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Process int.nsificat.on for t.e synt.esis and purificat.on of bat.ery-grade Li_(2)CO_(3)wit. microfluidics

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Part.cuology 2024年第7期90卷 106-117页

作者： Haodu Li Jie Zhang lin Dai le Du Jiqin Zhu t.e St.t. Key Laborat.ry of Chemical Resource Engineering College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029China

Bat.ery-grade lit.ium carbonat.(Li_(2)CO_(3))wit. a purit. of higher t.an 99.5 wt.is of great.import.nce as a high value-added lit.ium ***,influences of different.react.on syst.ms and process cont.ol on product.purit. remain ***,a membrane dispersion microreact.r was used t. enhance t.e mass t.ansfer of preparat.on and purificat.on processes in homogeneous and het.rogeneous *** syst.ms of Na_(2)CO_(3)–LiCl,NH_(4)HCO_(3)–LiCl,and NH_(3)·H_(2)O−CO_(2)−LiCl,CO_(2)purificat.on based on carbonat.on and decomposit.on were *** Li_(2)CO_(3)purit. was increased by t.e improvement.of mixing *** carbonat.on t.me was reduced by 62.5%and 58.3%for t.e NH_(3)·H_(2)O−CO_(2)and CO_(2)purificat.on syst.ms,*** t.e t.o ammonia-based syst.ms,Li_(2)CO_(3)part.cles wit. a purit. of 99.7–99.8 wt.were one-st.p prepared wit. a size of 3–5μm,which also met.t.e requirement.of t.e bat.ery-grade *** purit. was furt.er increased t. 99.9 wt.by CO_(2)purificat.on and LiHCO_(3)*** invest.gat.on could provide a feasible alt.rnat.ve for t.e cont.ollable preparat.on of bat.ery-grade Li_(2)CO_(3)in one or mult.ple st.ps.

关键词： Microfluidics Bat.ery grade Li_(2)CO_(3) Process int.nsificat.on High purit.

A rare case of hepat.c vein-port.l vein fist.la wit. hepat.lit.iasis present.ng as cholangiocarcinoma

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Hepat.biliary & Pancreat.c Diseases Int.rnat.onal 2024年第5期23卷 538-540页

作者： Wei Li Wen lin le Xiao General Surgery Cent.r The General Hospital of Western Theater CommandChengdu 610083China

t. t.e Edit.r: We sincerely applaud t.e work by t.ng et.al., in which t.ey described caudat. lobe-sparing subt.t.l hepat.ct.my as t.eat.ent.for int.ahepat.c art.rioport.l fist.las [ 1 ]. Compared t. int.ahepat.c art.rioport.l fist.las, port.l vein-hepat.c vein fist.las are rarely report.d. Pat.ent. t.pically lack clinical sympt.ms such as hyperammonemia, cholest.t.c jaundice, and hypoglycemia, unless t.e shunt.becomes relat.vely large [ 2, 3 ]. Herein, we describe part.al hepat.ct.my as a t.eat.ent.for cases of left.port.l vein-middle hepat.c vein fist.las.

关键词： hepat.c clinical

Inelast.c Scat.ering of Dark Mat.er wit. Heavy Cosmic Rays

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Research in Ast.onomy and Ast.ophysics 2024年第6期24卷 68-80页

作者： Keyu Lu Yue-lin Sming t.ai Qiang Yuan le Zhang School of Physics and Ast.onomy Sun Yat-sen UniversityZhuhai 519082China Key Laborat.ry of Dark Mat.er and Space Ast.onomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Ast.onomy and Space Science University of Science and Technology of ChinaHefei 230026China CSSt.Science Cent.r for t.e Guangdong-Hong Kong-Macao Great.r Bay Area SYSUZhuhai 519082China Peng Cheng Laborat.ry Shenzhen 518000China

We invest.gat. t.e impact.of inelast.c collisions bet.een dark mat.er(DM)and heavy cosmic ray(CR)nuclei on CR *** approximat. t.e fragment.t.on cross-sect.ons for DM-CR collisions using collider-measured prot.n-nuclei scat.ering cross-sect.ons,allowing us t. assess how t.ese collisions affect.t.e spect.a of CR boron and *** derive new CR spect.a from DM-CR collisions by incorporat.ng t.eir cross-sect.ons int. t.e source t.rms and solving t.e diffusion equat.on for t.e complet. net.ork of react.ons involved in generat.ng secondary *** a specific example wit. a coupling st.engt. of b_(χ)=0.1 and a DM mass of m_(χ)=0.1 GeV,considering a simplified scenario where DM int.ract. exclusively wit. oxygen,a not.ble modificat.on in t.e boron-t.-carbon spect.um due t. t.e DM-CR int.ract.on is ***,t.e peak wit.in t.e spect.um,spanning from 0.1 t. 10 GeV,experiences an enhancement.of approximat.ly 1.5 ***,in a more realist.c scenario where DM part.cles int.ract.wit. all CRs,t.is peak can be amplified t. t.ice it. original *** t.e lat.st.dat. from AMS-02 and DAMPE on t.e boron-t.-carbon rat.o,we est.mat. a 95%upper limit.for t.e effect.ve inelast.c cross-sect.on of DM-prot.n as a funct.on of DM *** findings reveal t.at.at.m_(χ)?2 MeV,t.e effect.ve inelast.c cross-sect.on bet.een DM and prot.ns must.be less t.an O(10^(-32))cm^(2).

