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World Journal of Gastroenterology 2024年第40期30卷 4376-4379页

作者： Gao-lin Wen jing-lin wang Department of Hepatobiliary Surgery The Affiliated Drum Tower Hospital of Nanjing University of Chinese MedicineNanjing 210008Jiangsu ProvinceChina Division of Hepatobiliary and Transplantation Surgery Department of General SurgeryNanjing Drum Tower HospitalNanjing 210008Jiangsu ProvinceChina

Surgical resection is a pivotal therapeutic approach for addressing hepatic space-occupying lesions,with liver volume restoration and hepatic functional recovery being crucial for assessing surgical *** preoperative albumin-bilirubin(ALBI)score,encompassing serum albumin and bilirubin levels,can be determined via blood analysis,effectively mitigating human error and providing an accurate depiction of liver *** hepatectomy ratio,which is the proportion of the liver volume removed to the total liver volume,is critical in preserving an adequate liver tissue volume to ensure postoperative hepatic functional compensation,minimize surgical complications,and reduce mortality *** the preoperative ALBI score and hepatectomy ratio aids surgeons in assessing the optimal timing and extent of partial *** introduction of preoperative albumin bilirubin score and hepatectomy percentage is beneficial for the surgeons to evaluate the timing and magnitude of partial liver resection.

关键词： Liver regeneration Partial hepatectomy Preoperative albumin bilirubin score Hepatectomy percentage

Superior machinability of steel enhanced with BN and MnS particles

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International Journal of Minerals,Metallurgy and Materials 2016年第3期23卷 276-282页

作者： Ya-nan Chen Yan-ping Bao Min wang Xiao-feng Cai lin-jing wang Li-hua Zhao State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083China National Engineering Research Center of Flat Rolling Equipment University of Science and Technology BeijingBeijing 100083China

The strategy that replacing part of MnS with BN was proposed in order to decrease the sulfur content in sulfur based free-cutting steel. The effects of BN and MnS inclusions on the microstructure and machinability of the steel were systematically investigated. The results show that most of the BN and MnS inclusions exist individually in the steel and only a small amount of them are in a composite state form- ing either isolated particles or clusters of particles. In the case of multi-phased steel, the theoretical calculation predicts that the volume of large BN particles should be 0.7 times of the volume of large MnS particles. The machinability of this type of BN and MnS alloy steel over a wide range of cutting speeds ranging from a low speed appropriate for drilling to a high speed appropriate for turning is confirmed as being equal to or superior to that of an MnS reference steel, even though the sulfur content in the composite steel is only half that of the MnS steel. The aptitude for cutting effect of 240 ppm nitrogen and 115 ppm boron in the composite steel is demonstrated to be equivalent or even better than 1000 ppm sulfur in MnS free-cutting steel.

关键词： boron nitride manganese sulfide inclusions machinability free cutting steel

A cluster-plus-glue-atom composition design approach designated for multi-principal element alloys

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Rare Metals 2022年第11期41卷 3839-3849页

作者： Xuan Liu Hui-Bin Ke Liang wang Yao-Jian Liang lin-jing wang Ben-Peng wang Lu wang Qun-Bo Fan Yun-Fei Xue School of Materials Science and Engineering Beijing Institute of TechnologyBeijing100081China Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing100081China

Multi-principal element alloys(MPEAs)have shown extraordinary properties in different ***,the composition design of MPEAs is still challenging due to the complicated interactions among principal elements(PEs),and even more challenging with precipitates *** can be either beneficial or detrimental in alloys,thus it is important to control precipitates formation on purpose during alloy *** this work,cluster-plus-glue-atom model(CGM)composition design method which is usually used to describe short-range order in traditional alloys has been successfully extended to MPEAs for precipitation *** key challenge of extending CGM to MPEAs is the determination of center atom since there are no solvent or solute in *** has found that the element type of center atom was related not only with chemical affinity,but also with atomic volume difference in MPEAs,which has inevitable effect on atomic *** on experimental data of MPEAs with precipitates,it was found that elements with either stronger chemical affinity or larger volume difference with other PEs would occupy the center site of ***,a cluster index(P_(C)),which considers both chemical affinity and atomic volume factors,was proposed to assist the determination of center atom in *** on the approach,a solid-solution Zr-Ti-V-Nb-Al BCC alloy was obtained by inhibiting the precipitation,while precipitation-strengthened Al-Cr-FeNi-V FCC alloy and Al-Co-Cr-Fe-Ni BCC alloy were designed by promoting the *** experimental results demonstrated that the approach could provide a relatively simple and accurate predication of precipitation and the compositions of precipitations were in line with PEs in cluster in *** research may open an effective way for composition design of MPEAs with desired phase structure.

