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Food Science and Human Wellness 2024年

作者： Lu Zhang Chun-yan Peng Wen-na Zhou Fei-yan Lu lin-ju xu Qing-hui Wen Xing Xie Zong-cai Tu National R&D Center of Freshwater Fish Processing， College of Life Science， Jiangxi Normal University State Key Laboratory of Food Science and Resources， Nanchang University

Effect of ellagitannins gut microbiota metabolites ellagic acid (EA) and urolithin A-urolithin D (UroA-UroD) on human serum albumin (HSA) glycation were firstly evaluated in this research. The inhibition mechanisms were investigated by methylglyoxal (MGO) trapping and radical scavenging ability assays， docking studies and Nano LC-Orbitrap-MS/MS technology. Results indicated that the inhibition of urolithins on HSA glycation was highly positive correlated with the number of phenolic hydroxy groups. Addition of UroD and EA could effectively enhance the content of free amino group， suppress dicarbonyl compounds and advanced glycation end-products (AGEs) formation， alleviated tryptophan and protein oxidation， inhibited HSA amyloid-like aggregation. They could also trap MGO and scavenge DPPH· and ABTS·+. Molecular docking indicated that EA and UroA-UroD interact with HSA mainly through hydrogen bound and hydrophobic interaction， among which two or three hydrogen bonds were formed. The number of glycation sites were reduced from 11 to 10， 10， 7， and 10， respectively， when 90 μmol/L of EA， UroA， UroC and UroD were added. However， weak inhibition was observed on UroA and UroB. These findings can provide scientific evidence for the application of ellagitannins-rich foods in alleviating diabetic complications.

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Chemoselective labeling-based spermatozoa glycan imaging reveals abnormal glycosylation in oligoasthenotspermia

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Chinese Chemical Letters 2024年第4期35卷 475-480页

作者： Lijia xu Tong Zhong Wei Zhao Bing Yao lin Ding Huangxian ju State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Department of Reproductive Medical Center Jinling HospitalSchool of MedicineNanjing UniversityNanjing 210002China Chemistry and Biomedicine Innovation Center(ChemBIC) Nanjing UniversityNanjing 210023China Center of Clinical Laboratory Science The Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer ResearchNanjing 210009China

Spermatogenesis, maturation, capacitation and fertilization are precisely regulated by glycosylation. However, the relationship between altered glycosylation patterns and the onset and development of reproductive disorders is unclear, mainly limited by the lack of in situ imaging techniques for spermatozoa glycosylation. We developed an efficient and highly specific spermatozoa glycan imaging technique based on the robust chemoselective labeling of sialic acid(Sia) and N-acetyl-D-galactosamine(Gal/GalNAc). We further proposed a “tandem glycan chemoselective labeling” strategy to achieve simultaneous imaging of two types of glycans on spermatozoa. We applied the developed method to the spermatozoa from oligozoospermic patients and diabetic mice and found that these spermatozoa showed higher levels of Sia and Gal/Gal NAc expression than the normal groups. Moreover, spermatozoa from diabetic mice showed a severe decrease in number, viability, and forward motility, suggesting that in vivo glucose metabolism disorders may lead to an elevated level of spermatozoa glycosylation and have a correlation with the development of oligoasthenotspermia. Our work provides a research tool to reveal the relationship between glycosylation modification and spermatozoa quality, and a promising clue for the development of glycan-based reproductive markers.

关键词： Spermatozoa Glycan Chemoselective labeling Oligoasthenotspermia Fluorescence imaging

Highly crystalline Y3Al5O12:Ce3+ phosphor-in-silica glass ceramics for high-power solid-state lighting

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Journal of Rare Earths 2024年第11期42卷 2051-2057页

作者： Shisheng lin Hang lin Hongyi Yang Pengfei Wang Ping Sui ju xu Yao Cheng Yuansheng Wang Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China Xiamen Institute of Rare-earth Materials Haixi InstitutesChinese Academy of Sciences College of Chemistry and Materials Science Fujian Normal University