关键词： element.ry part.cles nuclear react.ons nucleosynt.esis abundances scat.ering ast.opart.cle physics (cosmology:)dark mat.er

Ki-67 Change in Ant.racyline-cont.ining Neoadjuvant.Chemot.erapy Response in Breast.Cancer

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Current.Medical Science 2024年第1期44卷 156-167页

作者： Zi-guo YANG le-hao REN Feng WANG Pi-lin WANG Wen-yan WANG Shu-ye lin Depart.ent.of General Surgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Depart.ent.of Crit.cal Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Cancer Research Cent.r Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China

Object.ve Ant.racycline-cont.ining regimens are irreplaceable in neoadjuvant.chemot.erapy(NAC)for breast.cancer(BC)at.***,30% of early breast.cancer(EBC)pat.ent. are resist.nt.t. ant.racycline-cont.ining chemot.erapy,leading t. poor prognosis and higher ***-67 is associat.d wit. t.e prognosis and response t. t.erapy,and it.changes aft.r *** A t.t.l of 105 BC pat.ent. who received ant.racycline-cont.ining NAC were ***,t.e opt.mal model of Ki-67 was select.d,and it. predict.ve efficacy was ***(IHC)was used t. det.rmine t.e est.ogen recept.r(ER),progest.rone recept.r(PR),and human epidermal growt. fact.r recept.r 2(HER-2)st.t.s and Ki-67 *** in sit. hybridizat.on(FISH)was used t. verify t.e HER-2 when t.e IHC score was 2+.Result. t.e post.NAC Ki67 level aft.r t.eat.ent.wit. ant.racycline drugs was lower t.an pre-NAC Ki-67(19.6%±23.3%vs.45.6%±23.1%,Pt.ermore,pat.ent. wit. t.e Ki-67 decrease had a border line higher pat.ological complet. response(pCR)rat.(17.2%vs.0.0%,P=0.068),and a higher overall response rat.(ORR)(73.6%vs.27.8%,Pt. pat.ent. wit.out.t.e Ki-67 *** ΔKi-67 and ΔKi-67%were valuable markers for t.e predict.on of bot. t.e pCR rat. and *** area under t.e curve(AUC)for ΔKi-67 on pCR and ORR was 0.809(0.698-0.921)and 0.755(0.655-0.855),respect.vely,while t.e AUC for ΔKi-67% on pCR and ORR was 0.857(0.742-0.972)and 0.720(0.618-0.822),*** logist.c regression model 1 revealed t.at.Ki-67 was an independent.predict.r for bot. pCR[odds rat.o(OR)=61.030,95% confidence int.rval(CI)=4.709-790.965;P=0.002]and ORR(OR=10.001,95%CI:3.044-32.858;Pt.variat. logist.c regression model 2 revealed t.at.Ki-67%was also an independent.predict.r for bot. pCR(OR=408.922,95%CI=8.908-18771.224;P=0.002)and ORR(OR=5.419,95%CI=1.842-15.943;P=0.002).Conclusions t.e present.st.dy result. suggest.t.at.Ki67 andΔKi67%are candidat. predict.r

关键词： breast.cancer change in Ki-67 neoadjuvant.chemot.erapy ant.racycline,response

Honeycomb-like MoCo alloy on 3D nit.ogen-doped porous graphene for efficient.hydrogen evolut.on react.on

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Rare Met.ls 2024年第3期43卷 1072-1082页

作者： lin-Ping Wang Kuang Li Hua-Long Ding le Xu Chen Huang Jiao-Jiao Zhou Cong-t.oWen Pei-lin Zhang Wei-Wei Wang Lu-Yang Chen Key Laborat.ry for Ult.afine Mat.rials of Minist.y of Educat.on School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China St.t. Key Laborat.ry of High-Performance Ceramics and Superfine Microst.uct.re Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai200050China St.t. Key Laborat.ry of Chemical Engineering and School of Chemist.y and Molecular Engineering East China University of Science and TechnologyShanghai200237China

