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A Generic Strategy to Create Mechanically Interlocked Nanocomposite/Hydrogel Hybrid Electrodes for Epidermal Electronics

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Nano-Micro Letters 2024年第5期16卷 120-133页

作者： qian Wang yanyan Li Yong lin Yuping Sun Chong Bai Haorun Guo Ting Fang Gaohua Hu yanqing Lu Desheng Kong College of Engineering and Applied Sciences National Laboratory of Solid State Microstructureand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023People’s Republic of China State Key Laboratory of Analytical Chemistry for Life Science and Jiangsu Key Laboratory of Artificial Functional MaterialsNanjing UniversityNanjing 210023People’s Republic of China College of Chemical Engineering and Technology Engineering Research Center of Seawater Utilization Technology of Ministry of EducationState Key Laboratory of Reliability and Intelligence of Electrical EquipmentHebei University of TechnologyTianjin 300130People’s Republic of China Key Laboratory of Intelligent Optical Sensing and Manipulation Nanjing UniversityNanjing 210093People’s Republic of China

Stretchable electronics are crucial enablers for next-generation wearables intimately integrated into the human *** the primary compliant conductors used in these devices,metallic nanostructure/elastomer composites often struggle to form conformal contact with the textured *** electrodes have been consequently developed based on conductive nanocomposite and soft hydrogels to establish seamless skin-device ***,chemical modifications are typically needed for reliable bonding,which can alter their original *** overcome this limitation,this study presents a facile fabrication approach for mechanically interlocked nanocomposite/hydrogel hybrid *** this physical process,soft microfoams are thermally laminated on silver nanowire nanocomposites as a porous interface,which forms an interpenetrating network with the *** microfoam-enabled bonding strategy is generally compatible with various *** resulting interlocked hybrids have a 28-fold improved interfacial toughness compared to directly stacked *** electrodes achieve firm attachment to the skin and low contact impedance using tissue-adhesive *** have been successfully integrated into an epidermal sleeve to distinguish hand gestures by sensing mus-cle *** nanocomposite/hydrogel hybrids reported here offer a promising platform to combine the benefits of both materials for epidermal devices and systems.

关键词： Stretchable electronics Epidermal electronics Silver nanowire Conductive nanocomposites Hydrogel

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Overexpression of the peroxidase gene ZmPRX1 increases maize seedling drought tolerance by promoting root development and lignification

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The Crop Journal 2024年第3期12卷 753-765页

作者： Xiuzhen Zhai Xiaocui yan Tinashe Zenda Nan Wang Anyi Dong qian yang Yuan Zhong Yue Xing Huijun Duan State Key Laboratory of North China Crop Improvement and Regulation Key Laboratory of Crop Germplasm Resources in North China Ministry of EducationCollege of AgronomyHebei Agricultural UniversityBaoding 071001HebeiChina

Drought is a main abiotic stress factor hindering plant growth,development,and crop ***,it is crucial to understand the mechanisms by which plants cope with drought ***,the function of the maize peroxidase gene ZmPRX1 in drought stress tolerance was investigated by measurement of its expression in response to drought treatment both in a ZmPRX1 overexpression line and a mutant *** higher root lignin accumulation and seedling survival rate of the overexpression line than that of the wild type or mutant support a role for ZmPRX1 in maize drought tolerance by regulating root development and ***,yeast one-hybrid,Dule luciferase and ChIP-qPCR assays showed that ZmPRX1 is negatively regulated by a nuclear-localized ZmWRKY86 transcription *** gene could potentially be used for breeding of drought-tolerant cultivars.

关键词： Drought tolerance Maize ZmPRX1 Root development Lignin biosynthesis

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Helicobacter pylori infection alters gastric microbiota structure and biological functions in patients with gastric ulcer or duodenal ulcer

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World Journal of Gastroenterology 2024年第24期30卷 3076-3085页

作者： ling-Xiao Jin Yu-Peng Fang Chen-Mei Xia Teng-Wei Cai qian-qian Li Yu-Yin Wang Hai-Fan yan Xia Chen Department of Gastroenterology Wenling Hospital of Wenzhou Medical University(The First People’s Hospital of Wenling)Wenling 317500Zhejiang ProvinceChina

BACKGROUND Helicobacter pylori(***)infection is closely associated with gastrointestinal *** preliminary studies have indicated that *** infection had a significant impact on the mucosal microbiome structure in patients with gastric ulcer(GU)or duodenal ulcer(DU).AIM To investigate the contributions of *** infection and the mucosal microbiome to the pathogenesis and progression of ulcerative *** Patients with *** infection and either GU or DU,and healthy individuals without *** infection were *** or duodenal mucosal samples was obtained and subjected to metagenomic *** compositions of the microbial communities and their metabolic functions in the mucosal tissues were *** Compared with that in the healthy individuals,the gastric mucosal microbiota in the ***-positive patients with GU was dominated by ***,with signi-ficantly reduced *** intergroup differential functions,which were enriched in the ***-positive GU patients,were all derived from ***,particularly those concerning transfer RNA queuosine-modification and the synthesis of demethylmenaquinones or menaquinones.A significant enrichment of the uibE gene was detected in the synthesis *** was no significant difference in microbial diversity between the ***-positive DU patients and healthy *** *** infection significantly alters the gastric microbiota structure,diversity,and biological functions,which may be important contributing factors for GU.