关键词： Multi-principal element alloy(MPEA) Composition design Phase structure Cluster-plus-glue-atom model(CGM)

Selection of Yarrowia lipolytica Strains with High Protein Content from Yeasts Isolated from Different Marine Environments

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Journal of Ocean University of China 2007年第4期6卷 360-364页

作者： CHI Zhenming wang Fang wang lin LI jing wang Xianghong Unesco Chinese Center of Marine Biotechnology Ocean University of China Qingdao 266003 P. R. China

A total of 78 Yarrowia lipolytica yeast strains from seawater, sediments, mud of salterns, the guts of marine fish, and marine algae were obtained. After the crude protein of the yeasts was estimated by the method of Kjehldahl, we found that seven strains of the marine yeasts grown in soy bean cake hydrolysate with 20 g LZ of glucose for 48h at 28~C contained more than 41.0g protein per 100g of cell dry weight and the cell dry weight was more than 4.4g per L of the culture. Among them, strain SWJ-Ib contained the highest crude protein. The results of Biolog identification and molecular methods further confirmed that they indeed belonged to Y lipolytica.

关键词： Y. lipolytica single cell protein biolog molecular identification

FOXO1 Alleviates Liver Ischemia-reperfusion Injury by Regulating the Th17/Treg Ratio through the AKT/Stat3/FOXO1 Pathway

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1138-1147页

作者： Hao-Zhen Ren Sen-Zhe Xia Xue-Qian Qin An-Yin Hu jing-lin wang Department of Hepatobiliary Surgery Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingJi-angsuChina Department of Hepatobiliary Surgery Nanjing Drum Tower Hospital Clinical College of Jiangsu UniversityNanjingJiangsuChina Department of Hepatobiliary Surgery Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingJiangsuChina

Background and Aims:Hepatic ischemic reperfusion in-jury(IRI)occurring during surgery seriously affects patient *** specific mechanism of IRI has not been fully *** study aim was to explore the changes of in-flammatory environment,and the relationship of the Th17/Treg cell ratio and FOXO1 expression in hepatic ***:Liver samples at different ischemic times were collected from patients and *** expression of inflammatory markers and FOXO1 in the liver was detected by western blotting and *** changes of liver lymphocytes were analyzed by flow *** AKT/Stat3/FOXO1 pathway was veri-fied by targeting AKT with *** role of FOXO1 in liver inflammation and changes in lymphocyte phenotype was confirmed by upregulating FOXO1 with ***-sults:Prolonged ischemic time aggravates liver injury in both humans and mouse models of hepatic ***-stress caused Th17/Treg imbalance and FOXO1 down-regulation by activat-ing the AKT/Stat3/FOXO1 signaling *** of FOXO1 reversed the Th17/Treg cytokine imbalance and altered the inflammation environment in the ***:Liver IRI induced Th17/Treg *** of FOXO1 re-versed the imbalance and alleviated liver inflammation.

关键词： Liver ischemia-reperfusion injury Inflammatory factors Th17 Treg AKT/Stat3/FOXO1 pathway

Synthesis of micrometer SrAl_2Si_2O_8:Eu,Dy blue phosphor powders via sol-gel process

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功能材料与器件学报 2008年第1期14卷 197-200页

作者： PAN Wen NING Gui-ling lin Yuan wang jing State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012 China

In this paper,we report on long-persistence white phosphor SrAl2Si2O8:Eu2+,Dy3+ synthesized by the sol-gel *** luminescent materials prepared by the sol-gel method have many advantages,such as uniform composition,high purity,fine grains and low synthesis *** found that SrAl2Si2O8:Eu2+,Dy3+ phosphor prepared by the sol-gel method can provide more luminescent intensity and better afterglow characteristic compared with the same phosphor prepared by solid-state ***,the particle size and shape of phosphors should be optimized to obtain the maximum quantum efficiency through energy *** microstructure of the phosphor consisted of regular fine grains with an average size of about 0.5-1 μ*** 356 nm light excitation,the broadband emission of the phosphor continues from 350 to 650 nm and the emission peak is at about 414 nm,which can be viewed as the typical emission of Eu2+ ascribed to the 4f→5d transitions.