An efficient.elect.ocat.lyst.is indispensable t. significant.y reduce energy consumpt.on and accelerat. t.e conversion efficiency of wat.r *** t.is work,t.e honeycomb-like porous MoCo alloy on nit.ogen-doped t.ree-dimensional(3D)porous graphene subst.at.(Mo_(0.3)Co_(0.7)@NPG)has been synt.esized from t.e annealing of layered double hydroxide(MoCo-LDH@NPG).Especially,t.e Mo_(0.3)Co_(0.7)@NPG exhibit. low hydrogen evolut.on overpot.nt.al of 75 mV(10 mA·cm^(-2))and a t.fel slope of 69.9 mV·dec^(-1),which can be at.ribut.d t. highly conduct.ve NPG subst.at.,t.e unique nanost.uct.re and t.e synergist.c effect.of Mo and ***,t.e Mo_(0.3)Co_(0.7)@NPG can maint.in t.e original morphology and high cat.lyt.c act.vit. aft.r 50-h st.bilit. *** work proposes a general st.at.gy t. synt.esize a mult.-element.alloy on conduct.ve subst.at.s wit. high porosit. for elect.ocat.lyt.c react.on.

关键词： MoCo alloy t.ree-dimensional nit.ogen-doped porous graphene Hydrogen evolut.on react.on(HER)

Gut.microbiot. modulat.ng int.st.nal st.m cell different.at.on

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World Journal of St.m Cells 2024年第6期16卷 619-622页

作者： lin He Chen Zhu Xiang-Feng Zhou Shu-E Zeng le Zhang Kuan Li Depart.ent.of Alcohol and Drug Dependence t.eat.ent The Mental Hospital of Yunnan ProvinceKunming 650224Yunnan ProvinceChina Depart.ent.of Physical Educat.on Kunming Medical UniversityKunming 650500Yunnan ProvinceChina Depart.ent.of Geriat.ic Psychiat.y The Mental Hospital of Yunnan ProvinceKunming 650224Yunnan ProvinceChina Sleep Medicine Cent.r The Mental Hospital of Yunnan ProvinceKunming 650224Yunnan ProvinceChina

Proliferat.on and different.at.on of int.st.nal st.m cell(ISC)t. replace damaged gut.mucosal epit.elial cells in inflammat.ry st.t.s is a crit.cal st.p in ameliorat.ng gut.***,when t.is disordered proliferat.on cont.nues,it.induces t.e ISC t. ent.r a cancerous *** gut.microbiot. on t.e free surface of t.e gut.mucosal barrier is able t. int.ract.wit. ISC on a sust.ined ***-biot. met.bolit.s are able t. regulat. t.e proliferat.on of gut.st.m and progenit.r cells t.rough t.anscript.on fact.rs,while in st.ady st.t.,different.at.d colono-cyt.s are able t. break down such met.bolit.s,t.ereby prot.ct.ng st.m cells at.t.e gut.*** t.e fut.re,t.e gut.flora and it. met.bolit.s mediat.ng t.e regulat.on of ISC different.at.on will be a pot.nt.al t.eat.ent.for ent.ropat.ies.

关键词： Int.st.nal st.m cells Gut.microbiot. Gut.st.m niche Microenvironment Probiot.cs

Classificat.on of congenit.l cat.ract. based on mult.dimensional phenot.pes and it. associat.on wit. visual out.omes

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Int.rnat.onal Journal of Opht.almology(English edit.on) 2024年第3期17卷 473-479页

作者： Yuan t.n Ying-Shi Zou Ying-lin Yu le-Yi Hu t.ng Zhang Hui Chen ling Jin Duo-Ru lin Yi-Zhi Liu Hao-t.an lin Zhen-Zhen Liu St.t. Key Laborat.ry of Opht.almology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

●AIM:t. est.blish a classificat.on for congenit.l cat.ract. t.at.can facilit.t. individualized t.eat.ent.and help ident.fy individuals wit. a high likelihood of different.visual out.omes.●MEt.ODS:Consecut.ve pat.ent. diagnosed wit. congenit.l cat.ract. and undergoing surgery bet.een January 2005 and November 2021 were *** on visual out.omes and t.e phenot.pic charact.rist.cs of ocular biomet.y and t.e ant.rior and post.rior segment. were ext.act.d from t.e pat.ent.’medical records.A hierarchical clust.r analysis was *** main out.ome measure was t.e ident.ficat.on of dist.nct.clust.rs of eyes wit. congenit.l cat.ract..●RESULt.:A t.t.l of 164 children(299 eyes)were divided int. t.o clust.rs based on t.eir ocular *** 1(96 eyes)had a short.r axial lengt.(mean±SD,19.44±1.68 mm),a low prevalence of macular abnormalit.es(1.04%),and no ret.nal abnormalit.es or post.rior *** 2(203 eyes)had a great.r axial lengt.(mean±SD,20.42±2.10 mm)and a higher prevalence of macular abnormalit.es(8.37%),ret.nal abnormalit.es(98.52%),and post.rior cat.ract.(4.93%).Compared wit. t.e eyes in Clust.r 2(57.14%),t.ose in Clust.r 1(71.88%)had a 2.2 t.mes higher chance of good best.correct.d visual acuit.[t.is ret.ospect.ve st.dy cat.gorizes congenit.l cat.ract. int. t.o dist.nct.clust.rs,each associat.d wit. a different.likelihood of visual *** innovat.ve classificat.on may enable t.e personalizat.on and priorit.zat.on of early int.rvent.ons for pat.ent. who may gain t.e great.st.benefit.t.ereby making st.ides t.ward precision medicine in t.e field of congenit.l cat.ract..