The pursuit of high-brightness solid-state lighting（SSL） stimulates the development of all-inorganic color converters with high *** is required that the fluorescent material is able to cope with the extreme condition generated from the irradiation of high-power-density excitation *** such,in this work,we developed a new composite color converter,i,e.,Y3Al5O12:Ce3+phosphor-in-silica glass ceramic(YAG:Ce3+PiSGC).Remarkably,the amorphous SiO2matrix spontaneously transforms into tetragonal SiO2crystallites during co-sintering with crystallization fraction reaching up to>90%（almost full ceramization）.The activation energy for crystallization Ecand Avrami index n of amorphous silica oxide are 298.5 kJ/mol and 1.71,indicating the diffusion-controlled glass crystallization *** fabricated prototype high-power phosphor-converted white light-emitting diode（pc-wLED） and phosphor-converted white laser diode（pc-wLD） based on YAG:Ce3+PiSGC show satisfactory photometric/colorimetric *** developed color co nverters have combined merits of environmental protection property,cost-effective manufacturing,good luminescent performance,and easy *** study highlights a new kind of opto-functional composite material and its application as an efficient color converter in high-power solid-state lightings.

关键词： Glass ceramics Laser-driven white light Rare earths White light-emitting diode Y3Al5O12:Ce3+

The symmetric space,strong isotropy irreducibility and equigeodesic properties

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Science China Mathematics 2024年第1期67卷 129-148页

作者： Ming xu ju Tan School of Mathematical Sciences Capital Normal UniversityBeijing 100048China School of Microelectronics and Data Science Anhui University of TechnologyMa'anshan 243032China

A smooth curve on a homogeneous manifold G/H is called a Riemannian equigeodesic if it is a homogeneous geodesic for any G-invariant Riemannian *** homogeneous manifold G/H is called Riemannian equigeodesic,if for any x∈G/H and any nonzero y∈Tx(G/H),there exists a Riemannian equigeodesic c(t) with c(0)=x and ■(0)=*** two notions can be naturally transferred to the Finsler setting,which provides the definitions for Finsler equigeodesics and Finsler equigeodesic *** prove two classification theorems for Riemannian equigeodesic spaces and Finsler equigeodesic spaces,***,a homogeneous manifold G/H with a connected simply connected quasi compact G and a connected H is Riemannian equigeodesic if and only if it can be decomposed as a product of Euclidean factors and compact strongly isotropy irreducible ***,a homogeneous manifold G/H with a compact semisimple G is Finsler equigeodesic if and only if it can be locally decomposed as a product,in which each factor is Spin(7)/G2,G2/SU (3) or a symmetric space of compact *** results imply that the symmetric space and the strongly isotropy irreducible space of compact type can be interpreted by equigeodesic *** an application,we classify the homogeneous manifold G/H with a compact semisimple G such that all the G-invariant Finsler metrics on G/H are *** suggests a new project in homogeneous Finsler geometry,i.e.,to systematically study the homogeneous manifold G/H on which all the G-invariant Finsler metrics satisfy a certain geometric property.

关键词： equigeodesic equigeodesic space flag manifold orbit type stratification symmetric space strongly isotropy irreducible space

Durable Ru Nanocrystal with HfO_(2)Modification for Acidic Overall Water Splitting

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Nano-Micro Letters 2024年第9期16卷 462-477页

作者： Xiangkai Kong Jie xu Zhicheng ju Changle Chen School of Materials and Physics China University of Mining and TechnologyXuzhou 221116JiangsuPeople’s Republic of China Anhui Province Key Laboratory of Pollutant Sensitive Materials and Environmental Remediation Huaibei Normal UniversityHuaibei 235000AnhuiPeople’s Republic of China School of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230026AnhuiPeople’s Republic of China School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210023JiangsuPeople’s Republic of China

Durable and efficient bi-functional catalyst,that is capable of both oxygen evolution reaction and hydrogen evolution reaction under acidic condition,are highly desired for the commercialization of proton exchange membrane water ***,we report a robust L-Ru/HfO_(2)heterostructure constructed via confining crystalline Ru nanodomains by HfO_(2)*** assembled with a proton exchange membrane,the bi-functional L-Ru/HfO_(2)catalyst-based electrolyzer presents a voltage of 1.57 and 1.67 V to reach 100 and 300 mA cm^(-2)current density,prevailing most of previously reported Ru-based materials as well as commercial Pt/C||RuO_(2)*** is revealed that the synergistic effect of HfO_(2)modification and small crystalline domain formation significantly alleviates the over-oxidation of *** importantly,this synergistic effect facilitates a dual-site oxide path during the oxygen evolution procedure via optimization of the binding configurations of oxygenated *** a result,the Ru active sites maintain the metallic state along with reduced energy barrier for the rate-determining step(^(*)O→^(*)OOH).Both of water adsorption and dissociation(Volmer step)are strengthened,while a moderate hydrogen binding is achieved to accelerate the hydrogen desorption procedure(Tafel step).Consequently,the activity and stability of acidic overall water splitting are simultaneously enhanced.