关键词：蓝色磷光粉凝胶-溶胶法合成发光特性铕镝铝硅酸锶

Correlation between elevated FOXP3 expression and increased lymph node metastasis of gastric cancer

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Chinese Medical Journal 2010年第24期123卷 3545-3549页

作者： wang Li-hong SU lin wang jing-tong Department of Gastroenterology Peking University People's Hospital Beijing 100044 China

Background FOXP3 was thought to express in the T-cell lineage exclusively until recently when FOXP3 was shown to be expressed by cancer cells. It was indicated that FOXP3 may play a wider role in biology by endowing tumor cells with immune suppressive activity. However, researches between FOXP3 and lymph node metastasis of gastric cancer were relatively infrequent, so the present work was aimed to investigate the relationship between FOXP3 expression and lymph node metastasis in human gastric *** A total of 122 gastric cancer patients were enrolled in this study, and gastric tumor specimens and lymph nodes were acquired. Thirty patients who had chronic superficial gastritis diagnosed by gastroscopy contemporaneously in the Peking University People＇s Hospital were chosen randomly as the control group. Immunohistochemistry was performed to evaluate FOXP3 expression. A survival analysis on the 122 patients was then performed. Then, NCI-N87cell lines were used to confirm FOXP3 expression in gastric carcinoma cells. Finally, evaluation of FOXP3 expression in gastric tumor and peritumor tissues in 12 patients were conducted using immunohistochemistry and Western blotting. A X2 test or Fisher＇s exact test （bilateral） was conducted to compare the percentage of positive percentage staining between groups. Kaplan-Meier analysis was performed for survival *** FOXP3 was expressed by gastric cancer cells and peritumor epithelial cells. FOXP3 expression was increased in primary tumors （58.2%） than that in control group （26.7%）. In the lymph-node metastasis group, the incidence of lymph node metastasis which was less than 60% had a significant upregulation of FOXP3 in primary tumors and lymph ***, the frequency of FOXP3 expression had no relationship with *** FOXP3 probably has a relationship with lymph node metastasis of gastric cancer.

关键词： FOXP3 protein, human stomach neoplasms neoplasm metastasis prognosis

Acute liver failure:A clinically severe syndrome characterized by intricate mechanisms

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World Journal of Hepatology 2024年第7期16卷 1067-1069页

作者： Ran An jing-lin wang Division of Hepatobiliary and Transplantation Surgery Department of General SurgeryNanjing Drum Tower HospitalNanjing 210008Jiangsu ProvinceChina

Acute liver failure presents as a clinical syndrome characterized by swift deterioration and significant mortality *** underlying mechanisms are intricate,involving intricate interplays between various *** the current scarcity of treatment options,there's a pressing need to diligently uncover the disease's core mechanisms and administer targeted therapies accordingly.

关键词： Acute liver failure Hepatocyte Macrophage Necroptosis Pyroptosis Ferroptosis

High-level expression, purification and characterization of codon-optimized recombinant hemagglutinin 5 proteins in mammalian cells

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Chinese Medical Journal 2010年第8期123卷 1073-1077页

作者： YANG jing-lin wang Hong-liang wang Shun-xin YANG Peng LIU Kang-tai JIANG Cheng-yu National Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100005 China

Background Numerous Asian cases of avian influenza virus infection, especially the highly pathogenic strain H5N1, in humans have raised the concern that another influenza pandemic is close. However, there are no effective therapeutic drugs or preventative vaccines available. Hemagglutinin is the membrane glycoprotein of avian influenza virus responsible for receptor binding to human cells and the main immunogenic protein that elicits a strong immune response. Although this protein is of great importance to the study of pathogenesis and vaccine development, its expression and purification are difficult due to high levels of glycosylation. Methods In this study, we expressed codon-optimized, full-length hemagglutinin 5 （H5） protein fused with a human IgG Fc tag （H5-Fc） in HEK293 cells. To enhance secretion of this protein, we also deleted the transmembrane domain and the intracellular domain of the H5 protein （H5ATM-Fc）. Purified proteins were obtained using a protein A column. Results ELISA revealed that the yield of soluble H5ATM-Fc protein in the supernatant was about 20 mg/L. Western blotting and fluorescence activated cell sorter （FACS） indicated that the purified H5 protein was correctly folded and biologically active. Conclusion Purification of H5 proteins from mammalian cells could be used for large-scale production of recombinant H5 protein for basic scientific research or the development of vaccines.

关键词： hemagglutinin avian influenza protein purification mammalian cell expression

Research progress of acupuncture in the treatment of Parkinson's disease

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TMR Clinical Research 2020年第2期3卷 38-45页

作者： lin-jing wang Jia-Shuai Li Xue wang Ji-Yao Zhang Lu-Wen Zhu The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine Harbin 150001China Heilongjiang University of Chinese Medicine Harbin 150010China

Parkinson's disease(PD)is a common degenerative disease of the central nervous *** basic and clinical research of acupuncture therapy has witnessed several advances in the treatment of *** purpose of this study is to provide some ideas for clinical acupuncture therapy in the treatment of *** authors attempt to achieve this objective by systematically organizing the clinical efficacy studies of several acupuncture therapies for PD and elaborating the mechanisms of action in terms of secretion of substantia nigra dopaminergic neurons,level of oxidative stress,inflammatory response,excitotoxicity,and mitochondrial dysfunction.

关键词： Acupuncture Parkinson's disease Clinical research Mechanism of action Acknowledgments:The