关键词： Helicobacter pylori Gastric ulcer Duodenal ulcer Metagenomic sequencing Transfer RNA queuosine-modification Menaquinones

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Effect of lens surgery on health-related quality of life in preschool children with congenital ectopia lentis

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 66-72页

作者： yan-Qiao Huang qian-Zhong Cao Yi-Yao Wang Yi-Jing Zhou Dan-Ying Zheng State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

AIM:To evaluate the effect of lens surgery on health-related quality of life(HRQoL)of preschool children with congenital ectopia lentis(CEL).METHODS:A prospective self-controlled study was conducted in Zhongshan Ophthalmic *** aged from 5 to 7y whom were diagnosed with CEL and underwent phacoemulsification with scleral-fixated posterior chamber intraocular lens implantation and their parents were enrolled in this *** of them completed the child and proxy(parental)PedsQL™4.0 before and after the *** preoperative scores were compared to their postoperative *** analyses were performed based on gender and preoperative bilateral presenting visual acuity of the ***:Thirty-two children with CEL successfully underwent surgery without any complications,among whom 8 had monocular surgery and 24 had binocular *** and postoperative questionnaires were completed by 32 child-parent *** intervention could significantly improve the vision of affected children(P<0.001).The medians of physical,psychosocial and total health scores self-reported by the children were 68.75(62.50,81.25),65.00(60.00,80.00)and 67.39(60.87,78.26)preoperatively and were 93.75(87.50,100.00),90.00(83.33,96.67)and 89.13(85.32,95.65)*** preoperative scores of the affected children were significantly lower in all scales than age-matched healthy children(P<0.001).All the postoperative scores were significantly higher than the preoperative scores in affected children and their parents(P<0.001).In the physical functioning evaluation,the preoperative score reported by parents of girls was higher than parents of boys(P=0.041),and the postoperative score of girls was higher than that of boys(P=0.036).CONCLUSION:CEL is associated with significantly worse quality of life in preschool *** intervention can significantly improve the HRQoL in affected children from both personal and family perspective.

关键词： congenital ectopia lentis surgical intervention health-related quality of life preschool children

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A lithium–tin fluoride anode enabled by ionic/electronic conductive paths for garnet-based solid-state lithium metal batteries

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Rare Metals 2024年第2期43卷 575-587页

作者： Lei Zhang qian-Kun Meng Xiang-Ping Feng Ming Shen Yu-Qing Zhang Quan-Chao Zhuang Run-Guo Zheng Zhi-Yuan Wang yan-Hua Cui Hong-Yu Sun yan-Guo Liu School of Materials Science and Engineering Northeastern UniversityShenyang110819China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao066004China School of Materials and Physics China University of Mining&TechnologyXuzhou221116China Institute of Electronic Engineering China Academy of Engineering PhysicsMianyang621900China

The high energy density and stability of solid-state lithium metal batteries(SSLMBs)have garnered great ***-type oxides,especially Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO),with high ionic conductivity,wide electrochemical window,and stability to Li metal anode,are promising solid-state electrolyte(SSEs)materials for ***,Li/LLZTO interface issues including high interface resistance,inhomogeneous Li deposition,and Li dendrite growth have hindered the practical application of ***,a multi-functional Li–SnF_(2) composite anode with Li,LiF,and Li-Sn alloy was specifically designed and *** composite anode improves the wettability to LLZTO,constructing an intimate contact interface between it and ***,ionic/electronic conductive paths in situ formed at the interface can effectively uniform Li deposition and suppress Li *** solid-state symmetric cell exhibits low interface resistance(11Ω·cm^(2)) and high critical current density(1.3 mA·cm^(−2))at 25℃.The full SSLMB based on LiFePO_(4) or lini_(0.5)Co_(0.2)Mn_(0.3)O_(2) cathode also shows stable cycling performance and high rate *** work provides a new composite anode strategy for achieving high-energy density and high-safety SSLMBs.

