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Efficacy and safety of propofol target-controlled infusion combined with butorphanol for sedated colonoscopy

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World Journal of Clinical Cases 2023年第3期11卷 610-620页

作者： Feng Guo De-Feng Sun Yan Feng lin Yang jing-lin li Zhong-liang Sun Department of Anesthesiology No.967 HospitalJoint Logistics Support Force of Chinese People’s Liberation ArmyDalian 116011Liaoning ProvinceChina Department of Anesthesiology The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina Department of Neuroelectrophysiology The First Affiliated Hospital of Dalian Medical UniversityDalian 11601Liaoning ProvinceChina

BACKGROUND Propofol is a short-acting,rapid-recovering anesthetic widely used in sedated colonoscopy for the early detection,diagnosis and treatment of colon ***,the use of propofol alone may require high doses to achieve the induction of anesthesia in sedated colonoscopy,which has been associated with anesthesia-related adverse events(AEs),including hypoxemia,sinus bradycardia,and ***,propofol co-administrated with other anesthetics has been proposed to reduce the required dose of propofol,enhance the efficacy,and improve the satisfaction of patients receiving colonoscopy under *** To evaluate the efficacy and safety of propofol target-controlled infusion(TCI)in combination with butorphanol for sedation during *** In this controlled clinical trial,a total of 106 patients,who were scheduled for sedated colonoscopy,were prospectively recruited and assigned into three groups to receive different doses of butorphanol before propofol TCI:Low-dose butorphanol group(5μg/kg,group B1),high-dose butorphanol group(10μg/kg,group B2),and control group(normal saline,group C).Anesthesia was achieved by propofol *** primary outcome was the median effective concentration(EC50)of propofol TCI,which was measured using the up-and-down sequential *** secondary outcomes included AEs in perianesthesia and recovery *** The EC50 of propofol for TCI was 3.03μg/mL[95%confidence interval(CI):2.83-3.23μg/mL]in group B2,3.41μg/mL(95%CI:3.20-3.62μg/mL)in group B1,and 4.05μg/mL(95%CI:3.78-4.34μg/mL)in group *** amount of propofol necessary for anesthesia was 132 mg[interquartile range(IQR),125-144.75 mg]in group B2 and 142 mg(IQR,135-154 mg)in group ***,the awakening concentration was 1.1μg/mL(IQR,0.9-1.2μg/mL)in group B2 and 1.2μg/mL(IQR,1.025-1.5μg/mL)in group ***,the propofol TCI plus butorphanol groups(groups B1 and B2)had a lower incidence of anesthesia AEs,when compared to group ***

关键词： Colonoscopy Sedated colonoscopy Propofol Butorphanol Target-controlled infusion Effective concentration Adverse event

Selection of Yarrowia lipolytica Strains with High Protein Content from Yeasts Isolated from Different Marine Environments

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Journal of Ocean University of China 2007年第4期6卷 360-364页

作者： CHI Zhenming WANG Fang WANG lin li jing WANG Xianghong Unesco Chinese Center of Marine Biotechnology Ocean University of China Qingdao 266003 P. R. China

A total of 78 Yarrowia lipolytica yeast strains from seawater, sediments, mud of salterns, the guts of marine fish, and marine algae were obtained. After the crude protein of the yeasts was estimated by the method of Kjehldahl, we found that seven strains of the marine yeasts grown in soy bean cake hydrolysate with 20 g LZ of glucose for 48h at 28~C contained more than 41.0g protein per 100g of cell dry weight and the cell dry weight was more than 4.4g per L of the culture. Among them, strain SWJ-Ib contained the highest crude protein. The results of Biolog identification and molecular methods further confirmed that they indeed belonged to Y lipolytica.

关键词： Y. lipolytica single cell protein biolog molecular identification

Preparation and study of ultrafine flake-aluminum with high reactivity

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Defence Technology（防务技术） 2017年第4期13卷 234-238页

作者： Lei Xiao Jie liu Gazi Hao Xiang Ke Teng Chen Han Gao Yuan-bo Rong Cheng-su Jin jing-lin li Wei Jiang National Special Superfine Particle Engineering Research Center Nanjing University of Science and Technology Research Institute Gansu Yinguang Chemical Industry Group Co. Ltd.

To achieve aluminum particles with ultrafine granularity and high reactivity,the mechanical ball-milling method was adopted and three kinds of coatings,including stearic acid(SA),viton and dinitrotoluene(DNT),were *** effects of milling time and different coatings on granularity and reactivity of ultrafine aluminum particles were *** structures of prepared ultrafine aluminum were characterized by scanning electron microscopy,X-ray particle diffraction and the thermal properties were analyzed by TG/***,the reactivity of prepared ultrafine aluminum particles was comprehensively analyzed and judged according to several thermodynamic parameters,the maximal oxidation rate,the oxidation degree of aluminum and the enthalpy *** results revealed that aluminum particles prepared by the mechanical ball milling method were all flake-like and the particle sizes were below5 mm with nanometer-scale *** the crystal form of aluminum was found to be ***,the ultrafine flake aluminum coated with stearic acid after milling for 5 h showed the highest reactivity with 56.1% of oxidation degree before 660℃,0.945 mg/℃ of maximal oxidation rate and 20491 J/g of enthalpy change.