关键词： Ruthenium Hafnium dioxide Oxygen evolution catalysis Anti-oxidation

Distributed dynamic task allocation for unmanned aerial vehicle swarm systems:A networked evolutionary game-theoretic approach

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Chinese Journal of Aeronautics 2024年第6期37卷 182-204页

作者： Zhe ZHANG ju JIANG Haiyan xu Wen-An ZHANG College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China College of Economics and Management Nanjing University of Aeronautics and AstronauticsNanjing 211106China College of Information Engineering Zhejiang University of TechnologyHangzhou 310023China

Task allocation is a key aspect of Unmanned Aerial Vehicle(UAV)swarm collaborative *** an continuous increase of UAVs’scale and the complexity and uncertainty of tasks,existing methods have poor performance in computing efficiency,robustness,and realtime allocation,and there is a lack of theoretical analysis on the convergence and optimality of the *** paper presents a novel intelligent framework for distributed decision-making based on the evolutionary game theory to address task allocation for a UAV swarm system in uncertain scenarios.A task allocation model is designed with the local utility of an individual and the global utility of the ***,the paper analytically derives a potential function in the networked evolutionary potential game and proves that the optimal solution of the task allocation problem is a pure strategy Nash equilibrium of a finite strategy ***,a PayOff-based Time-Variant Log-linear Learning Algorithm(POTVLLA)is proposed,which includes a novel learning strategy based on payoffs for an individual and a time-dependent Boltzmann *** former aims to reduce the system’s computational burden and enhance the individual’s effectiveness,while the latter can ensure that the POTVLLA converges to the optimal Nash equilibrium with a probability of *** simulation results show that the approach is optimal,robust,scalable,and fast adaptable to environmental changes,even in some realistic situations where some UAVs or tasks are likely to be lost and increased,further validating the effectiveness and superiority of the proposed framework and algorithm.

关键词： Task allocation Unmanned Aerial Vehicles(UAV) Game theory Log-linear learning Distributed optimization algorithm

Paleoclimatic application of spectral parameters to the eolian red clay of the Jianzha Basin,northeastern margin of the Tibetan Plateau

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Science China Earth Sciences 2024年第6期67卷 1952-1966页

作者： Chaofeng FU ju’e TIAN Xinwen xu Yougui SONG jun ZUO Feng WANG lin CHEN Pengfei LI Xiaoke QIANG The School of Earth Science and Resources Chang’an UniversityXi’an 710054China State Key Laboratory of Loess and Quaternary Geology Institute of Earth and EnvironmentCASXi’an 710061China College of Urban and Environmental Science Northwest UniversityXi’an 710069China CAS Center for Excellence in Quaternary Science and Global Change Xi’an 710061China

Reflectance spectroscopy is rapid,inexpensive,and non-destructive and can provide important information about the mineralogy of rocks and *** measured the reflectance spectroscopy of Miocene red clay deposits on the northeastern margin of the Tibetan Plateau,with the aim of developing a rapid methodology for detecting paleoclimatic *** obtained visible/near-infrared(VNIR)and short-wave infrared(SWIR)spectroscopy data from the red clay in the Jianzha Basin,and analyzed their relationship with independent paleoclimatic records,including mineral contents and environmental magnetic *** results show that the VNIR parameters,including D500,D900,R500,and R900(where D and R represent the depth and reflectance of the absorption peaks around 500 and 900 nm,respectively)are temperature-sensitive and correlated with the magnetic susceptibility,frequency-dependent magnetic susceptibility,and the marine δ^(18)O *** results of frequency-domain analysis of the VNIR parameters show that they reflect climate change on orbital *** parameters,such as AS1400,D1400/D1900 and D1900(where AS represents the asymmetry of the absorption peaks around1400 nm),are correlated with the illite and montmorillonite content,and they are sensitive to the weathering *** spectral parameters of the eolian red clay in the Jianzha Basin reflect regional climatic changes caused by the uplift of the Tibetan Plateau at~8.5 Ma and global climatic cooling at~7.2 Ma,and thus they are applicable as both regional and global paleoenvironmental indicators.

