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Clinical and prognostic significance of CC chemokine receptor type 8 protein expression in gastrointestinal stromal tumors

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World Journal of Gastroenterology 2020年第31期26卷 4656-4668页

作者： huai-Liang Li lin-hua Wang yi-lin hu ying Feng Xiao-Hong Li yi-Fei Liu Peng Li Qin-Sheng Mao Wan-Jiang Xue Department of Gastrointestinal Surgery Nantong University Affiliated HospitalNantong 226001Jiangsu ProvinceChina Department of Intensive Care Unit Nantong University Affiliated HospitalNantong 226001Jiangsu ProvinceChina Department of Surgical Comprehensive Laboratory Nantong University Affiliated HospitalNantong 226001Jiangsu ProvinceChina Department of Pathology Nantong University Affiliated HospitalNantong 226001Jiangsu ProvinceChina

BACKGROUND Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal neoplasms of the gastrointestinal *** resection and tyrosine kinase inhibitors are defined as the main treatments but cannot cure patients with advanced GIST,which eventually develops into recurrence and acquired drug ***,it is necessary to identify prognostic biomarkers and new therapeutic targets for *** chemokine receptor type 8(CCR8)protein participates in regulation of immune *** studies on CCR8 in nonsmall cell lung cancer and colorectal cancer showed that it was highly expressed in tumor-infiltrating regulatory T cells and correlated with a poor *** To detect CCR8 expression in GIST tissues and analyze its relationships with clinicopathological features and prognosis in patients with *** Tissue samples were used for the tissue microarrays *** microarrays were then subjected to immunohistochemical analyses to detect CCR8 ***,Kaplan–Meier analysis was utilized to calculate the survival rate of patients with complete follow-up data,and the potential prognostic value of CCR8 was evaluated by Cox regression ***,a Gene Ontology/Kyoto Encyclopedia of Genes and Genomes single-gene enrichment chart of CCR8 was constructed using the STRING *** CCR8-positive signals were detected as brown or brown-yellow particles by immunohistochemistry located in the *** 125 tissue samples,74 had CCR8 high expression and 51 had low or negative *** analyses suggested CCR8 was significantly correlated with tumor size,mitotic index,AFIP-Miettinen risk classification and tumor ***–Meier and multivariate analyses showed that patients with low or negative CCR8 expression,mitotic index<5/high-power fields(HPF)and tumor diameter<5 cm had a better *** on the STRING database,CCR8 was significantly enriched in biological processes such as tumor im

关键词： Gastrointestinal stromal tumors CC chemokine receptor type 8 Malignant phenotype Prognosis STRING database Immune regulation

Storage of telecom-C-band heralded single photons with orbital-angular-momentum encoding in a crystal

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Science Bulletin 2019年第21期64卷 1577-1583页

作者： yi-lin hu Tian-Shu Yang Zong-Quan Zhou Jian Wang Xiao Liu Zong-Feng Li Pei-Yun Li Yu Ma Chao Liu Peng-Jun Liang Jun hu Xue Li Chuan-Feng Li Guang-Can Guo CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China

A memory-based quantum repeater architecture provides a solution to distribute quantum information to an arbitrary long *** quantum repeaters are likely to be built in optical-fiber networks which take advantage of the low-loss transmission between quantum memory *** quantum memory platforms have characteristic atomic transitions away from the telecommunication band.A nondegenerate photon pair source is therefore useful for connection of a quantum memory to optical ***,we report a high-brightness narrowband photon-pair source which is compatible with a rare-earth-ion-doped crystal Pr^3+:*** photon-pair source is generated through a cavityenhanced spontaneous parametric down-conversion process with the signal photon at 606 nm and the idler photon at 1540 ***,using the telecom C-band idler photons for heralding,we demonstrate the reversible transfer of orbital-angular-momentum qubit between the signal photon and the quantum memory based on Pr3^+:Y2SiO5.

关键词： Quantum repeater Quantum memory Heralded single photons Orbital angular momentum Telecommunication band

Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： yi Qi Xueying Chen Bowen Liu Xuliang lin Xueqing Qiu Yanlin Qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

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处置效应模型设定的稳健性评估

统计研究 2018年第8期35卷 116-128页

作者：马键林建浩胡毅广州大学经济与统计学院中山大学岭南学院中国科学院大学经济与管理学院

对基于非实验数据的处置效应研究,模型设定的稳健性关系到研究的可信性。本文基于子集分割思想,构建模型误设标准误差,即MMSE。特定情形下,本文证明正确设定的模型中MMSE与标准误差之比依概率收敛于0。蒙特卡洛实验表明,分割点选择不影... 详细信息

对基于非实验数据的处置效应研究,模型设定的稳健性关系到研究的可信性。本文基于子集分割思想,构建模型误设标准误差,即MMSE。特定情形下,本文证明正确设定的模型中MMSE与标准误差之比依概率收敛于0。蒙特卡洛实验表明,分割点选择不影响其渐近性质,但影响其有限样本表现,模型误设程度会影响比值的收敛性。将MMSE应用于实际案例分析,发现MMSE可以比较有效地识别有欠稳健的模型。

关键词：处置效应模型设定可信性子集分割

Janus MXene film with gradient structure for highly efficient terahertz and infrared electromagnetic absorption

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Nano Research 2025年第1期18卷 434-442页

作者： Shaodian Yang Weiqiang huang Zhiqiang lin Zibo Chen Rongliang Yang yi Jia Xuebin Liu Rui Wang Zhiping Zeng Yougen hu huanjun Chen Xuchun Gui11 State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510275China National Key Laboratory of Materials for Integrated Circuits Shenzhen Institute of Advanced Electronic MaterialsShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China China Academy of Aerospace Science and Innovation Beijing 100176China Guangdong Province Key Laboratory of Display Material and Technology Guangzhou 510275China School of Materials Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China