关键词： Solid-state lithium metal batteries(SSLMBs) Lithium-tin fluoride anode Ionic/electronic conductive Interface resistance Lithium dendrite

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Effects of traditional Chinese medicine on treatment outcomes in severe COVID-19 patients:a single-centre study

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Chinese Journal of Natural Medicines 2024年第1期22卷 89-96页

作者： XIAO Yongjiu LI Binbin LIU Chang HUANG Xiuyu MA ling qian Zhirong ZHANG Xiaopeng ZHANG qian LI Dunqing CAI Xiaoqing yan Xiangyong LUO Shuping XIANG Dawei XIAO Kun Emergency Department the 940th Hospital of Jiont Logistics Support Force of Chinese People’s Liberation ArmyLanzhou 730050China Scientific Research Center the Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518000China School of Medicine Nankai universityTianjin 300000China Department of Cardiology the 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyLanzhou 730050China Department of Radiation Oncology Fujian Medical University Union HospitalFuzhou 350000China Department of Traditional Chinese Medicine the 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyLanzhou 730050China Department of Geriatric Diseases the Seventh Medical Center of Chinese PLA General HospitalBeijing 100700China Health and Sport Administration Muskingum UniversityOhioanUSA Laboratory of Vaccine and Antibody Engineering Beijing Institute of BiotechnologyBeijing 100071China Department of Pulmonary and Critical Care Medicine the 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyLanzhou 730050China Center of Pulmonary&Critical Care Medicine Chinese People’s Liberation Army(PLA)General HospitalBeijing 100853China

As the search for effective treatments for COVID-19 continues,the high mortality rate among critically ill patients in Intensive Care Units(ICU)presents a profound *** study explores the potential benefits of traditional Chinese medicine(TCM)as a supplementary treatment for severe COVID-19.A total of 110 critically ill COVID-19 patients at the Intensive Care Unit(ICU)of Vulcan Hill Hospital between Feb.,2020,and April,2020(Wuhan,China)participated in this observational *** patients received standard supportive care protocols,with a subset of 81 also receiving TCM as an adjunct *** characteristics during the treatment period and the clinical outcome of each patient were closely monitored and *** findings indicated that the TCM group exhibited a significantly lower mortality rate compared with the non-TCM group(16 of 81 vs 24 of 29;0.3 vs 2.3 person/month).In the adjusted Cox proportional hazards models,TCM treatment was associated with improved survival odds(P<0.001).Furthermore,the analysis also revealed that TCM treatment could partially mitigate inflammatory responses,as evidenced by the reduced levels of proinflammatory cytokines,and contribute to the recovery of multiple organic functions,thereby potentially increasing the survival rate of critically ill COVID-19 patients.

关键词： COVID-19 Pneumonia Novel coronavirus Critically ill Traditional Chinese medicine Clinical outcome

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Enhancing photoresponsiveness of metal-organic polyhedra by modifying microenvironment

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Nano Research 2024年第6期17卷 5712-5717页

作者： Long Zheng Peng Tan qian Song Sheng-Tao Wang Min Li Xiao-Qin Liu lin-Bing Sun State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China

Photoresponsiveness of materials is critical to their tunability and efficiency in terminal *** metal-organic polyhedra(PMOPs)feature intrinsic pores and remote controllability,but aggregation of PMOPs in solid state hampers their photoresponsiveness ***,we report the construction of a new PMOP(Cu_(24)(C_(16)H_(12)N_(2)O_(4))_(12)(C_(18)H_(22)O_(5))12,denoted as MOP-PR-LA),where long alkyl(LA)chains act as the intermolecular poles,propping against adjacent PMOP molecules to create individual microenvironment benefiting the isomerization of photoresponsive(PR)*** ultraviolet(UV)-and visible-light irradiation,MOP-PR-LA is much easier to isomerize than the counterpart MOP-PR without *** propylene adsorption,MOP-PR has a low change of adsorption capacity(9.9%),while that of MOP-PR-LA reaches 58.6%.Density functional theory calculations revealed that PR in the cis state has a negative effect on adsorption,while the trans state of PR favors *** work might open an avenue for the construction of photoresponsive materials with high responsiveness and controllability.

关键词： photoresponsive adsorption metal-organic polyhedra azobenzene long alkyl chains propylene capture

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Study on the Mechanism of Glutamine Promoting the Synthesis of Colonic Mucin and Maintaining the Stability of Intestinal Microbiota in Septic Mice

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Food Science and Human Wellness 2024年

作者： yanyan Pan Gang yang Dan Wu yan Wei Shijun Fan lin Xia qian Chen qianying Huang Yongling Lu Xi Peng Clinical Medical Research Center Southwest Hospital Third Military Medical University (Army Medical University) Burn Department Ningbo No.2 Hospital nstitute of Burn Research State Key Laboratory of Trauma and Chemical Poisoning Southwest Hospital Third Military Medical University (Army Medical University)

