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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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窄带通信中基于Jordan标准型矩阵的喷泉码研究

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无线电通信技术 2017年第1期43卷 19-22页

作者：时琳川徐松毅杜文举中国电子科技集团公司第五十四研究所中国人民解放军69270部队

针对在窄带通信系统中应用分组级喷泉码技术面临分组数量很少导致译码失败率高的问题,提出采用类Jordan标准型编码图案的编译码算法,推导了改进算法的理论译码成功率,给出了分组长度的最佳取值范围。分析比较了在窄带通信系统中应用传统... 详细信息

针对在窄带通信系统中应用分组级喷泉码技术面临分组数量很少导致译码失败率高的问题,提出采用类Jordan标准型编码图案的编译码算法,推导了改进算法的理论译码成功率,给出了分组长度的最佳取值范围。分析比较了在窄带通信系统中应用传统ARQ机制与分组级喷泉码机制时的时延性能以及信道利用率,仿真结果证明应用分组级喷泉码机制可以提升窄带通信系统的性能。

关键词：喷泉码 ARQ Jordan标准型窄带通信

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Joint Communication-Caching-Computing Resource Allocation for Bidirectional Data Computation in IRS-Assisted Hybrid UAV-Terrestrial Network

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Chinese Journal of Electronics 2024年第4期33卷 1093-1103页

作者： Yangzhe LIAO lin LIU Yuanyan song Ning xu School of Information Engineering Wuhan University of Technology

Joint communication-caching-computing resource allocation in wireless inland waterway communications enables resource-constrained unmanned surface vehicles(USVs) to provision computation-intensive and latencysensitive tasks forward beyond fifth-generation(B5G) and sixth-generation(6G) era. The power of such resource allocation cannot be fully studied unless bidirectional data computation is properly managed. A novel intelligent reflecting surface(IRS)-assisted hybrid UAV-terrestrial network architecture is proposed with bidirectional tasks. The sum of uplink and downlink bandwidth minimization problem is formulated by jointly considering link quality, task execution mode selection, UAVs trajectory, and task execution latency constraints. A heuristic algorithm is proposed to solve the formulated challenging problem. We divide the original challenging problem into two subproblems, i.e., the joint optimization problem of USVs offloading decision, caching decision and task execution mode selection, and the joint optimization problem of UAVs trajectory and IRS phase shift-vector design. The Karush–Kuhn–Tucker conditions are utilized to solve the first subproblem and the enhanced differential evolution algorithm is proposed to solve the latter one. The results show that the proposed solution can significantly decrease bandwidth consumption in comparison with the selected advanced algorithms. The results also prove that the sum of bandwidth can be remarkably decreased by implementing a higher number of IRS elements.

关键词： Wireless communication Heuristic algorithms Bandwidth Network architecture Downlink Trajectory Resource management

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Effect of Y:Zn ratio on microstructure and emission of Er^(3+)/Yb^(3+) codoped Y_(2)O_(3)-ZnO ceramic phosphors

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Journal of Rare Earths 2023年第12期41卷 1883-1894,I0003页

作者： Boxu xu Chao song Jie song Rui Huang Shaomin lin Zhenxu lin Yi Zhang Dejian Hou Jun song School of Materials Science and Engineering Hanshan Normal UniversityChaozhou521041China Key Laboratory of Optoelectronic Devices and Systemsof MinistryofEducation and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhen518060China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan430070China

In this study,Er^(3+)/Yb^(3+)codoped Y_(2)O_(3)-ZnO ceramic phosphors were prepared by sol-gel *** samples had two emission bands,namely,green(535 nm) and red(660 nm),which are attributed to Er^(3+):^(2)H_(11/2)(^(4)S_(3/2))→^(4)I_(15/2)and Er^(3+):^(4)F_(9/2)→^(4)I_(15/2)radiative transitions,*** samples exhibited green-and red-emission intensity enhancement by 1.728 and 2.286 times that of the pure Y2O3host,respectively and by 514.468 and 214.341 times that of the pure ZnO *** emission intensities are first enhanced by lattice *** the change of Y:Zn ratio,the high surface energy is converted into low crystal surface resulting in the change of asymmetry crystal field for *** the intensity of the asymmetric crystal field reaches maximum,both emissions are further *** the high surface energy transforms into crystal surface energy,the microstructure changes into a compact mesoporous ***,the chemical stability of the samples improves significantly,and the final emission band of the three samples with mesoporous structures is continuously red.

关键词： Mesoporous Y_(2)0_(3) Zno Luminescence Rare earths Ceramic phosphors

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Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao Juan-Han Yu Yi-Hua Wang Yi-Xin Liu Lu xu lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

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Performance comparison of aero-ramp and transverse injector based on gas-pilot flame

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航空动力学报 2014年第2期29卷 405-419页

作者： song Gang-lin ZHANG Yan WEI Bao-xi TIAN Liang xu xu School of Astronautics Beijing University of Aeronautics and Astronautics Xichang Satellite Launch Center Chinese People's Liberation Amry General Armament Department Department of Civil Engineering Nanyang Institute of Technology

