteady Darcy-Forchheimer-Brinkman *** formulation is based on velocity gradient-velocity-pressure and the resulting scheme can be flexibly applied to fairly general polygonal *** relax the tangential continuity for velocity,which is the key ingredi-ent in achieving the uniform *** present well-posedness and error analysis for both the semi-discrete scheme and the fully discrete scheme,and the theories indicate that the error estimates for velocity are independent of *** numerical experiments are presented to confirm the theoretical findings.

关键词： Staggered DG method Brinkman-Forchheimer General meshes Uniformly stable

Anisotropic diffusion filtering for ultrasound speckle reduction

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Science China(Technological Sciences) 2014年第3期57卷 607-614页

作者： GUAN FaDa TON Phuc GE ShuaiPing zhao lina The University of Texas MD Anderson Cancer Center Houston TX 77054 USA Nanjing University of Aeronautics and Astronautics Roche Molecular Diagnostics Pleasanton CA 94588 USA The Fourth Military Medical University Xijing Hospital

Speckle noise has long been known as a limiting factor for the quality of an ultrasound B-mode *** this study,anisotropic diffusion filtering is proposed as an effective method for ultrasound speckle *** article provides a brief description of anisotropic diffusion filtering proposed by Perona and Malik,and compares its speckle filtering effects with other filtering methods including median,moving average,and frequency domain Gaussian *** this study,multiple filters are implemented in *** each filter,three different types of noisy images with speckle noise are *** results show that anisotropic filter can reduce the noise more effectively and meanwhile preserve the boundaries of the *** addition,this filter has more controllable filtering parameters and is independent on the information of the noise.

关键词： anisotropic diffusion filter ultrasound speckle reduction

Derivation and verification of minimum energy dissipation rate principle of fluid based on minimum entropy production rate principle

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International Journal of Sediment Research 2016年第1期31卷 16-24页

作者： Guobin Xu lina zhao Chih Ted Yang State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin University Civil and Environmental Engineering Department.Colorado State University

Based on non-equilibrium thermodynamics theory,minimum energy dissipation rate principle can be derived from minimum entropy production rate *** entropy production rate principle is equivalent to minimum energy dissipation rate *** order to verify the fluid motion following minimum energy dissipation rate principle,RNG k-εturbulence model and GMO model of Flow 3D were applied to simulate fluid motion in a straight rectangular *** results show that fluid motion satisfies the minimum energy dissipation rate *** validity of minimum energy dissipation rate of alluvial rivers has been tested with field *** a river system is at a relative equilibrium state,the value of its energy dissipation rate is at *** minimum value depends on the constraints applied to the river ***,due to the dynamic nature of a river,the minimum value may vary with respective to time and *** stream power and minimum unit stream power principles are special and simplified versions of the more general minimum energy dissipation rate principle.

关键词： Fluid Minimum energy dissipation rate Minimum entropy production rate Minimum stream power Minimum unit stream power Open system Steady non-equilibrium state

Partial Oxidation of Methane to Synthesis Gas over Hexaaluminates LaMAl_(11)O_(19-δ) catalysts

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Journal of Natural Gas Chemistry 2007年第1期16卷 60-63页

作者： Zhanlin Xu lina zhao Fang Pang Liang Wang Chunyan Niu College of Chemistry Jilin Normal University Siping 136000 Jilin China

A series of M-substituted hexaaluminates LaMAl11O19-δ （M=Fe, Co, Ni, Mn, and Cu） were prepared and characterized by XRD, XPS, TPR and TGA techniques, respectively. They exhibited different reducibility and catalytic activity for partial oxidation of methane （POM） to synthesis gas. Among the LaMAl11019-δ samples, LaNiAl11O19-δ showed the best catalytic activity for the topic reaction and selectivity for synthesis gas at 780 ℃ for 2 h. The conversion of CH4 was over 99.2%, and the product selectivity for both CO and H2 was above 90.3%.

关键词： partial oxidation CH4 synthesis gas hexaaluminates LaMAl11 O19-δ Fe Co Ni Mn Cu

Asymmetric nonlinear-mode-conversion in an optical waveguide with PT symmetry

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Frontiers of physics 2022年第5期17卷 183-190页

作者： Changdong Chen Youwen Liu lina zhao Xiaopeng Hu Yangyang Fu College of Physics Nanjing University of Aeronautics and AstronauticsNanjing 211100China Key Laboratory of Aerospace Information Materials and Physics(NUAA) MIITNanjing 211106China Collaborative Innovation Center of Light Manipulations and Applications Shandong Normal UniversityJinan 250358China National Laboratory of Solid State Microstructures College of Engineering and Applied Sciencesand School of PhysicsNanjing UniversityNanjing 210093China

Asymmetric mode transformation in waveguide is of great significance for on-chip integrated devices with one-way effect,while it is challenging to achieve asymmetric nonlinear-mode-conversion(NMC)due to the limitations imposed by *** this work,we theoretically proposed a new scheme for realizing asymmetric NMC by combining frequencydoubling process and periodic PT symmetric modulation in an optical *** engineering the one-way momentum from PT symmetric modulation,we have demonstrated the unidirectional conversion from pump to second harmonic with desired guided *** findings offer new opportunities for manipulating nonlinear optical fields with PT symmetry,which could further boost more exploration on on-chip nonlinear devices assisted by non-Hermitian optics.

关键词： nonlinear mode conversion meta-grating PT symmetry optical waveguide