Electromagnetic interference (EMI) shielding inhigh-frequency range, especially the rapidly growing terahertz(THz) frequency range, attracts increasing attention due tothe potential application of terahertz in 6G wirelesscommunication, and security inspection. However, traditionalconductive EMI films typically achieve high shieldingeffectiveness through strong reflection, which may causesecondary pollution to other devices. Here, a gradientstructure strategy was proposed to constructTi_(3)C_(2)Tx/hydroxypropyl methyl cellulose (HPMC) film, in whichthe content of Ti_(3)C_(2)Tx gradually increases along the thicknessdirection, resulting in different conductivity of the two surfaces(surface-M and surface-H) for the film. The obtained gradientfilmexhibits an EMI shielding efficiency of over 48.5 dB in theTHz range (0.2-1.6 THz) at a thickness of 40 μm. Especially,as the THz waves incident from the surface-H to the film, the absorption effectiveness reaches 48.2 dB (average absorbedpower loss up to 91.4%), and the reflection effectiveness is only 0.3 dB. In additions, the gradient-film also demonstrates ahigh absorption rate of 95.5% in the infrared band (2.5-16.7 μm). Moreover, the gradient-film exhibits an excellent tensilestress and Young’s modulus value of 173.1 MPa and 2.8 GPa, respectively. Therefore, the gradient-film proposed in thiswork, with excellent electromagnetic absorption in both THz and infrared band, provides a promising candidate for the nextgenerationEMI shielding applications.

关键词： electromagnetic interference shielding Janus film terahertz MXene

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： yi Ji Chaoyi Yang Xuerui Pang yibing Yan Yue Wu Zhi Geng Wenjie hu Panpan hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

STEP标准下的SDAI的模型与应用的研究

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计算机工程 1997年第S1期23卷 295-299页

作者：蔡千兵林翊胡远发复旦大学计算机系上海200433

产品漠型数据交换标准(STEP)规定了产品模型数据的表示、存取方法。该文着重讨论了STEP体系结构背景下的标准数据存取接口(SDAI)的模型定义,它的子模式:字典模式、对话模式、总体模式以及SDAI功能操作的确切含义和进一步实现的方法。提... 详细信息

产品漠型数据交换标准(STEP)规定了产品模型数据的表示、存取方法。该文着重讨论了STEP体系结构背景下的标准数据存取接口(SDAI)的模型定义,它的子模式:字典模式、对话模式、总体模式以及SDAI功能操作的确切含义和进一步实现的方法。提出了服务器端多个Server进程共同完成对数据和模式管理的实现方案。最后,给出一个应用实例供参考。

关键词：产品模型数据交换标准标准数据存取接口字典模式总体模式对话模式

农用聚磷酸铵在土壤中的有效性研究进展及在农业上的应用

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中国土壤与肥料 2018年第3期 1-6页

作者：杨旭张承林胡义熬邓兰生华南农业大学广东广州510642

近年来,农用聚磷酸铵作为一种新型肥料逐渐进入我国化肥领域,常用作高浓度液体复合肥料的基础磷肥。聚磷酸铵pH值近中性,结晶温度低,具有螯合性、缓释性,有着很大发展空间。本文综述了聚磷酸铵在土壤中有效性(溶解性与移动性)的影响因素... 详细信息

近年来,农用聚磷酸铵作为一种新型肥料逐渐进入我国化肥领域,常用作高浓度液体复合肥料的基础磷肥。聚磷酸铵pH值近中性,结晶温度低,具有螯合性、缓释性,有着很大发展空间。本文综述了聚磷酸铵在土壤中有效性(溶解性与移动性)的影响因素,重点分析水解速率、土壤矿物、土壤质地与水分对聚磷酸铵在土壤中的有效性,并分析聚磷酸铵在农业上的应用与发展前景。

关键词：聚磷酸铵土壤有效性农业应用

Dynamically self-adjustable liquid-liquid and self-adaptive softcontact solid-solid triboelectric nanogenerator for wave energy harvesting

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Nano Research 2025年第1期18卷 404-414页

作者： Yong Long Bingqi Zhao Jianan Niu Yuxiu Liu Wei Sha Jiangwen Wang Zhong lin Wang Weiguo hu Guangzhou Institute of Blue Energy Knowledge CityHuangpu DistrictGuangzhou 510555China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China

Water wave energy exhibits great potential toalleviate the global energy crisis. However, harvesting andutilizing wave energy are challenging due to its irregularity,randomness, and low frequency. Triboelectric nanogenerators(TENGs) have gained significant attention for harvesting waveenergy with high efficiency. This study presents a novelellipsoidal, pendulum-like TENG integrating both liquid-liquid(L-L) and solid-solid (S-S) triboelectricity (LS-TENG). Thisinnovative design enables continuous wave energy harvestingand self-powered marine environment monitoring under variousconditions, including temperature, humidity, and light intensity. The binary immiscible liquids within the LS-TENG’s innersoft balloon create dynamic, and self-adjustable L-L contact interfaces, significantly increasing the L-L contact area andenhancing L-L contact electrification (CE). The unique self-adaptive, soft S-S contact increases the S-S contact areacompared to traditional hard point contact, better adapting to the irregular movements of waves and promoting efficient S-SCE. The LS-TENG achieves highly efficient wave energy harvesting by coupling L-L and S-S CE. Furthermore, the uniquesoft contact design protects the S-S interfaces from mechanical wear and damage during long-term work. The LS-TENG’snovel structure provides an innovative and effective way for water wave energy harvesting.

关键词： self-adaptive soft-contact solid-solid liquid-liquid self-adjustable triboelectric nanogenerator