关键词： Visible/near-infrared spectroscopy Short-wave infrared spectroscopy Paleoclimatic indicators Red clay Tibetan Plateau

Numerical simulation on directional solidification and heat treatment processes of turbine blades

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China Foundry 2024年第5期21卷 476-490页

作者： Ye-yuan Hu ju-huai Ma Qing-yan xu School of Materials Science and Engineering Tsinghua UniversityKey Laboratory for Advanced Materials Processing TechnologyMinistry of EducationBeijing 100084China

Study on turbine blades is crucial due to their critical role in ensuring the efficient and reliable operation of aircraft ***-based single crystal superalloys are extensively used in the hot manufacturing of turbine blades due to their exceptional high-temperature mechanical *** hot manufacturing of single crystal blades involves directional solidification and heat *** manufacturing of these blades is time-consuming,capital-intensive,and often insufficient to meet industrial *** simulation techniques have gained widespread acceptance in blade manufacturing research due to their low energy consumption,high efficiency,and rapid turnaround *** article introduces the modeling and simulation of hot manufacturing in single crystal *** discussion outlines the prevalent mathematical models employed in numerical simulations related to blade hot *** encapsulates the advancements in research concerning macro to micro-level numerical simulation techniques for directional solidification and heat treatment ***,potential future trajectories for the numerical simulation of single crystal blade hot manufacturing are also discussed.

关键词： single crystal blades Ni-based superalloy directional solidification heat treatment numerical simulation

Boundary Behaviors for a Continuous-state Nonlinear Neveu’s Branching Process

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Acta Mathematica Sinica,English Series 2024年第8期40卷 2005-2016页

作者： lin Yu BAI xu YANG School of Mathematics and Information Science North Minzu UniversityYinchuan 750021P.R.China

By generalizing a criterion of Mufa Chen for Markov jump processes,we establish the necessary and sufficient conditions for the extinction,explosion and coming down from infinity of a continuous-state nonlinear Neveu... 详细信息

关键词： Continuous-state branching process nonlinear branching Neveu’s branching extinction explosion coming down from infinity

Towards a hybrid model-driven platform based on flux balance analysis and a machine learning pipeline for biosystem design

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Synthetic and Systems Biotechnology 2024年第1期9卷 33-42页

作者： Debiao Wu Feng xu Yaying xu Mingzhi Huang Zhimin Li ju Chu State Key Laboratory of Bioreactor Engineering East China University of Science and Technology130 Meilong RoadShanghai200237People’s Republic of China

Metabolic modeling and machine learning(ML)are crucial components of the evolving next-generation tools in systems and synthetic biology,aiming to unravel the intricate relationship between genotype,phenotype,and the ***,the comprehensive exploration of integrating these two frameworks,and fully harnessing the potential of fluxomic data,remains an unexplored *** this study,we present,rigorously evaluate,and compare ML-based techniques for data *** hybrid model revealed that the overexpression of six target genes and the knockout of seven target genes contribute to enhanced ethanol ***,we investigated the influence of succinate dehydrogenase(SDH)on ethanol biosynthesis in Saccharomyces cerevisiae through shake flask *** findings indicate a noticeable increase in ethanol yield,ranging from 6%to 10%,in SDH subunit gene knockout strains compared to the wild-type ***,in pursuit of a high-yielding strain for ethanol production,dual-gene deletion experiments were conducted targeting glycerol-3-phosphate dehydrogenase(GPD)and *** results unequivocally demonstrate significant enhancements in ethanol production for the engineered strains Δsdh4Δgpd1,Δsdh5Δgpd1,Δsdh6Δgpd1,Δsdh4Δgpd2,Δsdh5Δgpd2,and Δsdh6Δgpd2,with improvements of 21.6%,27.9%,and 22.7%,***,the results highlighted that integrating mechanistic flux features substantially improves the prediction of gene knockout strains not accounted for in metabolic *** addition,the finding in this study delivers valuable tools for comprehending and manipulating intricate phenotypes,thereby enhancing prediction accuracy and facilitating deeper insights into mechanistic aspects within the field of synthetic biology.

关键词： Metabolic modeling Machine learning Flux balance analysis Biosystems design Saccharomyces cerevisiae Succinate dehydrogenase