A direct performance comparison between the four-hole aero-ramp injector and single transverse injector in a dual-mode scramjet combustor was *** mixing characteristics of two injectors were calculated by solving the three-dimensional(3-D)compressible Reynolds-averaged Navier-Stokes equations(RANS),with the help of the shear-stress-transport(SST)k-ωturbulence *** numerical results show that the far field mixing efficiency of the aero-ramp injector is higher than that of the single transverse *** enthalpy vitiated air was heated to a total temperature of 1 200Kby hydrogen-oxygen combustion, entering the isolator entrance at a Mach number of ***-reacting experimental conditions involved sonic injection of nitrogen to safely simulate ethylene injected into the combustor at a jet-to-free stream momentum flux ratio of *** photographs were obtained to analyze the shock structure around the *** test conditions involved sonic injection of ethylene at the jet-to-free stream momentum flux ratios ranging from 0.5to *** speed camera was used to capture the flame structures in the near-field combustion. The experimental results show that the aero-ramp injector produce sustained combustion over a wider range of fuel-air ratios than the single transverse *** the identical jet-to-free stream momentum flux ratio,the aero-ramp has a larger isolator margin than the single transverse injector,demonstrating a better ability for avoiding ***,the air specific impulse and total temperature recovery of two injectors,which are calculated by the one-dimensional(1-D)performance analysis code,are almost identical.

关键词： dual-mode scramjet aero-ramp injector transverse injector gas-pilot flame mixing and combustion performance

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Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期 233-240页

作者： Peipei Liu Yantong Li Meng-Xiang Wu Hao Kang Xiao-Li Zhao lin xu linlin Liu Xiaodong Li Junfeng Fang Zhiwei Fang Ya Cheng Hai-Bo Yang Huakang Yu xueliang Shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

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Theoretical analysis of a method for segmented heat exchanger design

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Chinese Science Bulletin 2011年第20期56卷 2179-2184页

作者： song JiWei xu MingTian CHENG lin Institute of Thermal Science and Technology Shandong UniversityJinan 250061China

In the process of the design of heat exchangers,it is difficult to establish the factors governing the optimal points of the design objective functions due to the contradictions and uncertainties of the design *** variation of fluid properties is one of the main factors causing this type of *** design methods have not completely solved these *** the present work,based on the logarithmic mean temperature difference,a new heat exchanger design method(called the segmented design method) is proposed which takes into account the variation of fluid properties with respect to the *** this method,the whole heat exchanger is first divided into several *** by applying the principle of the conservation of energy and taking into account the initial conditions as well as the connecting conditions of the adjacent segments,the inlet and outlet temperatures of each segment are ***,the application of the logarithmic mean temperature difference method on each segment defines the heat transfer area.

关键词：设计方法换热器分段式对数平均温差不确定性流体性质出口温度应用程序

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Analysis and case study on multi-dimensional scalability of the Internet architecture

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Science in China(Series F) 2008年第11期51卷 1661-1680页

作者： xu Ke xu MingWei LI Qi lin song Department of Computer Science and Technology Tsinghua University Beijing 100084 China

This paper presents the definition of multi-dimensional scalability of the Internet architecture, and puts forward a mathematical method to evaluate Internet scalability based on a variety of constraints. Then, the method is employed to study the Internet scalability problem in performance, scale and service scalability. Based on the examples, theoretical analysis and experimental simulation are conducted to address the scalability issue. The results show that the proposed definition and evaluation method of multi-dimensional Internet scalability can effectively evaluate the scalability of the Internet in every aspect, thus providing rational suggestions and methods for evaluation of the next generation Internet architecture.

关键词： Internet architecture scalability performance scalability scale scalability service scalability

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E2E-MFERC:AMulti-Face Expression Recognition Model for Group Emotion Assessment

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Computers, Materials & Continua 2024年第4期79卷 1105-1135页

作者： lin Wang Juan Zhao Hu song Xiaolong xu Jiangsu Key Laboratory of Big Data Security&Intelligent Processing Nanjing University of Posts and TelecommunicationsNanjing210042China School of Network Security Jinling Institute of TechnologyNanjing211169China State Grid Jiangsu Electric Power Company Limited Nanjing210000China School of Computer Science Nanjing University of Posts and TelecommunicationsNanjing210042China

In smart classrooms, conducting multi-face expression recognition based on existing hardware devices to assessstudents’ group emotions can provide educators with more comprehensive and intuitive classroom effect analysis,thereby continuouslypromotingthe improvementof teaching ***,most existingmulti-face expressionrecognition methods adopt a multi-stage approach, with an overall complex process, poor real-time performance,and insufficient generalization ability. In addition, the existing facial expression datasets are mostly single faceimages, which are of low quality and lack specificity, also restricting the development of this research. This paperaims to propose an end-to-end high-performance multi-face expression recognition algorithm model suitable forsmart classrooms, construct a high-quality multi-face expression dataset to support algorithm research, and applythe model to group emotion assessment to expand its application value. To this end, we propose an end-to-endmulti-face expression recognition algorithm model for smart classrooms (E2E-MFERC). In order to provide highqualityand highly targeted data support for model research, we constructed a multi-face expression dataset inreal classrooms (MFED), containing 2,385 images and a total of 18,712 expression labels, collected from smartclassrooms. In constructing E2E-MFERC, by introducing Re-parameterization visual geometry group (RepVGG)block and symmetric positive definite convolution (SPD-Conv) modules to enhance representational capability;combined with the cross stage partial network fusion module optimized by attention mechanism (C2f_Attention),it strengthens the ability to extract key information;adopts asymptotic feature pyramid network (AFPN) featurefusion tailored to classroomscenes and optimizes the head prediction output size;achieves high-performance endto-end multi-face expression detection. Finally, we apply the model to smart classroom group emotion assessmentand provide design refe

关键词： Multi-face expression recognition smart classroom end-to-end detection group emotion assessment

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