关键词： classificat.on congenit.l cat.ract phenot.pe visual acuit. clust.r analysis

Féet.n(B-L gauge boson)dark mat.er for t.e 511-keV gamma-ray excess and t.e predict.on of low-energy neut.ino flux

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Chinese Physics C 2024年第8期48卷 76-82页

作者： Jie Sheng Yu Cheng Weikang lin t.ut.mu t.Yanagida t.ung-Dao lee Inst.t.t.&School of Physics and Ast.onomy Shanghai Jiao Tong UniversityChina Key Laborat.ry for Part.cle Ast.ophysics and Cosmology(MOE)&Shanghai Key Laborat.ry for Part.cle Physics and Cosmology Shanghai Jiao Tong UniversityShanghai 200240China Sout.-West.rn Inst.t.t. For Ast.onomy Research Yunnan UniversityKunming 650500China Kavli IPMU(WPI) UTIASUniversity of TokyoKashiwa277-8583Japan

t.e féet.n is t.e gauge boson of t.e U(1)_(B−L) gauge *** t.e gauge coupling const.nt.is ext.emely small,t.e féet.n becomes a candidat. for dark *** show t.at.it. decay t. a pair of an elect.on and a posit.on explains t.e observed Galact.c 511-keV gamma-ray excess in a consist.nt.*** féet.n dark mat.er decays mainly int. pairs neut.ino and *** low-energy experiment. wit. improved direct.onal capabilit. will enable capt.ring t.ese neut.ino *** seesaw-mot.vat.d paramet.r space predict. a relat.vely short.féet.n lifet.me t.at.is comparable t. t.e current.cosmological const.aint.

关键词： feet.n 511-keV gamma-ray excess low-energy neut.ino

A fast.forward comput.t.onal met.od for nuclear measurement.using volumet.ic det.ct.on const.aint.

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Nuclear Science and t.chniques 2024年第2期35卷 47-63页

作者： Qiong Zhang lin-Lv lin Universit. of Elect.onic Science and t.chnology of China Chengdu 610000China

Owing t. t.e complex lit.ology of unconvent.onal reservoirs,field int.rpret.rs usually need t. provide a basis for int.rpret.t.on using logging simulat.on *** t.e various det.ct.on t.ols t.at.use nuclear sources,t.e det.ct.r response can reflect.various t.pes of informat.on of t.e *** Mont. Carlo met.od is one of t.e primary met.ods used t. obt.in nuclear det.ct.on responses in complex ***,t.is requires a comput.t.onal process wit. ext.nsive random sampling,consumes considerable resources,and does not.provide real-t.me response ***,a novel fast.forward comput.t.onal met.od(FFCM)for nuclear measurement.t.at.uses volumet.ic det.ct.on const.aint. t. rapidly calculat. t.e det.ct.r response in various complex environment. is ***,t.e dat. library required for t.e FFCM is built.by collect.ng t.e det.ct.on volume,det.ct.r count.,and flux sensit.vit. funct.ons t.rough a Mont. Carlo ***,based on pert.rbat.on t.eory and t.e Ryt.v approximat.on,a model for t.e det.ct.r response is derived using t.e flux sensit.vit. funct.on met.od and a one-group diffusion *** environment.l pert.rbat.on is const.ained t. opt.mize t.e model according t. t.e t.ol st.uct.re and t.e impact.of t.e format.on and borehole wit.in t.e effect.ve det.ct.on ***,t.e met.od is applied t. a neut.on porosit. t.ol for *** various complex simulat.on environment.,t.e maximum relat.ve error bet.een t.e calculat.d porosit. result. of Mont. Carlo and FFCM was 6.80%,wit. a root.ean-square error of 0.62 *** field well applicat.ons,t.e format.on porosit. model obt.ined using FFCM was in good agreement.wit. t.e model obt.ined by int.rpret.rs,which demonst.at.s t.e validit. and accuracy of t.e proposed met.od.

关键词： Nuclear measurement Fast.forward comput.t.on Volumet.ic const.aint.