关键词： Aluminum Flake Surface coating Reactivity Thermal property

Correlation analysis of gene polymorphisms and β-lactam allergy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第7期16卷 632-639页

作者： jing li Xin-yue liU lin-jing li Chong-ge YOU Lei SHI Shang-di ZHANG Qian liU Jun WANG Ze-jing liU Ting-hong LV Centre of Laboratory Medicine Lanzhou University Second Hospital School of Basic Medical Science Lanzhou University

A total of 64 patients with β-lactam allergy and 30 control subjects were enrolled in a case-control study. This study is aimed to analyze the relationship between β-lactam allergy and 10 single nucleotide polymorphisms（SNPs） in interleukin-10（IL-10）, IL-13, IL-4Rα, high-affinity immunoglobulin E-receptor β chain（FcεRIβ）, interferon γ receptor 2（IFNGR2）, and CYP3A4, and within the Han Chinese population of Northwest China. Genotyping for the SNPs was conducted using the Sequenom Mass ARRAY platform. SPSS 17.0 was employed to analyze the statistical data and SHEsis was used to perform the haplotype reconstruction and analyze linkage disequilibrium of SNPs of IL-10 and IL-13. The results showed that the genotype distribution of CYP3A4 rs2242480/CT differed significantly between case and control groups of males（P=0.022; odds ratio（OR）=0.167, 95% confidence interval（CI）： 0.032–0.867）. Further analysis showed that CCA, CCG, and TAA haplotypes of IL-10 had no significant correlation in patients with β-lactam allergy. The correlation between CCT and CAC haplotypes of IL-13 and β-lactam allergy needs to be further studied. The analysis did not reveal any differences in the distribution of others gene polymorphisms between cases and controls.

关键词： Allergy β-Lactam Interleukin(IL) Pharmacogenomics Single nucleotide polymorphism(SNP)

Caspase-dependent retinal ganglion cell apoptosis in the rat model of acute diabetes

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Chinese Medical Journal 2008年第24期121卷 2566-2571页

作者： li Yong-hao ZHUO Ye-hong LU lin CHEN ling-yan HUANG Xin-hua ZHANG jing-lin li Shi-yi WANG Xiang-gui State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou Guangdong 510060 China

Background Neural apoptosis is generally believed to be mediated by two distinct pathways, caspase-dependant and caspase-independent pathways. This study investigated the apoptotic pathways involved in retinal ganglion cells in acute diabetes in rats. Methods Diabetes was induced in male Wistar rats by a peritoneal injection of streptozotocin （STZ）. Expression and localization of caspase-3 and apoptosis-inducing factor （AIF） proteins in the retina of diabetic rats was examined by Western blotting and immunohistochemistry analyses. Terminal transferase dUTP nick end labeling （TUNEL） assay and immunofluorescent staining specific for caspase-3 and AIF were applied to analyze for apoptosis of retinal ganglion cells. In addition, a caspase-3 inhibitor DEVD-CHO was injected intravitreally to further determine the apoptotic pathways of retinal ganglion cells triggered in acute diabetes. Results Two weeks after induction of diabetes, a significant increase in caspase-3 protein expression and localization occurred in the nerve fiber layer, ganglion cell layer, and inner plexiform layer of the retina. Four weeks after the onset of diabetes, the increase in caspase-3 expression was profound eight weeks postinduction of diabetes （P 〈0.05）. Meanwhile, no AIF protein expression was detected in this study. In addition, intravitreal administration of the caspase-3 inhibitor DEVD-CHO reduced apoptosis of retinal ganglion cells by its direct inhibitory action on caspase-3. Conclusion Caspase-dependent apoptotic pathways may be the main stimulant of STZ-induced retinal ganglion cell apoptosis in acute diabetes.

关键词： retinal ganglion cell apoptosis diabetic retinopathy

Designing Electronic Structures of Multiscale Helical Converters for Tailored Ultrabroad Electromagnetic Absorption

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Nano-Micro Letters 2025年第1期17卷 439-455页

作者： Zhaobo Feng Chongbo liu Xin li Guangsheng Luo Naixin Zhai Ruizhe Hu jing lin Jinbin Peng Yuhui Peng Renchao Che Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle School of Environmental and Chemical EngineeringNanchang Hangkong UniversityNanchang 330063People’s Republic of China School of Physics and Materials Nanchang UniversityNanchang 330031People’s Republic of China Key Laboratory of Nondestructive Testing Ministry of EducationNanchang Hangkong UniversityNanchang 330063People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering and TechnologyFudan UniversityShanghai 200438People’s Republic of China

Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)***,the relationship between configuration and electromagnetic(EM)loss mechanism has remained ***,drawing inspiration from the DNA transcription process,we report the successful synthesis of novel in situ Mn/N co-doped helical carbon nanotubes with ultrabroad EMWA *** calculation and EM simulation confirm that the orbital coupling and spin polarization of the Mn–N4–C configuration,along with cross polarization generated by the helical structure,endow the helical converters with enhanced EM *** a result,HMC-8 demonstrates outstanding EMWA performance,achieving a minimum reflection loss of−63.13 dB at an ultralow thickness of 1.29 *** precise tuning of the graphite domain size,HMC-7 achieves an effective absorption bandwidth(EAB)of 6.08 GHz at 2.02 mm ***,constructing macroscale gradient metamaterials enables an ultrabroadband EAB of 12.16 GHz at a thickness of only 5.00 mm,with the maximum radar cross section reduction value reaching 36.4 dB *** innovative approach not only advances the understanding of metal–nonmetal co-doping but also realizes broadband EMWA,thus contributing to the development of EMWA mechanisms and applications.

关键词： Metal-nonmetal co-doping 3d-2p orbital coupling Spin polarization Helical structure Broadband EM wave absorption

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi li Yin Wang Peifeng li Hai Zhu Dong Wang jing li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

Development of Simple Functional Markers for Low Glutelin Content Gene 1 (Lgc1) in Rice (Oryza sativa)

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Rice science 2010年第3期17卷 173-178页

作者： CHEN Tao TIAN Meng-xiang ZHANG Ya-dong ZHU Zhen ZHAO ling ZHAO Qing-yong lin jing ZHOU li-hui WANG Cai-lin Jiangsu High Quality Rice Research and Development Center Institute of Food Crops Jiangsu Academy of Agricultural SciencesNanjing 210014 China＂ #These authors contributed equally to this paper

Rice with low glutelin content is suitable as functional food for patients affected by kidney failure. Low glutelincontent gene Lgc1 in rice has a 3.5-kb deletion between two highly similar glutelin genes GluB4 and GluB5, which locates on the short arm of chromosome 2. To improve the selection efficiency in low glutelin-content rice breeding, two molecular markers designated as InDel-Lgc1-1 and InDel-Lgc1-2 were developed to detect the low glutelin-content gene Lgc1. A double PCR detection indicated that combined use of the two markers could easily distinguish the genotypes of Lgc1 from different rice varieties. Therefore, as a simple and low-cost technique, the molecular marker could be widely used to identify different varieties with Lgc1 gene and applied in marker-assisted selection of low glutelin-content rice.

关键词： Oryza sativa low glutelin-content gene functional marker double polymerase chain reaction

Expression of stromal cell-derived factor-1 in diabetic retinopathy

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Chinese Medical Journal 2010年第8期123卷 984-988页

作者： CHEN ling-yan ZHUO Ye-hong li Yong-hao HUANG Xin-hua ZHANG jing-lin li Shi-yi WANG Xiang-gui Lu lin Center Sun Yat-sen University Guangzhou Guangdong 510060 China

Background Neovascularization can cause vision loss in proliferative diabetic retinopathy （PDR） and may be affected by many factors. Stromal cell-derived factor-1 （SDF-1） is a potent stimulator of angiogenesis. The study was aimed to investigate the expression of SDF-1 and its correlation with vascular endothelial growth factor （VEGF） in the eyes with diabetic retinopathy. Methods The levels of SDF-1 and VEGF were measured by enzyme-linked immunosorbent assay in the vitreous of 41 eyes of 41 patients with PDR and 12 eyes of 12 patients with idiopathic macular hole （IMH）. Vitreous fluid samples and fibrovascular preretinal membranes were obtained at vitrectomy. SDF-1 and VEGF were localized using immunohistochemistry. Results The vitreous concentration of VEGF was significantly higher in eyes with PDR （（2143.7~1685.21） pg/ml） than in eyes with IMH （（142.42~72.83） pg/ml, P 〈0.001）. The vitreous level of SDF-1 was also significantly higher in eyes with PDR （（306.37~134.25） pg/ml） than in eyes with IMH （（86.91~55.05） pg/ml, P 〈0.001）. The concentrations of both VEGF and SDF-1 were higher in eyes with active PDR than in eyes with inactive PDR. Panretinal photocoagulation （PRP） could decrease the SDF-1 levels in the vitreous of PDR patients. The vitreous concentration of SDF-1 correlated with that of VEGF in eyes with PDR （r=0.61, P 〈0.001）. The costaining of SDF-1 and VEGF was confined to the vascular components in preretinal membranes. Conclusions SDF-1 protein is highly expressed in both the vitreous and preretinal membranes of PDR patients; SDF-1 may be correlated with VEGF in angiogenesis in PDR.

关键词： diabetic retinopathy stromal cell-derived factor vascular endothelial growth factor