Colonic mucus and gut microbiota closely linked through mutual regulatory effect. While their alterations during sepsis and whether glutamine can maintain the colonic mucus barrier and gut microbiota stability are unclear. Cecal ligation and puncture-induced sepsis in mice was utilized to observe changes in colonic mucus， gut microbiota， and their interaction with glutamine intervention. Our findings indicated that glutamine mitigated sepsis-induced intestinal damage and restores colonic mucus barrier function by augmenting mucin synthesis. Further analysis revealed that goblet cells were under oxidative stress after sepsis， resulting in anterior gradient-2 (AGR2)， the key mucin-modifying enzyme， being dissynthesized， and inhibiting mucin2 (MUC2) maturation. glutamine could ameliorates this situation by promoting the key enzyme glucose-6-phosphate dehydrogenase (G6PD) glycosylation in the pentose phosphate pathway， increasing the reduced nicotinamide adenine dinucleotide phosphate (NADPH) synthesis， reducing endoplasmic reticulum stress， and accelerating AGR2 synthesis and MUC2 maturation. Additionally， glutamine aided in maintaining gut microbiota stability during sepsis， up-regulating mucin-associated bacteria such as Akkermansia and Alistipes. These bacteria， intimately linked to mucin synthesis and degradation， may impact intestinal mucus stability. In conclusion， glutamine can maintain goblet cell redox balance， promotes AGR2 synthesis and MUC2 maturation， shields the mucus barrier， and potentially maintains gut microbiota stability by regulating the interaction between bacteria and mucus， thus alleviating sepsis-induced intestinal damage.

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Sporadic gastrinoma with refractory benign esophageal stricture:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1284-1289页

作者： qian-Nan Chen Bing-Qing Bai yan Xu Qiao Mei Xiao-Chang Liu Department of Gastroenterology First Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina

BACKGROUND Gastrinoma is characterized by an excessive release of gastrin,leading to hypersecretion of gastric acid,subsequently resulting in recurrent peptic ulcers,chronic diarrhea,and even esophageal *** case report aims to improve awareness and facilitate early diagnosis and treatment of gastrinoma by presenting a rare case of gastrinoma with refractory benign esophageal stricture(RBES).Additionally,it highlights the persistent challenges that gastroenterologists encounter in managing *** SUMMARY This case demonstrates a patient with gastrinoma who developed RBES and complete esophageal obstruction despite management with maximal acid suppressive therapy,multiple endoscopic bougie dilations and endoscopic incisional therapy(EIT).CONCLUSION It is essential to diagnose gastrinoma as early as possible,as inadequately controlled acid secretion over an extended period increases the risk of developing severe esophageal *** patients with esophageal strictures causing complete luminal obstruction,blind reopening EIT presents challenges and carries a high risk of perforation.

关键词： Gastrinoma Zollinger-Ellison syndrome Neuroendocrine neoplasm Chronic diarrhea Refractory benign esophageal stricture Case report

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A stepwise-responsive editor integrated with three copper ions for the treatment of oral squamous cell carcinoma

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Nano Research 2024年第6期17卷 5424-5434页

作者： Jinna Ren Jingying Hu Fan Dong yan Xu yang Peng Yuping qian Guanmeng Zhang Min Wang Yuguang Wang Department of Prosthodontics Hospital of StomatologyJilin UniversityChangchun 130021China Department of General Dentistry II Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Center of Digital Dentistry Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Department of Nursing Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China The VIP Department School and Hospital of StomatologyChina Medical UniversityLiaoning Provincial Key Laboratory of Oral DiseasesShenyang 110002China

Cuprotosis,a new type of cell death,provides great opportunities for the treatment of oral squamous cell carcinoma,as nanocarriers of copper ions can induce cuprotosis and immunogenic ***,we studied an editor that enables production of a nanoparticle“storm”in oral squamous cell carcinoma,maximizing the toxic effect of these particles and reprogramming the tumor microenvironment;as a result,T cells and natural killer(NK)cells can infiltrate the tumor microenvironment to activate an antitumor immune *** this basis,the editor can be combined with optical therapy to improve patient *** this study,the metal ratio was regulated in response to the nanocarrier of acid response ***,in the presence of a specific copper ion content,the nanocarrier could change the permeability of the tumor cell *** on these results,the nanoparticles were cracked in an acidic environment and then released copper ***,the nanoparticles contributed to cuprotosis and immunogenic *** addition,the editor could inhibit murine oral cancer 1(MOC1)tumors in C57BL/6 without *** rate of tumor growth inhibition was as high as approximately 80%.This strategy provides a new idea for ***,it can improve the interaction between immunotherapy and the copper-induced death of oral squamous cell *** all,this study will provide a new opportunity for the effective treatment of oral squamous cell carcinoma.

关键词： cuprotosis immunogenic death photothermal therapy tumor microenvironment immunotherapy

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